PE20090220A1 - Compuestos de tiadiazina, composiciones farmaceuticas que los comprende y su uso en el tratamiento de la hepatitis c - Google Patents

Compuestos de tiadiazina, composiciones farmaceuticas que los comprende y su uso en el tratamiento de la hepatitis c

Info

Publication number
PE20090220A1
PE20090220A1 PE2008000597A PE2008000597A PE20090220A1 PE 20090220 A1 PE20090220 A1 PE 20090220A1 PE 2008000597 A PE2008000597 A PE 2008000597A PE 2008000597 A PE2008000597 A PE 2008000597A PE 20090220 A1 PE20090220 A1 PE 20090220A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
tiadiazine
hepatitis
treatment
Prior art date
Application number
PE2008000597A
Other languages
English (en)
Inventor
Frank Ruebsam
Douglas E Murphy
Peter S Dragovich
Yuefen Zhou
Lijiang Chen
David Kucera
Fritz Blatter
Martin Viertelhaus
Chinh Viet Tran
Original Assignee
Anadys Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39831340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090220(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Anadys Pharmaceuticals Inc filed Critical Anadys Pharmaceuticals Inc
Publication of PE20090220A1 publication Critical patent/PE20090220A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE TIADIAZINA DE FORMULA I, EN EL QUE X ES N O CR3; A ES II O III; EL ANILLO B ES UN ARILO DE 6 MIEMBROS O HETEROCICLILO; R1 ES H, HALO, -CHR4-S(O)2R5, -C(S(O)2R5)=CHR4-, ENTRE OTROS; R4, R5 Y R6 SON H, ALQUILO(C1-C6), CICLOALQUILO(C3-C8), C(O)O-(ALQUILO(C1-C6)), ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), ALQUILEN(C1-C6)-ARILO, ENTRE OTROS; R3 ES H, HALO O ALQUILO(C1-C6); Z ES -(CR13R14)n- U O; n ES 1 O 2; R7 Y R8 SON H O ALQUILO(C1-C6); R9,R10,R11,R12,R13,R14,R15 Y R16 SON H, ALQUILO(C1-C6), HIDROXIDO O HALO. SON SELECCIONADOS (RAC-DI-EXO)-N-{3-[3-(4-FLUORO-BENCIL)-6-HIDROXI-4-OXO-3-AZA-TRICICLO[6.2.1.02,7]UNDEC-5-EN-5-IL]-1,1-DIOXO-1,4-DIHIDRO-1?6-BENZO[1,2,4]TIADIAZIN-7-IL}METANSULFONAMIDA, (1R,2S,7R,8S)-6-HIDROXI-5-(7-YODO-1,1-DIOXO-1,4-DIHIDRO-1?6-BENZO[1,2,4]TIADIAZIN-3-IL)-3-(3-METIL-BUTIL)-3-AZA-TRICICLO[6.2.1.02,7]UNDEC-5-EN-4-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON DE UTILIDAD EN EL TRATAMIENTO DE INFECCION POR VIRUS DE HEPATITIS C
PE2008000597A 2007-04-03 2008-04-02 Compuestos de tiadiazina, composiciones farmaceuticas que los comprende y su uso en el tratamiento de la hepatitis c PE20090220A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90747807P 2007-04-03 2007-04-03

Publications (1)

Publication Number Publication Date
PE20090220A1 true PE20090220A1 (es) 2009-03-12

Family

ID=39831340

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000597A PE20090220A1 (es) 2007-04-03 2008-04-02 Compuestos de tiadiazina, composiciones farmaceuticas que los comprende y su uso en el tratamiento de la hepatitis c

Country Status (23)

Country Link
US (6) US7939524B2 (es)
EP (1) EP2129224B1 (es)
JP (2) JP5739662B2 (es)
KR (1) KR101542516B1 (es)
CN (2) CN104086540B (es)
AR (1) AR065927A1 (es)
AU (1) AU2008237364B2 (es)
BR (1) BRPI0809685A2 (es)
CA (1) CA2682584C (es)
CL (1) CL2008000959A1 (es)
EA (1) EA017685B1 (es)
ES (1) ES2578302T3 (es)
HK (2) HK1137119A1 (es)
IL (2) IL201312A (es)
MX (1) MX2009010564A (es)
MY (1) MY157961A (es)
NZ (1) NZ580445A (es)
PE (1) PE20090220A1 (es)
TN (1) TN2009000398A1 (es)
TW (2) TWI427079B (es)
UA (1) UA100120C2 (es)
WO (1) WO2008124450A1 (es)
ZA (1) ZA200907673B (es)

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TW201026675A (en) * 2008-10-09 2010-07-16 Anadys Pharmaceuticals Inc 5,6-dihydro-1H-pyridin-2-one compounds
RU2012121847A (ru) 2009-10-28 2013-12-10 Анадис Фармасьютикалз, Инк. Дейтерированные соединения 5, 6-дигидро-1н-пиридин-2-она
MX2012007076A (es) 2009-12-18 2012-07-20 Boehringer Ingelheim Int Terapia combinada de hcv.
WO2012158271A1 (en) 2011-04-06 2012-11-22 Anadys Pharmaceuticals, Inc. Bridged polycyclic compounds as antiviral agents
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EP2858637A1 (en) * 2012-06-12 2015-04-15 F. Hoffmann-La Roche AG Combination of therapeutic agents for treating hcv infection
EP2943468B1 (en) 2013-01-14 2017-03-01 F. Hoffmann-La Roche AG A novel process for the preparation of n-(4-nitro-2-sulfamoyl-phenyl)-malonamic acid methyl ester and n-(4-amino-2-sulfamoyl-phenyl)-malonamic acid methyl ester
PL3068782T3 (pl) * 2013-11-13 2018-12-31 Vertex Pharmaceuticals Incorporated Sposoby wytwarzania inhibitorów replikacji wirusów grypy
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JP7435515B2 (ja) * 2021-03-17 2024-02-21 株式会社村田製作所 部品収容装置

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UA100120C2 (en) 2007-04-03 2012-11-26 Анадис Фармасьютикалз, Инк. 5,6-dihydro-1h-pyridin-2-one compounds
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Also Published As

Publication number Publication date
EP2129224A1 (en) 2009-12-09
US20150065492A1 (en) 2015-03-05
ES2578302T3 (es) 2016-07-22
CN101677563B (zh) 2014-06-25
CN101677563A (zh) 2010-03-24
EP2129224B1 (en) 2016-03-30
KR20090127437A (ko) 2009-12-11
TW201431830A (zh) 2014-08-16
US8101800B2 (en) 2012-01-24
CA2682584A1 (en) 2008-10-16
NZ580445A (en) 2012-01-12
IL201312A (en) 2015-05-31
US20140031346A1 (en) 2014-01-30
BRPI0809685A2 (pt) 2016-09-27
AR065927A1 (es) 2009-07-08
US8765741B2 (en) 2014-07-01
AU2008237364B2 (en) 2014-03-06
MX2009010564A (es) 2009-10-26
US7939524B2 (en) 2011-05-10
IL225694A (en) 2016-08-31
EA200970916A1 (ru) 2010-04-30
CN104086540A (zh) 2014-10-08
EP2129224A4 (en) 2011-01-05
HK1201822A1 (en) 2015-09-11
TW200906829A (en) 2009-02-16
JP5934403B2 (ja) 2016-06-15
AU2008237364A1 (en) 2008-10-16
CL2008000959A1 (es) 2008-11-03
CN104086540B (zh) 2017-04-12
KR101542516B1 (ko) 2015-08-06
JP2015134783A (ja) 2015-07-27
US8236948B2 (en) 2012-08-07
US20120302744A1 (en) 2012-11-29
ZA200907673B (en) 2014-04-30
US9156832B2 (en) 2015-10-13
TN2009000398A1 (en) 2010-12-31
UA100120C2 (en) 2012-11-26
EA017685B1 (ru) 2013-02-28
CA2682584C (en) 2017-03-14
US20120130068A1 (en) 2012-05-24
MY157961A (en) 2016-08-30
IL225694A0 (en) 2013-06-27
TWI427079B (zh) 2014-02-21
US8546602B2 (en) 2013-10-01
WO2008124450A1 (en) 2008-10-16
IL201312A0 (en) 2010-05-31
US20110166344A1 (en) 2011-07-07
HK1137119A1 (zh) 2010-07-23
JP5739662B2 (ja) 2015-06-24
TWI481588B (zh) 2015-04-21
JP2010523586A (ja) 2010-07-15
US20100034773A1 (en) 2010-02-11

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