PH12014501712B1 - Novel morpholinyl derivatives useful as mogat-2-inhibitors - Google Patents
Novel morpholinyl derivatives useful as mogat-2-inhibitorsInfo
- Publication number
- PH12014501712B1 PH12014501712B1 PH12014501712A PH12014501712A PH12014501712B1 PH 12014501712 B1 PH12014501712 B1 PH 12014501712B1 PH 12014501712 A PH12014501712 A PH 12014501712A PH 12014501712 A PH12014501712 A PH 12014501712A PH 12014501712 B1 PH12014501712 B1 PH 12014501712B1
- Authority
- PH
- Philippines
- Prior art keywords
- mogat
- inhibitors
- derivatives useful
- novel
- morpholinyl derivatives
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 125000002757 morpholinyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382037 | 2012-01-31 | ||
| US201261617093P | 2012-03-29 | 2012-03-29 | |
| EP12382433 | 2012-11-06 | ||
| PCT/US2013/022828 WO2013116065A1 (en) | 2012-01-31 | 2013-01-24 | Novel morpholinyl derivatives useful as mogat-2 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12014501712A1 PH12014501712A1 (en) | 2014-10-13 |
| PH12014501712B1 true PH12014501712B1 (en) | 2014-10-13 |
Family
ID=48905712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12014501712A PH12014501712B1 (en) | 2012-01-31 | 2014-07-30 | Novel morpholinyl derivatives useful as mogat-2-inhibitors |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8993568B2 (https=) |
| EP (1) | EP2809661B1 (https=) |
| JP (1) | JP5852269B2 (https=) |
| KR (1) | KR20140107641A (https=) |
| CN (1) | CN104080777B (https=) |
| AP (1) | AP2014007793A0 (https=) |
| AU (1) | AU2013215549B2 (https=) |
| BR (1) | BR112014018712A8 (https=) |
| CA (1) | CA2859992A1 (https=) |
| CL (1) | CL2014001862A1 (https=) |
| CO (1) | CO7020914A2 (https=) |
| CR (1) | CR20140325A (https=) |
| DO (1) | DOP2014000177A (https=) |
| EA (1) | EA024182B1 (https=) |
| ES (1) | ES2571577T3 (https=) |
| GT (1) | GT201400169A (https=) |
| IL (1) | IL233542A0 (https=) |
| MX (1) | MX2014008604A (https=) |
| PE (1) | PE20141789A1 (https=) |
| PH (1) | PH12014501712B1 (https=) |
| SG (1) | SG11201404508XA (https=) |
| WO (1) | WO2013116065A1 (https=) |
| ZA (1) | ZA201405227B (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9073856B2 (en) | 2012-01-23 | 2015-07-07 | Eli Lilly And Company | Phenyl methanesulfonamide derivatives useful as MGAT-2 inhibitors |
| BR112014018712A8 (pt) | 2012-01-31 | 2017-07-11 | Lilly Co Eli | Derivados de morfolinila úteis como inibidores de mogat-2 |
| AR089771A1 (es) | 2012-01-31 | 2014-09-17 | Lilly Co Eli | Derivados de bencil sulfonamida utiles como inhibidores de mogat-2 |
| US9416138B2 (en) | 2012-11-06 | 2016-08-16 | Eli Lilly And Company | Benzyl sulfonamide compounds useful as MoGAT-2 inhibitors |
| EP3395798A4 (en) | 2015-12-21 | 2019-07-17 | Shionogi & Co., Ltd | NON-AROMATIC HETEROCYCLIC DERIVATIVE HAVING MGAT2 INHIBITORY ACTIVITY |
| TWI782056B (zh) | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
| MX2021008050A (es) | 2019-01-11 | 2021-08-05 | Shionogi & Co | Derivado de dihidropirazolopirazinona que tiene actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat2). |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| GB9702194D0 (en) | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
| WO2000006539A1 (en) | 1998-07-31 | 2000-02-10 | Eli Lilly And Company | Alkenyl sulphonamide derivatives |
| AU5235699A (en) | 1998-07-31 | 2000-02-21 | Eli Lilly And Company | Sulfonamide derivatives |
| GB0408777D0 (en) | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| EP1655283A1 (en) | 2004-11-08 | 2006-05-10 | Evotec OAI AG | 11beta-HSD1 Inhibitors |
| EP1659113A1 (en) | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| EP2078719A4 (en) * | 2006-09-28 | 2009-11-11 | Dainippon Sumitomo Pharma Co | COMPOUND WITH BICYCLIC PYRIMIDINE STRUCTURE AND THE COMPOUND CONTAINING PHARMACEUTICAL COMPOSITION |
| TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
