PE20220345A1 - Derivados de alcohol como abridores del canal de potasio kv7 - Google Patents
Derivados de alcohol como abridores del canal de potasio kv7Info
- Publication number
- PE20220345A1 PE20220345A1 PE2022000184A PE2022000184A PE20220345A1 PE 20220345 A1 PE20220345 A1 PE 20220345A1 PE 2022000184 A PE2022000184 A PE 2022000184A PE 2022000184 A PE2022000184 A PE 2022000184A PE 20220345 A1 PE20220345 A1 PE 20220345A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- dimethylpentanamide
- trifluoromethoxy
- hydroxy
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical class CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- 229940127315 Potassium Channel Openers Drugs 0.000 title 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 2
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 2
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- GUBAUVBQJNTWJV-STQMWFEESA-N (3S)-3-hydroxy-4,4-dimethyl-N-[(1R)-2-(trifluoromethoxy)-1-[3-(trifluoromethoxy)phenyl]ethyl]pentanamide Chemical compound FC(OC=1C=C(C=CC=1)[C@H](COC(F)(F)F)NC(C[C@@H](C(C)(C)C)O)=O)(F)F GUBAUVBQJNTWJV-STQMWFEESA-N 0.000 abstract 1
- DZHRVMQRFKIUTR-STQMWFEESA-N (3S)-N-[(1R)-1-[3-(difluoromethoxy)phenyl]-2-(trifluoromethoxy)ethyl]-3-hydroxy-4,4-dimethylpentanamide Chemical compound FC(OC=1C=C(C=CC=1)[C@H](COC(F)(F)F)NC(C[C@@H](C(C)(C)C)O)=O)F DZHRVMQRFKIUTR-STQMWFEESA-N 0.000 abstract 1
- FKYDTEWCMGFQME-HOTGVXAUSA-N (3S)-N-[(1R)-2-cyclopropyloxy-1-[3-(difluoromethoxy)phenyl]ethyl]-3-hydroxy-4,4-dimethylpentanamide Chemical compound C1(CC1)OC[C@@H](C1=CC(=CC=C1)OC(F)F)NC(C[C@@H](C(C)(C)C)O)=O FKYDTEWCMGFQME-HOTGVXAUSA-N 0.000 abstract 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- -1 CF2CHF2 Chemical group 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 102000004257 Potassium Channel Human genes 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 108020001213 potassium channel Proteins 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19189750 | 2019-08-02 | ||
| CN201910734123 | 2019-08-09 | ||
| EP19191887 | 2019-08-15 | ||
| PCT/EP2020/071520 WO2021023617A1 (en) | 2019-08-02 | 2020-07-30 | Alcohol derivatives as kv7 potassium channel openers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20220345A1 true PE20220345A1 (es) | 2022-03-14 |
Family
ID=71894829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2022000184A PE20220345A1 (es) | 2019-08-02 | 2020-07-30 | Derivados de alcohol como abridores del canal de potasio kv7 |
Country Status (27)
| Country | Link |
|---|---|
| EP (2) | EP4461725A3 (enExample) |
| JP (2) | JP7720829B2 (enExample) |
| KR (1) | KR102957984B1 (enExample) |
| CN (1) | CN114206830B (enExample) |
| AU (1) | AU2020325517B2 (enExample) |
| BR (1) | BR112021006324A2 (enExample) |
| CA (1) | CA3148719A1 (enExample) |
| CL (1) | CL2022000221A1 (enExample) |
| CO (1) | CO2022000080A2 (enExample) |
| CR (1) | CR20220028A (enExample) |
| DO (1) | DOP2022000026A (enExample) |
| EC (1) | ECSP22008993A (enExample) |
| ES (1) | ES2989376T3 (enExample) |
| GE (2) | GEAP202415862A (enExample) |
| HR (1) | HRP20241444T1 (enExample) |
| HU (1) | HUE069310T2 (enExample) |
| IL (1) | IL290193B2 (enExample) |
| JO (1) | JOP20220017A1 (enExample) |
| MA (1) | MA56708B1 (enExample) |
| MX (1) | MX2022001063A (enExample) |
| PE (1) | PE20220345A1 (enExample) |
| PH (1) | PH12022550192A1 (enExample) |
| PL (1) | PL4007634T3 (enExample) |
| RS (1) | RS66130B1 (enExample) |
| SM (1) | SMT202400445T1 (enExample) |
| WO (1) | WO2021023617A1 (enExample) |
| ZA (1) | ZA202109598B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2989376T3 (es) * | 2019-08-02 | 2024-11-26 | H Lundbeck As | Derivados de alcohol como abridores del canal de potasio Kv7 |
| AU2024310446A1 (en) * | 2023-06-27 | 2026-01-22 | Saniona A/S | Kv7 modulators |
| WO2026132415A1 (en) * | 2024-12-20 | 2026-06-25 | Saniona A/S | Kv7 modulators |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893858B2 (en) | 2000-05-26 | 2005-05-17 | Bristol-Myers Squibb Company | Human kcnq5 potassium channel, methods and compositions thereof |
| WO2001096540A2 (en) | 2000-06-11 | 2001-12-20 | Dupont Pharmaceuticals Company | Hepatitis c protease exosite for inhibitor design |
| US7091202B2 (en) * | 2004-09-15 | 2006-08-15 | Bristol-Myers Squibb Company | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US20090118285A1 (en) | 2006-02-07 | 2009-05-07 | H. Lundbeck A/S | Use of kcnq-openers for treating or reducing the symptoms of schizophrenia |
| WO2007104717A1 (en) * | 2006-03-15 | 2007-09-20 | Neurosearch A/S | Quinazolinones and their use as potassium channels activators |
| CN101790374A (zh) | 2007-08-01 | 2010-07-28 | H.隆德贝克有限公司 | Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途 |
| TW201024286A (en) * | 2008-11-27 | 2010-07-01 | Neurosearch As | Novel compounds |
| EP2928860A1 (en) * | 2012-12-10 | 2015-10-14 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
| WO2014145852A2 (en) * | 2013-03-15 | 2014-09-18 | Knopp Biosciences Llc | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
| ES2749103T3 (es) * | 2014-09-12 | 2020-03-19 | Knopp Biosciences Llc | Benzoimidazol-1,2-ilamidas como activadores del canal Kv7 |
| JP2017095366A (ja) | 2015-11-18 | 2017-06-01 | 持田製薬株式会社 | 新規ビアリールアミド誘導体 |
| CN105663136A (zh) * | 2016-01-15 | 2016-06-15 | 河北中医学院 | 法舒地尔作为制备选择性Kv7离子通道激活剂药物的应用 |
| US10590067B2 (en) * | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
| ES3032221T3 (en) * | 2018-02-20 | 2025-07-16 | H Lundbeck As | Alcohol derivatives as kv7 potassium channel openers |
| ES2989376T3 (es) * | 2019-08-02 | 2024-11-26 | H Lundbeck As | Derivados de alcohol como abridores del canal de potasio Kv7 |
| US12508239B2 (en) * | 2019-08-02 | 2025-12-30 | H. Lundbeck A/S | Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures |
-
2020
- 2020-07-30 ES ES20749879T patent/ES2989376T3/es active Active
- 2020-07-30 HU HUE20749879A patent/HUE069310T2/hu unknown
- 2020-07-30 IL IL290193A patent/IL290193B2/en unknown
- 2020-07-30 RS RS20241162A patent/RS66130B1/sr unknown
- 2020-07-30 EP EP24203380.1A patent/EP4461725A3/en active Pending
- 2020-07-30 PE PE2022000184A patent/PE20220345A1/es unknown
- 2020-07-30 PL PL20749879.1T patent/PL4007634T3/pl unknown
- 2020-07-30 MX MX2022001063A patent/MX2022001063A/es unknown
- 2020-07-30 CA CA3148719A patent/CA3148719A1/en active Pending
- 2020-07-30 CR CR20220028A patent/CR20220028A/es unknown
- 2020-07-30 WO PCT/EP2020/071520 patent/WO2021023617A1/en not_active Ceased
- 2020-07-30 EP EP20749879.1A patent/EP4007634B1/en active Active
- 2020-07-30 GE GEAP202415862A patent/GEAP202415862A/en unknown
- 2020-07-30 SM SM20240445T patent/SMT202400445T1/it unknown
- 2020-07-30 KR KR1020227002204A patent/KR102957984B1/ko active Active
- 2020-07-30 BR BR112021006324A patent/BR112021006324A2/pt unknown
