PH12019502723A1 - Methods and compositions for treating excessive sleepiness - Google Patents
Methods and compositions for treating excessive sleepinessInfo
- Publication number
- PH12019502723A1 PH12019502723A1 PH12019502723A PH12019502723A PH12019502723A1 PH 12019502723 A1 PH12019502723 A1 PH 12019502723A1 PH 12019502723 A PH12019502723 A PH 12019502723A PH 12019502723 A PH12019502723 A PH 12019502723A PH 12019502723 A1 PH12019502723 A1 PH 12019502723A1
- Authority
- PH
- Philippines
- Prior art keywords
- methods
- compositions
- treating excessive
- excessive sleepiness
- sleepiness
- Prior art date
Links
- 208000032140 Sleepiness Diseases 0.000 title abstract 3
- 206010041349 Somnolence Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 230000037321 sleepiness Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 206010062519 Poor quality sleep Diseases 0.000 abstract 1
- NJVZDURTFWBXAM-VIFPVBQESA-N [(2S)-1-hydroxy-3-phenylpropan-2-yl]urea Chemical class C(N)(=O)N[C@@H](CC1=CC=CC=C1)CO NJVZDURTFWBXAM-VIFPVBQESA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 201000003631 narcolepsy Diseases 0.000 abstract 1
- 208000001797 obstructive sleep apnea Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762514176P | 2017-06-02 | 2017-06-02 | |
| PCT/US2018/035532 WO2018222954A1 (en) | 2017-06-02 | 2018-06-01 | Methods and compositions for treating excessive sleepiness |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12019502723A1 true PH12019502723A1 (en) | 2020-07-13 |
Family
ID=64455104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12019502723A PH12019502723A1 (en) | 2017-06-02 | 2019-12-02 | Methods and compositions for treating excessive sleepiness |
Country Status (12)
| Country | Link |
|---|---|
| US (7) | US10959976B2 (enExample) |
| EP (1) | EP3630072A4 (enExample) |
| JP (1) | JP2020528075A (enExample) |
| KR (3) | KR20240162165A (enExample) |
| CN (1) | CN111201014A (enExample) |
| AU (1) | AU2018278332B2 (enExample) |
| BR (1) | BR112019025286A2 (enExample) |
| CA (1) | CA3065522A1 (enExample) |
| MX (1) | MX390786B (enExample) |
| MY (1) | MY203401A (enExample) |
| PH (1) | PH12019502723A1 (enExample) |
| WO (1) | WO2018222954A1 (enExample) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11839597B2 (en) | 2016-07-22 | 2023-12-12 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10195151B2 (en) | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
| WO2018222954A1 (en) | 2017-06-02 | 2018-12-06 | Jazz Pharmaceuticals International Iii Limited | Methods and compositions for treating excessive sleepiness |
| WO2021001457A1 (en) * | 2019-07-04 | 2021-01-07 | Sandoz Ag | Crystalline (r)-2-amino-3-phenylpropylcarbamate acid addition salts |
| US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
| WO2023034944A1 (en) * | 2021-09-03 | 2023-03-09 | Axsome Therapeutics | Methods and compositions for ameliorating biomarkers associated with cardiovascular risk using (r)-2-amino-3-phenylpropyl carbamate |
| AU2023375326A1 (en) * | 2022-11-07 | 2025-05-22 | Axsome Therapeutics | Compositions and methods for treating insomnia |
| EP4626417A1 (en) * | 2022-11-30 | 2025-10-08 | Axsome Therapeutics | Methods and compositions for improving driving performance |
| US12005036B1 (en) | 2022-12-30 | 2024-06-11 | Axsome Malta Ltd. | Methods of administering solriamfetol to lactating women |
| US12036194B1 (en) | 2022-12-30 | 2024-07-16 | Axsome Malta Ltd. | Methods of administering solriamfetol to lactating women |
| US12090126B2 (en) | 2022-12-30 | 2024-09-17 | Axsome Malta Ltd. | Methods of administering solriamfetol to lactating women |
| US12102609B2 (en) | 2022-12-30 | 2024-10-01 | Axsome Malta Ltd. | Methods of administering solriamfetol to lactating women |
| US12064411B1 (en) * | 2022-12-30 | 2024-08-20 | Axsome Malta Ltd. | Methods of administering solriamfetol to lactating women |
