CN101903338A - 用作炎症调节剂的苯基乙酸衍生物 - Google Patents

用作炎症调节剂的苯基乙酸衍生物 Download PDF

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Publication number
CN101903338A
CN101903338A CN2008801215268A CN200880121526A CN101903338A CN 101903338 A CN101903338 A CN 101903338A CN 2008801215268 A CN2008801215268 A CN 2008801215268A CN 200880121526 A CN200880121526 A CN 200880121526A CN 101903338 A CN101903338 A CN 101903338A
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CN
China
Prior art keywords
compound
formula
alkyl
acid
transition
Prior art date
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Pending
Application number
CN2008801215268A
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English (en)
Chinese (zh)
Inventor
M·格里洛
李安蓉
刘纪文
J·C·梅迪娜
苏泳丽
王英才
J·乔纳
A·阿尔盖尔
J·米尔恩
J·默里
J·F·帕亚克
T·斯托尔茨
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Amgen Inc
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Amgen Inc
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Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CN101903338A publication Critical patent/CN101903338A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2008801215268A 2007-12-19 2008-12-18 用作炎症调节剂的苯基乙酸衍生物 Pending CN101903338A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US843307P 2007-12-19 2007-12-19
US61/008433 2007-12-19
PCT/US2008/013833 WO2009085177A1 (en) 2007-12-19 2008-12-18 Phenyl acetic acid derivatives as inflammation modulators

Publications (1)

Publication Number Publication Date
CN101903338A true CN101903338A (zh) 2010-12-01

Family

ID=40564868

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801215268A Pending CN101903338A (zh) 2007-12-19 2008-12-18 用作炎症调节剂的苯基乙酸衍生物

Country Status (20)

Country Link
US (1) US8183293B2 (https=)
EP (1) EP2231595B1 (https=)
JP (1) JP5437267B2 (https=)
KR (1) KR20100102668A (https=)
CN (1) CN101903338A (https=)
AR (1) AR071279A1 (https=)
AU (1) AU2008343924B2 (https=)
BR (1) BRPI0821197A2 (https=)
CA (1) CA2707789A1 (https=)
CL (1) CL2008003832A1 (https=)
CO (1) CO6321234A2 (https=)
CR (1) CR11572A (https=)
EA (1) EA201001029A1 (https=)
ES (1) ES2471919T3 (https=)
IL (1) IL206069A0 (https=)
MA (1) MA32013B1 (https=)
PE (1) PE20091526A1 (https=)
TN (1) TN2010000223A1 (https=)
TW (1) TW200940051A (https=)
WO (1) WO2009085177A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110831944A (zh) * 2017-07-04 2020-02-21 意大利合成制造有限公司 通过极有效制备中间体2,4,5-三氟苯乙酸来制备西他列汀的有效方法

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EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2790696A1 (en) 2011-12-16 2014-10-22 Atopix Therapeutics Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
US9974759B2 (en) * 2013-05-31 2018-05-22 Indiana University Research And Technology Corporation Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
ES2991300T3 (es) * 2015-02-13 2024-12-03 Inserm Institut Nat De La Sante Et De Larecherche Medicale Antagonistas de PTGDR-1 y/o PTGDR-2 para prevenir y/o tratar lupus eritematoso sistémico
AR107928A1 (es) 2016-03-22 2018-06-28 Merck Sharp & Dohme Moduladores alostéricos de receptores de acetilcolina nicotínicos

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110831944A (zh) * 2017-07-04 2020-02-21 意大利合成制造有限公司 通过极有效制备中间体2,4,5-三氟苯乙酸来制备西他列汀的有效方法
CN110831944B (zh) * 2017-07-04 2022-05-27 意大利合成制造有限公司 通过制备中间体2,4,5-三氟苯乙酸来制备西他列汀的方法

Also Published As

Publication number Publication date
CA2707789A1 (en) 2009-07-09
US8183293B2 (en) 2012-05-22
AU2008343924A1 (en) 2009-07-09
BRPI0821197A2 (pt) 2015-06-16
US20090275659A1 (en) 2009-11-05
TN2010000223A1 (en) 2011-11-11
CL2008003832A1 (es) 2010-03-26
PE20091526A1 (es) 2009-11-01
ES2471919T3 (es) 2014-06-27
JP2011507847A (ja) 2011-03-10
EP2231595B1 (en) 2014-04-23
CO6321234A2 (es) 2011-09-20
KR20100102668A (ko) 2010-09-24
CR11572A (es) 2010-08-13
TW200940051A (en) 2009-10-01
AR071279A1 (es) 2010-06-09
AU2008343924B2 (en) 2013-01-17
WO2009085177A1 (en) 2009-07-09
AU2008343924A2 (en) 2011-02-17
EA201001029A1 (ru) 2011-06-30
EP2231595A1 (en) 2010-09-29
IL206069A0 (en) 2010-11-30
JP5437267B2 (ja) 2014-03-12
MA32013B1 (fr) 2011-01-03

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Application publication date: 20101201