PE20190502A1 - Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos - Google Patents
Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismosInfo
- Publication number
- PE20190502A1 PE20190502A1 PE2019000295A PE2019000295A PE20190502A1 PE 20190502 A1 PE20190502 A1 PE 20190502A1 PE 2019000295 A PE2019000295 A PE 2019000295A PE 2019000295 A PE2019000295 A PE 2019000295A PE 20190502 A1 PE20190502 A1 PE 20190502A1
- Authority
- PE
- Peru
- Prior art keywords
- lactam
- spiro
- nmda
- bis
- same use
- Prior art date
Links
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 title abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662369534P | 2016-08-01 | 2016-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20190502A1 true PE20190502A1 (es) | 2019-04-10 |
Family
ID=59593195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019000295A PE20190502A1 (es) | 2016-08-01 | 2017-08-01 | Moduladores del receptor nmda spiro-lactam y bis-spiro-lactam y uso de los mismos |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11028095B2 (https=) |
| EP (1) | EP3490994B8 (https=) |
| JP (1) | JP2019527235A (https=) |
| KR (1) | KR102462288B1 (https=) |
| CN (1) | CN109661398B (https=) |
| AU (1) | AU2017306158B2 (https=) |
| BR (1) | BR112019001926A2 (https=) |
| CL (1) | CL2019000249A1 (https=) |
| CO (1) | CO2019000944A2 (https=) |
| EA (1) | EA201990425A1 (https=) |
| ES (1) | ES2979128T3 (https=) |
| IL (1) | IL264496B (https=) |
| MX (1) | MX383292B (https=) |
| PE (1) | PE20190502A1 (https=) |
| SG (1) | SG11201900546UA (https=) |
| WO (1) | WO2018026792A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011003015A (es) | 2008-09-18 | 2011-11-18 | Univ Northwestern | Moduladores del receptor de n-metil-d-aspartato, y usos de los mismos. |
| EA032649B1 (ru) | 2013-01-29 | 2019-06-28 | Аптиникс Инк. | Спиролактамные модуляторы nmda-рецептора и их применение |
| WO2018026782A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| EP3490994B8 (en) | 2016-08-01 | 2024-03-13 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
| JP2019527232A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタムｎｍｄａ修飾因子及びこれを用いた方法 |
| SG10202101055VA (en) | 2016-08-01 | 2021-03-30 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| MX385336B (es) | 2016-08-01 | 2025-03-18 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos. |
| US10416340B2 (en) | 2017-05-27 | 2019-09-17 | ADANI Systems, Inc. | Autonomous container-transportable system for vehicle scanning |
| WO2019152681A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
| CN112204031B (zh) | 2018-01-31 | 2024-05-24 | 元羿生物科技(香港)有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
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| EA032649B1 (ru) | 2013-01-29 | 2019-06-28 | Аптиникс Инк. | Спиролактамные модуляторы nmda-рецептора и их применение |
| SG11201505942YA (en) | 2013-01-29 | 2015-08-28 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| SG11201505862TA (en) * | 2013-01-29 | 2015-08-28 | Naurex Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| KR20150110586A (ko) | 2013-01-29 | 2015-10-02 | 노렉스, 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| BR112018073663A2 (pt) | 2016-05-19 | 2019-04-30 | Aptinyx Inc. | moduladores de receptores nmda spiro-lactâmicos e seus usos |
| SG10202101055VA (en) | 2016-08-01 | 2021-03-30 | Aptinyx Inc | Spiro-lactam nmda receptor modulators and uses thereof |
| MX385336B (es) | 2016-08-01 | 2025-03-18 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos. |
| JP2019527232A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタムｎｍｄａ修飾因子及びこれを用いた方法 |
| EP3490994B8 (en) | 2016-08-01 | 2024-03-13 | Tenacia Biotechnology (Hong Kong) Co., Limited | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
| WO2018026782A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
-
2017
- 2017-08-01 EP EP17751917.0A patent/EP3490994B8/en active Active
- 2017-08-01 JP JP2019505250A patent/JP2019527235A/ja not_active Ceased
- 2017-08-01 CN CN201780054216.8A patent/CN109661398B/zh active Active
- 2017-08-01 PE PE2019000295A patent/PE20190502A1/es unknown
- 2017-08-01 EA EA201990425A patent/EA201990425A1/ru unknown
- 2017-08-01 IL IL264496A patent/IL264496B/en unknown
- 2017-08-01 KR KR1020197005664A patent/KR102462288B1/ko active Active
- 2017-08-01 MX MX2019001322A patent/MX383292B/es unknown
- 2017-08-01 US US16/321,906 patent/US11028095B2/en active Active
- 2017-08-01 ES ES17751917T patent/ES2979128T3/es active Active
- 2017-08-01 WO PCT/US2017/044861 patent/WO2018026792A1/en not_active Ceased
- 2017-08-01 SG SG11201900546UA patent/SG11201900546UA/en unknown
- 2017-08-01 BR BR112019001926A patent/BR112019001926A2/pt not_active IP Right Cessation
- 2017-08-01 AU AU2017306158A patent/AU2017306158B2/en not_active Ceased
-
2019
- 2019-01-30 CO CONC2019/0000944A patent/CO2019000944A2/es unknown
- 2019-01-30 CL CL2019000249A patent/CL2019000249A1/es unknown
-
2021
- 2021-05-07 US US17/314,174 patent/US20220098211A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2019001322A (es) | 2019-09-11 |
| EP3490994A1 (en) | 2019-06-05 |
| AU2017306158B2 (en) | 2021-10-14 |
| KR102462288B1 (ko) | 2022-11-01 |
| IL264496A (https=) | 2019-03-31 |
| JP2019527235A (ja) | 2019-09-26 |
| EP3490994B8 (en) | 2024-03-13 |
| CA3031562A1 (en) | 2018-02-08 |
| US11028095B2 (en) | 2021-06-08 |
| EP3490994B1 (en) | 2024-02-07 |
| CO2019000944A2 (es) | 2019-02-08 |
| MX383292B (es) | 2025-03-13 |
| EP3490994C0 (en) | 2024-02-07 |
| CL2019000249A1 (es) | 2019-06-21 |
| CN109661398A (zh) | 2019-04-19 |
| US20200181159A1 (en) | 2020-06-11 |
| BR112019001926A2 (pt) | 2019-08-06 |
| ES2979128T3 (es) | 2024-09-24 |
| KR20190037276A (ko) | 2019-04-05 |
| CN109661398B (zh) | 2022-07-05 |
| IL264496B (en) | 2022-09-01 |
| SG11201900546UA (en) | 2019-02-27 |
| US20220098211A1 (en) | 2022-03-31 |
| WO2018026792A1 (en) | 2018-02-08 |
| AU2017306158A1 (en) | 2019-01-31 |
| EA201990425A1 (ru) | 2019-08-30 |
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