PH12015501835B1 - Methods for the synthesis of sphingomyelins and dihydrosphingomyelins - Google Patents
Methods for the synthesis of sphingomyelins and dihydrosphingomyelinsInfo
- Publication number
- PH12015501835B1 PH12015501835B1 PH12015501835A PH12015501835A PH12015501835B1 PH 12015501835 B1 PH12015501835 B1 PH 12015501835B1 PH 12015501835 A PH12015501835 A PH 12015501835A PH 12015501835 A PH12015501835 A PH 12015501835A PH 12015501835 B1 PH12015501835 B1 PH 12015501835B1
- Authority
- PH
- Philippines
- Prior art keywords
- synthesis
- dihydrosphingomyelins
- sphingomyelins
- methods
- present
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- LRYZPFWEZHSTHD-HEFFAWAOSA-O 2-[[(e,2s,3r)-2-formamido-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium Chemical class CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](NC=O)COP(O)(=O)OCC[N+](C)(C)C LRYZPFWEZHSTHD-HEFFAWAOSA-O 0.000 title abstract 2
- 229940106189 ceramide Drugs 0.000 abstract 1
- 150000001783 ceramides Chemical class 0.000 abstract 1
- 150000002001 dihydroceramides Chemical class 0.000 abstract 1
- 150000003410 sphingosines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/141—Esters of phosphorous acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/24—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/02—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of compounds containing imino groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361801641P | 2013-03-15 | 2013-03-15 | |
| EP13306056 | 2013-07-23 | ||
| PCT/IB2014/000494 WO2014140787A2 (en) | 2013-03-15 | 2014-03-14 | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12015501835A1 PH12015501835A1 (en) | 2015-11-09 |
| PH12015501835B1 true PH12015501835B1 (en) | 2015-11-09 |
Family
ID=51538203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12015501835A PH12015501835B1 (en) | 2013-03-15 | 2015-08-19 | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US20140316154A1 (enExample) |
| EP (3) | EP2970344A2 (enExample) |
| JP (2) | JP6438417B2 (enExample) |
| KR (1) | KR20150132188A (enExample) |
| CN (1) | CN105051051B (enExample) |
| AU (2) | AU2014229638B2 (enExample) |
| BR (1) | BR112015023558A2 (enExample) |
| CA (1) | CA2900902C (enExample) |
| DK (1) | DK3363805T3 (enExample) |
| ES (1) | ES3017659T3 (enExample) |
| HK (1) | HK1214266A1 (enExample) |
| MX (1) | MX387128B (enExample) |
| PH (1) | PH12015501835B1 (enExample) |
| SG (2) | SG11201506456VA (enExample) |
| WO (1) | WO2014140787A2 (enExample) |
| ZA (1) | ZA201505860B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8378068B2 (en) | 2009-02-16 | 2013-02-19 | Cerenis Therapeutics Holding Sa | Apolipoprotein A-I mimics |
| SG10201708237SA (en) | 2010-10-18 | 2017-11-29 | Cerenis Therapeutics Holding Sa | Compounds, compositions and methods useful for cholesterol mobilisation |
| US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| MX387128B (es) | 2013-03-15 | 2025-03-19 | Cerenis Therapeutics Holding Sa | Métodos para la síntesis de esfingomielinas y dihidroesfingomielinas. |
| US20190046608A1 (en) | 2017-08-10 | 2019-02-14 | Cerenis Therapeutics Holding Sa | Apomers |
| US20190048049A1 (en) | 2017-08-10 | 2019-02-14 | Cerenis Therapeutics Holding Sa | Cargomers |
| EP3778611B1 (en) * | 2018-03-27 | 2022-10-12 | NOF Corporation | Sphingomyelin-derived lipid and method for producing same |
| JP7303618B2 (ja) * | 2018-10-05 | 2023-07-05 | 日本精化株式会社 | スフィンゴリン脂質前駆体及びその製造方法、並びに、スフィンゴリン脂質の製造方法 |
| US20240033322A1 (en) | 2020-04-16 | 2024-02-01 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein-based complexes |
