PH16607A - Tri-and tetracyclic imidazo(1,5-a)(1,4)diazepine derivatives and method of use - Google Patents

Tri-and tetracyclic imidazo(1,5-a)(1,4)diazepine derivatives and method of use

Info

Publication number
PH16607A
PH16607A PH24651A PH24651A PH16607A PH 16607 A PH16607 A PH 16607A PH 24651 A PH24651 A PH 24651A PH 24651 A PH24651 A PH 24651A PH 16607 A PH16607 A PH 16607A
Authority
PH
Philippines
Prior art keywords
tri
diazepine derivatives
tetracyclic
imidazo
tetracyclic imidazo
Prior art date
Application number
PH24651A
Other languages
English (en)
Inventor
Willy Dr Haefely
Walter Dr Hunkeler
Emilio Dr Kyburz
Hanns Dr Mohler
Pieri Dr Lorenzo
Max Dr Gerecke
Polc Dr Petar
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27509256&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PH16607(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PH16607A publication Critical patent/PH16607A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/041,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/121,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/141,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/241,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26Two oxygen atoms, e.g. isatoic anhydride
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/42Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PH24651A 1979-10-04 1980-09-30 Tri-and tetracyclic imidazo(1,5-a)(1,4)diazepine derivatives and method of use PH16607A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH897179 1979-10-04
CH897279 1979-10-04
CH1066479 1979-11-30
CH1066579 1979-11-30
CH571680 1980-07-25

Publications (1)

Publication Number Publication Date
PH16607A true PH16607A (en) 1983-11-24

Family

ID=27509256

Family Applications (1)

Application Number Title Priority Date Filing Date
PH24651A PH16607A (en) 1979-10-04 1980-09-30 Tri-and tetracyclic imidazo(1,5-a)(1,4)diazepine derivatives and method of use

Country Status (23)

