PH12015502046B1 - Pyridinyl and fused pyridinyl triazolone derivatives - Google Patents

Pyridinyl and fused pyridinyl triazolone derivatives

Info

Publication number
PH12015502046B1
PH12015502046B1 PH12015502046A PH12015502046A PH12015502046B1 PH 12015502046 B1 PH12015502046 B1 PH 12015502046B1 PH 12015502046 A PH12015502046 A PH 12015502046A PH 12015502046 A PH12015502046 A PH 12015502046A PH 12015502046 B1 PH12015502046 B1 PH 12015502046B1
Authority
PH
Philippines
Prior art keywords
pyridinyl
fused
formula
triazolone derivatives
compounds
Prior art date
Application number
PH12015502046A
Other languages
English (en)
Other versions
PH12015502046A1 (en
Inventor
John David Lawson
Mark Sabat
Nicholas Scorah
Christopher Smith
Phong H Vu
Haixia Wang
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of PH12015502046A1 publication Critical patent/PH12015502046A1/en
Publication of PH12015502046B1 publication Critical patent/PH12015502046B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PH12015502046A 2013-03-11 2015-09-10 Pyridinyl and fused pyridinyl triazolone derivatives PH12015502046B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361776445P 2013-03-11 2013-03-11
PCT/US2014/022801 WO2014164558A1 (en) 2013-03-11 2014-03-10 Pyridinyl and fused pyridinyl triazolone derivatives

Publications (2)

Publication Number Publication Date
PH12015502046A1 PH12015502046A1 (en) 2016-01-18
PH12015502046B1 true PH12015502046B1 (en) 2019-01-23

Family

ID=50543655

Family Applications (1)

Application Number Title Priority Date Filing Date
PH12015502046A PH12015502046B1 (en) 2013-03-11 2015-09-10 Pyridinyl and fused pyridinyl triazolone derivatives

Country Status (43)

Country Link
US (4) US9402841B2 (enExample)
EP (2) EP3235814B1 (enExample)
JP (2) JP6271700B2 (enExample)
KR (1) KR102300612B1 (enExample)
CN (1) CN105121427B (enExample)
AP (1) AP2015008646A0 (enExample)
AR (1) AR095198A1 (enExample)
AU (1) AU2014249248B2 (enExample)
BR (1) BR112015020264B1 (enExample)
CA (1) CA2899948C (enExample)
CL (1) CL2015002370A1 (enExample)
CR (1) CR20150470A (enExample)
CY (1) CY1119356T1 (enExample)
DK (1) DK2970202T3 (enExample)
DO (1) DOP2015000184A (enExample)
EA (1) EA028584B1 (enExample)
EC (1) ECSP15042779A (enExample)
ES (2) ES2714166T3 (enExample)
GE (1) GEP201706778B (enExample)
HK (1) HK1245256B (enExample)
HR (1) HRP20170622T1 (enExample)
HU (1) HUE032720T2 (enExample)
IL (1) IL240353B (enExample)
JO (1) JO3377B1 (enExample)
LT (1) LT2970202T (enExample)
MA (1) MA38391B1 (enExample)
ME (1) ME02693B (enExample)
MX (1) MX364527B (enExample)
MY (1) MY183927A (enExample)
PE (1) PE20151889A1 (enExample)
PH (1) PH12015502046B1 (enExample)
PL (1) PL2970202T3 (enExample)
PT (1) PT2970202T (enExample)
RS (1) RS55879B1 (enExample)
SG (1) SG11201506112QA (enExample)
SI (1) SI2970202T1 (enExample)
SM (1) SMT201700218T1 (enExample)
TN (1) TN2015000342A1 (enExample)
TW (1) TWI637950B (enExample)
UA (1) UA114944C2 (enExample)
UY (1) UY35376A (enExample)
WO (1) WO2014164558A1 (enExample)
ZA (1) ZA201505996B (enExample)

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UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
CN115209899A (zh) 2019-10-14 2022-10-18 普林斯匹亚生物制药公司 通过施用(R)-2-[3-[4-氨基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧杂环丁-3-基)哌嗪-1-基]戊-2-烯腈治疗免疫性血小板减少症的方法
JP2023500906A (ja) 2019-11-08 2023-01-11 インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
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Also Published As

Publication number Publication date
ES2624439T3 (es) 2017-07-14
JP6462842B2 (ja) 2019-01-30
US9801872B2 (en) 2017-10-31
MA38391B1 (fr) 2018-09-28
DOP2015000184A (es) 2015-11-30
TWI637950B (zh) 2018-10-11
EA201591686A1 (ru) 2015-12-30
AU2014249248A1 (en) 2015-08-20
BR112015020264A2 (pt) 2017-07-18
MY183927A (en) 2021-03-17
SG11201506112QA (en) 2015-09-29
EP2970202A1 (en) 2016-01-20
ZA201505996B (en) 2016-11-30
US20160310483A1 (en) 2016-10-27
PE20151889A1 (es) 2015-12-26
AU2014249248B2 (en) 2017-08-17
KR102300612B1 (ko) 2021-09-09
ME02693B (me) 2017-10-20
UY35376A (es) 2014-10-31
MX2015011533A (es) 2016-02-03
MX364527B (es) 2019-04-30
CY1119356T1 (el) 2018-02-14
US20190224190A1 (en) 2019-07-25
ECSP15042779A (es) 2017-08-31
US20180015083A1 (en) 2018-01-18
CA2899948A1 (en) 2014-10-09
HK1220183A1 (en) 2017-04-28
EA028584B1 (ru) 2017-12-29
AR095198A1 (es) 2015-09-30
HK1245256B (en) 2019-09-27
CR20150470A (es) 2016-01-11
CA2899948C (en) 2021-11-16
IL240353A0 (en) 2015-09-24
EP3235814B1 (en) 2018-12-12
TN2015000342A1 (en) 2017-01-03
JP6271700B2 (ja) 2018-01-31
JP2016512515A (ja) 2016-04-28
RS55879B1 (sr) 2017-08-31
WO2014164558A1 (en) 2014-10-09
HRP20170622T1 (hr) 2017-06-30
JO3377B1 (ar) 2019-03-13
US10307414B2 (en) 2019-06-04
UA114944C2 (uk) 2017-08-28
SMT201700218T1 (it) 2017-07-18
BR112015020264B1 (pt) 2021-03-02
CN105121427A (zh) 2015-12-02
LT2970202T (lt) 2017-06-12
KR20150126687A (ko) 2015-11-12
SI2970202T1 (sl) 2017-07-31
US9402841B2 (en) 2016-08-02
PH12015502046A1 (en) 2016-01-18
TW201522328A (zh) 2015-06-16
PT2970202T (pt) 2017-05-03
CN105121427B (zh) 2018-04-10
EP2970202B1 (en) 2017-02-01
IL240353B (en) 2018-11-29
ES2714166T3 (es) 2019-05-27
DK2970202T3 (en) 2017-05-08
NZ710852A (en) 2020-12-18
MA38391A1 (fr) 2018-01-31
PL2970202T3 (pl) 2017-08-31
JP2018076357A (ja) 2018-05-17
AP2015008646A0 (en) 2015-08-31
CL2015002370A1 (es) 2016-03-11
GEP201706778B (en) 2017-11-27
HUE032720T2 (en) 2017-10-30
US20140256734A1 (en) 2014-09-11
EP3235814A1 (en) 2017-10-25

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