PE20081793A1 - Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona - Google Patents
Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-onaInfo
- Publication number
- PE20081793A1 PE20081793A1 PE2008000403A PE2008000403A PE20081793A1 PE 20081793 A1 PE20081793 A1 PE 20081793A1 PE 2008000403 A PE2008000403 A PE 2008000403A PE 2008000403 A PE2008000403 A PE 2008000403A PE 20081793 A1 PE20081793 A1 PE 20081793A1
- Authority
- PE
- Peru
- Prior art keywords
- pyridazin
- preparation
- phenylisoxazole
- methyl
- hydrazine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- YUQZAUWIHXYWKC-UHFFFAOYSA-N 3-methyl-4-phenyl-6h-[1,2]oxazolo[3,4-d]pyridazin-7-one Chemical compound CC=1ON=C(C(NN=2)=O)C=1C=2C1=CC=CC=C1 YUQZAUWIHXYWKC-UHFFFAOYSA-N 0.000 title abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 6
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical class OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DEL COMPUESTO 3-METIL-4-FENILISOXAZOLO[3,4-d]PIRIDAZIN-7(6H)-ONA, QUE COMPRENDE: A) HACER REACCIONAR 1-FENILBUTAN-1,3-DIONA CON 2-CLORO-2-(HIDROXIIMINO)ACETATO DE ETILO, CARACTERIZADO POR QUE SE REALIZA MEDIANTE LA ADICION DE METOXIDO SODICO SEGUIDO DE LA ADICION DE 2-CLORO-2-(HIDROXIIMINO)ACETATO DE ETILO Y LA REACCION MOLAR ENTRE EL PRIMERO Y ULTIMO ESTA COMPRENDIDA ENTRE 1,05 Y 1,15; B) HACER REACCIONAR HIDRAZINA O UN HIDRATO DE LA MISMA SOBRE LA MEZCLA RESULTANTE DE LA ETAPA ANTERIOR, CARACTERIZADO POR QUE LA RELACION MOLAR ENTRE LA HIDRAZINA Y EL COMPUESTO INICIAL ESTA COMPRENDIDA ENTRE 1,15 Y 1,25. DICHO PROCEDIMIENTO PROVEE A UN INTERMEDIO EN LA PREPARACION DE ALGUNOS DERIVADOS DE PIRIDAZIN-3(2H)-ONA. DICHO PROCEDIMIENTO PERMITE OBTENER EL COMPUESTO CON MAYORES RENDIMIENTOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200700564A ES2320954B1 (es) | 2007-03-02 | 2007-03-02 | Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona. |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081793A1 true PE20081793A1 (es) | 2008-12-18 |
Family
ID=38617235
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000403A PE20081793A1 (es) | 2007-03-02 | 2008-02-28 | Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo[3,4-d]piridazin-7-(6h)-ona |
Country Status (23)
Country | Link |
---|---|
US (1) | US20100137591A1 (es) |
EP (1) | EP2125830B1 (es) |
JP (1) | JP2010520158A (es) |
KR (1) | KR20090116753A (es) |
CN (1) | CN101679453A (es) |
AR (1) | AR065511A1 (es) |
AT (1) | ATE496923T1 (es) |
AU (1) | AU2008224206A1 (es) |
BR (1) | BRPI0807273A2 (es) |
CA (1) | CA2679619A1 (es) |
CL (1) | CL2008000598A1 (es) |
DE (1) | DE602008004742D1 (es) |
EC (1) | ECSP099558A (es) |
ES (1) | ES2320954B1 (es) |
IL (1) | IL200166A0 (es) |
MX (1) | MX2009009232A (es) |
NZ (1) | NZ578671A (es) |
PE (1) | PE20081793A1 (es) |
RU (1) | RU2009136314A (es) |
TW (1) | TW200844105A (es) |
UY (1) | UY30913A1 (es) |
WO (1) | WO2008107064A1 (es) |
ZA (1) | ZA200905193B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
ES2251867B1 (es) * | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5679696A (en) * | 1992-07-28 | 1997-10-21 | Rhone-Poulenc Rorer Limited | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group |
DE19533975A1 (de) * | 1995-09-14 | 1997-03-20 | Merck Patent Gmbh | Arylalkyl-diazinone |
DE19540475A1 (de) * | 1995-10-20 | 1997-04-24 | Schering Ag | Chirale Methylphenyloxazolidinone |
EP0901482B1 (en) * | 1996-05-20 | 2003-05-02 | Darwin Discovery Limited | Benzofuran carboxamides and their therapeutic use |
RU2170730C2 (ru) * | 1996-05-20 | 2001-07-20 | Дарвин Дискавери Лимитед | Хинолиновые карбоксамиды и фармацевтическая композиция на их основе |
CA2299399C (en) * | 1997-11-25 | 2004-04-06 | Warner-Lambert Company | Benzenesulfonamide inhibitors of pde-iv and their therapeutic use |
AU764005B2 (en) * | 1999-02-25 | 2003-08-07 | Merck Frosst Canada & Co. | PDE IV inhibiting compounds, compositions and methods of treatment |
US6699890B2 (en) * | 2000-12-22 | 2004-03-02 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
EP1435944B1 (en) * | 2001-10-16 | 2009-09-30 | Memory Pharmaceutical Corporation | 4(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes |
MY130622A (en) * | 2001-11-05 | 2007-07-31 | Novartis Ag | Naphthyridine derivatives, their preparation and their use as phosphodiesterase isoenzyme 4 (pde4) inhibitors |
ES2195785B1 (es) * | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
JP2006508987A (ja) * | 2002-11-19 | 2006-03-16 | メモリー・ファーマシューティカルズ・コーポレイション | ホスホジエステラーゼ4阻害剤 |
ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
JP2006523719A (ja) * | 2003-04-18 | 2006-10-19 | メモリー・ファーマシューティカルズ・コーポレイション | ホスホジエステラーゼ4抑制剤としてのピラゾール誘導体 |
ES2232306B1 (es) * | 2003-11-10 | 2006-08-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
ES2251866B1 (es) * | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
ES2251867B1 (es) * | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
EP2222639A1 (en) * | 2007-11-21 | 2010-09-01 | Decode Genetics EHF | Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders |
-
2007
- 2007-03-02 ES ES200700564A patent/ES2320954B1/es not_active Withdrawn - After Issue
-
2008
- 2008-02-12 UY UY30913A patent/UY30913A1/es unknown
- 2008-02-13 WO PCT/EP2008/001080 patent/WO2008107064A1/en active Application Filing
- 2008-02-13 CA CA002679619A patent/CA2679619A1/en not_active Abandoned
- 2008-02-13 RU RU2009136314/04A patent/RU2009136314A/ru not_active Application Discontinuation
- 2008-02-13 MX MX2009009232A patent/MX2009009232A/es unknown
- 2008-02-13 BR BRPI0807273-6A2A patent/BRPI0807273A2/pt not_active IP Right Cessation
- 2008-02-13 US US12/529,511 patent/US20100137591A1/en not_active Abandoned
- 2008-02-13 AU AU2008224206A patent/AU2008224206A1/en not_active Abandoned
- 2008-02-13 CN CN200880005978A patent/CN101679453A/zh active Pending
- 2008-02-13 DE DE602008004742T patent/DE602008004742D1/de active Active
- 2008-02-13 EP EP08707692A patent/EP2125830B1/en active Active
- 2008-02-13 AT AT08707692T patent/ATE496923T1/de not_active IP Right Cessation
- 2008-02-13 KR KR1020097017603A patent/KR20090116753A/ko not_active Application Discontinuation
- 2008-02-13 JP JP2009551112A patent/JP2010520158A/ja active Pending
- 2008-02-13 NZ NZ578671A patent/NZ578671A/en unknown
- 2008-02-25 TW TW097106455A patent/TW200844105A/zh unknown
- 2008-02-27 CL CL200800598A patent/CL2008000598A1/es unknown
- 2008-02-28 AR ARP080100823A patent/AR065511A1/es not_active Application Discontinuation
- 2008-02-28 PE PE2008000403A patent/PE20081793A1/es not_active Application Discontinuation
-
2009
- 2009-07-24 ZA ZA200905193A patent/ZA200905193B/xx unknown
- 2009-07-30 IL IL200166A patent/IL200166A0/en unknown
- 2009-08-04 EC EC2009009558A patent/ECSP099558A/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2008000598A1 (es) | 2008-09-05 |
TW200844105A (en) | 2008-11-16 |
EP2125830A1 (en) | 2009-12-02 |
BRPI0807273A2 (pt) | 2014-04-29 |
WO2008107064A1 (en) | 2008-09-12 |
CN101679453A (zh) | 2010-03-24 |
AR065511A1 (es) | 2009-06-10 |
UY30913A1 (es) | 2008-07-31 |
ZA200905193B (en) | 2010-05-26 |
CA2679619A1 (en) | 2008-09-12 |
KR20090116753A (ko) | 2009-11-11 |
RU2009136314A (ru) | 2011-04-10 |
EP2125830B1 (en) | 2011-01-26 |
ATE496923T1 (de) | 2011-02-15 |
AU2008224206A1 (en) | 2008-09-12 |
NZ578671A (en) | 2011-04-29 |
ES2320954B1 (es) | 2010-03-16 |
MX2009009232A (es) | 2009-10-12 |
US20100137591A1 (en) | 2010-06-03 |
ECSP099558A (es) | 2009-09-29 |
JP2010520158A (ja) | 2010-06-10 |
IL200166A0 (en) | 2010-04-15 |
ES2320954A1 (es) | 2009-05-29 |
DE602008004742D1 (de) | 2011-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |