PE20181293A1 - Plataforma de armazon de nudo de cistina - Google Patents

Plataforma de armazon de nudo de cistina

Info

Publication number
PE20181293A1
PE20181293A1 PE2018000390A PE2018000390A PE20181293A1 PE 20181293 A1 PE20181293 A1 PE 20181293A1 PE 2018000390 A PE2018000390 A PE 2018000390A PE 2018000390 A PE2018000390 A PE 2018000390A PE 20181293 A1 PE20181293 A1 PE 20181293A1
Authority
PE
Peru
Prior art keywords
amino acid
seq
loop
natural amino
cystine knot
Prior art date
Application number
PE2018000390A
Other languages
English (en)
Spanish (es)
Inventor
Rami Hannoush
Harini Kaluarachchi
Aaron NILE
Cameron Noland
Yingnan Zhang
Lijuan Zhou
Xinxin Gao
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20181293A1 publication Critical patent/PE20181293A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PE2018000390A 2015-09-15 2016-09-15 Plataforma de armazon de nudo de cistina PE20181293A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562219063P 2015-09-15 2015-09-15

Publications (1)

Publication Number Publication Date
PE20181293A1 true PE20181293A1 (es) 2018-08-07

Family

ID=57068206

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2018000390A PE20181293A1 (es) 2015-09-15 2016-09-15 Plataforma de armazon de nudo de cistina

Country Status (22)

Country Link
US (8) US10428125B2 (enExample)
EP (1) EP3350215B1 (enExample)
JP (2) JP7166916B2 (enExample)
KR (1) KR102846388B1 (enExample)
CN (4) CN108026162B (enExample)
AR (1) AR106032A1 (enExample)
AU (2) AU2016323445B2 (enExample)
BR (1) BR112018002263A2 (enExample)
CA (1) CA2996006A1 (enExample)
CL (2) CL2018000668A1 (enExample)
CO (1) CO2018002510A2 (enExample)
CR (1) CR20180169A (enExample)
IL (2) IL294568A (enExample)
MA (1) MA42828A (enExample)
MX (1) MX2018002922A (enExample)
MY (1) MY190552A (enExample)
PE (1) PE20181293A1 (enExample)
PH (1) PH12018500577A1 (enExample)
RU (1) RU2770384C2 (enExample)
TW (1) TWI799366B (enExample)
UA (1) UA125505C2 (enExample)
WO (1) WO2017049009A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI799366B (zh) 2015-09-15 2023-04-21 美商建南德克公司 胱胺酸結骨架平臺
WO2019233605A1 (en) * 2018-06-08 2019-12-12 BioNTech SE Compositions and methods for diagnosis and treatment of cancer
BR112022025227A2 (pt) 2020-06-11 2023-01-03 Genentech Inc Conjugados, composição farmacêutica, formulação líquida, métodos para preparar um conjugado, para aumentar a estabilidade, para tratar um indivíduo, para entregar um polipeptídeo de ligação, para entregar um peptídeo curto, para entregar um agente biologicamente ativo, método para reduzir a conjugação lipídio-proteína-esqueleto e método para aumentar a atividade biológica, uso do conjugado e sistema ou kit
WO2025193946A2 (en) * 2024-03-14 2025-09-18 Genentech, Inc. Peptides binding lrrc15 and uses thereof

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Also Published As

Publication number Publication date
CA2996006A1 (en) 2017-03-23
MA42828A (fr) 2018-07-25
CN120248097A (zh) 2025-07-04
CN108026162A (zh) 2018-05-11
BR112018002263A2 (en) 2018-09-18
US20240247034A1 (en) 2024-07-25
US11155586B2 (en) 2021-10-26
CN114805528A (zh) 2022-07-29
US10428125B2 (en) 2019-10-01
WO2017049009A1 (en) 2017-03-23
AU2021204400B2 (en) 2023-02-02
US11078243B2 (en) 2021-08-03
US20200325187A1 (en) 2020-10-15
US20170129927A1 (en) 2017-05-11
EP3350215A1 (en) 2018-07-25
JP2022130481A (ja) 2022-09-06
TW201717993A (zh) 2017-06-01
US20200231636A1 (en) 2020-07-23
AU2016323445A1 (en) 2018-03-01
AU2016323445B2 (en) 2021-04-01
UA125505C2 (uk) 2022-04-13
US20230174596A1 (en) 2023-06-08
KR20180052718A (ko) 2018-05-18
CN114591422A (zh) 2022-06-07
MY190552A (en) 2022-04-27
JP7602514B2 (ja) 2024-12-18
CO2018002510A2 (es) 2018-05-31
CN114591422B (zh) 2025-04-04
RU2770384C2 (ru) 2022-04-15
JP2018533912A (ja) 2018-11-22
TWI799366B (zh) 2023-04-21
US20200115424A1 (en) 2020-04-16
CN108026162B (zh) 2022-04-05
PH12018500577A1 (en) 2018-10-15
IL294568A (en) 2022-09-01
US11407794B2 (en) 2022-08-09
RU2018113442A3 (enExample) 2020-02-17
NZ740218A (en) 2025-05-02
AU2021204400A1 (en) 2021-07-22
EP3350215B1 (en) 2025-12-03
CR20180169A (es) 2018-04-24
HK1253318A1 (zh) 2019-06-14
IL257399A (en) 2018-04-30
US20180291069A1 (en) 2018-10-11
KR102846388B1 (ko) 2025-08-18
AR106032A1 (es) 2017-12-06
CL2018000668A1 (es) 2018-07-20
US10696721B2 (en) 2020-06-30
MX2018002922A (es) 2018-06-07
WO2017049009A8 (en) 2018-02-22
CL2020001781A1 (es) 2020-10-23
IL257399B (en) 2022-08-01
RU2018113442A (ru) 2019-10-16
JP7166916B2 (ja) 2022-11-08
US20200140498A1 (en) 2020-05-07

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