PH12279A - Biguanide dichlorcacetates and pharmaceutical preparations containing them - Google Patents

Biguanide dichlorcacetates and pharmaceutical preparations containing them

Info

Publication number
PH12279A
PH12279A PH17640A PH17640A PH12279A PH 12279 A PH12279 A PH 12279A PH 17640 A PH17640 A PH 17640A PH 17640 A PH17640 A PH 17640A PH 12279 A PH12279 A PH 12279A
Authority
PH
Philippines
Prior art keywords
dichlorcacetates
biguanide
pharmaceutical preparations
preparations containing
pharmaceutical
Prior art date
Application number
PH17640A
Other languages
English (en)
Inventor
U Fischer
E Lorch
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PH12279A publication Critical patent/PH12279A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24Y being a hetero atom
    • C07C279/26X and Y being nitrogen atoms, i.e. biguanides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PH17640A 1974-10-11 1975-10-08 Biguanide dichlorcacetates and pharmaceutical preparations containing them PH12279A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1369774A CH602612A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-10-11 1974-10-11

Publications (1)

Publication Number Publication Date
PH12279A true PH12279A (en) 1978-12-12

Family

ID=4394567

Family Applications (1)

Application Number Title Priority Date Filing Date
PH17640A PH12279A (en) 1974-10-11 1975-10-08 Biguanide dichlorcacetates and pharmaceutical preparations containing them

Country Status (26)

