GEAP202415862A - Alcohol derivatives as kv7 potassium channel openers - Google Patents
Alcohol derivatives as kv7 potassium channel openersInfo
- Publication number
- GEAP202415862A GEAP202415862A GEAP202415862A GEAP2024015862A GEAP202415862A GE AP202415862 A GEAP202415862 A GE AP202415862A GE AP202415862 A GEAP202415862 A GE AP202415862A GE AP2024015862 A GEAP2024015862 A GE AP2024015862A GE AP202415862 A GEAP202415862 A GE AP202415862A
- Authority
- GE
- Georgia
- Prior art keywords
- potassium channel
- alcohol derivatives
- channel openers
- activation
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19189750 | 2019-08-02 | ||
| CN201910734123 | 2019-08-09 | ||
| EP19191887 | 2019-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEAP202415862A true GEAP202415862A (en) | 2024-01-25 |
Family
ID=71894829
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP202415862A GEAP202415862A (en) | 2019-08-02 | 2020-07-30 | Alcohol derivatives as kv7 potassium channel openers |
| GEAP202015862A GEP20247629B (en) | 2019-08-02 | 2020-07-30 | Alcohol derivatives as kv7 potassium channel openers |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP202015862A GEP20247629B (en) | 2019-08-02 | 2020-07-30 | Alcohol derivatives as kv7 potassium channel openers |
Country Status (27)
| Country | Link |
|---|---|
| EP (2) | EP4461725A3 (enExample) |
| JP (2) | JP7720829B2 (enExample) |
| KR (1) | KR102957984B1 (enExample) |
| CN (1) | CN114206830B (enExample) |
| AU (1) | AU2020325517B2 (enExample) |
| BR (1) | BR112021006324A2 (enExample) |
| CA (1) | CA3148719A1 (enExample) |
| CL (1) | CL2022000221A1 (enExample) |
| CO (1) | CO2022000080A2 (enExample) |
| CR (1) | CR20220028A (enExample) |
| DO (1) | DOP2022000026A (enExample) |
| EC (1) | ECSP22008993A (enExample) |
| ES (1) | ES2989376T3 (enExample) |
| GE (2) | GEAP202415862A (enExample) |
| HR (1) | HRP20241444T1 (enExample) |
| HU (1) | HUE069310T2 (enExample) |
| IL (1) | IL290193B2 (enExample) |
| JO (1) | JOP20220017A1 (enExample) |
| MA (1) | MA56708B1 (enExample) |
| MX (1) | MX2022001063A (enExample) |
| PE (1) | PE20220345A1 (enExample) |
| PH (1) | PH12022550192A1 (enExample) |
| PL (1) | PL4007634T3 (enExample) |
| RS (1) | RS66130B1 (enExample) |
| SM (1) | SMT202400445T1 (enExample) |
| WO (1) | WO2021023617A1 (enExample) |
| ZA (1) | ZA202109598B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2989376T3 (es) * | 2019-08-02 | 2024-11-26 | H Lundbeck As | Derivados de alcohol como abridores del canal de potasio Kv7 |
| AU2024310446A1 (en) * | 2023-06-27 | 2026-01-22 | Saniona A/S | Kv7 modulators |
| WO2026132415A1 (en) * | 2024-12-20 | 2026-06-25 | Saniona A/S | Kv7 modulators |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893858B2 (en) | 2000-05-26 | 2005-05-17 | Bristol-Myers Squibb Company | Human kcnq5 potassium channel, methods and compositions thereof |
| WO2001096540A2 (en) | 2000-06-11 | 2001-12-20 | Dupont Pharmaceuticals Company | Hepatitis c protease exosite for inhibitor design |
| US7091202B2 (en) * | 2004-09-15 | 2006-08-15 | Bristol-Myers Squibb Company | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US20090118285A1 (en) | 2006-02-07 | 2009-05-07 | H. Lundbeck A/S | Use of kcnq-openers for treating or reducing the symptoms of schizophrenia |
