PE20212307A1 - Vectores de orthopoxvirus modificados - Google Patents
Vectores de orthopoxvirus modificadosInfo
- Publication number
- PE20212307A1 PE20212307A1 PE2021000922A PE2021000922A PE20212307A1 PE 20212307 A1 PE20212307 A1 PE 20212307A1 PE 2021000922 A PE2021000922 A PE 2021000922A PE 2021000922 A PE2021000922 A PE 2021000922A PE 20212307 A1 PE20212307 A1 PE 20212307A1
- Authority
- PE
- Peru
- Prior art keywords
- modified orthopoxvirus
- vectors
- orthopoxvirus vectors
- modified
- adaptability
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La solicitud se refiere a vectores de orthopoxvirus modificados, asi como a metodos para utilizar los mismos para el tratamiento de diversos canceres. La solicitud provee vectores de orthopoxvirus modificados que exhiben varias actividades terapeuticas beneficiosas, incluyendo aumentadas actividad oncolitica, dispersion de la infeccion, evasion inmune, persistencia tumoral, capacidad de incorporacion de secuencias de ADN exogenas, adaptabilidad para fabricacion a gran escala y seguridad
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862784372P | 2018-12-21 | 2018-12-21 | |
US201962872699P | 2019-07-10 | 2019-07-10 | |
US201962930524P | 2019-11-04 | 2019-11-04 | |
PCT/CA2019/051898 WO2020124273A1 (en) | 2018-12-21 | 2019-12-20 | Modified orthopoxvirus vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20212307A1 true PE20212307A1 (es) | 2021-12-10 |
Family
ID=71100021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021000922A PE20212307A1 (es) | 2018-12-21 | 2019-12-20 | Vectores de orthopoxvirus modificados |
Country Status (18)
Country | Link |
---|---|
US (2) | US20220380799A1 (es) |
EP (2) | EP3898998A4 (es) |
JP (2) | JP2022514420A (es) |
KR (2) | KR20210132002A (es) |
CN (2) | CN113454231A (es) |
AU (2) | AU2019404639A1 (es) |
BR (2) | BR112021011730A2 (es) |
CA (2) | CA3124301A1 (es) |
CL (1) | CL2021001646A1 (es) |
CO (1) | CO2021009354A2 (es) |
EC (1) | ECSP21053474A (es) |
IL (2) | IL284180A (es) |
MX (2) | MX2021007438A (es) |
PE (1) | PE20212307A1 (es) |
PH (1) | PH12021551436A1 (es) |
SG (1) | SG11202106460XA (es) |
TW (1) | TW202039851A (es) |
WO (2) | WO2020124274A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20200121297A (ko) | 2018-01-05 | 2020-10-23 | 오타와 하스피털 리서치 인스티튜트 | 변형된 오르토폭스바이러스 벡터 |
WO2021102307A1 (en) * | 2019-11-20 | 2021-05-27 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Vaccinia viruses and methods for using vaccinia viruses |
WO2023106839A1 (ko) * | 2021-12-07 | 2023-06-15 | 재단법인 아산사회복지재단 | Il-12를 발현하는 재조합 백시니아 바이러스 및 이의 용도 |
WO2023135313A1 (en) * | 2022-01-17 | 2023-07-20 | Nouscom Ag | Recombinant orthopox viral vector encoding immunostimulatory proteins for cancer treatment |
WO2023238106A1 (en) * | 2022-06-10 | 2023-12-14 | Transgene | Recombinant virus expressing interleukin-12 |
WO2024023740A1 (en) * | 2022-07-27 | 2024-02-01 | Astrazeneca Ab | Combinations of recombinant virus expressing interleukin-12 with pd-1/pd-l1 inhibitors |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2269619A1 (en) * | 2002-08-12 | 2011-01-05 | Jennerex Biotherapeutics ULC | Methods and compositions concerning poxviruses and cancer |
AU2003290528A1 (en) * | 2002-10-15 | 2004-05-04 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods and reagents for inducing immunity |
CA2705869C (en) * | 2007-11-19 | 2012-10-30 | Philippe Erbs | Poxviral oncolytic vectors |