Country Link
US (1) US4028402A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS51125718A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR209457A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT343676B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE834369A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR7506595A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1053258A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH602612A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CU (1) CU34371A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (1) DD123322A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2542598A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK140834B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES441673A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI752626A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2287221A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1473256A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE41807B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL48116A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU73557A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL7511890A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO753447L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH12279A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL95259B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE7511357L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU572200A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA755861B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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FR2401898A1 (fr) * 1977-09-05 1979-03-30 Aec Chim Organ Biolog Nouveau sel de l'acide patoique
US20020006899A1 (en) * 1998-10-06 2002-01-17 Pospisilik Andrew J. Use of dipeptidyl peptidase IV effectors for lowering blood pressure in mammals
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
EP1004304A4 (en) 1996-12-24 2002-10-16 Sumitomo Pharma COMPOSITION CONTAINING ASCORBIC ACID
DE19823831A1 (de) * 1998-05-28 1999-12-02 Probiodrug Ges Fuer Arzneim Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
DE19828114A1 (de) 1998-06-24 2000-01-27 Probiodrug Ges Fuer Arzneim Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19828113A1 (de) 1998-06-24 2000-01-05 Probiodrug Ges Fuer Arzneim Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de) 1998-07-31 2000-02-03 Probiodrug Ges Fuer Arzneim Verfahren zur Steigerung des Blutglukosespiegels in Säugern
US20030176357A1 (en) * 1998-10-06 2003-09-18 Pospisilik Andrew J. Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
DE19926233C1 (de) 1999-06-10 2000-10-19 Probiodrug Ges Fuer Arzneim Verfahren zur Herstellung von Thiazolidin
DE19940130A1 (de) * 1999-08-24 2001-03-01 Probiodrug Ges Fuer Arzneim Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
EP1228756A4 (en) * 1999-10-06 2004-06-09 Kurokawa Kiyoshi ACTIVE AGENTS AGAINST CARBONYL STRESS
US20080076811A1 (en) * 2000-01-21 2008-03-27 Bork Balkan Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents
AU2001254763A1 (en) 2000-03-31 2001-10-08 Prosidion Limited Method for the improvement of islet signaling in diabetes mellitus and for its prevention
FR2809310B1 (fr) 2000-05-26 2004-02-13 Centre Nat Rech Scient Utilisation de derives de biguanide pour fabriquer un medicament ayant un effet cicatrisant
JP2005097117A (ja) * 2000-06-30 2005-04-14 Chugai Pharmaceut Co Ltd 糖尿病治療剤
US7132104B1 (en) 2000-10-27 2006-11-07 Probiodrug Ag Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
CA2422889C (en) * 2000-10-27 2010-01-26 Probiodrug Ag Method for the treatment of neurological and neuropsychological disorders
US6890905B2 (en) 2001-04-02 2005-05-10 Prosidion Limited Methods for improving islet signaling in diabetes mellitus and for its prevention
DE10150203A1 (de) 2001-10-12 2003-04-17 Probiodrug Ag Peptidylketone als Inhibitoren der DPIV
US20030130199A1 (en) 2001-06-27 2003-07-10 Von Hoersten Stephan Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
US20040214762A1 (en) * 2001-08-16 2004-10-28 Hans-Ulrich Demuth Use of inhibitors of proline endopeptidase to modulate inositol (1,4,5) triphosphate concentration dependent on intracellular signal cascades
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
KR20040095241A (ko) 2002-02-28 2004-11-12 프로시디온 리미티드 글루타미닐계 dpiv 억제제
US20030232761A1 (en) * 2002-03-28 2003-12-18 Hinke Simon A. Novel analogues of glucose-dependent insulinotropic polypeptide
US20040033051A1 (en) * 2002-08-16 2004-02-19 Ip Kiril Kun Wan Method and system for producing and displaying visual presentations which inhibit off-screen duplication
US20040058876A1 (en) * 2002-09-18 2004-03-25 Torsten Hoffmann Secondary binding site of dipeptidyl peptidase IV (DP IV)
ATE461212T1 (de) * 2002-09-18 2010-04-15 Prosidion Ltd Sekundäre bindungsstelle von dipeptidylpeptidase iv (dp iv)
DE602004026289D1 (de) 2003-05-05 2010-05-12 Probiodrug Ag Glutaminylcyclase-hemmer
NZ572274A (en) 2003-05-05 2009-06-26 Probiodrug Ag Use of effectors of glutaminyl and glutamate cyclases
EA010108B1 (ru) * 2003-10-15 2008-06-30 Пробиодруг Аг Применение эффекторов глутаминил- и глутаматциклаз
US20050171112A1 (en) * 2003-11-03 2005-08-04 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
US20100099721A1 (en) * 2003-11-03 2010-04-22 Probiodrug Ag Novel compounds for the treatment of neurological disorders
CA2554809C (en) 2004-02-05 2014-04-29 Probiodrug Ag Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
EP2109447B1 (en) * 2007-01-29 2015-06-10 HanAll Biopharma Co., Ltd. N, n- dimethyl imidodicarbonimidic diamide acetate, method for producing the same and pharmaceutical compositions comprising the same
WO2008097861A2 (en) * 2007-02-02 2008-08-14 Braincells, Inc. MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS
KR101226669B1 (ko) * 2007-09-21 2013-01-25 한올바이오파마주식회사 N,n-디메틸 이미도디카르본이미딕 디아미드의 디카르복실산염, 그의 제조 방법 및 그의 약제학적 조성물
KR101104912B1 (ko) 2008-01-08 2012-01-12 한올바이오파마주식회사 N,n―디메틸 이미도디카르본이미딕 디아미드의 니코틴산염, 그의 제조방법 및 그를 포함하는 약제학적 조성물
CN102159539B (zh) * 2008-06-26 2014-04-16 矽烷实验室股份公司 用于血糖控制的新型二甲双胍甘氨酸盐
WO2010146604A2 (en) 2009-06-18 2010-12-23 Exemed Pharmaceuticals Processes for preparing metformin hydrochloride
WO2011049400A2 (ko) * 2009-10-23 2011-04-28 한올바이오파마주식회사 N,n-디메틸 이미도디카르본이미딕 디아미드의 산 부가염을 포함하는 항암용 약제학적 조성물
KR101324283B1 (ko) 2010-04-27 2013-11-01 한올바이오파마주식회사 바이구아나이드 화합물의 신규 염, 그의 제조방법, 그를 포함하는 약제학적 조성물
BR112019006401A2 (pt) 2016-09-30 2019-06-25 Laboratorios Silanes S A De C V glicinato de metformina, composições farmacêuticas que compreendem o mesmo e métodos de uso do mesmo
WO2018060962A2 (en) 2016-09-30 2018-04-05 Laboratorios Silanes S.A. De C.V. Metformin amino acid compounds and methods of using the same
CN106986791A (zh) * 2017-05-11 2017-07-28 杜剑平 一种治疗肿瘤的药物化合物及其制备方法和应用
CN107118130A (zh) * 2017-05-11 2017-09-01 杜剑平 一类治疗肿瘤的药物化合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3179562A (en) * 1961-08-23 1965-04-20 Du Pont Treatment of diabetes with alpha, alpha substituted acetic acid derivatives

Also Published As

Publication number Publication date
NL7511890A (nl) 1976-04-13
BR7506595A (pt) 1976-08-17
CU34371A (es) 1979-06-01
CH602612A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1978-07-31
JPS51125718A (en) 1976-11-02
DK457475A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-04-12
ES441673A1 (es) 1977-04-01
AU8497775A (en) 1977-03-24
SE7511357L (sv) 1976-04-12
BE834369A (fr) 1976-04-12
IE41807L (en) 1976-04-11
GB1473256A (en) 1977-05-11
ZA755861B (en) 1976-08-25
SU572200A3 (ru) 1977-09-05
US4028402A (en) 1977-06-07
DK140834B (da) 1979-11-26
DK140834C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-04-28
DD123322A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-12-12
AR209457A1 (es) 1977-04-29
FI752626A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-04-12
DE2542598A1 (de) 1976-04-22
AT343676B (de) 1978-06-12
IL48116A0 (en) 1975-11-25
ATA776375A (de) 1977-10-15
NO753447L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-04-13
IE41807B1 (en) 1980-03-26
IL48116A (en) 1979-07-25
CA1053258A (en) 1979-04-24
PL95259B1 (pl) 1977-10-31
FR2287221A1 (fr) 1976-05-07
LU73557A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-05-24

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