ES2060591T3 - Un procedimiento para preparar compuestos de pirazolotriazina. - Google Patents

Un procedimiento para preparar compuestos de pirazolotriazina.

Info

Publication number
ES2060591T3
ES2060591T3 ES87115806T ES87115806T ES2060591T3 ES 2060591 T3 ES2060591 T3 ES 2060591T3 ES 87115806 T ES87115806 T ES 87115806T ES 87115806 T ES87115806 T ES 87115806T ES 2060591 T3 ES2060591 T3 ES 2060591T3
Authority
ES
Spain
Prior art keywords
compounds
substitutes
alkyl
thiophenyl
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87115806T
Other languages
English (en)
Other versions
ES2060591T5 (es
Inventor
Setsuro Aig De Blanche Fujii
Hiroyuki Kawamura
Hiroshi Kiyokawa
Satoshi Yamada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27465636&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2060591(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES2060591T3 publication Critical patent/ES2060591T3/es
Application granted granted Critical
Publication of ES2060591T5 publication Critical patent/ES2060591T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPUESTOS DE PIRAZOLOTRIAZINA DE FORMULA (1) EN DONDE R'' ES OH O ALCANOILOXI; R2 ES H, OH, O SH; R3 ES (1) UN GRUPO HETEROCICLICO INSATURADO CONTENIENDO N O S TENIENDO 1-2 SUSTITUYENTES DE HALOGENO, NITRO, O TIOFENILO, (2) NAFTILO, (3) FENILO TENIENDO OPCIONALMENTE 1-3 SUSTITUYENTES DE (I) ALQUILO, (II) FENILO, (III) ALCOXICARBONILO, (IV) CIANO, (V) NITRO, (VI) ALCOXI, (VII) FENILALCOXI, (VIII) ALQUIL-TIOFENILO, (IX) FENOXI, (X) EL GRUPO (II), (R ES ALQUILO, ALQUILO HALOSUSTITUIDO, FENILO TENIENDO OPCIONALMENTE SUSTIUYENTES EN 1-3 Y PIRIDILO Y LAMBDA ES 0, 1 O 2; (XI) HALOGENO; (XII) FENILALQUILO, (XIII) CARBOXI, (XIV) ALCANOILO, (XV) BENZOILO, TENIENDO OPCIONALMENTE SUSTITUYENTES EN 1-3, (XVI) AMINO, (XVII) OH, (XVIII) ALCANOILOXI (XIX); DICHOS COMPUESTOS TIENEN UNA ACTIVIDAD INHIBITORIA DE LA XANTINA OXIDASA Y SON UTILES PARA EL TRATAMIENTO Y PROFILAXIS DE LA GOTA.
ES87115806T 1986-10-31 1987-10-28 Compuestos pirazolotriazina. Expired - Lifetime ES2060591T5 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP26100886 1986-10-31
JP7391187 1987-03-26
JP12068887 1987-05-18
JP15943787 1987-06-25

Publications (2)

Publication Number Publication Date
ES2060591T3 true ES2060591T3 (es) 1994-12-01
ES2060591T5 ES2060591T5 (es) 1996-02-16

Family

ID=27465636

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87115806T Expired - Lifetime ES2060591T5 (es) 1986-10-31 1987-10-28 Compuestos pirazolotriazina.

Country Status (8)

