PE20210173A1 - Compuestos de alquinileno sustituidos como agentes anticancerigenos - Google Patents

Compuestos de alquinileno sustituidos como agentes anticancerigenos

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Publication number
PE20210173A1
PE20210173A1 PE2020000981A PE2020000981A PE20210173A1 PE 20210173 A1 PE20210173 A1 PE 20210173A1 PE 2020000981 A PE2020000981 A PE 2020000981A PE 2020000981 A PE2020000981 A PE 2020000981A PE 20210173 A1 PE20210173 A1 PE 20210173A1
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Peru
Prior art keywords
alkyl
alkinylene
cancer agents
formula
compounds substituted
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PE2020000981A
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English (en)
Inventor
Dinesh Chikkanna
Vinayak V Khairnar
Muralidhara Ramachandra
Leena Khare Satyam
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Aurigene Discovery Tech Ltd
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Publication of PE20210173A1 publication Critical patent/PE20210173A1/es

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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invencion se refiere a compuestos de alquinileno sustituidos de formula (I), en donde, A es arilo o heteroarilo; X representa N-Ry o esta ausente; Y es O, S o NCN; B es arilo, cicloalquilo o heterocicloalquilo opcionalmente sustituidos; R1 es alquilo; R2 es hidrogeno o alquilo; R3 es -C(O)Ra, -S(O)2Ra, -NHS(O)2Ra, entre otros; R4 es alquilo, halo, haloalquilo, ciano; entre otros; m es 0, 1, 2 o 3; asi como los estereoisomeros y las sales farmaceuticamente aceptables de estos. Dichos compuestos inhiben uno o mas componentes de la senalizacion de EGFR que incluyen K-Ras, B-Raf, MEK y ERK; y la via del receptor de celulas B (BCR); siendo utiles como agentes anticancerigenos. Tambien refiere a una composicion farmaceuticas que lo comprende y metodos de preparacion del citado compuesto de formula (I).
PE2020000981A 2018-01-17 2019-01-17 Compuestos de alquinileno sustituidos como agentes anticancerigenos PE20210173A1 (es)

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IN201841001978 2018-01-17
PCT/IB2019/050387 WO2019142126A1 (en) 2018-01-17 2019-01-17 Substituted alkynylene compounds as anticancer agents

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BR112020014421A2 (pt) 2020-12-01
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US20210379055A1 (en) 2021-12-09
CL2020001882A1 (es) 2020-10-02
CU20200047A7 (es) 2021-03-11
UA128087C2 (uk) 2024-04-03
EP3740473A4 (en) 2021-11-10
MX2020007535A (es) 2020-12-07
EP3740473A1 (en) 2020-11-25
JP2021518836A (ja) 2021-08-05
IL275766B2 (en) 2024-05-01
JP7510347B2 (ja) 2024-07-03
CO2020010042A2 (es) 2020-11-20
MX2023007985A (es) 2023-07-18
AU2019208515A1 (en) 2020-09-03
PH12020500572A1 (en) 2021-05-17
EA202091481A1 (ru) 2020-12-03
WO2019142126A1 (en) 2019-07-25
CN118754861A (zh) 2024-10-11
AU2019208515B2 (en) 2024-05-30

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