EA201492256A1 - Пролекарства 5-(5-фенил-4-(пиридин-2-илметиламино)хиназолин-2-ил)пиридин-3-сульфонамида на основе фосфорамидной кислоты - Google Patents

Пролекарства 5-(5-фенил-4-(пиридин-2-илметиламино)хиназолин-2-ил)пиридин-3-сульфонамида на основе фосфорамидной кислоты

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Publication number
EA201492256A1
EA201492256A1 EA201492256A EA201492256A EA201492256A1 EA 201492256 A1 EA201492256 A1 EA 201492256A1 EA 201492256 A EA201492256 A EA 201492256A EA 201492256 A EA201492256 A EA 201492256A EA 201492256 A1 EA201492256 A1 EA 201492256A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyridine
ilmethylamino
procare
quinazoline
phenyl
Prior art date
Application number
EA201492256A
Other languages
English (en)
Other versions
EA024692B1 (ru
Inventor
Джаякумар С. Уорриер
Навнат Дняноба Ядев
Original Assignee
Бристол-Майерс Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристол-Майерс Сквибб Компани filed Critical Бристол-Майерс Сквибб Компани
Publication of EA201492256A1 publication Critical patent/EA201492256A1/ru
Publication of EA024692B1 publication Critical patent/EA024692B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65128—Six-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Abstract

Соединение структурной формулы Iгде R представляет собой Н или -РОН, или его фармацевтически приемлемая солевая форма. Соединения применимы в качестве ингибиторов функции калиевых каналов и в лечении и профилактике аритмии, связанных с Iнарушений и других опосредованных функцией ионных каналов нарушений.
EA201492256A 2012-06-11 2013-06-10 Пролекарства 5-(5-фенил-4-(пиридин-2-илметиламино)хиназолин-2-ил)пиридин-3-сульфонамида на основе фосфорамидной кислоты EA024692B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261657913P 2012-06-11 2012-06-11
PCT/US2013/044882 WO2013188254A1 (en) 2012-06-11 2013-06-10 Phosphoramidic acid prodrugs of 5 - [5 - phenyl- 4 - (pyridin- 2 - ylmethylamino) quinazolin- 2 - yl] pyridine- 3 - sulfonamide

Publications (2)

Publication Number Publication Date
EA201492256A1 true EA201492256A1 (ru) 2016-05-31
EA024692B1 EA024692B1 (ru) 2016-10-31

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201492256A EA024692B1 (ru) 2012-06-11 2013-06-10 Пролекарства 5-(5-фенил-4-(пиридин-2-илметиламино)хиназолин-2-ил)пиридин-3-сульфонамида на основе фосфорамидной кислоты

Country Status (34)

Country Link
US (1) US9238666B2 (ru)
EP (1) EP2858987B1 (ru)
JP (1) JP6234450B2 (ru)
KR (1) KR102092984B1 (ru)
CN (1) CN104350048B (ru)
AR (1) AR091402A1 (ru)
AU (1) AU2013274619B2 (ru)
BR (1) BR112014030629B1 (ru)
CA (1) CA2876359C (ru)
CL (1) CL2014003361A1 (ru)
CO (1) CO7160032A2 (ru)
CY (1) CY1120432T1 (ru)
DK (1) DK2858987T3 (ru)
EA (1) EA024692B1 (ru)
ES (1) ES2675314T3 (ru)
HK (1) HK1203928A1 (ru)
HR (1) HRP20180815T8 (ru)
HU (1) HUE039210T2 (ru)
IL (1) IL236074A (ru)
LT (1) LT2858987T (ru)
MX (1) MX356699B (ru)
MY (1) MY169219A (ru)
NZ (1) NZ703632A (ru)
PE (1) PE20150228A1 (ru)
PH (1) PH12014502747B1 (ru)
PL (1) PL2858987T3 (ru)
PT (1) PT2858987T (ru)
RS (1) RS57376B1 (ru)
SG (1) SG11201408076WA (ru)
SI (1) SI2858987T1 (ru)
TN (1) TN2014000499A1 (ru)
TW (1) TWI571470B (ru)
WO (1) WO2013188254A1 (ru)
ZA (1) ZA201500161B (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2616025T3 (es) * 2013-03-11 2017-06-09 Bristol-Myers Squibb Company Pirrolotriazinas como inhibidores de canales de iones potasio
CN105008366B (zh) * 2013-03-11 2017-11-14 百时美施贵宝公司 作为钾离子通道抑制剂的吡咯并哒嗪类化合物
US9050345B2 (en) * 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
US20180318268A1 (en) * 2015-11-19 2018-11-08 Biohaven Pharmaceutical Holding Company Ltd. Amine prodrugs of pharmaceutical compounds

