PH12021552025A1 - Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator - Google Patents
Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulatorInfo
- Publication number
- PH12021552025A1 PH12021552025A1 PH1/2021/552025A PH12021552025A PH12021552025A1 PH 12021552025 A1 PH12021552025 A1 PH 12021552025A1 PH 12021552025 A PH12021552025 A PH 12021552025A PH 12021552025 A1 PH12021552025 A1 PH 12021552025A1
- Authority
- PH
- Philippines
- Prior art keywords
- disorder
- relacorilant
- grm
- heteroaryl
- fused azadecalin
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962809327P | 2019-02-22 | 2019-02-22 | |
| US201962814441P | 2019-03-06 | 2019-03-06 | |
| US201962833517P | 2019-04-12 | 2019-04-12 | |
| PCT/US2020/019167 WO2020172501A1 (en) | 2019-02-22 | 2020-02-21 | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12021552025A1 true PH12021552025A1 (en) | 2022-08-22 |
Family
ID=72141382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2021/552025A PH12021552025A1 (en) | 2019-02-22 | 2020-02-21 | Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US11058670B2 (https=) |
| EP (1) | EP3927345A4 (https=) |
| JP (2) | JP7789561B2 (https=) |
| KR (2) | KR20210118971A (https=) |
| CN (1) | CN113490496A (https=) |
| AU (1) | AU2020226863B2 (https=) |
| BR (1) | BR112021015129A2 (https=) |
| CA (1) | CA3131263C (https=) |
| CL (1) | CL2021002145A1 (https=) |
| IL (1) | IL285771A (https=) |
| MX (1) | MX2021010135A (https=) |
| NZ (1) | NZ778399A (https=) |
| PH (1) | PH12021552025A1 (https=) |
| SG (1) | SG11202108964YA (https=) |
| UA (1) | UA129592C2 (https=) |
| WO (1) | WO2020172501A1 (https=) |
| ZA (1) | ZA202105633B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12226412B2 (en) | 2012-05-25 | 2025-02-18 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| CA3055076C (en) | 2017-03-31 | 2022-02-22 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
| FI3897589T3 (fi) | 2018-12-19 | 2026-01-13 | Corcept Therapeutics Inc | Farmaseuttisia formulaatioita, jotka sisältävät relakorilanttia, heteroaryyliketonifusoitua atsekaliiniyhdistettä |
| ES3008837T3 (en) * | 2018-12-21 | 2025-03-25 | Corcept Therapeutics Inc | Treatment of hypercoagulopathy in cushing's syndrome by administration of a glucocorticoid receptor modulator |
| JP7789561B2 (ja) | 2019-02-22 | 2025-12-22 | コーセプト セラピューティクス， インコーポレイテッド | レラコリラント、ヘテロアリール－ケトン縮合アザデカリングルココルチコイド受容体調節物質の治療用途 |
| US11285145B2 (en) | 2020-05-27 | 2022-03-29 | Corcept Therapeutics Incorporated | Concomitant administration of glucocorticoid receptor modulator relacorilant and paclitaxel, a dual substrate of CYP2C8 and CYP3A4 |
| WO2022134033A1 (en) | 2020-12-25 | 2022-06-30 | Corcept Therapeutics Incorporated | Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| WO2022166810A1 (zh) * | 2021-02-03 | 2022-08-11 | 江苏恒瑞医药股份有限公司 | 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用 |
| CN114907349A (zh) * | 2021-02-10 | 2022-08-16 | 江苏恒瑞医药股份有限公司 | 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用 |
| US20230372312A1 (en) * | 2022-05-20 | 2023-11-23 | Corcept Therapeutics Incorporated | Methods of Treating Cushing's syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient |
| CN117510490A (zh) * | 2022-08-03 | 2024-02-06 | 江苏恒瑞医药股份有限公司 | 一种稠合氮杂萘烷类衍生物的晶型及其制备方法 |
| IL319657A (en) | 2022-10-06 | 2025-05-01 | Corcept Therapeutics Inc | Glucocorticoid receptor modulator formulations |
| WO2024092195A1 (en) | 2022-10-28 | 2024-05-02 | Corcept Therapeutics Incorporated | Treatments for amyotrophic lateral sclerosis using dazucorilant |
| AU2023403359A1 (en) * | 2022-11-30 | 2025-05-29 | Corcept Therapeutics Incorporated | Treatments for cushing's syndrome that do not significantly affect cardiac rhythms |
