KR102846388B1 - 시스틴 노트 스캐폴드 플랫폼 - Google Patents

시스틴 노트 스캐폴드 플랫폼

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Publication number
KR102846388B1
KR102846388B1 KR1020187010195A KR20187010195A KR102846388B1 KR 102846388 B1 KR102846388 B1 KR 102846388B1 KR 1020187010195 A KR1020187010195 A KR 1020187010195A KR 20187010195 A KR20187010195 A KR 20187010195A KR 102846388 B1 KR102846388 B1 KR 102846388B1
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KR
South Korea
Prior art keywords
amino acid
delete delete
seq
certain embodiments
naturally occurring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020187010195A
Other languages
English (en)
Korean (ko)
Other versions
KR20180052718A (ko
Inventor
라미 한누쉬
하리니 칼루아라치치
애론 나일
카메론 놀란드
잉난 장
리쥐안 조우
신신 가오
Original Assignee
제넨테크, 인크.
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Application filed by 제넨테크, 인크. filed Critical 제넨테크, 인크.
Publication of KR20180052718A publication Critical patent/KR20180052718A/ko
Application granted granted Critical
Publication of KR102846388B1 publication Critical patent/KR102846388B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/168—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020187010195A 2015-09-15 2016-09-15 시스틴 노트 스캐폴드 플랫폼 Active KR102846388B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562219063P 2015-09-15 2015-09-15
US62/219,063 2015-09-15
PCT/US2016/052012 WO2017049009A1 (en) 2015-09-15 2016-09-15 Cystine knot scaffold platform

Publications (2)

Publication Number Publication Date
KR20180052718A KR20180052718A (ko) 2018-05-18
KR102846388B1 true KR102846388B1 (ko) 2025-08-18

Family

ID=57068206

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187010195A Active KR102846388B1 (ko) 2015-09-15 2016-09-15 시스틴 노트 스캐폴드 플랫폼

Country Status (22)

Country Link
US (8) US10428125B2 (enExample)
EP (1) EP3350215B1 (enExample)
JP (2) JP7166916B2 (enExample)
KR (1) KR102846388B1 (enExample)
CN (4) CN108026162B (enExample)
AR (1) AR106032A1 (enExample)
AU (2) AU2016323445B2 (enExample)
BR (1) BR112018002263A2 (enExample)
CA (1) CA2996006A1 (enExample)
CL (2) CL2018000668A1 (enExample)
CO (1) CO2018002510A2 (enExample)
CR (1) CR20180169A (enExample)
IL (2) IL294568A (enExample)
MA (1) MA42828A (enExample)
MX (1) MX2018002922A (enExample)
MY (1) MY190552A (enExample)
PE (1) PE20181293A1 (enExample)
PH (1) PH12018500577A1 (enExample)
RU (1) RU2770384C2 (enExample)
TW (1) TWI799366B (enExample)
UA (1) UA125505C2 (enExample)
WO (1) WO2017049009A1 (enExample)

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TWI799366B (zh) 2015-09-15 2023-04-21 美商建南德克公司 胱胺酸結骨架平臺
WO2019233605A1 (en) * 2018-06-08 2019-12-12 BioNTech SE Compositions and methods for diagnosis and treatment of cancer
BR112022025227A2 (pt) 2020-06-11 2023-01-03 Genentech Inc Conjugados, composição farmacêutica, formulação líquida, métodos para preparar um conjugado, para aumentar a estabilidade, para tratar um indivíduo, para entregar um polipeptídeo de ligação, para entregar um peptídeo curto, para entregar um agente biologicamente ativo, método para reduzir a conjugação lipídio-proteína-esqueleto e método para aumentar a atividade biológica, uso do conjugado e sistema ou kit
WO2025193946A2 (en) * 2024-03-14 2025-09-18 Genentech, Inc. Peptides binding lrrc15 and uses thereof

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Also Published As

Publication number Publication date
CA2996006A1 (en) 2017-03-23
MA42828A (fr) 2018-07-25
CN120248097A (zh) 2025-07-04
CN108026162A (zh) 2018-05-11
BR112018002263A2 (en) 2018-09-18
US20240247034A1 (en) 2024-07-25
US11155586B2 (en) 2021-10-26
CN114805528A (zh) 2022-07-29
US10428125B2 (en) 2019-10-01
WO2017049009A1 (en) 2017-03-23
AU2021204400B2 (en) 2023-02-02
US11078243B2 (en) 2021-08-03
US20200325187A1 (en) 2020-10-15
US20170129927A1 (en) 2017-05-11
EP3350215A1 (en) 2018-07-25
JP2022130481A (ja) 2022-09-06
TW201717993A (zh) 2017-06-01
US20200231636A1 (en) 2020-07-23
AU2016323445A1 (en) 2018-03-01
AU2016323445B2 (en) 2021-04-01
UA125505C2 (uk) 2022-04-13
US20230174596A1 (en) 2023-06-08
KR20180052718A (ko) 2018-05-18
CN114591422A (zh) 2022-06-07
MY190552A (en) 2022-04-27
JP7602514B2 (ja) 2024-12-18
CO2018002510A2 (es) 2018-05-31
CN114591422B (zh) 2025-04-04
RU2770384C2 (ru) 2022-04-15
JP2018533912A (ja) 2018-11-22
TWI799366B (zh) 2023-04-21
US20200115424A1 (en) 2020-04-16
CN108026162B (zh) 2022-04-05
PH12018500577A1 (en) 2018-10-15
IL294568A (en) 2022-09-01
US11407794B2 (en) 2022-08-09
RU2018113442A3 (enExample) 2020-02-17
NZ740218A (en) 2025-05-02
AU2021204400A1 (en) 2021-07-22
EP3350215B1 (en) 2025-12-03
CR20180169A (es) 2018-04-24
HK1253318A1 (zh) 2019-06-14
IL257399A (en) 2018-04-30
US20180291069A1 (en) 2018-10-11
AR106032A1 (es) 2017-12-06
CL2018000668A1 (es) 2018-07-20
US10696721B2 (en) 2020-06-30
MX2018002922A (es) 2018-06-07
WO2017049009A8 (en) 2018-02-22
CL2020001781A1 (es) 2020-10-23
IL257399B (en) 2022-08-01
RU2018113442A (ru) 2019-10-16
PE20181293A1 (es) 2018-08-07
JP7166916B2 (ja) 2022-11-08
US20200140498A1 (en) 2020-05-07

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