Country Link
US (10) US4316839A (ko)
EP (1) EP0027214B1 (ko)
JP (1) JPH01156968A (ko)
AR (1) AR227293A1 (ko)
AU (1) AU533641B2 (ko)
BR (1) BR8006404A (ko)
CA (1) CA1143728A (ko)
DE (1) DE3067868D1 (ko)
DK (1) DK168094B1 (ko)
FI (1) FI73683C (ko)
GB (1) GB2060632B (ko)
GR (1) GR70772B (ko)
HU (1) HU182675B (ko)
IE (1) IE50318B1 (ko)
IL (1) IL61160A (ko)
LU (1) LU88298I2 (ko)
MC (1) MC1355A1 (ko)
NL (1) NL930056I2 (ko)
NO (1) NO155774C (ko)
NZ (1) NZ195071A (ko)
PH (1) PH16607A (ko)
PT (1) PT71874B (ko)
ZW (1) ZW21580A1 (ko)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
CA1185602A (en) * 1981-02-27 1985-04-16 Emilio Kyburz Imidazodiazepines
CA1173441A (en) * 1981-02-27 1984-08-28 Hoffmann-La Roche Limited Imidazodiazepines
US4352817A (en) * 1981-02-27 1982-10-05 Hoffmann-La Roche Inc. Imidazo-diazepines and their use
CA1184175A (en) * 1981-02-27 1985-03-19 Walter Hunkeler Imidazodiazepines
CA1174673A (en) * 1981-02-27 1984-09-18 Walter Hunkeler Imidazodiazepines
MC1528A1 (fr) * 1982-07-21 1984-04-13 Hoffmann La Roche Imidazobenzodiazepines
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4723003A (en) * 1983-05-18 1988-02-02 Hoechst-Roussel Pharmaceuticals Inc. Benzopyrrolobenzodiazepines and quinobenzodiazepines
IL74070A (en) * 1984-01-19 1988-12-30 Hoffmann La Roche Imidazodiazepine derivatives,their manufacture and pharmaceutical compositions containing them
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4745112A (en) * 1985-05-17 1988-05-17 A/S Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method III
US4622320A (en) * 1985-05-17 1986-11-11 As Ferrosan Oxadiazolylimidazobenzodiazepine, compositions, and method
DK174086D0 (da) * 1986-04-16 1986-04-16 Ferrosan As Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
FI880814A (fi) * 1987-03-10 1988-09-11 Hoffmann La Roche Imidazodiazepin-derivat.
GB8720414D0 (en) * 1987-08-28 1987-10-07 Roussel Lab Ltd Chemical compounds
ATE82851T1 (de) * 1988-08-05 1992-12-15 Hoffmann La Roche Radioaktiv markierte benzodiazepinderivate.
US5096695A (en) * 1988-08-05 1992-03-17 Hoffmann-Laroche Inc. Radioiodine benzodiazepines as brain imaging agents
CA1327572C (en) * 1988-08-31 1994-03-08 F. Hoffmann-La Roche Ag Imidazodiazepine derivatives
GB8909700D0 (en) * 1989-04-27 1989-06-14 Roussel Lab Ltd Chemical compounds
CA2015336A1 (en) * 1989-05-19 1990-11-19 F. Hoffmann-La Roche Ag Imidazodiazepines for the treatment of neurological symptoms
FR2660310B1 (fr) * 1990-03-27 1992-06-05 Adir Nouveaux derives de la 4h-pyrrolo[1,2a] thieno[2,3-f] diazepine[1,4], leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5276028A (en) * 1990-06-22 1994-01-04 Nordisk A/S Imidazoquinoxaline compounds
US5371080A (en) * 1990-06-22 1994-12-06 Novo Nordisk A/S Imidazoquinazoline compounds and their use
TW201311B (ko) * 1991-06-17 1993-03-01 Hoffmann La Roche
US5565449A (en) * 1991-10-18 1996-10-15 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5438035A (en) * 1994-06-24 1995-08-01 American Cyanamid Company Methods for controlling undesirable plant species with benzodiazepine compounds
TW349100B (en) * 1994-11-11 1999-01-01 Hoffmann La Roche Oxazolyl- and thiazolylimidazo-benzo- and thienodiazepines
US5670640A (en) * 1996-02-02 1997-09-23 Hoffmann-La Roche Inc. Process for the manufacture of imidazodiazepine derivatives
GB2328940B (en) * 1997-09-05 1999-12-08 Dong Kook Pharm Co Ltd A process for preparing benzodiazepine derivatives
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
CN101039678B (zh) 2004-10-12 2011-06-15 弗·哈夫曼-拉罗切有限公司 用于治疗认知障碍的咪唑并[1,5-a]三唑并[1,5-d]苯并二氮杂䓬衍生物
RU2007112940A (ru) 2004-10-20 2008-11-27 Ф.Хоффманн-Ля Рош Аг (Ch) Производные имидазобензодиазепина
CN101084220B (zh) 2004-10-20 2010-12-15 弗·哈夫曼-拉罗切有限公司 卤素取代的苯并二氮杂*衍生物
ES2307230T3 (es) 2004-12-14 2008-11-16 F. Hoffmann-La Roche Ag Imidazo-benzodiacepinas tetraciclicas como moduladores de los receptores gaba.
CA2607226A1 (en) * 2005-05-16 2007-02-15 Wisys Technology Foundation, Inc. Gabaergic agents to treat memory deficits
EP2275095A3 (en) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス,インコーポレイティド Pde阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20070244143A1 (en) * 2006-03-08 2007-10-18 Braincells, Inc Modulation of neurogenesis by nootropic agents
US20100216734A1 (en) * 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US20100009983A1 (en) * 2006-05-09 2010-01-14 Braincells, Inc. 5 ht receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
JP2009536667A (ja) * 2006-05-09 2009-10-15 ブレインセルス,インコーポレイティド 5ht受容体介在性の神経新生
KR20090064418A (ko) * 2006-09-08 2009-06-18 브레인셀즈 인코퍼레이션 4-아실아미노피리딘 유도체 포함 조합물
WO2008036678A2 (en) * 2006-09-19 2008-03-27 Braincells, Inc. Combination comprising a peroxisome proliferator activated receptor agent and a second neurogenic agent for treating a nervous system disorder, increasing neurodifferentiation and increasing neurogenesis
WO2009024325A2 (en) * 2007-08-20 2009-02-26 Evotec Neurosciences Gmbh Treatment of sleep disorders
US20090054412A1 (en) * 2007-08-20 2009-02-26 John Alan Kemp Treatment of Sleep Disorders
US20090270373A1 (en) * 2008-04-11 2009-10-29 Cypress Biosciences, Inc. Treatment of down syndrom with benzodiazepine receptor antagonists
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
GB0917612D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd In vivo imaging agents
AU2012221704B2 (en) 2011-02-23 2013-12-05 Coeruleus Ltd. Flumazenil complexes, compositions comprising same and uses thereof
CN102267999B (zh) * 2011-07-15 2013-05-29 海南美兰史克制药有限公司 一种氟马西尼化合物及其制法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933794A (en) * 1971-08-04 1976-01-20 The Upjohn Company 2-(2-Alkynylamino)-3H-1,4-benzodiazepines
US4031079A (en) * 1975-09-22 1977-06-21 Mcneil Laboratories, Incorporated Intermediates for 2-aminobenzodiazepine-5-ones
US4002610A (en) * 1975-09-22 1977-01-11 Mcneil Laboratories, Incorporated 2-Aminobenzodiazepine-5-ones
US4118386A (en) * 1977-04-04 1978-10-03 Hoffmann-La Roche Inc. Synthesis of imidazo[1,5-a]diazepine-3-carboxylates
CA1143728A (en) * 1979-10-04 1983-03-29 Max Gerecke Imidazodiazepine derivatives
ZA806016B (en) * 1979-10-04 1981-09-30 Hoffmann La Roche Imidazodiazepine derivatives
JPH089074B2 (ja) * 1987-07-02 1996-01-31 株式会社アマダ タレツトパンチプレス