| EP4642446A2 (en) * | 2022-12-30 | 2025-11-05 | Axsome Malta Ltd. | Methods of administering solriamfetol to lactating women |
| US11771666B1 (en) | 2022-12-30 | 2023-10-03 | Axsome Malta Ltd. | Methods of administering solriamfetol to lactating women |
| WO2024249560A1 (en) * | 2023-05-30 | 2024-12-05 | Axsome Therapeutics, Inc. | Solriamfetol for treating cognitive impairment in a subject with impaired cognition associated with obstructive sleep apnea and excessive daytime sleepiness |
| WO2025042959A1 (en) * | 2023-08-21 | 2025-02-27 | Axsome Therapeutics, Inc. | Use of solriamfetol for the treatment of orphan diseases |
| WO2025064549A1 (en) * | 2023-09-18 | 2025-03-27 | Axsome Therapeutics, Inc. | Solriamfetol for improving cognitive health in apnea patients |
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| DE2939660A1 (de) | 1979-09-29 | 1981-04-16 | Basf Ag, 6700 Ludwigshafen | Neue carbamate, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
| CZ285762B6 (cs) | 1993-06-10 | 1999-11-17 | Eli Lilly And Company | Farmaceutický prostředek vhodný pro prevenci dávení a zvracení a pro ošetřování sexuální dysfunkce savců a jeho použití |
| DE9311004U1 (de) | 1993-07-23 | 1993-10-14 | Mauser-Werke GmbH, 50321 Brühl | Palettencontainer |
| KR100197892B1 (ko) | 1994-09-09 | 1999-06-15 | 남창우 | 신규한 페닐알킬아미노 카바메이트 화합물과 그의 제조방법 |
| KR0173862B1 (ko) | 1995-02-11 | 1999-04-01 | 조규향 | O-카바모일-(d)-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| US5756817C1 (en) | 1995-02-11 | 2001-04-17 | Sk Corp | O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same |
| KR0173863B1 (ko) | 1995-04-10 | 1999-04-01 | 조규향 | 페닐에 치환체가 있는 o-카바모일-페닐알라닌올 화합물과 그의 약제학적으로 유용한 염 및 이들의 제조방법 |
| CN1076016C (zh) | 1996-10-10 | 2001-12-12 | Sk株式会社 | O－氨基甲酰基－苯丙胺醇化合物、其药学上有用的盐和它们的制备方法 |
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| RU2300372C2 (ru) | 2001-02-27 | 2007-06-10 | Орто-Макнейл Фармасьютикал, Инк. | Карбаматы для применения для предотвращения или лечения биполярного расстройства |
| BR0207830A (pt) | 2001-02-27 | 2004-06-22 | Ortho Mcneil Pharm Inc | Compostos de carbamato para uso em prevenir ou tratar distúrbios de ansiedade |
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| US20050203130A1 (en) | 2003-12-02 | 2005-09-15 | Erik Buntinx | Use of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| CN101132787A (zh) | 2004-10-28 | 2008-02-27 | Sk株式会社 | 抑郁的辅助疗法 |
| BRPI0613697A2 (pt) | 2005-06-08 | 2011-01-25 | Sk Holdings Co Ltd | tratamento de distúrbios de sono-vigìlia |
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| CN101557804A (zh) | 2006-10-13 | 2009-10-14 | 詹森药业有限公司 | 氨基甲酸苯基烷基氨基酯组合物 |
| US8771735B2 (en) | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
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| US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
| KR101783632B1 (ko) | 2009-11-06 | 2017-10-10 | 에스케이바이오팜 주식회사 | 주의력 결핍/과잉행동 장애(ａｄｈｄ)의 치료 방법 |
| EP2496227B1 (en) | 2009-11-06 | 2019-05-22 | SK Biopharmaceuticals Co., Ltd. | Methods for treating fibromyalgia syndrome |
| EP2566462B1 (en) | 2010-05-04 | 2020-07-08 | Jazz Pharmaceuticals Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
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| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
| US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| US9050302B2 (en) | 2013-03-01 | 2015-06-09 | Jazz Pharmaceuticals Ireland Limited | Method of administration of gamma hydroxybutyrate with monocarboxylate transporters |
| WO2014164969A1 (en) | 2013-03-13 | 2014-10-09 | Aerial Biopharma, Llc | Treatment of cataplexy |
| KR20160030955A (ko) | 2013-07-12 | 2016-03-21 | 에스케이바이오팜 주식회사 | 금연의 촉진 |
| WO2015010014A1 (en) | 2013-07-18 | 2015-01-22 | Jazz Pharmaceuticals International Iii Limited | Treatment for obesity |
| TWI698415B (zh) | 2014-02-28 | 2020-07-11 | 南韓商愛思開生物製藥股份有限公司 | 胺基羰基胺基甲酸酯化合物 |
| US10195151B2 (en) | 2016-09-06 | 2019-02-05 | Jazz Pharmaceuticals International Iii Limited | Formulations of (R)-2-amino-3-phenylpropyl carbamate |
| WO2018222954A1 (en) | 2017-06-02 | 2018-12-06 | Jazz Pharmaceuticals International Iii Limited | Methods and compositions for treating excessive sleepiness |
| US10940133B1 (en) | 2020-03-19 | 2021-03-09 | Jazz Pharmaceuticals Ireland Limited | Methods of providing solriamfetol therapy to subjects with impaired renal function |
-
2018
- 2018-06-01 WO PCT/US2018/035532 patent/WO2018222954A1/en not_active Ceased
- 2018-06-01 KR KR1020247036596A patent/KR20240162165A/ko active Pending
- 2018-06-01 MX MX2019014409A patent/MX390786B/es unknown
- 2018-06-01 MY MYPI2019007118A patent/MY203401A/en unknown
- 2018-06-01 BR BR112019025286-0A patent/BR112019025286A2/pt not_active Application Discontinuation
- 2018-06-01 US US16/618,735 patent/US10959976B2/en active Active
- 2018-06-01 AU AU2018278332A patent/AU2018278332B2/en active Active
- 2018-06-01 CN CN201880049345.2A patent/CN111201014A/zh active Pending
- 2018-06-01 CA CA3065522A patent/CA3065522A1/en active Pending
- 2018-06-01 KR KR1020197038348A patent/KR20200016889A/ko not_active Ceased
- 2018-06-01 KR KR1020237033870A patent/KR102726728B1/ko active Active
- 2018-06-01 EP EP18810236.2A patent/EP3630072A4/en active Pending
- 2018-06-01 JP JP2020516785A patent/JP2020528075A/ja active Pending
-
2019
- 2019-12-02 PH PH12019502723A patent/PH12019502723A1/en unknown
-
2020
- 2020-05-19 US US16/877,717 patent/US10912754B2/en active Active
-
2021
- 2021-03-25 US US17/212,079 patent/US11648232B2/en active Active
-
2023
- 2023-05-12 US US18/316,841 patent/US11865098B1/en active Active
- 2023-12-08 US US18/534,234 patent/US20240180866A1/en not_active Abandoned
-
2024
- 2024-02-20 US US18/582,125 patent/US20240189270A1/en not_active Abandoned
- 2024-12-17 US US18/983,605 patent/US20250114322A1/en active Pending
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|---|---|---|---|---|
| US12115143B2 (en) | 2016-07-22 | 2024-10-15 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12115144B2 (en) | 2016-07-22 | 2024-10-15 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12478604B1 (en) | 2016-07-22 | 2025-11-25 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
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| US12226377B2 (en) | 2019-03-01 | 2025-02-18 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US12167991B2 (en) | 2019-03-01 | 2024-12-17 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
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| US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US12303478B2 (en) | 2019-03-01 | 2025-05-20 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12295926B1 (en) | 2022-02-07 | 2025-05-13 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
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| US11865098B1 (en) | 2024-01-09 |
| US20200281886A1 (en) | 2020-09-10 |
| KR20200016889A (ko) | 2020-02-17 |
| KR20240162165A (ko) | 2024-11-14 |
| MX2019014409A (es) | 2022-03-17 |
| US20200163927A1 (en) | 2020-05-28 |
| US11648232B2 (en) | 2023-05-16 |
| WO2018222954A1 (en) | 2018-12-06 |
| US20210205257A1 (en) | 2021-07-08 |
| US10912754B2 (en) | 2021-02-09 |
| MY203401A (en) | 2024-06-26 |
| US10959976B2 (en) | 2021-03-30 |
| KR20230145525A (ko) | 2023-10-17 |
| BR112019025286A2 (pt) | 2020-06-23 |
| CA3065522A1 (en) | 2018-12-06 |
| JP2020528075A (ja) | 2020-09-17 |
| NZ760594A (en) | 2025-05-02 |
| US20240033243A1 (en) | 2024-02-01 |
| MX390786B (es) | 2025-03-21 |
| CN111201014A (zh) | 2020-05-26 |
| US20240180866A1 (en) | 2024-06-06 |
| AU2018278332B2 (en) | 2022-05-19 |
| KR102726728B1 (ko) | 2024-11-05 |
| US20240189270A1 (en) | 2024-06-13 |
| US20250114322A1 (en) | 2025-04-10 |
| EP3630072A4 (en) | 2021-03-10 |
| AU2018278332A1 (en) | 2020-01-30 |
| EP3630072A1 (en) | 2020-04-08 |
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