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US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
GB9514380D0 (en) * 1995-07-13 1995-09-13 Knoll Ag Therapeutic agents
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
AU767456B2 (en) 1998-07-06 2003-11-13 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
ES2215474B1 (es) 2002-12-24 2005-12-16 J. URIACH & CIA S.A. Nuevos derivados de fosforamida.
AR049847A1 (es) 2004-07-29 2006-09-06 Merck & Co Inc Inhibidores de los canales de potasio
EP1838690A2 (en) * 2004-12-21 2007-10-03 Devgen N.V. Compounds with kv4 ion channel activity
PL2473487T3 (pl) 2009-09-03 2017-07-31 Bristol-Myers Squibb Company Chinazoliny jako inhibitory kanałów jonowych potasowych
CN102984941B (zh) 2009-09-04 2016-08-17 密执安大学评议会 用于治疗白血病的组合物和方法
AR079814A1 (es) 2009-12-31 2012-02-22 Otsuka Pharma Co Ltd Compuestos heterociclicos, composiciones farmaceuticas que los contienen y sus usos
AU2011270701B2 (en) * 2010-06-24 2015-05-14 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
EP2970199A1 (en) * 2013-03-11 2016-01-20 Bristol-Myers Squibb Company Isoquinolines as potassium ion channel inhibitors
US9050345B2 (en) * 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
US9242966B2 (en) * 2013-03-11 2016-01-26 Bristol-Myers Squibb Company Phthalazines as potassium ion channel inhibitors

Also Published As

Publication number Publication date
LT2858987T (lt) 2018-07-10
AU2013274619B2 (en) 2017-09-28
PE20150228A1 (es) 2015-02-19
TW201402592A (zh) 2014-01-16
MX356699B (es) 2018-06-11
ZA201500161B (en) 2017-04-26
SI2858987T1 (en) 2018-06-29
NZ703632A (en) 2016-01-29
US20150175641A1 (en) 2015-06-25
KR102092984B1 (ko) 2020-03-24
HRP20180815T1 (hr) 2018-06-29
EP2858987B1 (en) 2018-04-25
EA024692B1 (ru) 2016-10-31
CA2876359A1 (en) 2013-12-19
US9238666B2 (en) 2016-01-19
MX2014014525A (es) 2015-02-24
CO7160032A2 (es) 2015-01-15
DK2858987T3 (en) 2018-07-30
WO2013188254A1 (en) 2013-12-19
AU2013274619A1 (en) 2015-01-29
MY169219A (en) 2019-03-19
CA2876359C (en) 2020-01-21
CL2014003361A1 (es) 2015-05-29
EP2858987A1 (en) 2015-04-15
BR112014030629A2 (pt) 2017-06-27
IL236074A0 (en) 2015-02-01
ES2675314T3 (es) 2018-07-10
JP6234450B2 (ja) 2017-11-22
KR20150023667A (ko) 2015-03-05
RS57376B1 (sr) 2018-08-31
BR112014030629B1 (pt) 2021-12-21
PH12014502747A1 (en) 2015-02-02
PL2858987T3 (pl) 2018-08-31
IL236074A (en) 2016-08-31
SG11201408076WA (en) 2015-01-29
HUE039210T2 (hu) 2018-12-28
CN104350048B (zh) 2016-12-07
TN2014000499A1 (en) 2016-03-30
HRP20180815T8 (hr) 2019-02-08
TWI571470B (zh) 2017-02-21
JP2015521598A (ja) 2015-07-30
AR091402A1 (es) 2015-02-04
CY1120432T1 (el) 2019-07-10
HK1203928A1 (en) 2015-11-06
PH12014502747B1 (en) 2015-02-02
CN104350048A (zh) 2015-02-11
PT2858987T (pt) 2018-07-04

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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