PE20110120A1 - Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamico - Google Patents
Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamicoInfo
- Publication number
- PE20110120A1 PE20110120A1 PE2010000996A PE2010000996A PE20110120A1 PE 20110120 A1 PE20110120 A1 PE 20110120A1 PE 2010000996 A PE2010000996 A PE 2010000996A PE 2010000996 A PE2010000996 A PE 2010000996A PE 20110120 A1 PE20110120 A1 PE 20110120A1
- Authority
- PE
- Peru
- Prior art keywords
- hydroxy
- methyl
- ester
- metoxyphenylcarbamoyl
- piperidin
- Prior art date
Links
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 title abstract 6
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title abstract 5
- 239000002253 acid Substances 0.000 title abstract 4
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 title abstract 3
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000001384 succinic acid Substances 0.000 abstract 2
- -1 2-FURANYLCARBONYL Chemical class 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 229960000289 fluticasone propionate Drugs 0.000 abstract 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0602778.3A GB0602778D0 (en) | 2006-02-10 | 2006-02-10 | Novel compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110120A1 true PE20110120A1 (es) | 2011-03-08 |
Family
ID=36119909
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2010000996A PE20110120A1 (es) | 2006-02-10 | 2007-02-08 | Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamico |
| PE2007000135A PE20071249A1 (es) | 2006-02-10 | 2007-02-08 | Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000135A PE20071249A1 (es) | 2006-02-10 | 2007-02-08 | Sal de acido succinico de 1-[2-(2-cloro-4-{[(r)-2-hidroxi-2-(8-hidroxi-2-oxo-1,2-dihidroquinolin-5-il)etilamino]metil}-5-metoxifenilcarbamoil)etil]piperidin-4-il ester del acido bifenil-2-ilcarbamico |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US7960551B2 (OSRAM) |
| EP (1) | EP1981872B1 (OSRAM) |
| JP (1) | JP5616021B2 (OSRAM) |
| KR (1) | KR101488691B1 (OSRAM) |
| CN (1) | CN101379057B (OSRAM) |
| AR (2) | AR059409A1 (OSRAM) |
| AU (1) | AU2007213767B2 (OSRAM) |
| BR (1) | BRPI0707559B8 (OSRAM) |
| CA (1) | CA2641769C (OSRAM) |
| CR (1) | CR10227A (OSRAM) |
| CY (1) | CY1119238T1 (OSRAM) |
| DK (1) | DK1981872T3 (OSRAM) |
| EA (1) | EA016580B1 (OSRAM) |
| ES (1) | ES2640226T3 (OSRAM) |
| GB (1) | GB0602778D0 (OSRAM) |
| HR (1) | HRP20171304T1 (OSRAM) |
| HU (1) | HUE034315T2 (OSRAM) |
| IL (1) | IL193103A (OSRAM) |
| JO (1) | JO3389B1 (OSRAM) |
| LT (1) | LT1981872T (OSRAM) |
| MA (1) | MA30273B1 (OSRAM) |
| MY (1) | MY153656A (OSRAM) |
| NO (1) | NO341343B1 (OSRAM) |
| NZ (1) | NZ570242A (OSRAM) |
| PE (2) | PE20110120A1 (OSRAM) |
| PL (1) | PL1981872T3 (OSRAM) |
| PT (1) | PT1981872T (OSRAM) |
| SG (1) | SG169404A1 (OSRAM) |
| SI (1) | SI1981872T1 (OSRAM) |
| TW (1) | TWI401251B (OSRAM) |
| UA (1) | UA100364C2 (OSRAM) |
| WO (1) | WO2007090859A1 (OSRAM) |
| ZA (1) | ZA200806782B (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8519138B2 (en) * | 2009-04-14 | 2013-08-27 | Glaxo Group Limited | Process for the preparation of a biphenyl-2-yl carbamic acid ester |
| AU2015234331B2 (en) * | 2009-04-23 | 2017-08-03 | Theravance Biopharma R&D Ip, Llc | Diamide compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity |
| CN102405218B (zh) | 2009-04-23 | 2014-06-04 | 施万制药 | 具蕈毒碱受体拮抗剂和β2 肾上腺素受体激动剂活性的二酰胺化合物 |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| ITRM20110083U1 (it) | 2010-05-13 | 2011-11-14 | De La Cruz Jose Antonio Freire | Piastra per la costruzione di carrelli per aeroplani |
| EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
| AR083115A1 (es) * | 2010-09-30 | 2013-01-30 | Theravance Inc | Sales oxalato cristalinas de un compuesto diamida |
| WO2013017494A1 (en) * | 2011-08-02 | 2013-02-07 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Pharmaceutical composition of oxidised avidin suitable for inhalation |
| EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
| JP6307091B2 (ja) | 2012-12-18 | 2018-04-04 | アルミラル・ソシエダッド・アノニマＡｌｍｉｒａｌｌ， Ｓ．Ａ． | β２アドレナリンアゴニスト活性およびＭ３ムスカリンアンタゴニスト活性を有する新規のシクロヘキシルおよびキヌクリジニルカルバメート誘導体 |
| TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
| TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β２腎上腺素受體促效劑二者之活性的２－胺基－１－羥乙基－８－羥基喹啉－２（１Ｈ）－酮衍生物之鹽 |
| TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有ｍａｂａ化合物和皮質類固醇之組合 |
| TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β２腎上腺素促效劑及Ｍ３蕈毒拮抗劑活性之新穎雙環衍生物 |
| GB201500447D0 (en) * | 2015-01-12 | 2015-02-25 | Glaxosmithkline Ip Dev Ltd | Novel Combination Product |
| CN106632257B (zh) * | 2016-12-15 | 2019-02-12 | 上海市奉贤区中心医院 | Gsk961081及其中间体的合成方法 |
| US11484531B2 (en) | 2018-08-30 | 2022-11-01 | Theravance Biopharma R&D Ip, Llc | Methods for treating chronic obstructive pulmonary disease |
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| DE3134590A1 (de) | 1981-09-01 | 1983-03-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue benzo-heterocyclen |
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-
2006
- 2006-02-10 GB GBGB0602778.3A patent/GB0602778D0/en not_active Ceased
-
2007
- 2007-02-08 NZ NZ570242A patent/NZ570242A/en not_active IP Right Cessation
- 2007-02-08 HU HUE07704449A patent/HUE034315T2/en unknown
- 2007-02-08 WO PCT/EP2007/051196 patent/WO2007090859A1/en not_active Ceased
- 2007-02-08 AU AU2007213767A patent/AU2007213767B2/en not_active Ceased
- 2007-02-08 BR BRPI0707559A patent/BRPI0707559B8/pt not_active IP Right Cessation
- 2007-02-08 CA CA2641769A patent/CA2641769C/en active Active
- 2007-02-08 SI SI200731963T patent/SI1981872T1/sl unknown
- 2007-02-08 EA EA200801691A patent/EA016580B1/ru unknown
- 2007-02-08 PE PE2010000996A patent/PE20110120A1/es active IP Right Grant
- 2007-02-08 JP JP2008553758A patent/JP5616021B2/ja not_active Expired - Fee Related
- 2007-02-08 JO JOP/2007/0037A patent/JO3389B1/ar active
- 2007-02-08 PL PL07704449T patent/PL1981872T3/pl unknown
- 2007-02-08 PT PT77044493T patent/PT1981872T/pt unknown
- 2007-02-08 LT LTEP07704449.3T patent/LT1981872T/lt unknown
- 2007-02-08 US US11/672,536 patent/US7960551B2/en active Active
- 2007-02-08 HR HRP20171304TT patent/HRP20171304T1/hr unknown
- 2007-02-08 CN CN2007800050282A patent/CN101379057B/zh not_active Expired - Fee Related
- 2007-02-08 EP EP07704449.3A patent/EP1981872B1/en active Active
- 2007-02-08 PE PE2007000135A patent/PE20071249A1/es not_active Application Discontinuation
- 2007-02-08 ES ES07704449.3T patent/ES2640226T3/es active Active
- 2007-02-08 TW TW096104636A patent/TWI401251B/zh not_active IP Right Cessation
- 2007-02-08 DK DK07704449.3T patent/DK1981872T3/en active
- 2007-02-08 AR ARP070100537A patent/AR059409A1/es not_active Application Discontinuation
- 2007-02-08 SG SG201100933-9A patent/SG169404A1/en unknown
- 2007-02-08 KR KR20087022160A patent/KR101488691B1/ko not_active Expired - Fee Related
- 2007-08-02 UA UAA200809940A patent/UA100364C2/ru unknown
-
2008
- 2008-07-29 IL IL193103A patent/IL193103A/en active IP Right Grant
- 2008-08-05 NO NO20083425A patent/NO341343B1/no unknown
- 2008-08-05 ZA ZA200806782A patent/ZA200806782B/xx unknown
- 2008-08-08 MY MYPI20083025A patent/MY153656A/en unknown
- 2008-08-20 CR CR10227A patent/CR10227A/es not_active Application Discontinuation
- 2008-09-10 MA MA31228A patent/MA30273B1/fr unknown
-
2016
- 2016-04-15 AR ARP160101036A patent/AR104288A2/es not_active Application Discontinuation
-
2017
- 2017-08-22 CY CY20171100887T patent/CY1119238T1/el unknown
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