| CA2715527A1 (en) * | 2007-12-05 | 2009-06-11 | Michael Higginbottom | New compounds iv |
| WO2009086303A2 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009119726A1 (ja) | 2008-03-28 | 2009-10-01 | 萬有製薬株式会社 | メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体 |
| WO2009147211A1 (en) * | 2008-06-04 | 2009-12-10 | Biovitrum Ab (Publ) | New compounds v |
| AU2010216633A1 (en) | 2009-02-23 | 2011-09-08 | Msd K.K. | Pyrimidin-4(3H)-one derivatives |
| JP2014051434A (ja) | 2010-12-28 | 2014-03-20 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン誘導体 |
| US9073856B2 (en) | 2012-01-23 | 2015-07-07 | Eli Lilly And Company | Phenyl methanesulfonamide derivatives useful as MGAT-2 inhibitors |
| AR089771A1 (es) | 2012-01-31 | 2014-09-17 | Lilly Co Eli | Derivados de bencil sulfonamida utiles como inhibidores de mogat-2 |
| BR112014018712A8 (pt) | 2012-01-31 | 2017-07-11 | Lilly Co Eli | Derivados de morfolinila úteis como inibidores de mogat-2 |
| US9416138B2 (en) | 2012-11-06 | 2016-08-16 | Eli Lilly And Company | Benzyl sulfonamide compounds useful as MoGAT-2 inhibitors |
-
2013
- 2013-01-24 BR BR112014018712A patent/BR112014018712A8/pt not_active IP Right Cessation
- 2013-01-24 EA EA201491227A patent/EA024182B1/ru not_active IP Right Cessation
- 2013-01-24 JP JP2014554806A patent/JP5852269B2/ja not_active Expired - Fee Related
- 2013-01-24 CN CN201380007113.8A patent/CN104080777B/zh not_active Expired - Fee Related
- 2013-01-24 AU AU2013215549A patent/AU2013215549B2/en not_active Ceased
- 2013-01-24 ES ES13702564T patent/ES2571577T3/es active Active
- 2013-01-24 WO PCT/US2013/022828 patent/WO2013116065A1/en not_active Ceased
- 2013-01-24 EP EP13702564.9A patent/EP2809661B1/en active Active
- 2013-01-24 CA CA2859992A patent/CA2859992A1/en not_active Abandoned
- 2013-01-24 KR KR1020147021129A patent/KR20140107641A/ko not_active Abandoned
- 2013-01-24 PE PE2014001194A patent/PE20141789A1/es not_active Application Discontinuation
- 2013-01-24 SG SG11201404508XA patent/SG11201404508XA/en unknown
- 2013-01-24 MX MX2014008604A patent/MX2014008604A/es unknown
- 2013-01-24 US US14/372,833 patent/US8993568B2/en not_active Expired - Fee Related
- 2013-01-24 AP AP2014007793A patent/AP2014007793A0/xx unknown
-
2014
- 2014-07-07 IL IL233542A patent/IL233542A0/en unknown
- 2014-07-08 CR CR20140325A patent/CR20140325A/es unknown
- 2014-07-15 CL CL2014001862A patent/CL2014001862A1/es unknown
- 2014-07-16 ZA ZA2014/05227A patent/ZA201405227B/en unknown
- 2014-07-24 CO CO14161421A patent/CO7020914A2/es unknown
- 2014-07-29 GT GT201400169A patent/GT201400169A/es unknown
- 2014-07-30 PH PH12014501712A patent/PH12014501712B1/en unknown
- 2014-07-30 DO DO2014000177A patent/DOP2014000177A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5852269B2 (ja) | 2016-02-03 |
| PE20141789A1 (es) | 2014-11-19 |
| EA024182B1 (ru) | 2016-08-31 |
| CN104080777A (zh) | 2014-10-01 |
| US8993568B2 (en) | 2015-03-31 |
| WO2013116065A1 (en) | 2013-08-08 |
| CA2859992A1 (en) | 2013-08-08 |
| KR20140107641A (ko) | 2014-09-04 |
| CL2014001862A1 (es) | 2014-11-14 |
| CO7020914A2 (es) | 2014-08-11 |
| PH12014501712A1 (en) | 2014-10-13 |
| ZA201405227B (en) | 2016-05-25 |
| GT201400169A (es) | 2015-08-27 |
| BR112014018712A2 (https=) | 2017-06-20 |
| AU2013215549B2 (en) | 2015-09-03 |
| ES2571577T3 (es) | 2016-05-26 |
| AP2014007793A0 (en) | 2014-07-31 |
| MX2014008604A (es) | 2014-08-22 |
| HK1199024A1 (zh) | 2015-06-19 |
| EP2809661B1 (en) | 2016-04-06 |
| JP2015504917A (ja) | 2015-02-16 |
| IL233542A0 (en) | 2014-08-31 |
| EP2809661A1 (en) | 2014-12-10 |
| US20150005305A1 (en) | 2015-01-01 |
| SG11201404508XA (en) | 2014-10-30 |
| CR20140325A (es) | 2014-08-25 |
| AU2013215549A1 (en) | 2014-07-17 |
| DOP2014000177A (es) | 2014-08-31 |
| BR112014018712A8 (pt) | 2017-07-11 |
| CN104080777B (zh) | 2015-12-09 |
| EA201491227A1 (ru) | 2015-01-30 |
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