| WO2007104717A1 (en) * | 2006-03-15 | 2007-09-20 | Neurosearch A/S | Quinazolinones and their use as potassium channels activators |
| CN101790374A (zh) | 2007-08-01 | 2010-07-28 | H.隆德贝克有限公司 | Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途 |
| TW201024286A (en) * | 2008-11-27 | 2010-07-01 | Neurosearch As | Novel compounds |
| EP2928860A1 (en) * | 2012-12-10 | 2015-10-14 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
| WO2014145852A2 (en) * | 2013-03-15 | 2014-09-18 | Knopp Biosciences Llc | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
| ES2749103T3 (es) * | 2014-09-12 | 2020-03-19 | Knopp Biosciences Llc | Benzoimidazol-1,2-ilamidas como activadores del canal Kv7 |
| JP2017095366A (ja) | 2015-11-18 | 2017-06-01 | 持田製薬株式会社 | 新規ビアリールアミド誘導体 |
| CN105663136A (zh) * | 2016-01-15 | 2016-06-15 | 河北中医学院 | 法舒地尔作为制备选择性Kv7离子通道激活剂药物的应用 |
| US10590067B2 (en) * | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
| ES3032221T3 (en) * | 2018-02-20 | 2025-07-16 | H Lundbeck As | Alcohol derivatives as kv7 potassium channel openers |
| ES2989376T3 (es) * | 2019-08-02 | 2024-11-26 | H Lundbeck As | Derivados de alcohol como abridores del canal de potasio Kv7 |
| US12508239B2 (en) * | 2019-08-02 | 2025-12-30 | H. Lundbeck A/S | Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures |
-
2020
- 2020-07-30 ES ES20749879T patent/ES2989376T3/es active Active
- 2020-07-30 HU HUE20749879A patent/HUE069310T2/hu unknown
- 2020-07-30 IL IL290193A patent/IL290193B2/en unknown
- 2020-07-30 RS RS20241162A patent/RS66130B1/sr unknown
- 2020-07-30 EP EP24203380.1A patent/EP4461725A3/en active Pending
- 2020-07-30 PE PE2022000184A patent/PE20220345A1/es unknown
- 2020-07-30 PL PL20749879.1T patent/PL4007634T3/pl unknown
- 2020-07-30 MX MX2022001063A patent/MX2022001063A/es unknown
- 2020-07-30 CA CA3148719A patent/CA3148719A1/en active Pending
- 2020-07-30 CR CR20220028A patent/CR20220028A/es unknown
- 2020-07-30 WO PCT/EP2020/071520 patent/WO2021023617A1/en not_active Ceased
- 2020-07-30 EP EP20749879.1A patent/EP4007634B1/en active Active
- 2020-07-30 GE GEAP202415862A patent/GEAP202415862A/en unknown
- 2020-07-30 SM SM20240445T patent/SMT202400445T1/it unknown
- 2020-07-30 KR KR1020227002204A patent/KR102957984B1/ko active Active
- 2020-07-30 BR BR112021006324A patent/BR112021006324A2/pt unknown
- 2020-07-30 CN CN202080051950.0A patent/CN114206830B/zh active Active
- 2020-07-30 MA MA56708A patent/MA56708B1/fr unknown
- 2020-07-30 PH PH1/2022/550192A patent/PH12022550192A1/en unknown
- 2020-07-30 HR HRP20241444TT patent/HRP20241444T1/hr unknown
- 2020-07-30 AU AU2020325517A patent/AU2020325517B2/en active Active
- 2020-07-30 GE GEAP202015862A patent/GEP20247629B/en unknown
- 2020-07-30 JP JP2022505198A patent/JP7720829B2/ja active Active
-
2021
- 2021-11-25 ZA ZA2021/09598A patent/ZA202109598B/en unknown
-
2022
- 2022-01-11 CO CONC2022/0000080A patent/CO2022000080A2/es unknown
- 2022-01-25 JO JOP/2022/0017A patent/JOP20220017A1/ar unknown
- 2022-01-27 CL CL2022000221A patent/CL2022000221A1/es unknown
- 2022-02-02 DO DO2022000026A patent/DOP2022000026A/es unknown
- 2022-02-04 EC ECSENADI20228993A patent/ECSP22008993A/es unknown
-
2025
- 2025-07-03 JP JP2025112976A patent/JP7897992B2/ja active Active
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