| EP4135838A1 (en) | 2020-04-16 | 2023-02-22 | Abionyx Pharma SA | Cer-001 therapy for treating kidney disease |
| WO2021209808A1 (en) | 2020-04-16 | 2021-10-21 | Abionyx Pharma Sa | Cer-001 therapy for treating kidney disease |
| MX2023003877A (es) | 2020-10-01 | 2023-04-18 | Abionyx Pharma Sa | Composiciones que comprenden complejos basados en proteina de union a lipidos para usarse en el tratamiento de enfermedades oculares. |
| AU2022258815A1 (en) | 2021-04-15 | 2023-10-19 | Abionyx Pharma Sa | Use of lipid binding protein-based complexes in organ preservation solutions |
| WO2023194798A1 (en) | 2022-04-06 | 2023-10-12 | Abionyx Pharma Sa | Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes |
| EP4504150A1 (en) | 2022-04-06 | 2025-02-12 | Abionyx Pharma SA | Methods for treating eye diseases using lipid binding protein-based complexes |
| US20250360184A1 (en) | 2022-06-10 | 2025-11-27 | Abionyx Pharma Sa | Methods for treating acute conditions using lipid binding protein-based complexes |
| WO2023237927A2 (en) | 2022-06-10 | 2023-12-14 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using lipid binding protein -based complexes |
| CA3260759A1 (en) | 2022-06-28 | 2024-01-04 | Abionyx Pharma Sa | SPHINGOMYELIN COMPOUNDS AND SYNTHETIC PROCESSES |
| IL322074A (en) | 2023-01-13 | 2025-09-01 | Abionyx Pharma Sa | Treatment using a lipid-binding protein molecule |
| WO2025093929A1 (en) | 2023-10-31 | 2025-05-08 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0146810A3 (de) | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| US5220043A (en) * | 1991-03-21 | 1993-06-15 | Ohio University | Synthesis of D-erythro-sphingomyelins |
| US5766627A (en) | 1993-11-16 | 1998-06-16 | Depotech | Multivescular liposomes with controlled release of encapsulated biologically active substances |
| KR100241300B1 (ko) | 1993-11-16 | 2000-03-02 | Sheldon A. Schaffer | 활성물질의 조절된 방출성을 갖는 소포 |
| AU765809B2 (en) * | 1998-02-12 | 2003-10-02 | Emory University | Sphingolipid derivatives and their methods of use |
| JP2004002215A (ja) * | 2002-05-23 | 2004-01-08 | National Institute Of Advanced Industrial & Technology | スフィンゴ脂質誘導体の製造方法 |
| JP2007517860A (ja) | 2004-01-15 | 2007-07-05 | バイオラブ・リミテッド | スフィンゴミエリン、その中間体及びその調製方法 |
| CA2566559C (en) | 2004-05-17 | 2014-05-06 | Inex Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
| ES2317259T3 (es) * | 2004-06-29 | 2009-04-16 | Jado Technologies Gmbh | Esfingolipidos contra procesos patologicos en baldas lipidicas. |
| JP2006045113A (ja) | 2004-08-04 | 2006-02-16 | Kemikurea:Kk | リン酸エステル類 |
| JP4825947B2 (ja) | 2004-08-04 | 2011-11-30 | 学校法人関西学院 | 不飽和アミノジオール類の製造方法 |
| US8206750B2 (en) | 2005-03-24 | 2012-06-26 | Cerenis Therapeutics Holding S.A. | Charged lipoprotein complexes and their uses |
| US7470664B2 (en) * | 2005-07-20 | 2008-12-30 | Merck & Co., Inc. | HCV NS3 protease inhibitors |
| JP2007204384A (ja) | 2006-01-31 | 2007-08-16 | Kemikurea:Kk | 光学活性リン酸誘導体およびこれを用いた光学活性スフィンゴシン１−リン酸誘導体の製造方法 |
| WO2008096880A1 (ja) * | 2007-02-09 | 2008-08-14 | Gifu University | スフィンゴ糖脂質の合成法 |
| US8093395B2 (en) | 2007-03-09 | 2012-01-10 | Otsuka Chemical Co., Ltd. | Sphingosine compound, method for producing the same, and sphingomyelinase inhibitor |
| CN102231978B (zh) | 2008-10-07 | 2016-01-20 | 耶路撒冷希伯来大学伊森姆研究发展公司 | 包含包埋在聚合物基质中的脂质体的组合物和其使用方法 |
| DK2673296T3 (en) | 2011-02-07 | 2019-02-18 | Cerenis Therapeutics Holding Sa | LIPOPROTEIN COMPLEXES AND PREPARATION AND APPLICATIONS THEREOF |
| FR3000959B1 (fr) * | 2013-01-14 | 2015-08-21 | Holis Technologies | Nouveaux intermediaires de synthese permettant d'acceder avec de bons rendements a des derives de sphingosines, ceramides et sphingomyelines |
