PE20181038A1 - Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132h - Google Patents
Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132hInfo
- Publication number
- PE20181038A1 PE20181038A1 PE2018000133A PE2018000133A PE20181038A1 PE 20181038 A1 PE20181038 A1 PE 20181038A1 PE 2018000133 A PE2018000133 A PE 2018000133A PE 2018000133 A PE2018000133 A PE 2018000133A PE 20181038 A1 PE20181038 A1 PE 20181038A1
- Authority
- PE
- Peru
- Prior art keywords
- inhibitor
- isocitrate dehydrogenase
- acid
- idh1
- mutated isocitrate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se refiere a un aducto formado por el acido (2E)-but-2-enedioico y un acido 3-(2-{[4-4-trifluorometoxi)fenil]amino}-1-[(1R,5R)-3,3,5-trimetilciclohexil]-1H-benzimidazol-5-il)propanoico que comprende una molecula de acido fumarico a cuatro moleculas de acido 3-(2-{[4-4-trifluorometoxi)fenil]amino}-1-[(1R,5R)-3,3,5-trimetilciclohexil]-1H-benzimidazol-5-il)propanoico. Dicho aducto en su forma cristalina posee picos maximos en un difractograma de rayos X (2 theta) tales como 5,4; 6,8; 10,2; 10,3; 10,8; 11,1; 16,8 y 21,6. La presente invencion es util para el tratamiento y profilaxis de tumores
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15178419 | 2015-07-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20181038A1 true PE20181038A1 (es) | 2018-07-03 |
Family
ID=53758092
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2018000133A PE20181038A1 (es) | 2015-07-27 | 2016-07-22 | Inhibidor de la isocitrato deshidrogenasa mutada idh1 r132h |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10344004B2 (es) |
| EP (1) | EP3328837B1 (es) |
| JP (1) | JP6804516B2 (es) |
| KR (1) | KR20180030789A (es) |
| CN (1) | CN107810181B (es) |
| AR (1) | AR105493A1 (es) |
| AU (1) | AU2016300980B2 (es) |
| BR (1) | BR112018001534A2 (es) |
| CA (1) | CA2993473A1 (es) |
| CL (1) | CL2018000249A1 (es) |
| CO (1) | CO2018000793A2 (es) |
| CR (1) | CR20180053A (es) |
| CU (1) | CU20180014A7 (es) |
| DO (1) | DOP2018000027A (es) |
| EA (1) | EA201890386A1 (es) |
| EC (1) | ECSP18006465A (es) |
| ES (1) | ES2860693T3 (es) |
| HK (1) | HK1252449A1 (es) |
| IL (1) | IL256024A (es) |
| MX (1) | MX2018001205A (es) |
| NI (1) | NI201800014A (es) |
| PE (1) | PE20181038A1 (es) |
| SV (1) | SV2018005621A (es) |
| TN (1) | TN2018000038A1 (es) |
| TW (1) | TW201708193A (es) |
| WO (1) | WO2017016992A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA031655B1 (ru) | 2014-02-11 | 2019-02-28 | Байер Фарма Акциенгезельшафт | Бензимидазол-2-амины в качестве ингибиторов midhi |
| WO2015121209A1 (en) | 2014-02-11 | 2015-08-20 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| US10137110B2 (en) | 2014-10-23 | 2018-11-27 | Bayer Pharma Aktiengesellschaft | 1-cyclohexyl-2-phenylaminobenzimidazoles as mIDH1 inhibitors for the treatment of tumors |
