MX2009000999A - Derivados de quinuclidina como antagonistas de m3. - Google Patents

Derivados de quinuclidina como antagonistas de m3.

Info

Publication number
MX2009000999A
MX2009000999A MX2009000999A MX2009000999A MX2009000999A MX 2009000999 A MX2009000999 A MX 2009000999A MX 2009000999 A MX2009000999 A MX 2009000999A MX 2009000999 A MX2009000999 A MX 2009000999A MX 2009000999 A MX2009000999 A MX 2009000999A
Authority
MX
Mexico
Prior art keywords
optionally substituted
antagonists
thienyl
substituted phenyl
quinuclidine derivatives
Prior art date
Application number
MX2009000999A
Other languages
English (en)
Inventor
Gabriele Amari
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of MX2009000999A publication Critical patent/MX2009000999A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Los derivados de quinuclidina de fórmula general (I) en forma de enantiómeros individuales o mezclas de los mismos son útiles en la preparación de un medicamento para la prevención y terapia de enfermedades respiratorias tales como asma, enfermedad pulmonar obstructiva crónica (COPD), bronquitis crónica, tos y enfisema (ver fórmula (I)) en donde R1 se elige entre H, F, CI, Br, I y alquilo C1-C4; R2es 2- o 3-tienilo opcionalmente sustituido, o fenilo sustituido; R3es (CH2)1-4-COR4 o (CH2)1-4-S(O)nR4 en donde R4 es fenilo opcionalmente sustituido o 2- o 3-tienilo opcionalmente sustituido; n es 0, 1 o 2 x es un anión farmacéuticamente aceptable.
MX2009000999A 2006-07-26 2007-07-23 Derivados de quinuclidina como antagonistas de m3. MX2009000999A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06117883A EP1882691A1 (en) 2006-07-26 2006-07-26 Quinuclidine derivatives as M3 antagonists
PCT/EP2007/057585 WO2008012290A2 (en) 2006-07-26 2007-07-23 Quinuclidine derivatives as m3 antagonists

Publications (1)

Publication Number Publication Date
MX2009000999A true MX2009000999A (es) 2009-04-15

Family

ID=37890216

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009000999A MX2009000999A (es) 2006-07-26 2007-07-23 Derivados de quinuclidina como antagonistas de m3.

Country Status (16)

Country Link
US (1) US7838534B2 (es)
EP (2) EP1882691A1 (es)
JP (1) JP5331688B2 (es)
KR (1) KR20090033443A (es)
CN (1) CN101490049A (es)
AR (1) AR062104A1 (es)
AU (1) AU2007278231B2 (es)
BR (1) BRPI0713826A2 (es)
CA (1) CA2658649A1 (es)
CL (1) CL2007002159A1 (es)
EA (1) EA017698B1 (es)
MX (1) MX2009000999A (es)
PE (1) PE20080407A1 (es)
TW (1) TW200817398A (es)
WO (1) WO2008012290A2 (es)
ZA (1) ZA200901124B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1345937B1 (en) 2000-12-22 2005-09-28 Almirall Prodesfarma AG Quinuclidine carbamate derivatives and their use as m3 antagonists
ES2246170B1 (es) * 2004-07-29 2007-04-01 Almirall Prodesfarma, S.A. Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
EP2080508A1 (en) 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Dry powder formulation comprising an anticholinergic drug
EP2080523A1 (en) 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Compositions comprising an antimuscarinic and a long-acting beta-agonist
EP2080507A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Pharmaceutical formulations comprising an anticholinergic drug
EP2154136A1 (en) * 2008-08-08 2010-02-17 CHIESI FARMACEUTICI S.p.A. Quinuclidine carbonate derivatives and medicinal compositions thereof
EP2206712A1 (en) * 2008-12-23 2010-07-14 CHIESI FARMACEUTICI S.p.A. "Alkaloid aminoester derivatives and medicinal composition thereof"
RU2569846C2 (ru) * 2010-06-22 2015-11-27 КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. Алкалоидные производные сложных аминоэфиров и включающие их лекарственные композиции
CN102947299B (zh) 2010-06-22 2015-07-15 奇斯药制品公司 生物碱氨基酯衍生物及其药物组合物
BR112012032330A2 (pt) * 2010-06-22 2016-11-08 Chiesi Farma Spa formulação em pó seco inalável, uso de uma formulação em pó seco, inalador de pó seco e embalagem
BR112012032332A2 (pt) 2010-06-22 2016-11-08 Chiesi Farma Spa composto, uso de um composto, composição farmacêutica, combinação de um composto e dispositivo
KR20130141534A (ko) 2010-11-26 2013-12-26 키에시 파르마슈티시 엣스. 피. 에이. 글리신 유도체 및 무스카린 수용체 길항제로서의 이들의 용도
US20120220557A1 (en) 2011-02-17 2012-08-30 Chiesi Farmaceutici S.P.A. Liquid propellant-free formulation comprising an antimuscarinic drug
EP2702041A1 (en) 2011-04-29 2014-03-05 Chiesi Farmaceutici S.p.A. Alkaloid ester and carbamate derivatives and medicinal compositions thereof
WO2013098145A1 (en) 2011-12-30 2013-07-04 Chiesi Farmaceutici S.P.A. Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2213703T5 (es) * 2000-06-27 2011-11-02 Laboratorios S.A.L.V.A.T., S.A. Carbamatos derivados de arilalquilaminas.
DE10064816A1 (de) * 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
EP1345937B1 (en) * 2000-12-22 2005-09-28 Almirall Prodesfarma AG Quinuclidine carbamate derivatives and their use as m3 antagonists
CN1832948B (zh) * 2001-12-20 2011-06-15 基耶西药品股份公司 1-烷基-1-氮*双环[2.2.2]辛烷氨基甲酸酯衍生物及其用作蕈毒碱受体拮抗剂的用途
ES2203327B1 (es) * 2002-06-21 2005-06-16 Almirall Prodesfarma, S.A. Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.

Also Published As

Publication number Publication date
EA200970158A1 (ru) 2009-06-30
AR062104A1 (es) 2008-10-15
TW200817398A (en) 2008-04-16
CA2658649A1 (en) 2008-01-31
EP1882691A1 (en) 2008-01-30
EA017698B1 (ru) 2013-02-28
WO2008012290A2 (en) 2008-01-31
AU2007278231A1 (en) 2008-01-31
BRPI0713826A2 (pt) 2015-05-12
KR20090033443A (ko) 2009-04-03
WO2008012290A3 (en) 2008-03-13
EP2049533A2 (en) 2009-04-22
CN101490049A (zh) 2009-07-22
PE20080407A1 (es) 2008-06-17
AU2007278231B2 (en) 2012-08-16
CL2007002159A1 (es) 2008-01-04
JP2009544659A (ja) 2009-12-17
US20080039493A1 (en) 2008-02-14
ZA200901124B (en) 2010-05-26
JP5331688B2 (ja) 2013-10-30
US7838534B2 (en) 2010-11-23

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