KR102957984B1 - Kv7 칼륨 채널 오프너로서의 알코올 유도체 - Google Patents

Kv7 칼륨 채널 오프너로서의 알코올 유도체

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Publication number
KR102957984B1
KR102957984B1 KR1020227002204A KR20227002204A KR102957984B1 KR 102957984 B1 KR102957984 B1 KR 102957984B1 KR 1020227002204 A KR1020227002204 A KR 1020227002204A KR 20227002204 A KR20227002204 A KR 20227002204A KR 102957984 B1 KR102957984 B1 KR 102957984B1
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KR
South Korea
Prior art keywords
difluoromethoxy
phenyl
ethyl
trifluoromethoxy
hydroxy
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020227002204A
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English (en)
Korean (ko)
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KR20220041084A (ko
Inventor
아네테 그라벤 삼스
마리오 로트렌더
크레스티안 라르센
샤오팡 왕
드바시스 다스
지안 홍
수 휘 천
Original Assignee
하. 룬드벡 아크티에셀스카브
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Publication of KR20220041084A publication Critical patent/KR20220041084A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
KR1020227002204A 2019-08-02 2020-07-30 Kv7 칼륨 채널 오프너로서의 알코올 유도체 Active KR102957984B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP19189750.3 2019-08-02
EP19189750 2019-08-02
CN201910734123.0 2019-08-09
CN201910734123 2019-08-09
EP19191887 2019-08-15
EP19191887.9 2019-08-15
PCT/EP2020/071520 WO2021023617A1 (en) 2019-08-02 2020-07-30 Alcohol derivatives as kv7 potassium channel openers

Publications (2)

Publication Number Publication Date
KR20220041084A KR20220041084A (ko) 2022-03-31
KR102957984B1 true KR102957984B1 (ko) 2026-04-27

Family

ID=71894829

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227002204A Active KR102957984B1 (ko) 2019-08-02 2020-07-30 Kv7 칼륨 채널 오프너로서의 알코올 유도체

Country Status (27)

Country Link
EP (2) EP4461725A3 (enExample)
JP (2) JP7720829B2 (enExample)
KR (1) KR102957984B1 (enExample)
CN (1) CN114206830B (enExample)
AU (1) AU2020325517B2 (enExample)
BR (1) BR112021006324A2 (enExample)
CA (1) CA3148719A1 (enExample)
CL (1) CL2022000221A1 (enExample)
CO (1) CO2022000080A2 (enExample)
CR (1) CR20220028A (enExample)
DO (1) DOP2022000026A (enExample)
EC (1) ECSP22008993A (enExample)
ES (1) ES2989376T3 (enExample)
GE (2) GEAP202415862A (enExample)
HR (1) HRP20241444T1 (enExample)
HU (1) HUE069310T2 (enExample)
IL (1) IL290193B2 (enExample)
JO (1) JOP20220017A1 (enExample)
MA (1) MA56708B1 (enExample)
MX (1) MX2022001063A (enExample)
PE (1) PE20220345A1 (enExample)
PH (1) PH12022550192A1 (enExample)
PL (1) PL4007634T3 (enExample)
RS (1) RS66130B1 (enExample)
SM (1) SMT202400445T1 (enExample)
WO (1) WO2021023617A1 (enExample)
ZA (1) ZA202109598B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2989376T3 (es) * 2019-08-02 2024-11-26 H Lundbeck As Derivados de alcohol como abridores del canal de potasio Kv7
AU2024310446A1 (en) * 2023-06-27 2026-01-22 Saniona A/S Kv7 modulators
WO2026132415A1 (en) * 2024-12-20 2026-06-25 Saniona A/S Kv7 modulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190256456A1 (en) 2018-02-20 2019-08-22 H. Lundbeck A/S Alcohol derivatives as kv7 potassium channel openers