| CA2988356A1 (en) | 2015-06-08 | 2016-12-15 | Bayer Pharma Aktiengesellschaft | N-menthylbenzimidazoles as midh1 inhibitors |
| JP6824952B2 (ja) | 2015-07-07 | 2021-02-03 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | ｍＩＤＨ１阻害剤としての２−アリール−および２−アリールアルキル−ベンズイミダゾール |
| CN108026052B (zh) | 2015-07-16 | 2021-10-08 | 德国癌症研究公共权益基金会 | 作为mIDH1抑制剂的5-羟烷基苯并咪唑类 |
| EP3121166A1 (en) | 2015-07-21 | 2017-01-25 | Bayer Pharma Aktiengesellschaft | Fused imidazoles as midh1 inhibitors |
| TW201718513A (zh) | 2015-07-27 | 2017-06-01 | 拜耳製藥公司 | 製備經取代之３－（２－苯胺－１－環己基－１ｈ－苯并咪唑－５－基）丙酸衍生物之方法 |
| WO2019015672A1 (zh) * | 2017-07-21 | 2019-01-24 | 南京明德新药研发股份有限公司 | 吡啶并咪唑类化合物及其应用 |
| EP3661559A1 (en) | 2017-08-01 | 2020-06-10 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Combination of midh1 inhibitors and dna hypomethylating agents (hma) |
| CN108948205B (zh) * | 2018-07-13 | 2021-09-28 | 北京金岱生物科技有限公司 | 抗idh1r132h单克隆抗体及其应用 |
| TWI760017B (zh) * | 2019-12-23 | 2022-04-01 | 大陸商昆藥集團股份有限公司 | 一種ｉｄｈ１突變體抑制劑的鹽型、晶型及其製備方法 |
| EP4186525A4 (en) | 2020-07-21 | 2024-04-03 | Daiichi Sankyo Co Ltd | COMBINATION DRUG OF TEMOZOLOMIDE AND MUTATED IDH1 ENZYME INHIBITOR |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2445345B1 (en) * | 2009-06-23 | 2014-08-27 | The Translational Genomics Research Institute | Benzamide derivatives |
| JP5808818B2 (ja) * | 2010-11-25 | 2015-11-10 | ラツィオファーム・ゲーエムベーハー | アファチニブの新規塩及び多形形態 |
| KR20140069235A (ko) * | 2011-09-27 | 2014-06-09 | 노파르티스 아게 | 돌연변이체 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온 |
| WO2015121209A1 (en) | 2014-02-11 | 2015-08-20 | Bayer Pharma Aktiengesellschaft | Benzimidazol-2-amines as midh1 inhibitors |
| EA031655B1 (ru) * | 2014-02-11 | 2019-02-28 | Байер Фарма Акциенгезельшафт | Бензимидазол-2-амины в качестве ингибиторов midhi |
| US10137110B2 (en) * | 2014-10-23 | 2018-11-27 | Bayer Pharma Aktiengesellschaft | 1-cyclohexyl-2-phenylaminobenzimidazoles as mIDH1 inhibitors for the treatment of tumors |
| CN107108522B (zh) * | 2014-10-23 | 2020-12-01 | 德国癌症研究中心 | 作为mIDH1抑制剂的苯并咪唑-2-胺 |
| CA2988356A1 (en) * | 2015-06-08 | 2016-12-15 | Bayer Pharma Aktiengesellschaft | N-menthylbenzimidazoles as midh1 inhibitors |
| JP6824952B2 (ja) | 2015-07-07 | 2021-02-03 | ドイチェス クレープスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェン レヒツ | ｍＩＤＨ１阻害剤としての２−アリール−および２−アリールアルキル−ベンズイミダゾール |
| CN108026052B (zh) | 2015-07-16 | 2021-10-08 | 德国癌症研究公共权益基金会 | 作为mIDH1抑制剂的5-羟烷基苯并咪唑类 |
| EP3121166A1 (en) * | 2015-07-21 | 2017-01-25 | Bayer Pharma Aktiengesellschaft | Fused imidazoles as midh1 inhibitors |
| TW201718513A (zh) | 2015-07-27 | 2017-06-01 | 拜耳製藥公司 | 製備經取代之３－（２－苯胺－１－環己基－１ｈ－苯并咪唑－５－基）丙酸衍生物之方法 |
-
2016
- 2016-07-14 TW TW105122262A patent/TW201708193A/zh unknown