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| JP3160941B2 (ja) | 1991-06-17 | 2001-04-25 | 東レ株式会社 | カルバゾール誘導体および免疫抑制剤 |
| FR2697252B1 (fr) | 1992-10-28 | 1994-12-09 | Fournier Ind & Sante | Dérivés de 1,2,3,5,6,7,8,8a-octahydro-5,5,8a-triméthyl-(8abeta)-6-isoquinolineamine, leur procédé de préparation et leur utilisation en thérapeutique. |
| JPH09505030A (ja) | 1993-08-06 | 1997-05-20 | スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ | ヒドロイソキノリン誘導体 |
| US5696130A (en) | 1994-12-22 | 1997-12-09 | Ligand Pharmaceuticals Incorporated | Tricyclic steroid receptor modulator compounds and methods |
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| ES3008837T3 (en) * | 2018-12-21 | 2025-03-25 | Corcept Therapeutics Inc | Treatment of hypercoagulopathy in cushing's syndrome by administration of a glucocorticoid receptor modulator |
| JP7789561B2 (ja) | 2019-02-22 | 2025-12-22 | コーセプト セラピューティクス， インコーポレイテッド | レラコリラント、ヘテロアリール－ケトン縮合アザデカリングルココルチコイド受容体調節物質の治療用途 |
-
2020
- 2020-02-21 JP JP2021549571A patent/JP7789561B2/ja active Active
- 2020-02-21 MX MX2021010135A patent/MX2021010135A/es unknown
- 2020-02-21 NZ NZ778399A patent/NZ778399A/en unknown
- 2020-02-21 BR BR112021015129-0A patent/BR112021015129A2/pt not_active Application Discontinuation
- 2020-02-21 US US16/797,421 patent/US11058670B2/en active Active
- 2020-02-21 KR KR1020217030352A patent/KR20210118971A/ko not_active Ceased
- 2020-02-21 EP EP20759882.2A patent/EP3927345A4/en active Pending
- 2020-02-21 UA UAA202105300A patent/UA129592C2/uk unknown
- 2020-02-21 SG SG11202108964YA patent/SG11202108964YA/en unknown
- 2020-02-21 WO PCT/US2020/019167 patent/WO2020172501A1/en not_active Ceased
- 2020-02-21 CA CA3131263A patent/CA3131263C/en active Active
- 2020-02-21 PH PH1/2021/552025A patent/PH12021552025A1/en unknown
- 2020-02-21 KR KR1020257016944A patent/KR20250076696A/ko active Pending
- 2020-02-21 AU AU2020226863A patent/AU2020226863B2/en active Active
- 2020-02-21 CN CN202080015826.9A patent/CN113490496A/zh active Pending
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2021
- 2021-06-09 US US17/343,524 patent/US11590113B2/en active Active
- 2021-08-10 ZA ZA2021/05633A patent/ZA202105633B/en unknown
- 2021-08-13 CL CL2021002145A patent/CL2021002145A1/es unknown
- 2021-08-22 IL IL285771A patent/IL285771A/en unknown
-
2022
- 2022-12-20 US US18/084,866 patent/US11684612B2/en active Active
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2023
- 2023-05-09 US US18/144,979 patent/US12097192B2/en active Active
- 2023-10-12 JP JP2023176874A patent/JP2024009951A/ja active Pending
-
2024
- 2024-07-19 US US18/777,823 patent/US20250009721A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022523376A (ja) | 2022-04-22 |
| US11684612B2 (en) | 2023-06-27 |
| ZA202105633B (en) | 2023-02-22 |
| US20210338643A1 (en) | 2021-11-04 |
| CN113490496A (zh) | 2021-10-08 |
| US11590113B2 (en) | 2023-02-28 |
| UA129592C2 (uk) | 2025-06-11 |
| US20250009721A1 (en) | 2025-01-09 |
| EP3927345A1 (en) | 2021-12-29 |
| MX2021010135A (es) | 2021-09-23 |
| US20230346756A1 (en) | 2023-11-02 |
| WO2020172501A1 (en) | 2020-08-27 |
| US20200268723A1 (en) | 2020-08-27 |
| EP3927345A4 (en) | 2022-12-21 |
| CA3131263C (en) | 2024-01-02 |
| AU2020226863A1 (en) | 2021-08-12 |
| IL285771A (en) | 2021-10-31 |
| SG11202108964YA (en) | 2021-09-29 |
| US12097192B2 (en) | 2024-09-24 |
| CA3131263A1 (en) | 2020-08-27 |
| KR20250076696A (ko) | 2025-05-29 |
| JP7789561B2 (ja) | 2025-12-22 |
| JP2024009951A (ja) | 2024-01-23 |
| AU2020226863B2 (en) | 2023-04-06 |
| KR20210118971A (ko) | 2021-10-01 |
| NZ778399A (en) | 2024-11-29 |
| US11058670B2 (en) | 2021-07-13 |
| BR112021015129A2 (pt) | 2021-09-28 |
| US20230131372A1 (en) | 2023-04-27 |
| CL2021002145A1 (es) | 2022-01-28 |
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