PH17562A - 2-guanidino-4-heteroarylthiazoles and pharmaceutical compositions - Google Patents

2-guanidino-4-heteroarylthiazoles and pharmaceutical compositions

Info

Publication number
PH17562A
PH17562A PH26341A PH26341A PH17562A PH 17562 A PH17562 A PH 17562A PH 26341 A PH26341 A PH 26341A PH 26341 A PH26341 A PH 26341A PH 17562 A PH17562 A PH 17562A
Authority
PH
Philippines
Prior art keywords
heteroarylthiazoles
guanidino
pharmaceutical compositions
pharmaceutical
compositions
Prior art date
Application number
PH26341A
Other languages
English (en)
Inventor
John Lawrence Lamattina
Christopher Andrew Lipinski
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PH17562A publication Critical patent/PH17562A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PH26341A 1980-10-14 1981-10-13 2-guanidino-4-heteroarylthiazoles and pharmaceutical compositions PH17562A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19623180A 1980-10-14 1980-10-14
US06/293,574 US4374843A (en) 1980-10-14 1981-08-20 2-Guanidino-4-heteroarylthiazoles

Publications (1)

Publication Number Publication Date
PH17562A true PH17562A (en) 1984-10-01

Family

ID=26891753

Family Applications (3)

Application Number Title Priority Date Filing Date
PH26341A PH17562A (en) 1980-10-14 1981-10-13 2-guanidino-4-heteroarylthiazoles and pharmaceutical compositions
PH28741A PH17856A (en) 1980-10-14 1983-04-06 Intermediates for 2-guanidino-4-heteroarylthiazoles
PH28740A PH18467A (en) 1980-10-14 1983-04-06 2-guaniding-4-heteroarylthiazoles

Family Applications After (2)

Application Number Title Priority Date Filing Date
PH28741A PH17856A (en) 1980-10-14 1983-04-06 Intermediates for 2-guanidino-4-heteroarylthiazoles
PH28740A PH18467A (en) 1980-10-14 1983-04-06 2-guaniding-4-heteroarylthiazoles

Country Status (28)

Country Link
US (1) US4374843A (fr)
EP (1) EP0050458B1 (fr)
KR (1) KR850001858B1 (fr)
AR (3) AR228674A1 (fr)
AT (1) ATE11048T1 (fr)
AU (2) AU530589B2 (fr)
CA (1) CA1156239A (fr)
CS (1) CS231182B2 (fr)
DD (4) DD207913A5 (fr)
DE (1) DE3168067D1 (fr)
DK (1) DK453181A (fr)
ES (4) ES8301978A1 (fr)
FI (1) FI75821C (fr)
GR (1) GR75098B (fr)
HK (1) HK52387A (fr)
HU (2) HU191895B (fr)
IE (1) IE51642B1 (fr)
IL (1) IL64035A (fr)
KE (1) KE3707A (fr)
MY (1) MY8700512A (fr)
NO (1) NO159654C (fr)
NZ (1) NZ198629A (fr)
PH (3) PH17562A (fr)
PL (3) PL133712B1 (fr)
PT (1) PT73817B (fr)
SG (1) SG23487G (fr)
SU (1) SU1153829A3 (fr)
YU (4) YU42434B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482723A (en) * 1983-04-11 1984-11-13 Pfizer Inc. Process for preparation of 4-acetyl-2-substituted-imidazoles
US4435396A (en) 1982-05-10 1984-03-06 Pfizer Inc. Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
GB2122988B (en) * 1982-06-17 1986-06-11 Toyama Chemical Co Ltd Process for producing 2-(2-aminothiazol-4-yl) glyoxylic acid derivative; intermediates
EP0156644A1 (fr) * 1984-04-02 1985-10-02 Pfizer Inc. Procédé et intermédiaires pour acétyl-4 imidazoles
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4567179A (en) * 1984-10-11 1986-01-28 Pfizer, Inc. Antiinflammatory salts of piroxicam
US4632993A (en) * 1984-10-11 1986-12-30 Pfizer Inc. Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
US4591595A (en) * 1984-10-11 1986-05-27 Pfizer Inc. 2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis
WO1986003203A1 (fr) * 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Derives de thienylthiazole
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
EP0259085B1 (fr) * 1986-08-29 1991-08-21 Pfizer Inc. Guanidino-2 aryl-4 thiazole pour le traitement de l'ulcère peptique
DE3750023T2 (de) * 1986-10-29 1994-09-29 Pfizer, Inc., New York, N.Y. Verfahren zur Herstellung von 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)Thiazol und dessen kristallinisches Dihydrochlorid-Trihydrat.
IL95548A0 (en) * 1989-09-15 1991-06-30 Fujisawa Pharmaceutical Co Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
WO1992016526A1 (fr) * 1991-03-13 1992-10-01 Fujisawa Pharmaceutical Co., Ltd. Derives de thiazole
EP0928793B1 (fr) * 1998-01-02 2002-05-15 F. Hoffmann-La Roche Ag Dérivés de thiazole
AU2006282428A1 (en) * 2005-08-23 2007-03-01 Ube Industries, Ltd. Method for producing 1-substituted-5-acylimidazole compound
US9499533B2 (en) 2012-03-27 2016-11-22 Shionogi & Co., Ltd. Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity
EP4196793A1 (fr) 2020-08-11 2023-06-21 Université de Strasbourg Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1516777A (fr) * 1966-08-02 1968-02-05 Innothera Lab Sa Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
US3519637A (en) * 1966-12-06 1970-07-07 Hoffmann La Roche 1-(4-thiazolylmethyl)nitroimidazole derivatives
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
US3950353A (en) * 1971-03-09 1976-04-13 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds
HU168776B (fr) * 1973-11-09 1976-07-28
DE2614189A1 (de) * 1976-04-02 1977-10-20 Hoechst Ag Therapeutisch wirksame ureido- und semicarbazido-derivate des tiazols und verfahren zu ihrer herstellung
NZ186965A (en) * 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
JPS54132566A (en) * 1978-01-18 1979-10-15 Ici Ltd Guanidine derivative*its manufacture and secretion controlling pharmaceutical composition containing it
DE3069889D1 (en) * 1979-01-18 1985-02-14 Ici Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
AU518569B2 (en) * 1979-08-07 1981-10-08 Farmos-Yhtyma Oy 4-benzyl- and 4-benzoyl imidazole derivatives