- 2016-07-22 WO PCT/EP2016/067477 patent/WO2017016992A1/en active Application Filing
- 2016-07-22 EP EP16741332.7A patent/EP3328837B1/en active Active
- 2016-07-22 ES ES16741332T patent/ES2860693T3/es active Active
- 2016-07-22 JP JP2018504187A patent/JP6804516B2/ja active Active
- 2016-07-22 US US15/748,014 patent/US10344004B2/en not_active Expired - Fee Related
- 2016-07-22 KR KR1020177036977A patent/KR20180030789A/ko unknown
- 2016-07-22 EA EA201890386A patent/EA201890386A1/ru unknown
- 2016-07-22 BR BR112018001534A patent/BR112018001534A2/pt not_active Application Discontinuation
- 2016-07-22 CR CR20180053A patent/CR20180053A/es unknown
- 2016-07-22 PE PE2018000133A patent/PE20181038A1/es unknown
- 2016-07-22 AU AU2016300980A patent/AU2016300980B2/en not_active Ceased
- 2016-07-22 CU CUP2018000014A patent/CU20180014A7/es unknown
- 2016-07-22 CA CA2993473A patent/CA2993473A1/en not_active Abandoned
- 2016-07-22 CN CN201680038633.9A patent/CN107810181B/zh active Active
- 2016-07-22 TN TNP/2018/000038A patent/TN2018000038A1/en unknown
- 2016-07-22 MX MX2018001205A patent/MX2018001205A/es unknown
- 2016-07-27 AR ARP160102274A patent/AR105493A1/es unknown
-
2017
- 2017-11-30 IL IL256024A patent/IL256024A/en unknown
-
2018
- 2018-01-26 DO DO2018000027A patent/DOP2018000027A/es unknown
- 2018-01-26 NI NI201800014A patent/NI201800014A/es unknown
- 2018-01-26 EC ECIEPI20186465A patent/ECSP18006465A/es unknown
- 2018-01-26 CO CONC2018/0000793A patent/CO2018000793A2/es unknown
- 2018-01-26 CL CL2018000249A patent/CL2018000249A1/es unknown
- 2018-01-26 SV SV2018005621A patent/SV2018005621A/es unknown
- 2018-09-13 HK HK18111750.7A patent/HK1252449A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN107810181B (zh) | 2021-06-22 |
| JP2018521095A (ja) | 2018-08-02 |
| CR20180053A (es) | 2018-03-20 |
| NI201800014A (es) | 2018-09-06 |
| TW201708193A (zh) | 2017-03-01 |
| US10344004B2 (en) | 2019-07-09 |
| ES2860693T3 (es) | 2021-10-05 |
| MX2018001205A (es) | 2018-04-24 |
| CU20180014A7 (es) | 2018-06-05 |
| WO2017016992A1 (en) | 2017-02-02 |
| CL2018000249A1 (es) | 2018-07-06 |
| AU2016300980B2 (en) | 2020-12-24 |
| EP3328837B1 (en) | 2021-01-06 |
| EP3328837A1 (en) | 2018-06-06 |
| CA2993473A1 (en) | 2017-02-02 |
| ECSP18006465A (es) | 2018-04-30 |
| CN107810181A (zh) | 2018-03-16 |
| BR112018001534A2 (pt) | 2018-09-11 |
| SV2018005621A (es) | 2018-12-05 |
| CO2018000793A2 (es) | 2018-05-10 |
| US20180222870A1 (en) | 2018-08-09 |
| HK1252449A1 (zh) | 2019-05-24 |
| AU2016300980A1 (en) | 2017-12-21 |
| TN2018000038A1 (en) | 2019-07-08 |
| DOP2018000027A (es) | 2018-02-28 |
| IL256024A (en) | 2018-01-31 |
| EA201890386A1 (ru) | 2018-08-31 |
| AR105493A1 (es) | 2017-10-11 |
| JP6804516B2 (ja) | 2020-12-23 |
| KR20180030789A (ko) | 2018-03-26 |
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