PE34696A1 - Derivado de acetidinilalquil-lactama - Google Patents

Derivado de acetidinilalquil-lactama

Info

Publication number
PE34696A1
PE34696A1 PE1995275289A PE27528995A PE34696A1 PE 34696 A1 PE34696 A1 PE 34696A1 PE 1995275289 A PE1995275289 A PE 1995275289A PE 27528995 A PE27528995 A PE 27528995A PE 34696 A1 PE34696 A1 PE 34696A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
conr3r4
preference
direct link
Prior art date
Application number
PE1995275289A
Other languages
English (en)
Inventor
Donald Stuart Middleton
Sandra Dora Meadows
Alan Patrick Marchington
Alexander Roderick Mackenzie
Original Assignee
Pfizer Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Res & Dev filed Critical Pfizer Res & Dev
Publication of PE34696A1 publication Critical patent/PE34696A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R ES CICLOALQUILO DE C3-C7, ARILO o ALQUILO DE C1-C6, ESTANDO DICHO ALQUILO DE C1-C6 OPCIONALMENTE SUSTITUIDO POR COOH, UN COMPUESTO PREFERIDO ES 5-CARBOXIPENTILO; R1 ES FENILO, NAFTILO, BENZOTIENILO ENTRE OTROS, CADA UNO SUSTITUIDO OPCIONALMENTE POR UNO o DOS SUSTITUYENTES CADA UNO SELECCIONADO INDEPENDIENTEMENTE DE ALQUILO DE C1-C4, ALCOXI DE C1-C4, HALO Y TRIFLUOROMETILO, DE PREFERENCIA HALO; R2 ES -CO2H, -CONR3R4,-CONR5 (CICLOALQUILO DE C3-C7) ENTRE OTROS, DE PREFERENCIA -CONR3R4; R3 Y R4 ESTAN SELECCIONADOS CADA UNO INDEPENDIENTEMENTE DE H y ALQUILO DE C1-C4 OPCIONALMENTE SUSTITUIDO POR OH, ALCOXI DE C1-C4, AMINO ENTRE OTROS; R5 Y R6 ESTAN SELECCIONADOS DE H, ALQUILO DE C1-C4, CICLOALQUILO DE C3-C7-ALQUILO DE C1-C4 ENTRE OTROS; X ES ALQUILENO DE C1-C4 DE PREFERENCIA ETILENO o PROPILENO; X1 ES UN ENLACE DIRECTO o ALQUILENO DE C1-C6, DE PREFERENCIA ENLACE DIRECTO; m ES 0, 1 o 2. ES USADO EN EL TRATAMIENTO DE UNA ENFERMEDAD INFLAMATORIA TAL COMO ARTRITIS, PSORIASIS, ASMA, ENTRE OTRAS, PRODUCIENDO UN EFECTO ANTAGONISTA SOBRE UNA TAQUICININA QUE ACTUA EN EL RECEPTOR HUMANO NK1, NK2, NK3 o COMBINACION DE ELLAS
PE1995275289A 1994-08-09 1995-08-03 Derivado de acetidinilalquil-lactama PE34696A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9416084A GB9416084D0 (en) 1994-08-09 1994-08-09 Lactams
GB9417898A GB9417898D0 (en) 1994-08-09 1994-09-06 Lactams

Publications (1)

Publication Number Publication Date
PE34696A1 true PE34696A1 (es) 1996-10-01

Family

ID=10759627

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1995275289A PE34696A1 (es) 1994-08-09 1995-08-03 Derivado de acetidinilalquil-lactama

Country Status (5)

Country Link
KR (1) KR100218626B1 (es)
CO (1) CO4410338A1 (es)
GB (2) GB9416084D0 (es)
PE (1) PE34696A1 (es)
PL (1) PL183180B1 (es)

Also Published As

Publication number Publication date
CO4410338A1 (es) 1997-01-09
GB9416084D0 (en) 1994-09-28
KR100218626B1 (ko) 1999-09-01
KR970704729A (ko) 1997-09-06
PL183180B1 (pl) 2002-05-31
GB9417898D0 (en) 1994-10-26
PL318534A1 (en) 1997-06-23

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed