PE20170952A1 - Productos farmaceuticos y composiciones liquidas estables de anticuerpos contra il-17 - Google Patents
Productos farmaceuticos y composiciones liquidas estables de anticuerpos contra il-17Info
- Publication number
- PE20170952A1 PE20170952A1 PE2017001096A PE2017001096A PE20170952A1 PE 20170952 A1 PE20170952 A1 PE 20170952A1 PE 2017001096 A PE2017001096 A PE 2017001096A PE 2017001096 A PE2017001096 A PE 2017001096A PE 20170952 A1 PE20170952 A1 PE 20170952A1
- Authority
- PE
- Peru
- Prior art keywords
- antibodies against
- liquid compositions
- pharmaceutical products
- stable liquid
- product
- Prior art date
Links
- 239000007788 liquid Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 229940127557 pharmaceutical product Drugs 0.000 title abstract 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 229930195722 L-methionine Natural products 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229960004452 methionine Drugs 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960004540 secukinumab Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se refiere a un producto farmaceutico que comprende: a) un envase donde el contenido de oxigeno es inferior a 12%; y b) una composicion farmaceutica liquida con un pH de 5.2 a 6.2, donde dicha composicion a su vez comprende: i) 20 mg/mL a 175 mg/mL de secukinumab y ii) 2.5 mM a 20 mM de L-metionina. Dicho producto es util en el tratamiento de trastornos mediados por IL-17 tales como trastornos autoinmunitarios como por ejemplo la psoriasis, espondilitis anquilosante, entre otros
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462095210P | 2014-12-22 | 2014-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20170952A1 true PE20170952A1 (es) | 2017-07-13 |
Family
ID=55135471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2017001096A PE20170952A1 (es) | 2014-12-22 | 2015-12-21 | Productos farmaceuticos y composiciones liquidas estables de anticuerpos contra il-17 |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US11801300B2 (es) |
| EP (2) | EP4372005A3 (es) |
| JP (4) | JP6770974B2 (es) |
| KR (3) | KR102506173B1 (es) |
| CN (5) | CN107257692B (es) |
| AR (1) | AR103173A1 (es) |
| AU (1) | AU2015370522B2 (es) |
| BR (1) | BR112017013240A2 (es) |
| CA (1) | CA2971800A1 (es) |
| CL (1) | CL2017001638A1 (es) |
| CO (1) | CO2017005950A2 (es) |
| DK (1) | DK3237001T3 (es) |
| EA (1) | EA033824B1 (es) |
| EC (1) | ECSP17047155A (es) |
| ES (1) | ES2976305T3 (es) |
| FI (1) | FI3237001T3 (es) |
| HR (1) | HRP20240253T1 (es) |
| HU (1) | HUE066126T2 (es) |
| IL (3) | IL310604A (es) |
| LT (1) | LT3237001T (es) |
| MX (1) | MX2017008412A (es) |
| PE (1) | PE20170952A1 (es) |
| PH (1) | PH12017500966A1 (es) |
| PL (1) | PL3237001T3 (es) |
| PT (1) | PT3237001T (es) |
| RS (1) | RS65387B1 (es) |
| SG (1) | SG11201703828VA (es) |
| SI (1) | SI3237001T1 (es) |
| TN (1) | TN2017000181A1 (es) |
| TW (1) | TW201641104A (es) |
| WO (1) | WO2016103153A1 (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR103172A1 (es) * | 2014-12-22 | 2017-04-19 | Novartis Ag | Reducción selectiva de residuos de cisteina en anticuerpos il-17 |
| JP2019521156A (ja) * | 2016-07-19 | 2019-07-25 | ノバルティス アーゲー | Ｉｌ−１７アンタゴニストを用いて初発プラーク型乾癬を治療する方法 |
| TW201919582A (zh) * | 2017-07-24 | 2019-06-01 | 美商再生元醫藥公司 | 穩定化之抗體組合物及其製法 |
| KR20200083996A (ko) * | 2017-11-02 | 2020-07-09 | 노파르티스 아게 | 인터류킨-17(il-17)을 사용하여 건병증을 치료하는 방법 |
| GB201719447D0 (en) * | 2017-11-23 | 2018-01-10 | Ucb Biopharma Sprl | Pharmaceutical composition |
| CA3083971A1 (en) * | 2017-11-30 | 2019-06-06 | Bio-Thera Solutions, Ltd. | Liquid formulation of humanized antibody for treating il-6 related diseases |
| CN111303283A (zh) * | 2018-12-12 | 2020-06-19 | 上海君实生物医药科技股份有限公司 | 抗il-17a抗体及其应用 |
| US11634485B2 (en) | 2019-02-18 | 2023-04-25 | Eli Lilly And Company | Therapeutic antibody formulation |
| RU2754760C2 (ru) * | 2019-04-02 | 2021-09-07 | Закрытое Акционерное Общество "Биокад" | Водная фармацевтическая композиция анти-il17a антитела и ее применение |
| CN110179746A (zh) * | 2019-05-17 | 2019-08-30 | 通化东宝生物科技有限公司 | 一种稳定的苏金单抗注射剂及其制备方法 |
| CN110124030A (zh) * | 2019-06-10 | 2019-08-16 | 通化东宝生物科技有限公司 | 一种苏金单抗注射液及其制备方法 |
| CA3155108A1 (en) | 2019-09-20 | 2021-03-25 | Novartis Ag | Methods of treating autoimmune diseases using interleukin-17 (il-17) antagonists |
| CN110585430B (zh) * | 2019-09-29 | 2023-09-08 | 华博生物医药技术（上海）有限公司 | 一种人源化抗人il-17a单克隆抗体的药物组合物 |
| AR121183A1 (es) | 2019-11-19 | 2022-04-27 | Novartis Ag | Métodos de tratamiento de la nefritis lúpica con antagonistas de interleucina-17 (il-17) |
| CN112915201B (zh) * | 2019-12-06 | 2023-06-27 | 珠海市丽珠单抗生物技术有限公司 | 包含抗il-17抗体的液体制剂 |
| CN117529506A (zh) * | 2021-06-11 | 2024-02-06 | 海南先声药业有限公司 | 抗人il-17抗体和taci的双功能融合蛋白分子 |
| CN113999300B (zh) * | 2021-12-13 | 2022-09-13 | 青岛润达生物科技有限公司 | 一种高效提取卵黄抗体的复合沉降剂及方法 |
| CN114452383B (zh) * | 2022-02-17 | 2023-06-06 | 中国中医科学院中药研究所 | 司库奇尤单抗在治疗糖尿病溃疡中的用途 |
| WO2024156841A1 (en) | 2023-01-27 | 2024-08-02 | Fresenius Kabi Deutschland Gmbh | Biopharmaceutical composition |
| EP4406553A1 (en) | 2023-01-27 | 2024-07-31 | Fresenius Kabi Deutschland GmbH | Stable secukinumab biopharmaceutical composition |
| CN117883376B (zh) * | 2024-03-14 | 2024-06-25 | 北京四环生物制药有限公司 | 含重组人白细胞介素-2的药物制剂及其制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5272135A (en) | 1991-03-01 | 1993-12-21 | Chiron Ophthalmics, Inc. | Method for the stabilization of methionine-containing polypeptides |
| ATE338120T2 (de) | 1998-11-27 | 2006-09-15 | Ucb Sa | Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung |
| US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| AU783306B2 (en) * | 1999-10-04 | 2005-10-13 | Novartis Vaccines And Diagnostics, Inc. | Stabilized liquid polypeptide-containing pharmaceutical compositions |
| US20030104996A1 (en) * | 2001-08-30 | 2003-06-05 | Tiansheng Li | L-methionine as a stabilizer for NESP/EPO in HSA-free formulations |
| KR100913714B1 (ko) | 2001-11-08 | 2009-08-24 | 패시트 바이오테크 코포레이션 | Ｉｇｇ 항체의 안정한 액상 약학 제형물 |
| EP2277522B1 (en) | 2002-03-01 | 2012-11-21 | UCB Manufacturing, Inc. | Methods for increasing or decreasing bone density and identifying molecules |
| WO2003106657A2 (en) | 2002-06-14 | 2003-12-24 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
| US7381409B2 (en) | 2003-06-16 | 2008-06-03 | Celltech R&D, Inc. | Antibodies specific for sclerostin and methods of screening and use therefor |
| US8461155B2 (en) | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
| GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| NZ560844A (en) * | 2005-03-08 | 2008-08-29 | Pharmacia & Upjohn Co Llc | Anti-MAdCAM antibody compositions |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
| KR20080099290A (ko) | 2006-01-31 | 2008-11-12 | 노파르티스 아게 | 암 치료용 ｉｌ-17 길항 항체 |
| EP2094731A2 (en) | 2006-11-10 | 2009-09-02 | UCB Pharma S.A. | Anti human sclerostin antibodies |
| WO2008061013A2 (en) | 2006-11-10 | 2008-05-22 | Amgen Inc. | Antibody-based diagnostics and therapeutics |
| BRPI0807205A2 (pt) | 2007-02-02 | 2014-07-22 | Novartis Ag | Moduladores de ligantes esclerostina para tratamento de distúrbios relacionados ao osso |
| EP2131860B1 (en) | 2007-03-20 | 2013-12-18 | Eli Lilly & Company | Anti-sclerostin antibodies |
| CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
| TWI489993B (zh) | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法 |