Also Published As

Publication number Publication date
PT71874A (en) 1980-11-01
US4346035A (en) 1982-08-24
PT71874B (en) 1982-03-31
IL61160A0 (en) 1980-11-30
LU88298I2 (fr) 1994-05-04
DK391280A (da) 1981-04-05
DE3067868D1 (en) 1984-06-20
NL930056I1 (nl) 1993-09-01
US4346031A (en) 1982-08-24
US4346036A (en) 1982-08-24
AU533641B2 (en) 1983-12-01
ZW21580A1 (en) 1981-04-29
GB2060632A (en) 1981-05-07
EP0027214B1 (de) 1984-05-16
NO155774C (no) 1987-05-27
NZ195071A (en) 1984-08-24
US4316839A (en) 1982-02-23
JPH0369913B2 (ko) 1991-11-05
NL930056I2 (nl) 1993-11-16
NO155774B (no) 1987-02-16
IE50318B1 (en) 1986-04-02
GR70772B (ko) 1983-03-22
US4359420A (en) 1982-11-16
US4346033A (en) 1982-08-24
GB2060632B (en) 1983-11-02
BR8006404A (pt) 1981-04-14
US4346030A (en) 1982-08-24
NO802946L (no) 1981-04-06
JPH01156968A (ja) 1989-06-20
AR227293A1 (es) 1982-10-15
IE802056L (en) 1981-04-04
HU182675B (en) 1984-02-28
MC1355A1 (fr) 1981-08-10
FI73683B (fi) 1987-07-31
EP0027214A1 (de) 1981-04-22
US4346032A (en) 1982-08-24
US4346034A (en) 1982-08-24
US4363762A (en) 1982-12-14
IL61160A (en) 1983-07-31
FI73683C (fi) 1987-11-09
CA1143728A (en) 1983-03-29
AU6278280A (en) 1981-04-09
FI803135L (fi) 1981-04-05
DK168094B1 (da) 1994-02-07

Similar Documents

Publication Publication Date Title
PH16607A (en) Tri-and tetracyclic imidazo(1,5-a)(1,4)diazepine derivatives and method of use
PH19881A (en) Tetracyclic t-butyl imidazo(1,5-a)(1,4)-diazepine-1-carboxylates,medicament containing same and method of use thereof
IL83139A (en) 1,2,4-triazolo (1,5-a) pyrimidine-2-sulfonyl chlorides and their preparation
ZA897699B (en) Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors
DE3065270D1 (en) Substituted pyrazolo (1,5-a) pyrimidines, and their preparation
PH21839A (en) Imidazo derivatives and their method of use
AU516873B2 (en) IMIDAZO[1, 5-a][1, 4]BENZODIAZEPINE DERIVATIVES
AU538500B2 (en) Pyrazolo(3,4-b)(1,5) benzodiazepine derivatives
PH23147A (en) Imidazo/1,5-a/pyridine derivatives
SG61182G (en) Indolo(2,3-a)quinolizidines,preparation and therapeutic use
AR230748A1 (es) Procedimiento para la preparacion de derivados de imidazo(1,2-a)tien(3,2-d)pirimidim-6,9-(5h,7h)-diona y compuestos para su exclusivo uso como intermediarios en dicho procedimiento
GB2031426B (en) Imidazo(2',1':2,3)thiazolo(5,4-c)pyridines and related compounds
GB2103207B (en) Substituted pyrrolo]2,1-bquinazolines and pyrido]2,1-bquinazolines and process for their prepara
PH14437A (en) Imidazolylethoxy derivatives of pyrazolo(3,4-b)pyridine-5-methanols
IL84112A0 (en) Derivatives of imidazo(4,5-b)pyridinone-2,their preparation and therapeutic use
GB2016002B (en) Amino derivatives of pyrazolo(1,5-a)s triazine
GB8609765D0 (en) Imidazo(1 5-a)pyridine derivatives
GB1551166A (en) Pyrazolo (1,5-a)quinoxaline-3-carboxylic acid and derivatives thereof
ZA831407B (en) Substituted ethenyl derivatives of 1h-pyrazolo(1,5-a)pyrimidine and process for their preparation
GB2116971B (en) Substituted 1h-pyrazolo (1 5-a) pyrimidines and process for their preparation
AU512354B2 (en) Triazolo[4,3-a]benzodiazepine preparation
IL60027A0 (en) 9-hydrazono-6,7,8,9-tetrahydro-4h-pyrido(1,2-a)pyrimidin-4-one derivatives and process for their preparation
IL56414A0 (en) Benzo-(thieno or pyrazolo(1,4)diazepine compounds and their preparation
EP0145591A3 (en) Pyrrolo(3,2,1-hi)indole derivatives, their preparation and their therapeutical use
ZA831611B (en) Substituted 1h-pyrazolo(1,5-a)pyrimidines and process for their preparation

Legal Events

Date Code Title Description
AT Record of annual fee payments

Year of fee payment: 13