PE20081167A1 - Sal de alisquireno - Google Patents
Sal de alisquirenoInfo
- Publication number
- PE20081167A1 PE20081167A1 PE2007001529A PE2007001529A PE20081167A1 PE 20081167 A1 PE20081167 A1 PE 20081167A1 PE 2007001529 A PE2007001529 A PE 2007001529A PE 2007001529 A PE2007001529 A PE 2007001529A PE 20081167 A1 PE20081167 A1 PE 20081167A1
- Authority
- PE
- Peru
- Prior art keywords
- salt
- alisquirene
- refers
- orotic acid
- aldosterone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UNA SAL DE ALISQUIRENO DE FORMULA (I) CON ACIDO OROTICO (VITAMINA B13) QUE PRESENTA UN PATRON DE DIFRACCION EN POLVO DE RAYOS X CON LOS SIGUIENTES PICOS EXPRESADOS EN GRADOS 2 TETA: 4.4(st), 8.7(m), 10.5(w), 14.4(m), 17.7(st), 19.3(m), 19.9(w), 20.8(w), 22.2(st), 23.0(m), 25.2(w), 26.8(m). DONDE LAS FORMAS DE DICHA SAL PUEDEN SER CRISTALINA, PARCIALMENTE CRISTALINA, AMORFA Y POLIMORFA. SE REFIERE TAMBIEN A COMPOSICIONES FARMACEUTICAS QUE ADEMAS CONTIENEN UN ANTAGONISTA DE ALDOSTERONA, UN INHIBIDOR DE LA SINTASA DE ALDOSTERONA, UN DIURETICO, ENTRE OTROS; Y A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE A) DISOLVER LA BASE LIBRE DE ALISQUIRENO Y EL ACIDO OROTICO EN UN SOLVENTE ORGANICO; B) CONCENTRAR EL SOLVENTE DE LA SOLUCION MIXTA MEDIANTE CALENTAMIENTO HASTA LA PRECIPITACION; Y C) FILTRAR Y SECAR LA PASTA PARA OBTENER LA SAL. DICHA SAL ES UN INHIBIDOR DE RENINA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06123758 | 2006-11-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081167A1 true PE20081167A1 (es) | 2008-10-03 |
Family
ID=38002048
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001529A PE20081167A1 (es) | 2006-11-09 | 2007-11-07 | Sal de alisquireno |
Country Status (16)
Country | Link |
---|---|
US (1) | US20100130616A1 (es) |
EP (1) | EP2089356B1 (es) |
JP (1) | JP2010509254A (es) |
KR (1) | KR20090081010A (es) |
CN (1) | CN101528672A (es) |
AR (1) | AR063597A1 (es) |
AT (1) | ATE555082T1 (es) |
AU (1) | AU2007316878B2 (es) |
BR (1) | BRPI0718701A2 (es) |
CA (1) | CA2665073A1 (es) |
CL (1) | CL2007003216A1 (es) |
MX (1) | MX2009004628A (es) |
PE (1) | PE20081167A1 (es) |
RU (1) | RU2456267C2 (es) |
TW (1) | TW200838836A (es) |
WO (1) | WO2008055669A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2205232A2 (en) * | 2007-09-28 | 2010-07-14 | Novartis Ag | Galenical formulations of aliskiren |
CA2724746A1 (en) * | 2008-05-23 | 2009-11-26 | Teva Pharmaceuticals Industries Ltd. | Aliskiren monofumarate and processes for preparation thereof |
WO2010091277A2 (en) | 2009-02-05 | 2010-08-12 | Teva Pharmaceutical Industries Ltd. | Solid state forms of aliskiren compounds |
WO2010089105A2 (en) | 2009-02-05 | 2010-08-12 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Moisture-activated granulation process |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
JP4900755B2 (ja) * | 2000-07-05 | 2012-03-21 | ノバルティス ファーマ アーゲー | 置換オクタノイルアミドの調製方法 |
NZ536555A (en) * | 2002-05-17 | 2007-03-30 | Novartis Ag | Pharmaceutical composition comprising a renin inhibitor, a calcium channel blocker and a diuretic |
CA2534664C (en) * | 2003-09-04 | 2012-10-30 | Cephalon, Inc. | Modafinil compositions |
AR048431A1 (es) * | 2004-03-17 | 2006-04-26 | Novartis Ag | Formulaciones galenicas de compuestos organicos |
-
2007
- 2007-11-07 US US12/312,384 patent/US20100130616A1/en not_active Abandoned
- 2007-11-07 RU RU2009121646/04A patent/RU2456267C2/ru not_active IP Right Cessation
- 2007-11-07 AR ARP070104954A patent/AR063597A1/es unknown
- 2007-11-07 WO PCT/EP2007/009644 patent/WO2008055669A1/en active Application Filing
- 2007-11-07 PE PE2007001529A patent/PE20081167A1/es not_active Application Discontinuation
- 2007-11-07 JP JP2009535624A patent/JP2010509254A/ja not_active Ceased
- 2007-11-07 BR BRPI0718701-7A patent/BRPI0718701A2/pt not_active IP Right Cessation
- 2007-11-07 CN CNA2007800398021A patent/CN101528672A/zh active Pending
- 2007-11-07 AT AT07819654T patent/ATE555082T1/de active
- 2007-11-07 KR KR1020097011750A patent/KR20090081010A/ko not_active Application Discontinuation
- 2007-11-07 MX MX2009004628A patent/MX2009004628A/es active IP Right Grant
- 2007-11-07 EP EP07819654A patent/EP2089356B1/en not_active Not-in-force
- 2007-11-07 CA CA002665073A patent/CA2665073A1/en not_active Abandoned
- 2007-11-07 AU AU2007316878A patent/AU2007316878B2/en not_active Ceased
- 2007-11-08 TW TW096142251A patent/TW200838836A/zh unknown
- 2007-11-08 CL CL200703216A patent/CL2007003216A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2007316878B2 (en) | 2011-07-14 |
TW200838836A (en) | 2008-10-01 |
US20100130616A1 (en) | 2010-05-27 |
RU2456267C2 (ru) | 2012-07-20 |
AU2007316878A1 (en) | 2008-05-15 |
ATE555082T1 (de) | 2012-05-15 |
WO2008055669A1 (en) | 2008-05-15 |
AR063597A1 (es) | 2009-02-04 |
CL2007003216A1 (es) | 2008-06-13 |
JP2010509254A (ja) | 2010-03-25 |
RU2009121646A (ru) | 2010-12-20 |
MX2009004628A (es) | 2009-05-15 |
EP2089356B1 (en) | 2012-04-25 |
CA2665073A1 (en) | 2008-05-15 |
KR20090081010A (ko) | 2009-07-27 |
EP2089356A1 (en) | 2009-08-19 |
CN101528672A (zh) | 2009-09-09 |
BRPI0718701A2 (pt) | 2013-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR077242A1 (es) | Formas cristalinas del 2-{4-[n-(5,6-difenilpirazin-2-il)-n-isopropilamino]butiloxi}n-(metilsulfonil)acetamida, composiciones farmaceuticas que las contienen, metodo para prepararlas y uso de las mismas en el tratamiento de isquemias, insuficiencia coronaria y asma, entre otras enfermedades. | |
CO6410293A2 (es) | Nueva formula cristalina vi de la agomelatina preparación y uso de la misma | |
CL2012000059A1 (es) | Compuestos derivados de pirazolo[1,5-a]pirimidina; proceso de preparacion; composicion farmaceutica que los comprende; y su uso como inhbidores de trk-quinasa para el tratamiento de enfermedades o trastornos tales como dolor, cancer, inflamacion; entre otras. | |
ECSP066541A (es) | Nuevos derivados de piridazin-3(2h)-ona | |
NI201200184A (es) | Morfolinopirimidinas y su uso en terapia | |
CL2011002115A1 (es) | Compuestos derivados de 5-fenil-1h-piridin-2-ona y 5-fenil-pirazin-2-ona, inhibidores de la tirosina-quinasa de bruton (btk); proceso de preparación de los compuestos, compuesto intermediario, composición farmacéutica y uso en el tratamiento de enfermedades inflamatorias y/o autoinmunes. | |
PE20120083A1 (es) | Sal monotosilato del compuesto 2-metil-2-[4-(3-metil-2-oxo-8-quinolin-3-il-2, 3-dihidro-imidazo-[4,5-c]-quinolin-1-il)-fenil]-propionitrilo en su forma cristalina a | |
NI201000209A (es) | Derivados de isoxazol y su uso como potenciadores de los receptores metabotrópicos de glutamato | |
RU2013109393A (ru) | Безилатная соль ингибитора втк | |
DOP2010000387A (es) | Compuestos pirazolicos 436 | |
BRPI0511933B8 (pt) | derivados de quinazolinona, seu uso e seu processo de preparação, e composição farmacêutica | |
UY30444A1 (es) | Derivados de pirimidina, procesos para su preparacinn, composiciones farmaccuticos y usos de los mismos. | |
UY31069A1 (es) | Nuevos derivados de imidazoquinola, composiciones conteniendolos, proceso de preparacion y aplicaciones | |
RU2008139905A (ru) | Фармацевтическая композиция для наружного применения | |
UY30472A1 (es) | Nuevos derivados de pirimidina, procesos para su preparacion composiciones farmacéuticas conteniédolos, procesos para su preparacion y aplicaciones. | |
ECSP109922A (es) | Compuestos de pirazol y su uso como inhibidores raf | |
PE20081167A1 (es) | Sal de alisquireno | |
DE602006021539D1 (en) | Morpholine als 5ht2c-agonisten | |
DOP2009000200A (es) | Derivados de 2-amino-5,7-dihidro-6h-pirrolo[3,4-d] pimiridina como inhibidores hsp-90 para tratar el cancer | |
CO6541539A2 (es) | Procesos para preparar las formas cristalinas a y b de ilaprazol y proceso para convertir las formas cristalinas | |
MX2009000281A (es) | Derivados tetrahidroisoquinolina, metodos de preparacion y usos medicinales de los mismos. | |
BRPI0606923A2 (pt) | substáncia para uso como um medicamento, uso de uma substáncia, método de manufatura de uma substáncia para uso como um medicamento, formulação farmacêutica, e, método de manufatura de uma formulação farmacêutica | |
BR112017007953A2 (pt) | forma cristalina de um bissulfato inibidor de jak quinase e método de preparação desse | |
UY30356A1 (es) | Derivados de 3-halo-n-(2.(4-fluorofenil)-4-oxobutil)-n-metil-5-(trifluorometil)benzamida y composiciones de los mismos. | |
UY28911A1 (es) | Profármacos de esteroides con acción androgénica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |