PE52796A1 - Antagonista de los receptores o-1c adrenergicos - Google Patents
Antagonista de los receptores o-1c adrenergicosInfo
- Publication number
- PE52796A1 PE52796A1 PE1995285263A PE28526395A PE52796A1 PE 52796 A1 PE52796 A1 PE 52796A1 PE 1995285263 A PE1995285263 A PE 1995285263A PE 28526395 A PE28526395 A PE 28526395A PE 52796 A1 PE52796 A1 PE 52796A1
- Authority
- PE
- Peru
- Prior art keywords
- compound
- formula
- sea
- alkyl
- nitrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE AL COMPUESTO DE OXAZOL DE FORMULA I DONDE: R1 Y R3 SE SELECCIONAN DE H, OH, ALQUILO DE C1-C6 ENTRE OTROS; R2 ES DE H, ALQUILO DE C1-C6, ALCOXI DE C1-C6 ENTRE OTROS; W ES UNA CADENA DE ALQUILENO DE C1-C6 o NITROGENO; m ES O o 1; X ES CH o NITROGENO, CON LA CONDICION QUE CUANDO W ES NITROGENO ENTONCES X ES CH; q ES UN NUMERO ENTERO DE 1 A 4 CON LA CONDICION QUE CUANDO R1 ES FENILO o FENILO MONO O DISUSTITUIDO CON HALOGENO, METILO o METOXI, R2 SEA H o METILO, R3 SEA H, OH o ALCOXI DE C1-C6, W SEA (CH2), m SEA 1 y X SEA CH; TAMBIEN SE REFIERE AL PROCESO DE PREPARACION QUE COMPRENDE: a) REACCION DE UN COMPUESTO DE FORMULA (8a) CON EL COMPUESTO DE FORMULA LG-(CH2)q-R3; o b) PARA LA PREPARACION DE UN COMPUESTO DE FORMULA I, DONDE R3 ES FENILO SUSTITUIDO CON AL MENOS UN GRUPO C1-6 ALQUILSULFONILAMINO C1-6 ALQUILO, SE HACE REACCIONAR EL COMPUESTO DE FORMULA II, EN DONDE R3 ES FENILO SUSTITUIDO CON AL MENOS UN GRUPO AMINO C1-6 ALQUILO, CON UN REACTIVO ADECUADO PARA INTRODUCIR UN GRUPO C1-6 ALQUILSULFONILO, Y OPCIONALMENTE: i) CONVERTIR EL COMPUESTO OBTENIDO A UNA SAL; ii) REMOVER CUALQUIERA DE LOS GRUPOS PROTECTORES; iii) CONVERTIR UN COMPUESTO DE FORMULA I O UNA SAL DEL MISMO, EN UNA SAL O SOLVATO FARMACEUTICAMENTE ACEPTABLE. ES USADO EN EL TRATAMIENTO DE HIPERPLASIA PROSTATICA BENIGNA, ARRITMIA, GLAUCOMA ENTRE OTROS
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9423638A GB9423638D0 (en) | 1994-11-23 | 1994-11-23 | Antagonists of a- 1c adrenergic receptors |
| GBGB9506282.4A GB9506282D0 (en) | 1995-03-28 | 1995-03-28 | Antagonists of A-1C adrenergic receptors |
| GBGB9519885.9A GB9519885D0 (en) | 1995-09-29 | 1995-09-29 | Antagonists of a-1 adrenergic receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE52796A1 true PE52796A1 (es) | 1996-12-25 |
Family
ID=27267484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1995285263A PE52796A1 (es) | 1994-11-23 | 1995-11-22 | Antagonista de los receptores o-1c adrenergicos |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6090825A (es) |
| EP (1) | EP0793658A1 (es) |
| JP (1) | JPH10509713A (es) |
| AR (1) | AR002249A1 (es) |
| AU (1) | AU4174096A (es) |
| IL (1) | IL116082A0 (es) |
| PE (1) | PE52796A1 (es) |
| WO (1) | WO1996016049A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000055143A1 (en) * | 1999-03-17 | 2000-09-21 | F. Hoffmann-La Roche Ag | Oxazolone derivatives and their use as alpha-1 adrenoreceptor modulators |
| US6355641B1 (en) | 1999-03-17 | 2002-03-12 | Syntex (U.S.A.) Llc | Oxazolone derivatives and uses thereof |
| US20040216749A1 (en) * | 2003-01-23 | 2004-11-04 | Hosheng Tu | Vasomodulation during glaucoma surgery |
| CN1980901A (zh) * | 2004-06-30 | 2007-06-13 | 万有制药株式会社 | 联芳基衍生物 |
| WO2010080873A1 (en) * | 2009-01-08 | 2010-07-15 | Glaxo Group Limited | Oxazoles as modulators of chemokine receptors |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| JP2017100949A (ja) * | 2014-04-01 | 2017-06-08 | 大日本住友製薬株式会社 | ５員環ヘテロアリール誘導体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1033040B (it) * | 1970-02-21 | 1979-07-10 | Serono Ist Farm | 4 5 difenilossazoli 2 amminometil e 2,2 amminoetil sostituiti |
| US3966748A (en) * | 1975-05-08 | 1976-06-29 | American Cyanamid Company | Para-fluorophenyl-N-heterocyclic substituted butanes |
| US4101660A (en) * | 1976-02-12 | 1978-07-18 | Mitsubishi Chemical Industries Limited | 2-Aminomethyl-5-phenyloxazoles and the pharmaceutically acceptable acid addition salts thereof |
| US5324723A (en) * | 1987-09-10 | 1994-06-28 | Merck Sharpe & Dohme Ltd. | Oxazoles and thiazoles for the treatment of senile dementia |
| ES2125285T3 (es) * | 1992-07-31 | 1999-03-01 | Bristol Myers Squibb Co | Derivados inhibidores de la reabsorcion de adenosina de difenil-oxazoles, tiazoles e imidazoles. |
-
1995
- 1995-11-20 EP EP95940209A patent/EP0793658A1/en not_active Ceased
- 1995-11-20 JP JP8516561A patent/JPH10509713A/ja active Pending
- 1995-11-20 WO PCT/EP1995/004552 patent/WO1996016049A1/en not_active Application Discontinuation
- 1995-11-20 AU AU41740/96A patent/AU4174096A/en not_active Abandoned
- 1995-11-20 US US08/849,016 patent/US6090825A/en not_active Expired - Fee Related
- 1995-11-21 IL IL11608295A patent/IL116082A0/xx unknown
- 1995-11-22 AR ARP950100260A patent/AR002249A1/es unknown
- 1995-11-22 PE PE1995285263A patent/PE52796A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6090825A (en) | 2000-07-18 |
| IL116082A0 (en) | 1996-01-31 |
| AR002249A1 (es) | 1998-03-11 |
| AU4174096A (en) | 1996-06-17 |
| WO1996016049A1 (en) | 1996-05-30 |
| EP0793658A1 (en) | 1997-09-10 |
| JPH10509713A (ja) | 1998-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |