PE20081793A1 - Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona - Google Patents

Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona

Info

Publication number
PE20081793A1
PE20081793A1 PE2008000403A PE2008000403A PE20081793A1 PE 20081793 A1 PE20081793 A1 PE 20081793A1 PE 2008000403 A PE2008000403 A PE 2008000403A PE 2008000403 A PE2008000403 A PE 2008000403A PE 20081793 A1 PE20081793 A1 PE 20081793A1
Authority
PE
Peru
Prior art keywords
pyridazin
preparation
phenylisoxazole
methyl
hydrazine
Prior art date
Application number
PE2008000403A
Other languages
English (en)
Inventor
Masia Xavier Serra
Hereu Iolanda Marchueta
Original Assignee
Almirall Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Lab filed Critical Almirall Lab
Publication of PE20081793A1 publication Critical patent/PE20081793A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DEL COMPUESTO 3-METIL-4-FENILISOXAZOLO[3,4-d]PIRIDAZIN-7(6H)-ONA, QUE COMPRENDE: A) HACER REACCIONAR 1-FENILBUTAN-1,3-DIONA CON 2-CLORO-2-(HIDROXIIMINO)ACETATO DE ETILO, CARACTERIZADO POR QUE SE REALIZA MEDIANTE LA ADICION DE METOXIDO SODICO SEGUIDO DE LA ADICION DE 2-CLORO-2-(HIDROXIIMINO)ACETATO DE ETILO Y LA REACCION MOLAR ENTRE EL PRIMERO Y ULTIMO ESTA COMPRENDIDA ENTRE 1,05 Y 1,15; B) HACER REACCIONAR HIDRAZINA O UN HIDRATO DE LA MISMA SOBRE LA MEZCLA RESULTANTE DE LA ETAPA ANTERIOR, CARACTERIZADO POR QUE LA RELACION MOLAR ENTRE LA HIDRAZINA Y EL COMPUESTO INICIAL ESTA COMPRENDIDA ENTRE 1,15 Y 1,25. DICHO PROCEDIMIENTO PROVEE A UN INTERMEDIO EN LA PREPARACION DE ALGUNOS DERIVADOS DE PIRIDAZIN-3(2H)-ONA. DICHO PROCEDIMIENTO PERMITE OBTENER EL COMPUESTO CON MAYORES RENDIMIENTOS
PE2008000403A 2007-03-02 2008-02-28 Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona PE20081793A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200700564A ES2320954B1 (es) 2007-03-02 2007-03-02 Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.

Publications (1)

Publication Number Publication Date
PE20081793A1 true PE20081793A1 (es) 2008-12-18

Family

ID=38617235

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000403A PE20081793A1 (es) 2007-03-02 2008-02-28 Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona

Country Status (23)

Country Link
US (1) US20100137591A1 (es)
EP (1) EP2125830B1 (es)
JP (1) JP2010520158A (es)
KR (1) KR20090116753A (es)
CN (1) CN101679453A (es)
AR (1) AR065511A1 (es)
AT (1) ATE496923T1 (es)
AU (1) AU2008224206A1 (es)
BR (1) BRPI0807273A2 (es)
CA (1) CA2679619A1 (es)
CL (1) CL2008000598A1 (es)
DE (1) DE602008004742D1 (es)
EC (1) ECSP099558A (es)
ES (1) ES2320954B1 (es)
IL (1) IL200166A0 (es)
MX (1) MX2009009232A (es)
NZ (1) NZ578671A (es)
PE (1) PE20081793A1 (es)
RU (1) RU2009136314A (es)
TW (1) TW200844105A (es)
UY (1) UY30913A1 (es)
WO (1) WO2008107064A1 (es)
ZA (1) ZA200905193B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679696A (en) * 1992-07-28 1997-10-21 Rhone-Poulenc Rorer Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group
DE19533975A1 (de) * 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl-diazinone
DE19540475A1 (de) * 1995-10-20 1997-04-24 Schering Ag Chirale Methylphenyloxazolidinone
EP0901482B1 (en) * 1996-05-20 2003-05-02 Darwin Discovery Limited Benzofuran carboxamides and their therapeutic use
RU2170730C2 (ru) * 1996-05-20 2001-07-20 Дарвин Дискавери Лимитед Хинолиновые карбоксамиды и фармацевтическая композиция на их основе
CA2299399C (en) * 1997-11-25 2004-04-06 Warner-Lambert Company Benzenesulfonamide inhibitors of pde-iv and their therapeutic use
AU764005B2 (en) * 1999-02-25 2003-08-07 Merck Frosst Canada & Co. PDE IV inhibiting compounds, compositions and methods of treatment
US6699890B2 (en) * 2000-12-22 2004-03-02 Memory Pharmaceuticals Corp. Phosphodiesterase 4 inhibitors
EP1435944B1 (en) * 2001-10-16 2009-09-30 Memory Pharmaceutical Corporation 4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes
MY130622A (en) * 2001-11-05 2007-07-31 Novartis Ag Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors
ES2195785B1 (es) * 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
JP2006508987A (ja) * 2002-11-19 2006-03-16 メモリー・ファーマシューティカルズ・コーポレイション ホスホジエステラーゼ4阻害剤
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
JP2006523719A (ja) * 2003-04-18 2006-10-19 メモリー・ファーマシューティカルズ・コーポレイション ホスホジエステラーゼ4抑制剤としてのピラゾール誘導体
ES2232306B1 (es) * 2003-11-10 2006-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251866B1 (es) * 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
EP2222639A1 (en) * 2007-11-21 2010-09-01 Decode Genetics EHF Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders

Also Published As

Publication number Publication date
CL2008000598A1 (es) 2008-09-05
TW200844105A (en) 2008-11-16
EP2125830A1 (en) 2009-12-02
BRPI0807273A2 (pt) 2014-04-29
WO2008107064A1 (en) 2008-09-12
CN101679453A (zh) 2010-03-24
AR065511A1 (es) 2009-06-10
UY30913A1 (es) 2008-07-31
ZA200905193B (en) 2010-05-26
CA2679619A1 (en) 2008-09-12
KR20090116753A (ko) 2009-11-11
RU2009136314A (ru) 2011-04-10
EP2125830B1 (en) 2011-01-26
ATE496923T1 (de) 2011-02-15
AU2008224206A1 (en) 2008-09-12
NZ578671A (en) 2011-04-29
ES2320954B1 (es) 2010-03-16
MX2009009232A (es) 2009-10-12
US20100137591A1 (en) 2010-06-03
ECSP099558A (es) 2009-09-29
JP2010520158A (ja) 2010-06-10
IL200166A0 (en) 2010-04-15
ES2320954A1 (es) 2009-05-29
DE602008004742D1 (de) 2011-03-10

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FD Application declared void or lapsed