PE20091526A1 - Derivados del acido fenilacetico como moduladores de la inflamacion - Google Patents
Derivados del acido fenilacetico como moduladores de la inflamacionInfo
- Publication number
- PE20091526A1 PE20091526A1 PE2008002152A PE2008002152A PE20091526A1 PE 20091526 A1 PE20091526 A1 PE 20091526A1 PE 2008002152 A PE2008002152 A PE 2008002152A PE 2008002152 A PE2008002152 A PE 2008002152A PE 20091526 A1 PE20091526 A1 PE 20091526A1
- Authority
- PE
- Peru
- Prior art keywords
- derivatives
- modulators
- inflammation
- acid
- phenylacetic acid
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical class OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical class O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 2
- MNZLRXAPLZGIRC-UHFFFAOYSA-N 2-chloro-4-cyclopropylbenzenesulfonamide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC=C1C1CC1 MNZLRXAPLZGIRC-UHFFFAOYSA-N 0.000 abstract 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical group ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 201000004624 Dermatitis Diseases 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 102100029100 Hematopoietic prostaglandin D synthase Human genes 0.000 abstract 1
- 101000988802 Homo sapiens Hematopoietic prostaglandin D synthase Proteins 0.000 abstract 1
- 102000009389 Prostaglandin D receptors Human genes 0.000 abstract 1
- 108050000258 Prostaglandin D receptors Proteins 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Chemical group 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- BHMBVRSPMRCCGG-UHFFFAOYSA-N prostaglandine D2 Natural products CCCCCC(O)C=CC1C(CC=CCCCC(O)=O)C(O)CC1=O BHMBVRSPMRCCGG-UHFFFAOYSA-N 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US843307P | 2007-12-19 | 2007-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091526A1 true PE20091526A1 (es) | 2009-11-01 |
Family
ID=40564868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008002152A PE20091526A1 (es) | 2007-12-19 | 2008-12-19 | Derivados del acido fenilacetico como moduladores de la inflamacion |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8183293B2 (https=) |
| EP (1) | EP2231595B1 (https=) |
| JP (1) | JP5437267B2 (https=) |
| KR (1) | KR20100102668A (https=) |
| CN (1) | CN101903338A (https=) |
| AR (1) | AR071279A1 (https=) |
| AU (1) | AU2008343924B2 (https=) |
| BR (1) | BRPI0821197A2 (https=) |
| CA (1) | CA2707789A1 (https=) |
| CL (1) | CL2008003832A1 (https=) |
| CO (1) | CO6321234A2 (https=) |
| CR (1) | CR11572A (https=) |
| EA (1) | EA201001029A1 (https=) |
| ES (1) | ES2471919T3 (https=) |
| IL (1) | IL206069A0 (https=) |
| MA (1) | MA32013B1 (https=) |
| PE (1) | PE20091526A1 (https=) |
| TN (1) | TN2010000223A1 (https=) |
| TW (1) | TW200940051A (https=) |
| WO (1) | WO2009085177A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
| SG11201402796SA (en) | 2011-12-16 | 2014-06-27 | Atopix Therapeutics Ltd | Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis |
| US9974759B2 (en) * | 2013-05-31 | 2018-05-22 | Indiana University Research And Technology Corporation | Beta 2 adrenoceptor antagonists for treating orthostatic hypotension |
| JP6770522B2 (ja) * | 2015-02-13 | 2020-10-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 全身性エリテマトーデスを予防し、及び／又は、治療するためのｐｔｇｄｒ−１及び／又はｐｔｇｄｒ−２アンタゴニスト |
| UA120571C2 (uk) | 2016-03-22 | 2019-12-26 | Мерк Шарп Енд Дохме Корп. | Алостеричні модулятори нікотинових ацетилхолінових рецепторів |
| EP3424927B1 (en) * | 2017-07-04 | 2019-04-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8704158D0 (en) | 1987-02-23 | 1987-04-01 | Wellcome Found | Substituted hydantoin compounds |
| US5849780A (en) | 1992-01-30 | 1998-12-15 | Sanofi | 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
| JP3894949B2 (ja) | 1993-06-30 | 2007-03-22 | ザ、ウェルカム、ファンデーション、リミテッド | 抗アテローム性動脈硬化症ジアリール化合物 |
| US5545669A (en) * | 1994-06-02 | 1996-08-13 | Adams; Jerry L. | Anti-inflammatory compounds |
| ES2180664T3 (es) * | 1994-12-20 | 2003-02-16 | Hoffmann La Roche | Derivados de aril- y heteroarilsulfonamida, obtencion y uso de los mismos en calidad de antagonistas de endotelina. |
| US6008234A (en) * | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
| EP0929547B1 (en) | 1996-09-12 | 2002-11-27 | Schering Aktiengesellschaft | Benzamidine derivatives substituted by cyclic amino acid or cycl ic hydroxy acid derivatives and their use as anti-coagulants |
| TW523506B (en) | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
| JPH11202458A (ja) | 1998-01-16 | 1999-07-30 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| US5929250A (en) | 1997-01-23 | 1999-07-27 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| WO1999055663A1 (en) | 1998-04-29 | 1999-11-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of impdh enzyme |
| AR023659A1 (es) | 1998-09-18 | 2002-09-04 | Vertex Pharma | Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos |
| US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| HK1044532A1 (zh) | 1999-03-01 | 2002-10-25 | 辉瑞产品公司 | 用作甲状腺受体配体的草氨酸及衍生物 |
| EP1176139B1 (en) | 1999-03-10 | 2005-05-18 | Shionogi & Co., Ltd. | Medicinal compositions with 2.2.1] and 3.1.1] bicycloskeleton antagonistic to both of pgd 2?/txa 2? receptors |
| WO2001014882A1 (fr) | 1999-08-23 | 2001-03-01 | Bml, Inc. | Identification des proprietes d'une substance pour les recepteurs de prostaglandine d |
| US6531291B1 (en) * | 1999-11-10 | 2003-03-11 | The Trustees Of Columbia University In The City Of New York | Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof |
| EP1255750A1 (en) | 2000-02-01 | 2002-11-13 | Millenium Pharmaceuticals, Inc. | INDOLE AND BENZIMIDAZOLE INHIBITORS OF FACTOR Xa |
| US20010047027A1 (en) | 2000-04-12 | 2001-11-29 | Marc Labelle | Prostaglandin D2 receptor antagonists |
| JPWO2001094309A1 (ja) | 2000-06-02 | 2004-02-05 | 塩野義製薬株式会社 | Ｐｇｄ２／ｔｘａ２両受容体拮抗性医薬組成物 |
| US6878522B2 (en) * | 2000-07-07 | 2005-04-12 | Baiyong Li | Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2 |
| AU2002229611A1 (en) | 2000-12-08 | 2002-06-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of active compounds capable of modulating the intracellular pathway triggered by the dp receptor in langerhans cells |
| EP1347959A1 (de) | 2000-12-27 | 2003-10-01 | Bayer Aktiengesellschaft | Indol-derivate |
| AU2002302248B2 (en) | 2001-05-23 | 2008-03-06 | Merck Frosst Canada Ltd. | Dihydropyrrolo[1,2-A]indole and tetrahydropyrido[1,2-A]-indole derivatives as prostaglandin D2 receptor antagonists |
| CN101284773A (zh) | 2001-08-09 | 2008-10-15 | 小野药品工业株式会社 | 羧酸衍生物及以它为活性成分的药剂 |
| SE0200411D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0200356D0 (sv) | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| MXPA04009095A (es) | 2002-03-19 | 2004-12-06 | Ono Pharmaceutical Co | Compuesto de acido carboxilico y agente farmaceutico que comprende el compuesto como ingrediente activo. |
| AU2003231509A1 (en) | 2002-05-16 | 2003-12-02 | Shionogi And Co., Ltd. | Compound exhibiting pgd 2 receptor antagonism |
| WO2003097042A1 (en) | 2002-05-16 | 2003-11-27 | Shionogi & Co., Ltd. | Pgd2 receptor antagonist |
| GB2388540A (en) | 2002-05-17 | 2003-11-19 | Bayer Ag | New use of Ramatroban |
| TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0201635D0 (sv) | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| PL377314A1 (pl) * | 2002-12-20 | 2006-01-23 | Amgen Inc. | Modulatory astmy i zapaleń na tle alergicznym |
| ATE386715T1 (de) | 2003-11-25 | 2008-03-15 | Lilly Co Eli | Modulatoren des peroxisomproliferatoraktivierten rezeptors |
| EP1937632A1 (en) * | 2005-10-06 | 2008-07-02 | Astra Zeneca AB | Novel compounds |
| AU2007331471C1 (en) * | 2006-12-15 | 2013-07-25 | Glaxo Group Limited | Benzamide derivatives as EP4 receptor agonists |
| US7960567B2 (en) * | 2007-05-02 | 2011-06-14 | Amgen Inc. | Compounds and methods useful for treating asthma and allergic inflammation |
| KR20120046762A (ko) | 2009-07-31 | 2012-05-10 | 판미라 파마슈티칼스, 엘엘씨 | Ｄｐ2 수용체 길항제의 피부 제형 |
| EP2461809A4 (en) | 2009-07-31 | 2013-06-19 | Panmira Pharmaceuticals Llc | OPHTHALMIC PHARMACEUTICAL COMPOSITIONS OF DP2 RECEPTOR ANTAGONSITES |
-
2008
- 2008-12-18 ES ES08867490.8T patent/ES2471919T3/es active Active
- 2008-12-18 EP EP08867490.8A patent/EP2231595B1/en active Active
- 2008-12-18 AU AU2008343924A patent/AU2008343924B2/en not_active Ceased
- 2008-12-18 CA CA2707789A patent/CA2707789A1/en not_active Abandoned
- 2008-12-18 KR KR1020107015813A patent/KR20100102668A/ko not_active Withdrawn
- 2008-12-18 EA EA201001029A patent/EA201001029A1/ru unknown
- 2008-12-18 US US12/317,066 patent/US8183293B2/en active Active
- 2008-12-18 CN CN2008801215268A patent/CN101903338A/zh active Pending
- 2008-12-18 WO PCT/US2008/013833 patent/WO2009085177A1/en not_active Ceased
- 2008-12-18 JP JP2010539482A patent/JP5437267B2/ja not_active Expired - Fee Related
- 2008-12-18 BR BRPI0821197-3A patent/BRPI0821197A2/pt not_active IP Right Cessation
- 2008-12-19 AR ARP080105608A patent/AR071279A1/es not_active Application Discontinuation
- 2008-12-19 CL CL2008003832A patent/CL2008003832A1/es unknown
- 2008-12-19 PE PE2008002152A patent/PE20091526A1/es not_active Application Discontinuation
- 2008-12-19 TW TW097149926A patent/TW200940051A/zh unknown
-
2010
- 2010-05-20 TN TN2010000223A patent/TN2010000223A1/fr unknown
- 2010-05-30 IL IL206069A patent/IL206069A0/en unknown
- 2010-07-14 MA MA33012A patent/MA32013B1/fr unknown
- 2010-07-19 CO CO10087808A patent/CO6321234A2/es not_active Application Discontinuation
- 2010-07-19 CR CR11572A patent/CR11572A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CL2008003832A1 (es) | 2010-03-26 |
| IL206069A0 (en) | 2010-11-30 |
| US20090275659A1 (en) | 2009-11-05 |
| CA2707789A1 (en) | 2009-07-09 |
| TW200940051A (en) | 2009-10-01 |
| CO6321234A2 (es) | 2011-09-20 |
| AU2008343924A1 (en) | 2009-07-09 |
| US8183293B2 (en) | 2012-05-22 |
| JP2011507847A (ja) | 2011-03-10 |
| BRPI0821197A2 (pt) | 2015-06-16 |
| EA201001029A1 (ru) | 2011-06-30 |
| EP2231595A1 (en) | 2010-09-29 |
| MA32013B1 (fr) | 2011-01-03 |
| CN101903338A (zh) | 2010-12-01 |
| AU2008343924B2 (en) | 2013-01-17 |
| AR071279A1 (es) | 2010-06-09 |
| WO2009085177A1 (en) | 2009-07-09 |
| ES2471919T3 (es) | 2014-06-27 |
| CR11572A (es) | 2010-08-13 |
| KR20100102668A (ko) | 2010-09-24 |
| AU2008343924A2 (en) | 2011-02-17 |
| JP5437267B2 (ja) | 2014-03-12 |
| TN2010000223A1 (en) | 2011-11-11 |
| EP2231595B1 (en) | 2014-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal | ||
| AE | Restoration of lapsed or forfeited application | ||
| FD | Application declared void or lapsed |