Country Link
US (1) US4824834A (es)
EP (1) EP0269859B2 (es)
JP (1) JPH0641466B2 (es)
KR (1) KR950001021B1 (es)
CN (1) CN1017708B (es)
DE (1) DE3787707T2 (es)
DK (1) DK539287A (es)
ES (1) ES2060591T5 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2691317B2 (ja) * 1989-08-25 1997-12-17 株式会社大塚製薬工場 4―ヒドロキシ―8―(3―低級アルコキシ―4―フェニルスルフィニルフェニル)ピラゾロ〔1,5―a〕―1,3,5―トリアジン光学活性体の塩類及びその製造方法
GB2244487B (en) * 1990-05-29 1994-02-02 Ici Plc Azole derivatives
US5420128A (en) * 1990-10-09 1995-05-30 Otsuka Pharmaceutical Co., Ltd. Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor
AU667575B2 (en) * 1992-10-20 1996-03-28 Otsuka Pharmaceutical Co., Ltd. Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor
CA2102001C (en) * 1992-12-01 2001-04-17 George K. Castle Reinforcement system for mastic intumescent fire protection coatings
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
NZ333777A (en) * 1996-07-24 2000-07-28 Du Pont Pharm Co (1,5-a) pyrazolo and triazole triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
ATE375344T1 (de) * 1996-07-24 2007-10-15 Bristol Myers Squibb Pharma Co Azolotriazine und pyrimidine
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US6124289A (en) 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
AU4331500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
DK1206474T3 (da) * 1999-08-27 2004-10-04 Abbott Lab Sulfonylphenylpyrazolforbindelser anvendelige som cox-2-inhibitorer
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
US6524492B2 (en) * 2000-12-28 2003-02-25 Peach State Labs, Inc. Composition and method for increasing water and oil repellency of textiles and carpet
FR2842809A1 (fr) * 2002-07-26 2004-01-30 Greenpharma Sas NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7208596B2 (en) * 2003-11-25 2007-04-24 Bristol-Myers Squibb Pharma Company Processes for the preparation of pyrazolo[1,5-a]-1,3,5-triazines and intermediates thereof
US7153961B2 (en) * 2003-11-25 2006-12-26 Bristol-Myers Squibb Pharma Co. Salt and crystalline form thereof of a corticotropin releasing factor receptor antagonist
BRPI0918430A2 (pt) 2008-08-14 2015-11-24 Bayer Cropscience Ag 4-fenil-1h-pirazóis inseticidas.
WO2011161201A1 (en) 2010-06-22 2011-12-29 Kancera Ab Bisarylsulfonamides useful as kinase inhibitors in the treatment of inflammation and cancer
US10000449B2 (en) 2011-12-22 2018-06-19 Kancera Ab Bisarylsulfonamides useful in the treatment of inflammation and cancer
EP2794009B1 (en) * 2011-12-22 2017-08-30 Kancera AB Bisarylsulfonamides useful in the treatment of inflammation and cancer
CN104311441B (zh) * 2014-09-27 2016-01-20 张远强 一类氯代萘环的丁二酸酰胺衍生物、其制备方法及用途
CN104193644B (zh) * 2014-09-27 2015-12-02 张远强 甲氧萘环的丁二酸酰胺衍生物、其制备方法及用途
CN111220611B (zh) * 2020-02-18 2022-05-10 北京工业大学 一种三嗪三吡唑化合物在阴离子检测中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865824A (en) * 1972-03-07 1975-02-11 Icn Pharmaceuticals 2-Aryl-7-substituted pyrazolo {8 1,5{i a{b {9 1,3,5-triazines
US3910907A (en) * 1973-07-09 1975-10-07 Icn Pharmaceuticals Pyrazolo(1,5-a)-1,3,5-triazines
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
CH635587A5 (fr) * 1978-01-09 1983-04-15 Aron Sa Derives amines de pyrazolo (1,5-a) s.triazine, therapeutiquement actifs et leurs procedes de preparation.
US4565815A (en) * 1982-12-30 1986-01-21 Biomeasure, Inc. Pyrazolo[1,5-a]-1,3,5-triazines
AU2192683A (en) * 1982-12-30 1984-07-05 Biomeasure Incorporated Pyrazolo(1,5-alpha)-1,3,5-triazines

Also Published As

Publication number Publication date
CN1017708B (zh) 1992-08-05
JPS6479184A (en) 1989-03-24
KR880005133A (ko) 1988-06-28
EP0269859B1 (en) 1993-10-06
KR950001021B1 (ko) 1995-02-07
CN87107217A (zh) 1988-05-11
ES2060591T5 (es) 1996-02-16
DE3787707T2 (de) 1994-02-03
JPH0641466B2 (ja) 1994-06-01
DK539287D0 (da) 1987-10-15
DK539287A (da) 1988-05-01
EP0269859A3 (en) 1990-02-07
US4824834A (en) 1989-04-25
DE3787707D1 (de) 1993-11-11
EP0269859B2 (en) 1995-10-18
EP0269859A2 (en) 1988-06-08

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