| US9708354B2 (en) | 2013-03-15 | 2017-07-18 | Cerenis Therapeutics Holding Sa | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins |
| MX387128B (es) * | 2013-03-15 | 2025-03-19 | Cerenis Therapeutics Holding Sa | Métodos para la síntesis de esfingomielinas y dihidroesfingomielinas. |
-
2014
- 2014-03-14 MX MX2015012877A patent/MX387128B/es unknown
- 2014-03-14 BR BR112015023558A patent/BR112015023558A2/pt not_active Application Discontinuation
- 2014-03-14 HK HK16102047.1A patent/HK1214266A1/zh unknown
- 2014-03-14 CA CA2900902A patent/CA2900902C/en active Active
- 2014-03-14 EP EP14729036.5A patent/EP2970344A2/en not_active Withdrawn
- 2014-03-14 WO PCT/IB2014/000494 patent/WO2014140787A2/en not_active Ceased
- 2014-03-14 DK DK18160532.0T patent/DK3363805T3/da active
- 2014-03-14 JP JP2015562366A patent/JP6438417B2/ja active Active
- 2014-03-14 EP EP18160532.0A patent/EP3363805B1/en active Active
- 2014-03-14 ES ES20214357T patent/ES3017659T3/es active Active
- 2014-03-14 US US14/213,269 patent/US20140316154A1/en not_active Abandoned
- 2014-03-14 EP EP20214357.4A patent/EP3842443B1/en active Active
- 2014-03-14 CN CN201480015700.6A patent/CN105051051B/zh active Active
- 2014-03-14 KR KR1020157025911A patent/KR20150132188A/ko not_active Withdrawn
- 2014-03-14 SG SG11201506456VA patent/SG11201506456VA/en unknown
- 2014-03-14 AU AU2014229638A patent/AU2014229638B2/en active Active
- 2014-03-14 SG SG10201804887YA patent/SG10201804887YA/en unknown
-
2015
- 2015-04-22 US US14/693,520 patent/US9643915B2/en active Active
- 2015-08-14 ZA ZA2015/05860A patent/ZA201505860B/en unknown
- 2015-08-19 PH PH12015501835A patent/PH12015501835B1/en unknown
-
2017
- 2017-04-04 US US15/478,532 patent/US20170204122A1/en not_active Abandoned
-
2018
- 2018-06-21 JP JP2018117808A patent/JP2018168171A/ja active Pending
- 2018-11-21 AU AU2018267598A patent/AU2018267598A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12015501835A1 (en) | Methods for the synthesis of sphingomyelins and dihydrosphingomyelins | |
| MY191169A (en) | Anti-fcrh5 antibodies | |
| PH12014502132A1 (en) | Anti-lgr5 antibodies and immunoconjugates | |
| PH12014501605A1 (en) | Anti-lrp5 antibodies and methods of use | |
| MX2015012326A (es) | Anticuerpos anti-crth2 y su uso. | |
| MX342240B (es) | Anticuerpos anti-fgfr4 y metodos de uso. | |
| MX2020002289A (es) | Anticuerpos anti-alfa-sinucleina y metodos de uso. | |
| MX2013015311A (es) | Polipeptidos de enlace de pcsk9 y metodos de uso. | |
| MX2014002053A (es) | Anticuerpos anti -mcsp y metodos de uso. | |
| PH12015501954A1 (en) | Anti-b7-h4 antibodies and immunoconjugates | |
| MX2015013901A (es) | Anticuerpos anti-il-4 y anticuerpos biespecificos y sus usos. | |
| PH12014500841B1 (en) | ANTI-HtrA1 ANTIBODIES AND METHODS OF USE | |
| MX2013001473A (es) | Anticuerpos contra il-18r1 y usos de los mismos. | |
| MX2014014376A (es) | Anticuerpos de anti-biotina y metodos de uso. | |
| IN2013MU00848A (enExample) | ||
| SG10201710426SA (en) | Methods for the biomethanation of h2 and co2 | |
| MX357675B (es) | Anticuerpos anti-jagged y métodos de uso. | |
| MX353951B (es) | Anticuerpos de anti-teofilina y metodos de uso. | |
| ZA201603457B (en) | Novel method for the synthesis of agomelatine | |
| PH12016501201A1 (en) | Synthesis of ent-progesterone and intermediates thereof | |
| PH12018500508A1 (en) | Methods for the synthesis of spingomyelins and dihydrosphingomyelins | |
| MX2015012902A (es) | Sintesis de ent-progesterona e intermediarios de la misma. | |
| MX2015010789A (es) | Anticuerpos anti-pcsm. | |
| IN2013CH05395A (enExample) | ||
| IN2013MU01524A (enExample) |