PE20200739A1 - Pirrolopirimidinas como potenciadores de cftr - Google Patents

Pirrolopirimidinas como potenciadores de cftr

Info

Publication number
PE20200739A1
PE20200739A1 PE2019001045A PE2019001045A PE20200739A1 PE 20200739 A1 PE20200739 A1 PE 20200739A1 PE 2019001045 A PE2019001045 A PE 2019001045A PE 2019001045 A PE2019001045 A PE 2019001045A PE 20200739 A1 PE20200739 A1 PE 20200739A1
Authority
PE
Peru
Prior art keywords
group
alkyl
cftr
carbonitrile
pyrrolo
Prior art date
Application number
PE2019001045A
Other languages
English (en)
Spanish (es)
Inventor
Joseph Walter Strohbach
David Christopher Limburg
John Paul Mathias
Atli Thorarensen
Rajiah Aldrin Denny
Christoph Wolfgang Zapf
Daniel Elbaum
Lori Krim Gavrin
Ivan Viktorovich Efremov
Original Assignee
Cystic Fibrosis Found Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cystic Fibrosis Found Therapeutics Inc filed Critical Cystic Fibrosis Found Therapeutics Inc
Publication of PE20200739A1 publication Critical patent/PE20200739A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
PE2019001045A 2016-11-18 2017-11-17 Pirrolopirimidinas como potenciadores de cftr PE20200739A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662423919P 2016-11-18 2016-11-18
PCT/US2017/062148 WO2018094137A1 (en) 2016-11-18 2017-11-17 Pyrrolopyrimidines as cftr potentiators

Publications (1)

Publication Number Publication Date
PE20200739A1 true PE20200739A1 (es) 2020-07-24

Family

ID=62144793

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2019001045A PE20200739A1 (es) 2016-11-18 2017-11-17 Pirrolopirimidinas como potenciadores de cftr

Country Status (21)

Country Link
US (5) US10301315B2 (https=)
EP (2) EP3541390B1 (https=)
JP (3) JP6978507B2 (https=)
KR (2) KR102585398B1 (https=)
CN (2) CN110337294B (https=)
AU (2) AU2017362350B2 (https=)
CL (1) CL2019001334A1 (https=)
CO (1) CO2019005993A2 (https=)
CR (1) CR20190292A (https=)
DO (1) DOP2019000126A (https=)
EC (1) ECSP19043120A (https=)
ES (1) ES2983686T3 (https=)
IL (3) IL314404B2 (https=)
MX (2) MX2021012639A (https=)
PE (1) PE20200739A1 (https=)
PH (1) PH12019501098A1 (https=)
PL (1) PL3541390T3 (https=)
RU (2) RU2757457C2 (https=)
SG (1) SG10202106949XA (https=)
UA (1) UA125400C2 (https=)
WO (1) WO2018094137A1 (https=)

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TWI867024B (zh) 2019-08-14 2024-12-21 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑
TWI899097B (zh) 2019-08-14 2025-10-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
CA3150162A1 (en) 2019-08-14 2021-02-18 Vertex Pharmaceuticals Incorporated Crystalline forms of cftr modulators
CN111138439B (zh) * 2020-01-17 2021-06-25 厦门大学 氟代吡咯并嘧啶类化合物及其制备方法和应用
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KR20230052954A (ko) 2020-08-20 2023-04-20 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 점액 과다분비를 특징으로 하는 호흡기 질환의 치료 방법
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Also Published As

Publication number Publication date
SG10202106949XA (en) 2021-07-29
JP6978507B2 (ja) 2021-12-08
JP2023182694A (ja) 2023-12-26
IL266668B (en) 2022-10-01
RU2757457C2 (ru) 2021-10-18
CL2019001334A1 (es) 2019-11-15
JP7592814B2 (ja) 2024-12-02
EP3541390C0 (en) 2024-05-01
IL296279A (en) 2022-11-01
CN110337294A (zh) 2019-10-15
EP3541390B1 (en) 2024-05-01
NZ754085A (en) 2025-05-02
KR20190110088A (ko) 2019-09-27
JP2022024023A (ja) 2022-02-08
EP3541390A1 (en) 2019-09-25
ES2983686T3 (es) 2024-10-24
PH12019501098A1 (en) 2019-09-09
MX387203B (es) 2025-03-18
US20180141954A1 (en) 2018-05-24
RU2021129721A (ru) 2021-11-26
AU2022201816A1 (en) 2022-04-07
AU2017362350A1 (en) 2019-06-20
JP2020510668A (ja) 2020-04-09
JP7360434B2 (ja) 2023-10-12
US20190225621A1 (en) 2019-07-25
KR102585398B1 (ko) 2023-10-10
BR112019010167A2 (pt) 2019-09-17
MX2019005822A (es) 2019-09-09
AU2017362350B2 (en) 2021-12-23
IL314404A (en) 2024-09-01
CN115850268B (zh) 2025-06-27
IL266668A (en) 2019-07-31
US12612409B2 (en) 2026-04-28
IL314404B1 (en) 2025-09-01
EP4424311A3 (en) 2024-12-18
IL266668B2 (en) 2023-02-01
EP4424311A2 (en) 2024-09-04
RU2019118623A (ru) 2020-12-21
WO2018094137A1 (en) 2018-05-24
PL3541390T3 (pl) 2024-09-09
AU2022201816B2 (en) 2024-02-15
IL314404B2 (en) 2026-01-01
EP3541390A4 (en) 2020-06-24
KR102824092B1 (ko) 2025-06-25
UA125400C2 (uk) 2022-03-02
AU2022201816A8 (en) 2022-04-21
US10301315B2 (en) 2019-05-28
KR20230146104A (ko) 2023-10-18
DOP2019000126A (es) 2019-08-30
MX2021012639A (es) 2022-10-03
CN115850268A (zh) 2023-03-28
CN110337294B (zh) 2022-11-01
ECSP19043120A (es) 2019-08-30
US20200017512A1 (en) 2020-01-16
CA3044050A1 (en) 2018-05-24
US10494374B2 (en) 2019-12-03
US20210171534A1 (en) 2021-06-10
CO2019005993A2 (es) 2019-07-31
CR20190292A (es) 2019-09-03
US20230250100A1 (en) 2023-08-10
RU2019118623A3 (https=) 2021-03-18

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