PE20080407A1 - Derivados de quinuclidina como antagonistas de m3 - Google Patents

Derivados de quinuclidina como antagonistas de m3

Info

Publication number
PE20080407A1
PE20080407A1 PE2007000959A PE2007000959A PE20080407A1 PE 20080407 A1 PE20080407 A1 PE 20080407A1 PE 2007000959 A PE2007000959 A PE 2007000959A PE 2007000959 A PE2007000959 A PE 2007000959A PE 20080407 A1 PE20080407 A1 PE 20080407A1
Authority
PE
Peru
Prior art keywords
antagonists
azoniabiciclo
trifluorbenzyl
fluorphenyl
carbamoyloxy
Prior art date
Application number
PE2007000959A
Other languages
English (en)
Inventor
Gabriele Amari
Andrea Rizzi
Ricardo Patacchini
Valentina Cenacchi
Gino Villetti
Ruiz Juan Lorenzo Catena
Masip Isabel Masip
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of PE20080407A1 publication Critical patent/PE20080407A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA Ic DONDE R1 ES F, Cl, Br, ENTRE OTROS; R2 ES 3,4,5-TRIFLUORFENILO; 3,4-DIFLUORFENILO, ENTRE OTROS; X ES UN ANION. SON COMPUESTOS PREFERIDOS: (3R)-3-[(3-FLUOROFENIL)-(3,4,5-TRIFLUORBENCIL)-CARBAMOILOXI]-1-(2-OXO-2-FENILETIL)-1-AZONIABICICLO[2.2.2]OCTANO, BROMURO; (3R)-3-[(3-FLUORFENIL) -(3,4,5-TRIFLUORBENCIL)-CARBAMOILOXI]-1-(2-OXO-2-(4-FLUORFENIL)ETIL)-1-AZONIABICICLO[2.2.2]OCTANO-BROMURO; ENTRE OTROS. SE REFIERE TAMBIEN UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS DESCRITOS SON MODULADORES DEL RECEPTOR MUSCARINICO M3, UTILES EN EL TRATAMIETO Y PREVENCION DE ENFERMEDADES RESPIRATORIAS TALES COMO ASMA, BRONQUITIS CRONICA, ENFISEMA Y DEMAS RELACIONADAS
PE2007000959A 2006-07-26 2007-07-24 Derivados de quinuclidina como antagonistas de m3 PE20080407A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06117883A EP1882691A1 (en) 2006-07-26 2006-07-26 Quinuclidine derivatives as M3 antagonists

Publications (1)

Publication Number Publication Date
PE20080407A1 true PE20080407A1 (es) 2008-06-17

Family

ID=37890216

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000959A PE20080407A1 (es) 2006-07-26 2007-07-24 Derivados de quinuclidina como antagonistas de m3

Country Status (16)

Country Link
US (1) US7838534B2 (es)
EP (2) EP1882691A1 (es)
JP (1) JP5331688B2 (es)
KR (1) KR20090033443A (es)
CN (1) CN101490049A (es)
AR (1) AR062104A1 (es)
AU (1) AU2007278231B2 (es)
BR (1) BRPI0713826A2 (es)
CA (1) CA2658649A1 (es)
CL (1) CL2007002159A1 (es)
EA (1) EA017698B1 (es)
MX (1) MX2009000999A (es)
PE (1) PE20080407A1 (es)
TW (1) TW200817398A (es)
WO (1) WO2008012290A2 (es)
ZA (1) ZA200901124B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1345937T3 (da) 2000-12-22 2006-01-16 Almirall Prodesfarma Ag Quinuclidincarbamatderivater og deres anvendelse som M3-antagonister
ES2246170B1 (es) * 2004-07-29 2007-04-01 Almirall Prodesfarma, S.A. Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
EP2080507A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Pharmaceutical formulations comprising an anticholinergic drug
EP2080508A1 (en) 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Dry powder formulation comprising an anticholinergic drug
EP2080523A1 (en) 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Compositions comprising an antimuscarinic and a long-acting beta-agonist
EP2154136A1 (en) 2008-08-08 2010-02-17 CHIESI FARMACEUTICI S.p.A. Quinuclidine carbonate derivatives and medicinal compositions thereof
EP2206712A1 (en) * 2008-12-23 2010-07-14 CHIESI FARMACEUTICI S.p.A. "Alkaloid aminoester derivatives and medicinal composition thereof"
SG186427A1 (en) * 2010-06-22 2013-01-30 Chiesi Farma Spa Dry powder formulation comprising an antimuscarinic drug
EP2585458B1 (en) 2010-06-22 2015-01-07 Chiesi Farmaceutici S.p.A. Alkaloid aminoester derivatives and medicinal compositions thereof
KR20130087405A (ko) 2010-06-22 2013-08-06 키에시 파르마슈티시 엣스. 피. 에이. 알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
BR112012032333A2 (pt) 2010-06-22 2016-11-08 Chiesi Farma Spa composto, uso de um composto, composição farmacêutica, combinação de um composto e dispositivo
WO2012069275A1 (en) 2010-11-26 2012-05-31 Chiesi Farmaceutici S.P.A. Glycine derivatives and their use as muscarinic receptor antagonists
US20120220557A1 (en) 2011-02-17 2012-08-30 Chiesi Farmaceutici S.P.A. Liquid propellant-free formulation comprising an antimuscarinic drug
EP2702041A1 (en) 2011-04-29 2014-03-05 Chiesi Farmaceutici S.p.A. Alkaloid ester and carbamate derivatives and medicinal compositions thereof
WO2013098145A1 (en) 2011-12-30 2013-07-04 Chiesi Farmaceutici S.P.A. Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6610001A (en) * 2000-06-27 2002-01-08 S A L V A T Lab Sa Carbamates derived from arylalkylamines
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
DK1345937T3 (da) * 2000-12-22 2006-01-16 Almirall Prodesfarma Ag Quinuclidincarbamatderivater og deres anvendelse som M3-antagonister
JP4505227B2 (ja) * 2001-12-20 2010-07-21 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ １−アルキル−１−アゾニアビシクロ［２．２．２］オクタンカルバメート誘導体およびムスカリンレセプターアンタゴニストとしてのそれらの使用
ES2203327B1 (es) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
CN101490049A (zh) 2009-07-22
AU2007278231B2 (en) 2012-08-16
WO2008012290A3 (en) 2008-03-13
MX2009000999A (es) 2009-04-15
AR062104A1 (es) 2008-10-15
CL2007002159A1 (es) 2008-01-04
ZA200901124B (en) 2010-05-26
EA200970158A1 (ru) 2009-06-30
TW200817398A (en) 2008-04-16
JP5331688B2 (ja) 2013-10-30
CA2658649A1 (en) 2008-01-31
US20080039493A1 (en) 2008-02-14
EP2049533A2 (en) 2009-04-22
EP1882691A1 (en) 2008-01-30
JP2009544659A (ja) 2009-12-17
AU2007278231A1 (en) 2008-01-31
US7838534B2 (en) 2010-11-23
WO2008012290A2 (en) 2008-01-31
EA017698B1 (ru) 2013-02-28
BRPI0713826A2 (pt) 2015-05-12
KR20090033443A (ko) 2009-04-03

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