PE20160673A1 (es) * | 2013-08-22 | 2016-07-21 | Univ Of Pittsburgh - Of The Commonwealth System Of Higher Education | Terapias inmuno-oncoliticas |
RU2696312C2 (ru) * | 2014-07-16 | 2019-08-01 | Трансген Са | Онколитический вирус для экспрессии модуляторов иммунологических контрольных точек |
KR20200121297A (ko) * | 2018-01-05 | 2020-10-23 | 오타와 하스피털 리서치 인스티튜트 | 변형된 오르토폭스바이러스 벡터 |
-
2019
- 2019-12-20 CN CN201980091966.1A patent/CN113454231A/zh active Pending
- 2019-12-20 CA CA3124301A patent/CA3124301A1/en active Pending
- 2019-12-20 WO PCT/CA2019/051899 patent/WO2020124274A1/en unknown
- 2019-12-20 JP JP2021535804A patent/JP2022514420A/ja active Pending
- 2019-12-20 KR KR1020217022871A patent/KR20210132002A/ko unknown
- 2019-12-20 US US17/415,606 patent/US20220380799A1/en active Pending
- 2019-12-20 AU AU2019404639A patent/AU2019404639A1/en active Pending
- 2019-12-20 PE PE2021000922A patent/PE20212307A1/es unknown
- 2019-12-20 BR BR112021011730-0A patent/BR112021011730A2/pt not_active Application Discontinuation
- 2019-12-20 BR BR112021012078-5A patent/BR112021012078A2/pt not_active Application Discontinuation
- 2019-12-20 US US17/415,575 patent/US20220056480A1/en active Pending
- 2019-12-20 JP JP2021535833A patent/JP2022516006A/ja active Pending
- 2019-12-20 CA CA3124287A patent/CA3124287A1/en active Pending
- 2019-12-20 TW TW108147116A patent/TW202039851A/zh unknown
- 2019-12-20 MX MX2021007438A patent/MX2021007438A/es unknown
- 2019-12-20 MX MX2021007439A patent/MX2021007439A/es unknown
- 2019-12-20 KR KR1020217022872A patent/KR20210132003A/ko unknown
- 2019-12-20 EP EP19899693.6A patent/EP3898998A4/en active Pending
- 2019-12-20 EP EP19898487.4A patent/EP3898997A4/en active Pending
- 2019-12-20 AU AU2019410148A patent/AU2019410148A1/en active Pending
- 2019-12-20 WO PCT/CA2019/051898 patent/WO2020124273A1/en unknown
- 2019-12-20 SG SG11202106460XA patent/SG11202106460XA/en unknown
- 2019-12-20 CN CN201980092788.4A patent/CN113661246A/zh active Pending
-
2021
- 2021-06-17 PH PH12021551436A patent/PH12021551436A1/en unknown
- 2021-06-18 CL CL2021001646A patent/CL2021001646A1/es unknown
- 2021-06-19 IL IL284180A patent/IL284180A/en unknown
- 2021-06-20 IL IL284188A patent/IL284188A/en unknown
- 2021-07-16 CO CONC2021/0009354A patent/CO2021009354A2/es unknown
- 2021-07-20 EC ECSENADI202153474A patent/ECSP21053474A/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL284180A (en) | 2021-08-31 |
MX2021007439A (es) | 2021-08-05 |
CA3124301A1 (en) | 2020-06-25 |
CA3124287A1 (en) | 2020-06-25 |
WO2020124273A1 (en) | 2020-06-25 |
MX2021007438A (es) | 2021-09-21 |
JP2022514420A (ja) | 2022-02-10 |
CL2021001646A1 (es) | 2022-02-18 |
EP3898998A4 (en) | 2022-10-05 |
BR112021011730A2 (pt) | 2021-08-31 |
SG11202106460XA (en) | 2021-07-29 |
BR112021012078A2 (pt) | 2021-08-31 |
KR20210132003A (ko) | 2021-11-03 |
IL284188A (en) | 2021-08-31 |
US20220056480A1 (en) | 2022-02-24 |
WO2020124274A1 (en) | 2020-06-25 |
EP3898998A1 (en) | 2021-10-27 |
EP3898997A4 (en) | 2022-11-16 |
CN113661246A (zh) | 2021-11-16 |
ECSP21053474A (es) | 2021-11-18 |
AU2019410148A1 (en) | 2021-08-12 |
PH12021551436A1 (en) | 2021-12-06 |
JP2022516006A (ja) | 2022-02-24 |
KR20210132002A (ko) | 2021-11-03 |
EP3898997A1 (en) | 2021-10-27 |
TW202039851A (zh) | 2020-11-01 |
US20220380799A1 (en) | 2022-12-01 |
CO2021009354A2 (es) | 2021-11-19 |
CN113454231A (zh) | 2021-09-28 |
AU2019404639A1 (en) | 2021-08-12 |
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