| EP2628486A3 (en) | 2007-12-14 | 2013-10-30 | Amgen, Inc. | Method for treating bone fracture with anti-sclerostin antibodies |
| PE20091174A1 (es) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| WO2010100179A2 (en) | 2009-03-05 | 2010-09-10 | Novartis Ag | Self-forming gel system for sustained drug delivery |
| WO2011008770A2 (en) | 2009-07-14 | 2011-01-20 | Biogen Idec Ma Inc. | Methods for inhibiting yellow color and peroxide formation in a composition |
| EP2361636A1 (en) | 2010-02-26 | 2011-08-31 | CSL Behring AG | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
| WO2012028683A1 (en) | 2010-09-02 | 2012-03-08 | Novartis Ag | Antibody gel system for sustained drug delivery |
| EP4137514A1 (en) * | 2010-10-08 | 2023-02-22 | Novartis AG | Methods of treating psoriasis using il-17 antagonists |
| JP2014503482A (ja) * | 2010-11-05 | 2014-02-13 | ノバルティス アーゲー | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| WO2013077907A1 (en) * | 2011-11-21 | 2013-05-30 | Novartis Ag | Methods of treating psoriatic arthritis (psa) using il-17 antagonists and psa response or non- response alleles |
| LT2822590T (lt) * | 2012-03-07 | 2017-01-25 | Eli Lilly And Company | Il-17 antikūno kompozicija |
| US8883979B2 (en) * | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
-
2015
- 2015-12-18 AR ARP150104193A patent/AR103173A1/es unknown
- 2015-12-21 LT LTEPPCT/IB2015/059836T patent/LT3237001T/lt unknown
- 2015-12-21 CN CN201580076632.9A patent/CN107257692B/zh active Active
- 2015-12-21 JP JP2017551391A patent/JP6770974B2/ja active Active
- 2015-12-21 DK DK15823805.5T patent/DK3237001T3/da active
- 2015-12-21 KR KR1020177016756A patent/KR102506173B1/ko active IP Right Grant
- 2015-12-21 IL IL310604A patent/IL310604A/en unknown
- 2015-12-21 KR KR1020237043038A patent/KR20230173742A/ko not_active Application Discontinuation
- 2015-12-21 TN TN2017000181A patent/TN2017000181A1/en unknown
- 2015-12-21 US US15/538,257 patent/US11801300B2/en active Active
- 2015-12-21 PE PE2017001096A patent/PE20170952A1/es not_active Application Discontinuation
- 2015-12-21 SG SG11201703828VA patent/SG11201703828VA/en unknown
- 2015-12-21 CA CA2971800A patent/CA2971800A1/en active Pending
- 2015-12-21 CN CN202111362173.4A patent/CN114452380A/zh active Pending
- 2015-12-21 TW TW104143009A patent/TW201641104A/zh unknown
- 2015-12-21 IL IL287328A patent/IL287328B2/en unknown
- 2015-12-21 SI SI201531997T patent/SI3237001T1/sl unknown
- 2015-12-21 EA EA201791422A patent/EA033824B1/ru not_active IP Right Cessation
- 2015-12-21 BR BR112017013240A patent/BR112017013240A2/pt not_active Application Discontinuation
- 2015-12-21 CN CN202111364411.5A patent/CN113855800A/zh active Pending
- 2015-12-21 EP EP24155578.8A patent/EP4372005A3/en active Pending
- 2015-12-21 EP EP15823805.5A patent/EP3237001B1/en active Active
- 2015-12-21 WO PCT/IB2015/059836 patent/WO2016103153A1/en active Application Filing
- 2015-12-21 MX MX2017008412A patent/MX2017008412A/es unknown
- 2015-12-21 ES ES15823805T patent/ES2976305T3/es active Active
- 2015-12-21 HU HUE15823805A patent/HUE066126T2/hu unknown
- 2015-12-21 KR KR1020237007135A patent/KR102614921B1/ko active IP Right Grant
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- 2015-12-21 CN CN202111362275.6A patent/CN113876947A/zh active Pending
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- 2015-12-21 AU AU2015370522A patent/AU2015370522B2/en active Active
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2017
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2019
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2021
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2023
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