PE20081137A1 - Nuevas heteroaril-carboxamidas - Google Patents

Nuevas heteroaril-carboxamidas

Info

Publication number
PE20081137A1
PE20081137A1 PE2007001435A PE2007001435A PE20081137A1 PE 20081137 A1 PE20081137 A1 PE 20081137A1 PE 2007001435 A PE2007001435 A PE 2007001435A PE 2007001435 A PE2007001435 A PE 2007001435A PE 20081137 A1 PE20081137 A1 PE 20081137A1
Authority
PE
Peru
Prior art keywords
alkyl
heteroaryl
cyane
oxadiazol
thiophene
Prior art date
Application number
PE2007001435A
Other languages
English (en)
Inventor
Katrin Groebke Zbinden
Wolfgang Haap
Hans Hilpert
Bernd Kuhn
Narendra Panday
Fabienne Ricklin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38962608&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081137(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20081137A1 publication Critical patent/PE20081137A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A ES UN ANILLO HETEROARILO CON UN ATOMO DE OXIGENO Y UNO O DOS ATOMOS DE NITROGENO; R1 Y R2 SON CADA UNO H, ALQUILO C1-C6; X ES ARILENO, HETEROCICLILENO, HETEROARILENO, OPCIONALMENTE SUSTITUIDOS POR C1-C6 ALQUILO, HALOGENO, CIANO, AMINO, ENTRE OTROS; Y ES H, ARILO, HETEROARILO, HETEROCICLILO, OPCIONALMENTE SUSTITUIDOS POR F, ALCOXI C1-C6, CIANO, NITRO, ENTRE OTROS; Z ES ARILO O HETEROARILO SUSTITUIDOS POR ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; m ES 1-2. SON COMPUESTOS PREFERIDOS: [2-FLUOR-4-(2-OXO-2H-PIRIDIN-1-IL)-FENIL]-AMIDA DEL ACIDO 3-{[(5-CLORO-TIOFENO-2-CARBONIL)-AMINO]-METIL}-[1,2,4]OXADIAZOL-5-CARBOXILICO; [4-(3-OXO-MORFOLIN-4-IL)-FENIL]-AMIDA DEL ACIDO 3-{[(5-CLORO-TIOFENO-2-CARBONIL)-AMINO]-METIL}-[1,2,4]OXADIAZOL-5-CARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS INHIBEN EL FACTOR DE COAGULACION Xa SIENDO UTILES EN TRATAMIENTO DE TRASTORNOS TROMBOTICOS, ANGINA DE PECHO, INFARTO AL MIOCARDIO, ENTRE OTROS
PE2007001435A 2006-10-25 2007-10-23 Nuevas heteroaril-carboxamidas PE20081137A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06122944 2006-10-25

Publications (1)

Publication Number Publication Date
PE20081137A1 true PE20081137A1 (es) 2008-08-15

Family

ID=38962608

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001435A PE20081137A1 (es) 2006-10-25 2007-10-23 Nuevas heteroaril-carboxamidas

Country Status (15)

Country Link
US (1) US7718679B2 (es)
EP (1) EP2076511A1 (es)
JP (1) JP5095745B2 (es)
KR (1) KR101124879B1 (es)
CN (1) CN101528737B (es)
AR (1) AR063516A1 (es)
AU (1) AU2007308197A1 (es)
BR (1) BRPI0718064A2 (es)
CA (1) CA2666922A1 (es)
CL (1) CL2007003039A1 (es)
IL (1) IL198025A0 (es)
MX (1) MX2009003975A (es)
PE (1) PE20081137A1 (es)
TW (1) TW200845971A (es)
WO (1) WO2008049747A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1491535A4 (en) * 2002-03-07 2009-09-23 Sds Biotech Corp SUBSTITUTED ISOXAZOLALKYLAMINE DERIVATIVE AND FUNGICIDE FOR AGRICULTURE AND GARDENING
CA2565437A1 (en) * 2004-06-18 2006-01-05 Millennium Pharmaceuticals, Inc. Factor xa inhibitors
DE102004045796A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
DE102004047255A1 (de) * 2004-09-29 2006-04-13 Merck Patent Gmbh Prolinderivate

Also Published As

Publication number Publication date
MX2009003975A (es) 2009-04-27
KR20090057324A (ko) 2009-06-04
TW200845971A (en) 2008-12-01
IL198025A0 (en) 2009-12-24
KR101124879B1 (ko) 2012-04-12
EP2076511A1 (en) 2009-07-08
CN101528737A (zh) 2009-09-09
AR063516A1 (es) 2009-01-28
CA2666922A1 (en) 2008-05-02
JP5095745B2 (ja) 2012-12-12
CN101528737B (zh) 2012-07-04
US20080103143A1 (en) 2008-05-01
JP2010507613A (ja) 2010-03-11
AU2007308197A1 (en) 2008-05-02
BRPI0718064A2 (pt) 2013-11-05
WO2008049747A1 (en) 2008-05-02
CL2007003039A1 (es) 2008-05-30
US7718679B2 (en) 2010-05-18

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