PE20080892A1 - N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida - Google Patents
N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamidaInfo
- Publication number
- PE20080892A1 PE20080892A1 PE2007001423A PE2007001423A PE20080892A1 PE 20080892 A1 PE20080892 A1 PE 20080892A1 PE 2007001423 A PE2007001423 A PE 2007001423A PE 2007001423 A PE2007001423 A PE 2007001423A PE 20080892 A1 PE20080892 A1 PE 20080892A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- iliden
- quinolin
- benzamide
- piperidin
- Prior art date
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title abstract 10
- -1 2-HYDROXYETHYL Chemical class 0.000 title abstract 5
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- WRFKSVINLIQRKF-UHFFFAOYSA-N 1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC=N1 WRFKSVINLIQRKF-UHFFFAOYSA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 abstract 1
- 239000001095 magnesium carbonate Substances 0.000 abstract 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 abstract 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000454 talc Substances 0.000 abstract 1
- 229910052623 talc Inorganic materials 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 239000001993 wax Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86232706P | 2006-10-20 | 2006-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080892A1 true PE20080892A1 (es) | 2008-09-11 |
Family
ID=39314285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001423A PE20080892A1 (es) | 2006-10-20 | 2007-10-19 | N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida |
| PE2012001060A PE20140634A1 (es) | 2006-10-20 | 2012-07-24 | N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012001060A PE20140634A1 (es) | 2006-10-20 | 2012-07-24 | N-(2-hidroxietil)-n-metil-4-(quinolin-8-il(1-(tiazol-4-ilmetil)piperidin-4-iliden)metil)benzamida |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US7659286B2 (OSRAM) |
| EP (1) | EP2079735B1 (OSRAM) |
| JP (1) | JP4668346B2 (OSRAM) |
| KR (1) | KR20090065534A (OSRAM) |
| CN (1) | CN101528739B (OSRAM) |
| AR (1) | AR063345A1 (OSRAM) |
| AT (1) | ATE543818T1 (OSRAM) |
| AU (2) | AU2007313515B2 (OSRAM) |
| BR (1) | BRPI0717631A2 (OSRAM) |
| CA (1) | CA2667041C (OSRAM) |
| CL (1) | CL2007003009A1 (OSRAM) |
| CO (1) | CO6180450A2 (OSRAM) |
| CY (1) | CY1112718T1 (OSRAM) |
| DK (1) | DK2079735T3 (OSRAM) |
| ES (1) | ES2379519T3 (OSRAM) |
| HR (1) | HRP20120344T1 (OSRAM) |
| IL (1) | IL197876A0 (OSRAM) |
| MX (1) | MX2009003974A (OSRAM) |
| MY (1) | MY148880A (OSRAM) |
| NO (1) | NO20091969L (OSRAM) |
| NZ (1) | NZ577060A (OSRAM) |
| PE (2) | PE20080892A1 (OSRAM) |
| PL (1) | PL2079735T3 (OSRAM) |
| PT (1) | PT2079735E (OSRAM) |
| RS (1) | RS52260B (OSRAM) |
| RU (1) | RU2454414C2 (OSRAM) |
| SA (1) | SA07280549B1 (OSRAM) |
| SI (1) | SI2079735T1 (OSRAM) |
| TW (1) | TW200826939A (OSRAM) |
| UA (1) | UA97648C2 (OSRAM) |
| UY (1) | UY30652A1 (OSRAM) |
| WO (1) | WO2008048171A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060010811A (ko) * | 2003-05-16 | 2006-02-02 | 아스트라제네카 아베 | 디아릴메틸리덴 피페리딘 유도체, 그의 제조 및 그의 용도 |
| MY148880A (en) * | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
| JP2011520956A (ja) * | 2008-05-20 | 2011-07-21 | アストラゼネカ・アクチエボラーグ | 不安大うつ病性障害を処置する方法 |
| CN101906078B (zh) * | 2009-06-08 | 2012-02-01 | 上海威智医药科技有限公司 | 噻唑衍生物的合成方法 |
| CN102106807B (zh) * | 2009-12-29 | 2013-03-27 | 上海中西制药有限公司 | 一种固体制剂的制备方法及所得固体制剂 |
| DK3233825T3 (da) * | 2014-12-19 | 2020-06-29 | Pharmnovo Ab | Diarylmethylidenpiperidinderivater og deres anvendelse som deltaopioidreceptoragonister |
| US11286728B2 (en) | 2018-09-21 | 2022-03-29 | Postle Industries, Inc. | Helical hardbanding |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898339A (en) | 1957-07-29 | 1959-08-04 | Wm S Merrell Co | N-substituted benzhydrol, benzhydryl, and benzhydrylidene piperidine |
| US4581171A (en) | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| TW548271B (en) | 1996-12-20 | 2003-08-21 | Astra Pharma Inc | Novel piperidine derivatives having an exocyclic double bond with analgesic effects |
| DK1049676T3 (da) * | 1997-12-24 | 2006-01-16 | Ortho Mcneil Pharm Inc | 4-[Aryl(piperidin-4-yl)]aminobenzamider, som binder til delta-opioidreceptoren |