- 2020-07-30 CN CN202080051950.0A patent/CN114206830B/zh active Active
- 2020-07-30 MA MA56708A patent/MA56708B1/fr unknown
- 2020-07-30 PH PH1/2022/550192A patent/PH12022550192A1/en unknown
- 2020-07-30 HR HRP20241444TT patent/HRP20241444T1/hr unknown
- 2020-07-30 AU AU2020325517A patent/AU2020325517B2/en active Active
- 2020-07-30 GE GEAP202015862A patent/GEP20247629B/en unknown
- 2020-07-30 JP JP2022505198A patent/JP7720829B2/ja active Active
-
2021
- 2021-11-25 ZA ZA2021/09598A patent/ZA202109598B/en unknown
-
2022
- 2022-01-11 CO CONC2022/0000080A patent/CO2022000080A2/es unknown
- 2022-01-25 JO JOP/2022/0017A patent/JOP20220017A1/ar unknown
- 2022-01-27 CL CL2022000221A patent/CL2022000221A1/es unknown
- 2022-02-02 DO DO2022000026A patent/DOP2022000026A/es unknown
- 2022-02-04 EC ECSENADI20228993A patent/ECSP22008993A/es unknown
-
2025
- 2025-07-03 JP JP2025112976A patent/JP7897992B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20210397A1 (es) | Derivados de n-(fenil)-2-(fenil)pirimidina-4-carboxamida y compuestos relacionados como inhibidores hpki para tratar el cancer | |
| CO2019003482A2 (es) | Compuestos derivados de ciclobutano o azetidina 1,3 disustituidos como inhibidores de la prostaglandina d sintasa hematopoyética | |
| AR070513A1 (es) | Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sis-tema dopaminergico como por ejemplo esquizofrenia y trastorno depresivo mayor | |
| PE20191541A1 (es) | Composiciones y metodos para inhibir la accion de la arginasa | |
| PE20252740A1 (es) | Metodos de sintesis de compuestos para tratar ciertas leucemias | |
| MX2021014350A (es) | Compuestos de 1-oxo-isoindolin-5-carboxamida sustituida, composiciones de los mismos y metodos de tratamiento con los mismos. | |
| BR112018012921A2 (pt) | compostos pirazol ou seus sais, seus métodos de preparação, composições herbicidas e seu uso | |
| AR086474A1 (es) | Compuestos de pirazol pesticidas | |
| DOP2021000211A (es) | Inhibidores de dihidroorotato deshidrogenasa | |
| PE20180030A1 (es) | Compuestos biciclicos de sulfonamida cetona | |
| AR065015A1 (es) | Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer | |
| PE20061290A1 (es) | Derivados de 1-benzil-indol-2-carboxamida | |
| MA31444B1 (fr) | Agents de lutte contre les parasites invertebres | |
| RU2014149183A (ru) | Проницаемые ингибиторы гликозидазы и их применения | |
| CO6260005A2 (es) | Composiciones agricolas que comprenden dialquil amidas como solvente | |
| HRP20050543A2 (en) | Substituted indolepyridinium as anti-infective compounds | |
| DOP2022000070A (es) | Inhibidor de diacilglicerol aciltransferasa 2 | |
| PY1981130A (es) | Herbicidas de piridazinona e intermedios de piridazinona utilizados para preparar un herbicida | |
| MX2019010169A (es) | Compuestos novedosos utiles como abridores del canal de potasio. | |
| PE20240217A1 (es) | Preparacion de derivados de oxindol como nuevos inhibidores de la diacilglicerol o-aciltransferasa 2 | |
| PE20181039A1 (es) | Metodo para preparar derivados de acido 3-(2-anilino-1-ciclohexil-1h-bencimidazol-5-il)propanoico sustituido | |
| MX2016008536A (es) | Derivados de fluoro-naftilo. | |
| PE20190964A1 (es) | Inhibidores de dopamina-b-hidroxilasa penetrantes de la barrera hematoencefalica | |
| PE20221411A1 (es) | Pirrolidinonas sustituidas con pirazol como herbicidas | |
| UY38941A (es) | Nuevas sulfiliminas o sulfoximinas que contienen compuestos heterocíclicos fungicidas |