RU2770384C2 - Платформа на основе каркаса цистинового узла - Google Patents

Платформа на основе каркаса цистинового узла Download PDF

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Publication number
RU2770384C2
RU2770384C2 RU2018113442A RU2018113442A RU2770384C2 RU 2770384 C2 RU2770384 C2 RU 2770384C2 RU 2018113442 A RU2018113442 A RU 2018113442A RU 2018113442 A RU2018113442 A RU 2018113442A RU 2770384 C2 RU2770384 C2 RU 2770384C2
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Prior art keywords
seq
amino acid
alanine
vegf
peptide
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RU2018113442A
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English (en)
Russian (ru)
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RU2018113442A3 (enExample
RU2018113442A (ru
Inventor
Рами ХЭННОУШ
Харини КАЛУАРАЧЧИ
Аарон НАЙЛ
Кэмерон НОЛАНД
Иннань ЧЖАН
Лицзюань ЧЖОУ
Синьсинь ГАО
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Дженентек, Инк.
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Publication of RU2018113442A publication Critical patent/RU2018113442A/ru
Publication of RU2018113442A3 publication Critical patent/RU2018113442A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
RU2018113442A 2015-09-15 2016-09-15 Платформа на основе каркаса цистинового узла RU2770384C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562219063P 2015-09-15 2015-09-15
US62/219,063 2015-09-15
PCT/US2016/052012 WO2017049009A1 (en) 2015-09-15 2016-09-15 Cystine knot scaffold platform

Publications (3)

Publication Number Publication Date
RU2018113442A RU2018113442A (ru) 2019-10-16
RU2018113442A3 RU2018113442A3 (enExample) 2020-02-17
RU2770384C2 true RU2770384C2 (ru) 2022-04-15

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EP (1) EP3350215B1 (enExample)
JP (2) JP7166916B2 (enExample)
KR (1) KR102846388B1 (enExample)
CN (4) CN108026162B (enExample)
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CA (1) CA2996006A1 (enExample)
CL (2) CL2018000668A1 (enExample)
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IL (2) IL294568A (enExample)
MA (1) MA42828A (enExample)
MX (1) MX2018002922A (enExample)
MY (1) MY190552A (enExample)
PE (1) PE20181293A1 (enExample)
PH (1) PH12018500577A1 (enExample)
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TW (1) TWI799366B (enExample)
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TWI799366B (zh) 2015-09-15 2023-04-21 美商建南德克公司 胱胺酸結骨架平臺
WO2019233605A1 (en) * 2018-06-08 2019-12-12 BioNTech SE Compositions and methods for diagnosis and treatment of cancer
BR112022025227A2 (pt) 2020-06-11 2023-01-03 Genentech Inc Conjugados, composição farmacêutica, formulação líquida, métodos para preparar um conjugado, para aumentar a estabilidade, para tratar um indivíduo, para entregar um polipeptídeo de ligação, para entregar um peptídeo curto, para entregar um agente biologicamente ativo, método para reduzir a conjugação lipídio-proteína-esqueleto e método para aumentar a atividade biológica, uso do conjugado e sistema ou kit
WO2025193946A2 (en) * 2024-03-14 2025-09-18 Genentech, Inc. Peptides binding lrrc15 and uses thereof

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CA2996006A1 (en) 2017-03-23
MA42828A (fr) 2018-07-25
CN120248097A (zh) 2025-07-04
CN108026162A (zh) 2018-05-11
BR112018002263A2 (en) 2018-09-18
US20240247034A1 (en) 2024-07-25
US11155586B2 (en) 2021-10-26
CN114805528A (zh) 2022-07-29
US10428125B2 (en) 2019-10-01
WO2017049009A1 (en) 2017-03-23
AU2021204400B2 (en) 2023-02-02
US11078243B2 (en) 2021-08-03
US20200325187A1 (en) 2020-10-15
US20170129927A1 (en) 2017-05-11
EP3350215A1 (en) 2018-07-25
JP2022130481A (ja) 2022-09-06
TW201717993A (zh) 2017-06-01
US20200231636A1 (en) 2020-07-23
AU2016323445A1 (en) 2018-03-01
AU2016323445B2 (en) 2021-04-01
UA125505C2 (uk) 2022-04-13
US20230174596A1 (en) 2023-06-08
KR20180052718A (ko) 2018-05-18
CN114591422A (zh) 2022-06-07
MY190552A (en) 2022-04-27
JP7602514B2 (ja) 2024-12-18
CO2018002510A2 (es) 2018-05-31
CN114591422B (zh) 2025-04-04
JP2018533912A (ja) 2018-11-22
TWI799366B (zh) 2023-04-21
US20200115424A1 (en) 2020-04-16
CN108026162B (zh) 2022-04-05
PH12018500577A1 (en) 2018-10-15
IL294568A (en) 2022-09-01
US11407794B2 (en) 2022-08-09
RU2018113442A3 (enExample) 2020-02-17
NZ740218A (en) 2025-05-02
AU2021204400A1 (en) 2021-07-22
EP3350215B1 (en) 2025-12-03
CR20180169A (es) 2018-04-24
HK1253318A1 (zh) 2019-06-14
IL257399A (en) 2018-04-30
US20180291069A1 (en) 2018-10-11
KR102846388B1 (ko) 2025-08-18
AR106032A1 (es) 2017-12-06
CL2018000668A1 (es) 2018-07-20
US10696721B2 (en) 2020-06-30
MX2018002922A (es) 2018-06-07
WO2017049009A8 (en) 2018-02-22
CL2020001781A1 (es) 2020-10-23
IL257399B (en) 2022-08-01
RU2018113442A (ru) 2019-10-16
PE20181293A1 (es) 2018-08-07
JP7166916B2 (ja) 2022-11-08
US20200140498A1 (en) 2020-05-07

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