| US6492375B2 (en) | 1998-06-30 | 2002-12-10 | Neuromed Technologies, Inc. | Partially saturated calcium channel blockers |
| SE9904673D0 (sv) | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| EP1242398A2 (en) | 1999-12-20 | 2002-09-25 | Neuromed Technologies, Inc. | Partially saturated calcium channel blockers |
| US6552036B2 (en) | 2000-03-03 | 2003-04-22 | Ortho-Mcneil Pharmaceutical, Inc. | 3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives |
| SE0001208D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| SE0101768D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| US20040204404A1 (en) | 2002-09-30 | 2004-10-14 | Robert Zelle | Human N-type calcium channel blockers |
| SE0300105D0 (sv) * | 2003-01-16 | 2003-01-16 | Astrazeneca Ab | Diarylmethylidene piperdine derivatives, preparations thereof and uses thereof |
| SE0301442D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations therof and uses thereof |
| KR20060010811A (ko) | 2003-05-16 | 2006-02-02 | 아스트라제네카 아베 | 디아릴메틸리덴 피페리딘 유도체, 그의 제조 및 그의 용도 |
| SE0301444D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301445D0 (sv) * | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0301441D0 (sv) | 2003-05-16 | 2003-05-16 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| SE0400025D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof |
| WO2005087742A1 (en) | 2004-03-08 | 2005-09-22 | Exelixis, Inc. | Metabolic kinase modulators and methods of use as pesticides |
| MY148880A (en) | 2006-10-20 | 2013-06-14 | Astrazeneca Ab | N-(2-hydroxyethyl)-n-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide, the process of making it as well as its use for the treatment of pain, anxiety and depression |
-
2007
- 2007-10-09 MY MYPI20091593A patent/MY148880A/en unknown
- 2007-10-18 TW TW096139052A patent/TW200826939A/zh unknown
- 2007-10-19 WO PCT/SE2007/000924 patent/WO2008048171A1/en not_active Ceased
- 2007-10-19 PT PT07835125T patent/PT2079735E/pt unknown
- 2007-10-19 UY UY30652A patent/UY30652A1/es not_active Application Discontinuation
- 2007-10-19 NZ NZ577060A patent/NZ577060A/en not_active IP Right Cessation
- 2007-10-19 RS RS20120166A patent/RS52260B/sr unknown
- 2007-10-19 CA CA2667041A patent/CA2667041C/en not_active Expired - Fee Related
- 2007-10-19 AR ARP070104641A patent/AR063345A1/es not_active Application Discontinuation
- 2007-10-19 ES ES07835125T patent/ES2379519T3/es active Active
- 2007-10-19 CN CN2007800390975A patent/CN101528739B/zh not_active Expired - Fee Related
- 2007-10-19 AU AU2007313515A patent/AU2007313515B2/en not_active Ceased
- 2007-10-19 PL PL07835125T patent/PL2079735T3/pl unknown
- 2007-10-19 KR KR1020097007893A patent/KR20090065534A/ko not_active Ceased
- 2007-10-19 DK DK07835125.1T patent/DK2079735T3/da active
- 2007-10-19 BR BRPI0717631-7A patent/BRPI0717631A2/pt not_active IP Right Cessation
- 2007-10-19 HR HRP20120344TT patent/HRP20120344T1/hr unknown
- 2007-10-19 US US11/875,014 patent/US7659286B2/en not_active Expired - Fee Related
- 2007-10-19 JP JP2009533278A patent/JP4668346B2/ja not_active Expired - Fee Related
- 2007-10-19 UA UAA200903085A patent/UA97648C2/ru unknown
- 2007-10-19 MX MX2009003974A patent/MX2009003974A/es active IP Right Grant
- 2007-10-19 SI SI200730905T patent/SI2079735T1/sl unknown
- 2007-10-19 CL CL200703009A patent/CL2007003009A1/es unknown
- 2007-10-19 PE PE2007001423A patent/PE20080892A1/es not_active Application Discontinuation
- 2007-10-19 EP EP07835125A patent/EP2079735B1/en active Active
- 2007-10-19 AT AT07835125T patent/ATE543818T1/de active
- 2007-10-19 RU RU2009111337/04A patent/RU2454414C2/ru not_active IP Right Cessation
- 2007-10-20 SA SA7280549A patent/SA07280549B1/ar unknown
-
2009
- 2009-03-26 IL IL197876A patent/IL197876A0/en unknown
- 2009-03-31 CO CO0903310009033100A patent/CO6180450A2/es not_active Application Discontinuation
- 2009-05-20 NO NO20091969A patent/NO20091969L/no not_active Application Discontinuation
- 2009-12-21 US US12/643,202 patent/US7977355B2/en not_active Expired - Fee Related
-
2010
- 2010-10-06 AU AU2010226996A patent/AU2010226996A1/en not_active Abandoned
-
2012
- 2012-04-25 CY CY20121100389T patent/CY1112718T1/el unknown
- 2012-07-24 PE PE2012001060A patent/PE20140634A1/es not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |