PE20080660A1 - Aptameros marcados con 68ga - Google Patents

Aptameros marcados con 68ga

Info

Publication number
PE20080660A1
PE20080660A1 PE2007001205A PE2007001205A PE20080660A1 PE 20080660 A1 PE20080660 A1 PE 20080660A1 PE 2007001205 A PE2007001205 A PE 2007001205A PE 2007001205 A PE2007001205 A PE 2007001205A PE 20080660 A1 PE20080660 A1 PE 20080660A1
Authority
PE
Peru
Prior art keywords
marked
ligands
compounds
refers
type
Prior art date
Application number
PE2007001205A
Other languages
English (en)
Inventor
Ludger Dinkelborg
Matthias Friebe
Maren Hecht
Lutz Lehmann
Bernhard Noll
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PE20080660A1 publication Critical patent/PE20080660A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A COMPUESTOS DE FORMULA A-B-L-C DONDE A ES UN APTAMERO QUE SE UNE A TENASCINA-C Y QUE COMPRENDE DE 10 A 50 NUCLEOTIDOS; B ESTA AUSENTE O ES UNA ESTRUCTURA DE UNION TAL COMO UNA HEXIL AMINA; L ES UN CONECTOR TAL COMO MERCAPTO ACETIL DIGLICINA (MAG2); C ES UN QUELANTE IONICO METALICO TAL COMO LIGANDOS DEL TIPO 1,4,7-TRIS(2-MERCAPTOETIL)-1,4,7-TRIAZA-CICLONONANO, LIGANDOS DEL TIPO 1,4,7-TRIAZACICLONONANO, 1,4,7-TRIACETICO, LIGANDOS TRIPODALES, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS ESTAN MARCADOS CON UN ION DEL METAL LANTANIDO, GALIO, IODO, LUTECIO O INDIO SIENDO UTILES COMO AGENTES PARA DIAGNOSTICO POR IMAGENES
PE2007001205A 2006-09-08 2007-09-07 Aptameros marcados con 68ga PE20080660A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06090165A EP1897562A1 (en) 2006-09-08 2006-09-08 Aptamers labelled with Gallium-68

Publications (1)

Publication Number Publication Date
PE20080660A1 true PE20080660A1 (es) 2008-08-01

Family

ID=37564205

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001205A PE20080660A1 (es) 2006-09-08 2007-09-07 Aptameros marcados con 68ga

Country Status (10)

Country Link
US (1) US20090068103A1 (es)
EP (2) EP1897562A1 (es)
JP (1) JP2010502201A (es)
AR (1) AR062698A1 (es)
CA (1) CA2662693A1 (es)
CL (1) CL2007002575A1 (es)
PE (1) PE20080660A1 (es)
TW (1) TW200812626A (es)
UY (1) UY30574A1 (es)
WO (1) WO2008028534A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI497076B (zh) 2010-06-25 2015-08-21 Univ Nat Cheng Kung 適合體及ｃ－反應蛋白檢測方法
DE102010026062A1 (de) * 2010-06-30 2012-01-05 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Aptamer-Komplex zur Detektion eines krankhaften Gewebes
KR20220139425A (ko) 2012-07-13 2022-10-14 웨이브 라이프 사이언시스 리미티드 키랄 제어
KR102084472B1 (ko) * 2013-10-21 2020-03-04 연세대학교 산학협력단 다양한 압타머에 적용 가능한 방사성동위원소 표지된 핵산 구조체 개발 및 표지방법
CN111856035B (zh) * 2020-07-30 2022-04-22 谱度众合(武汉)生命科技有限公司 一种tnc蛋白检测试剂的应用及试剂盒

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232071B1 (en) * 1990-06-11 2001-05-15 Gilead Sciences, Inc. Tenascin-C nucleic acid ligands

Also Published As

Publication number Publication date
JP2010502201A (ja) 2010-01-28
EP1897562A1 (en) 2008-03-12
UY30574A1 (es) 2008-05-02
TW200812626A (en) 2008-03-16
EP2063917A1 (en) 2009-06-03
WO2008028534A1 (en) 2008-03-13
AR062698A1 (es) 2008-11-26
US20090068103A1 (en) 2009-03-12
CL2007002575A1 (es) 2008-05-23
CA2662693A1 (en) 2008-03-13

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Legal Events

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