CL2008003832A1 - Compuestos derivados del acido 2-(4-(2-(((2-cloro-fenil)sulfonil)metil)-4-(carbamoil)fenoxi)-2-fluorofenil) acetico, forma cristalina anhidra ll de un compuesto especifico; procesos de preparacion; compuestos intermediario, composicion farmaceutica; y uso en el tratamiento de enfermedades inflamatorias, tales como epoc, rinitis, asma y la dermatitis. - Google Patents

Compuestos derivados del acido 2-(4-(2-(((2-cloro-fenil)sulfonil)metil)-4-(carbamoil)fenoxi)-2-fluorofenil) acetico, forma cristalina anhidra ll de un compuesto especifico; procesos de preparacion; compuestos intermediario, composicion farmaceutica; y uso en el tratamiento de enfermedades inflamatorias, tales como epoc, rinitis, asma y la dermatitis.

Info

Publication number
CL2008003832A1
CL2008003832A1 CL2008003832A CL2008003832A CL2008003832A1 CL 2008003832 A1 CL2008003832 A1 CL 2008003832A1 CL 2008003832 A CL2008003832 A CL 2008003832A CL 2008003832 A CL2008003832 A CL 2008003832A CL 2008003832 A1 CL2008003832 A1 CL 2008003832A1
Authority
CL
Chile
Prior art keywords
copd
rhinitis
dermatitis
pharmaceutical composition
acetic acid
Prior art date
Application number
CL2008003832A
Other languages
English (en)
Spanish (es)
Inventor
Liu Jiwen
C Medina Julio
Grillo Mark
Li An-Rong
Su Yongli
Wang Yingcai
Jona Janan
Allgeier Alan
Milne Jacqueline
m Jerry
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CL2008003832A1 publication Critical patent/CL2008003832A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CL2008003832A 2007-12-19 2008-12-19 Compuestos derivados del acido 2-(4-(2-(((2-cloro-fenil)sulfonil)metil)-4-(carbamoil)fenoxi)-2-fluorofenil) acetico, forma cristalina anhidra ll de un compuesto especifico; procesos de preparacion; compuestos intermediario, composicion farmaceutica; y uso en el tratamiento de enfermedades inflamatorias, tales como epoc, rinitis, asma y la dermatitis. CL2008003832A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US843307P 2007-12-19 2007-12-19

Publications (1)

Publication Number Publication Date
CL2008003832A1 true CL2008003832A1 (es) 2010-03-26

Family

ID=40564868

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003832A CL2008003832A1 (es) 2007-12-19 2008-12-19 Compuestos derivados del acido 2-(4-(2-(((2-cloro-fenil)sulfonil)metil)-4-(carbamoil)fenoxi)-2-fluorofenil) acetico, forma cristalina anhidra ll de un compuesto especifico; procesos de preparacion; compuestos intermediario, composicion farmaceutica; y uso en el tratamiento de enfermedades inflamatorias, tales como epoc, rinitis, asma y la dermatitis.

Country Status (20)

Country Link
US (1) US8183293B2 (https=)
EP (1) EP2231595B1 (https=)
JP (1) JP5437267B2 (https=)
KR (1) KR20100102668A (https=)
CN (1) CN101903338A (https=)
AR (1) AR071279A1 (https=)
AU (1) AU2008343924B2 (https=)
BR (1) BRPI0821197A2 (https=)
CA (1) CA2707789A1 (https=)
CL (1) CL2008003832A1 (https=)
CO (1) CO6321234A2 (https=)
CR (1) CR11572A (https=)
EA (1) EA201001029A1 (https=)
ES (1) ES2471919T3 (https=)
IL (1) IL206069A0 (https=)
MA (1) MA32013B1 (https=)
PE (1) PE20091526A1 (https=)
TN (1) TN2010000223A1 (https=)
TW (1) TW200940051A (https=)
WO (1) WO2009085177A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2790696A1 (en) 2011-12-16 2014-10-22 Atopix Therapeutics Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
US9974759B2 (en) * 2013-05-31 2018-05-22 Indiana University Research And Technology Corporation Beta 2 adrenoceptor antagonists for treating orthostatic hypotension
ES2991300T3 (es) * 2015-02-13 2024-12-03 Inserm Institut Nat De La Sante Et De Larecherche Medicale Antagonistas de PTGDR-1 y/o PTGDR-2 para prevenir y/o tratar lupus eritematoso sistémico
AR107928A1 (es) 2016-03-22 2018-06-28 Merck Sharp & Dohme Moduladores alostéricos de receptores de acetilcolina nicotínicos
ES2733477T3 (es) * 2017-07-04 2019-11-29 Fis Fabbrica Italiana Sintetici Spa Procedimiento eficaz para la preparación de sitagliptina a través de una preparación muy eficaz del intermedio ácido 2,4,5-trifluorofenilacético

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8704158D0 (en) 1987-02-23 1987-04-01 Wellcome Found Substituted hydantoin compounds
US5849780A (en) 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
JP3894949B2 (ja) 1993-06-30 2007-03-22 ザ、ウェルカム、ファンデーション、リミテッド 抗アテローム性動脈硬化症ジアリール化合物
US5545669A (en) 1994-06-02 1996-08-13 Adams; Jerry L. Anti-inflammatory compounds
WO1996019455A1 (en) 1994-12-20 1996-06-27 F. Hoffmann-La Roche Ag Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists
US6008234A (en) 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
ATE228513T1 (de) 1996-09-12 2002-12-15 Schering Ag Durch cyclische aminosäuren oder cyclische hydroxysäuren substituierte benzamidinderivate und deren verwendung als antikoagulantien
TW523506B (en) 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
JPH11202458A (ja) 1998-01-16 1999-07-30 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US5929250A (en) 1997-01-23 1999-07-27 Smithkline Beecham Corporation IL-8 receptor antagonists
AU3665199A (en) 1998-04-29 1999-11-16 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
AR023659A1 (es) 1998-09-18 2002-09-04 Vertex Pharma Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
US6248739B1 (en) 1999-01-08 2001-06-19 Pharmacia & Upjohn Company Quinolinecarboxamides as antiviral agents
EA004229B1 (ru) 1999-03-01 2004-02-26 Пфайзер Продактс Инк. Оксаминовые кислоты и их производные в качестве лигандов тиреоидных рецепторов
US7105564B1 (en) 1999-03-10 2006-09-12 Shionogi & Co., Ltd. Pharmaceutical composition comprising a dual antagonist against PGD2/TXA2 receptors having a [2.2.1] or [3.1.1] bicyclic skeleton
JP3486408B2 (ja) 1999-08-23 2004-01-13 株式会社ビー・エム・エル 物質のヒトプロスタグランジンｄ２受容体に対する性質の同定方法
US6531291B1 (en) 1999-11-10 2003-03-11 The Trustees Of Columbia University In The City Of New York Antimicrobial activity of gemfibrozil and related compounds and derivatives and metabolites thereof
US20020072530A1 (en) 2000-02-01 2002-06-13 Bing-Yan Zhu Indole and benzimidazole inhibitors of factor Xa
US20010047027A1 (en) 2000-04-12 2001-11-29 Marc Labelle Prostaglandin D2 receptor antagonists
US7084136B2 (en) 2000-06-02 2006-08-01 Shionogi & Co., Ltd. Drug composition antagonistic to both PGD2/TXA2 receptors
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
AU2002229611A1 (en) 2000-12-08 2002-06-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of active compounds capable of modulating the intracellular pathway triggered by the dp receptor in langerhans cells
WO2002051805A1 (de) 2000-12-27 2002-07-04 Bayer Aktiengesellschaft Indol-derivate
JP4279561B2 (ja) 2001-05-23 2009-06-17 メルク フロスト カナダ リミテツド プロスタグランジンＤ２受容体拮抗薬としてのジヒドロピロロ［１，２−ａ］インドールおよびテトラヒドロピリド［１，２−ａ］−インドール誘導体
MXPA04001253A (es) 2001-08-09 2004-06-03 Ono Pharmaceutical Co Derivados de acidos carboxilicos y agente farmaceutico que comprende los mismos como ingrediente activo.
SE0200356D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
ATE516277T1 (de) 2002-03-19 2011-07-15 Ono Pharmaceutical Co Carbonsäureverbindungen und arzneimittel, die diese verbindungen als wirkstoffe enthalten
AU2003231513A1 (en) 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Pgd2 receptor antagonist
EP2423190A1 (en) 2002-05-16 2012-02-29 Shionogi&Co., Ltd. Compounds Exhibiting PGD 2 Receptor Antagonism
GB2388540A (en) 2002-05-17 2003-11-19 Bayer Ag New use of Ramatroban
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
ZA200505523B (en) 2002-12-20 2006-09-27 Amgen Inc Asthma and allergic inflammation modulators
US20070082907A1 (en) 2003-11-25 2007-04-12 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
US8148572B2 (en) * 2005-10-06 2012-04-03 Astrazeneca Ab Compounds
US20080167377A1 (en) * 2006-12-15 2008-07-10 Alessandra Gaiba Novel compounds
US7960567B2 (en) 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
KR20120038544A (ko) 2009-07-31 2012-04-23 판미라 파마슈티칼스, 엘엘씨 Ｄｐ2 수용체 길항제의 안과용 약학 조성물
CN102596193A (zh) 2009-07-31 2012-07-18 潘米拉制药公司 Dp2受体拮抗的皮肤调配物

Also Published As

Publication number Publication date
CA2707789A1 (en) 2009-07-09
US8183293B2 (en) 2012-05-22
AU2008343924A1 (en) 2009-07-09
BRPI0821197A2 (pt) 2015-06-16
US20090275659A1 (en) 2009-11-05
TN2010000223A1 (en) 2011-11-11
PE20091526A1 (es) 2009-11-01
ES2471919T3 (es) 2014-06-27
JP2011507847A (ja) 2011-03-10
EP2231595B1 (en) 2014-04-23
CO6321234A2 (es) 2011-09-20
KR20100102668A (ko) 2010-09-24
CR11572A (es) 2010-08-13
TW200940051A (en) 2009-10-01
AR071279A1 (es) 2010-06-09
AU2008343924B2 (en) 2013-01-17
WO2009085177A1 (en) 2009-07-09
CN101903338A (zh) 2010-12-01
AU2008343924A2 (en) 2011-02-17
EA201001029A1 (ru) 2011-06-30
EP2231595A1 (en) 2010-09-29
IL206069A0 (en) 2010-11-30
JP5437267B2 (ja) 2014-03-12
MA32013B1 (fr) 2011-01-03

Similar Documents

Publication Publication Date Title
BR112015009913A8 (pt) composições farmacêuticas para o tratamento de doenças mediadas por cftr
ECSP10010594A (es) Derivados de acido ciclopentanocarboxilico condensados sustituidos con acilamino y su uso como productos farmaceuticos
MX2010008583A (es) Novedosos formas cristalinas de acido 4-[4-(2-adamantilcarbamoil)- 5-ter-butil-pirazol-1-il]benzoico.
CL2011000425A1 (es) Compuestos derivados de heteroariloxi amidas del acido benzoico sustituido, inhibidores de map-quinasa p38; procedimiento de preparacion de los compuestos; composicion farmaceutica; procedimiento para preparar dicha composicion; y uso en el tratamiento de enfermedades de las vias aereas como epoc y asma.
PE20120989A1 (es) Sales de disacarina, acido difumarico, acido d-1-hidroxi-2-naftoico y monobenzoico del 2-(4-((2-amino-4-metil-6-(pentilamino) pirimidin-5-il) metil) fenil) acetato de 4-(dimetilamino) butilo
PH12014502363A1 (en) N-aryltriazole compounds as lpar antagonists
PH12014502789A1 (en) N-alkyltriazole compounds as lpar antagonists
CL2012003722A1 (es) Compuestos derivados del acido naf-2-ilacetico; composicion farmaceutica; y uso para el tratamiento del sida.
CL2008000422A1 (es) El compuesto acido 4-[4-(2-adamantilcarbamoil)-5-terbutilpirazol-1-il]-benzoico; composicion farmaceutica; su uso como inhibidor de 11bhsd1, util en el tratamiento de la diabetes tipo 2 y la obesidad.
WO2012117000A8 (en) 3-amino-pyridines as gpbar1 agonists
CL2008000690A1 (es) Compuestos derivados del acido indol-3-propionico; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hiperlipidemia, hipertension; entre otras.
BR112014014809A2 (pt) composições farmacêuticas compreendendo glitazonas e ativadores de nrf2
CL2008003832A1 (es) Compuestos derivados del acido 2-(4-(2-(((2-cloro-fenil)sulfonil)metil)-4-(carbamoil)fenoxi)-2-fluorofenil) acetico, forma cristalina anhidra ll de un compuesto especifico; procesos de preparacion; compuestos intermediario, composicion farmaceutica; y uso en el tratamiento de enfermedades inflamatorias, tales como epoc, rinitis, asma y la dermatitis.
BR112013003439A2 (pt) "inibidores de oxadiazol de produção de leucotrieno"
TN2013000529A1 (en) Trpm8 antagonists and their use in treatments
CL2014000296A1 (es) Compuestos derivados de sulfoxidos de 2-(piperidin-1-il)-dihidrotieno[3,2-d]pirimidina; metodo de preparacion; compuestos intermediarios; y uso para tratar enfermedades inflamatorias o alergicas tales como epoc y asma.
NZ601121A (en) 5-alkynyl-pyrimidines
ECSP14013173A (es) 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil) carbamimidoil)pirazina-2-carboxamida
CL2009000198A1 (es) Compuestos derivados del acido {2'-[(amino n,n-disustituido)-metil]-bifenil-3-il} acetico, mediadores de prostaglandina d2; composicion farmaceutica que los comprende; y su uso en el tratamiento de una enfermedad respiratoria, alergica o inflamatoria, tal como el asma, epoc o rinitis alergica.
WO2012090043A8 (en) Novel solid state forms of azilsartan medoxomil and preparation thereof
CR20160465A (es) Polimorfo b de la n-(2-aminofenil)-4-[n-(piridin-3-il) metoxicarbonilamino-metil] benzamida (ms-275)
PH12014502364A1 (en) Substituted pyrazole compounds as lpar antagonists
WO2013012485A3 (en) Novel crystalline forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
BR112013030264A2 (pt) ácidos acéticos de benzociclohepteno
WO2011047055A8 (en) Novel mek inhibitors, useful in the treatment of diseases