Also Published As

Publication number Publication date
ES506216A0 (es) 1982-12-16
HU186788B (en) 1985-09-30
NO159654B (no) 1988-10-17
YU42076B (en) 1988-04-30
YU42077B (en) 1988-04-30
EP0050458A3 (en) 1982-09-01
US4374843A (en) 1983-02-22
AU7628781A (en) 1982-04-22
KE3707A (en) 1987-04-03
CS231182B2 (en) 1984-10-15
SG23487G (en) 1987-07-10
PT73817B (en) 1983-11-07
IE812384L (en) 1982-04-14
AU548992B2 (en) 1986-01-09
MY8700512A (en) 1987-12-31
EP0050458B1 (fr) 1985-01-02
IE51642B1 (en) 1987-01-21
PH18467A (en) 1985-07-18
CS750081A2 (en) 1984-02-13
AR228674A1 (es) 1983-03-30
PT73817A (en) 1981-11-01
PL241644A1 (en) 1983-11-21
AU3206284A (en) 1984-11-29
DE3168067D1 (en) 1985-02-14
DD207718A5 (de) 1984-03-14
YU105283A (en) 1983-10-31
AU530589B2 (en) 1983-07-21
FI75821B (fi) 1988-04-29
AR228675A1 (es) 1983-03-30
ES8306750A1 (es) 1983-06-01
NO159654C (no) 1989-01-25
ES515158A0 (es) 1983-06-01
CA1156239A (fr) 1983-11-01
HK52387A (en) 1987-07-17
SU1153829A3 (ru) 1985-04-30
ATE11048T1 (de) 1985-01-15
PH17856A (en) 1985-01-09
FI813177L (fi) 1982-04-15
DD207719A5 (de) 1984-03-14
PL134491B1 (en) 1985-08-31
AR229703A1 (es) 1983-10-31
ES8301978A1 (es) 1982-12-16
PL241643A1 (en) 1983-11-21
YU42078B (en) 1988-04-30
ES8306751A1 (es) 1983-06-01
YU246481A (en) 1983-10-31
NO813442L (no) 1982-04-15
EP0050458A2 (fr) 1982-04-28
IL64035A (en) 1986-01-31
PL135331B1 (en) 1985-10-31
PL233430A1 (en) 1983-11-21
YU105183A (en) 1983-10-31
DD202293A5 (de) 1983-09-07
KR850001858B1 (ko) 1985-12-28
YU42434B (en) 1988-08-31
ES515159A0 (es) 1983-06-01
FI75821C (fi) 1988-08-08
GR75098B (fr) 1984-07-13
DK453181A (da) 1982-04-15
YU105383A (en) 1983-10-31
DD207913A5 (de) 1984-03-21
ES8306749A1 (es) 1983-06-01
NZ198629A (en) 1985-02-28
KR830007638A (ko) 1983-11-04
PL133712B1 (en) 1985-06-29
HU191895B (en) 1987-04-28
IL64035A0 (en) 1982-01-31
ES515157A0 (es) 1983-06-01

Similar Documents

Publication Publication Date Title
PH24267A (en) Androstane carbothioates and pharmaceutical compositions containing the same
ZA813465B (en) Pharmaceutical composition
NZ201520A (en) Substituted aminopyridazines and pharmaceutical compositions
PH17562A (en) 2-guanidino-4-heteroarylthiazoles and pharmaceutical compositions
NZ196775A (en) Allergen-polysarcosine conjugates and pharmaceutical compositions
PH20168A (en) 7-carboxymethoxyphenylacetamino-3-cephem derivatives and their pharmaceutical compositions
ZA81136B (en) Pharmaceutical compositions
NZ198862A (en) Enkephalin derivatives and pharmaceutical compositions
JPS5795911A (en) Antiepileptic and antineuralgic pharmaceutical composition
IL64054A0 (en) Imidazolylpyridines and pharmaceutical compositions containing them
GB2072504B (en) Pharmaceutical compositions
IL60376A (en) 3-diphenylmethyleneazetidines and pharmaceutical compositions containing them
ZA815700B (en) Pharmaceutical compositions
NZ197736A (en) Pentapeptides and pharmaceutical compositions
IL70379A (en) Spiro-oxazolidones,-thiazolidones and-imidazolidones and pharmaceutical compositions containing them
IL59177A0 (en) Spiro-quinolylhydantoins and pharmaceutical compositions containing them
NZ205732A (en) Thiatriazine derivatives and pharmaceutical compositions
NZ203649A (en) 2-beta-d-ribofuranosylselenazole-4-carboxamide derivatives and pharmaceutical compositions
DE3176849D1 (en) Pharmaceutical composition comprising 4-carbamoyl-imidazolium-5-olate
PT73952A (en) Pharmaceutical compositions
IL68668A0 (en) Piperidinoquinazolines and pharmaceutical compositions containing them
IL62146A0 (en) Guanylamidines and pharmaceutical compositions containing them
ZA814056B (en) Pharmaceutical bicyclo-octatriene compounds and compositions
GB2077265B (en) N-trifluoroacetyladriamycin-14-o-hemiglutarate and hemiadipate and therapeutic compositions containing the same
NZ196464A (en) Steroid-spiro-oxathiazolidine derivatives and pharmaceutical compositions