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US6893858B2 (en) 2000-05-26 2005-05-17 Bristol-Myers Squibb Company Human kcnq5 potassium channel, methods and compositions thereof
WO2001096540A2 (en) 2000-06-11 2001-12-20 Dupont Pharmaceuticals Company Hepatitis c protease exosite for inhibitor design
US7091202B2 (en) * 2004-09-15 2006-08-15 Bristol-Myers Squibb Company 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators
US7790770B2 (en) * 2005-11-23 2010-09-07 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US20090118285A1 (en) 2006-02-07 2009-05-07 H. Lundbeck A/S Use of kcnq-openers for treating or reducing the symptoms of schizophrenia
WO2007104717A1 (en) * 2006-03-15 2007-09-20 Neurosearch A/S Quinazolinones and their use as potassium channels activators
CN101790374A (zh) 2007-08-01 2010-07-28 H.隆德贝克有限公司 Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途
TW201024286A (en) * 2008-11-27 2010-07-01 Neurosearch As Novel compounds
EP2928860A1 (en) * 2012-12-10 2015-10-14 H. Lundbeck A/S New positive allosteric modulators of nicotinic acetylcholine receptor
WO2014145852A2 (en) * 2013-03-15 2014-09-18 Knopp Biosciences Llc Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators
ES2749103T3 (es) * 2014-09-12 2020-03-19 Knopp Biosciences Llc Benzoimidazol-1,2-ilamidas como activadores del canal Kv7
JP2017095366A (ja) 2015-11-18 2017-06-01 持田製薬株式会社 新規ビアリールアミド誘導体
CN105663136A (zh) * 2016-01-15 2016-06-15 河北中医学院 法舒地尔作为制备选择性Kv7离子通道激活剂药物的应用
ES3032221T3 (en) * 2018-02-20 2025-07-16 H Lundbeck As Alcohol derivatives as kv7 potassium channel openers
ES2989376T3 (es) * 2019-08-02 2024-11-26 H Lundbeck As Derivados de alcohol como abridores del canal de potasio Kv7
US12508239B2 (en) * 2019-08-02 2025-12-30 H. Lundbeck A/S Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190256456A1 (en) 2018-02-20 2019-08-22 H. Lundbeck A/S Alcohol derivatives as kv7 potassium channel openers

Also Published As

Publication number Publication date
RS66130B1 (sr) 2024-11-29
EP4007634C0 (en) 2024-10-02
MX2022001063A (es) 2022-02-14
ES2989376T3 (es) 2024-11-26
HUE069310T2 (hu) 2025-02-28
CN114206830B (zh) 2024-07-30
EP4461725A3 (en) 2025-01-15
CL2022000221A1 (es) 2022-10-07
KR20220041084A (ko) 2022-03-31
JP7897992B2 (ja) 2026-07-30
JOP20220017A1 (ar) 2023-01-30
GEP20247629B (en) 2024-06-10
BR112021006324A2 (pt) 2022-02-15
CO2022000080A2 (es) 2022-01-17
DOP2022000026A (es) 2022-03-31
PH12022550192A1 (en) 2022-11-21
CR20220028A (es) 2022-03-02
MA56708B1 (fr) 2024-12-31
JP7720829B2 (ja) 2025-08-08
IL290193B1 (en) 2024-08-01
CN114206830A (zh) 2022-03-18
ECSP22008993A (es) 2022-03-31
ZA202109598B (en) 2024-04-24
AU2020325517A1 (en) 2022-02-24
EP4461725A2 (en) 2024-11-13
GEAP202415862A (en) 2024-01-25
IL290193A (en) 2022-03-01
SMT202400445T1 (it) 2024-11-15
JP2022543203A (ja) 2022-10-11
PL4007634T3 (pl) 2024-11-25
AU2020325517B2 (en) 2025-08-28
IL290193B2 (en) 2024-12-01
WO2021023617A1 (en) 2021-02-11
JP2025160211A (ja) 2025-10-22
PE20220345A1 (es) 2022-03-14
CA3148719A1 (en) 2021-02-11
EP4007634B1 (en) 2024-10-02
EP4007634A1 (en) 2022-06-08
HRP20241444T1 (hr) 2024-12-20

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