PE20080398A1 - Proceso para la preparacion de un derivado taxano - Google Patents

Proceso para la preparacion de un derivado taxano

Info

Publication number
PE20080398A1
PE20080398A1 PE2007000562A PE2007000562A PE20080398A1 PE 20080398 A1 PE20080398 A1 PE 20080398A1 PE 2007000562 A PE2007000562 A PE 2007000562A PE 2007000562 A PE2007000562 A PE 2007000562A PE 20080398 A1 PE20080398 A1 PE 20080398A1
Authority
PE
Peru
Prior art keywords
carbonate
preparation
trichlorometil
boc
beta
Prior art date
Application number
PE2007000562A
Other languages
English (en)
Inventor
Bruno Gabetta
Daniele Ciceri
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of PE20080398A1 publication Critical patent/PE20080398A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE REFIERE A UN PROCESO PARA LA PREPARACION DE 13-(N-BOC-BETA-ISOBUTILSERINIL)-14-BETA-HIDROXIBACATIN III-1,14-CARBONATO QUE COMPRENDE: A) ACETILACION DEL GRUPO 10-HIDROXI DE 14BETA-HIDROXI-10-DESACETILBACATINA III; B) REACCION CON BIS(TRICLOROMETIL)CARBONATO PARA OBTENER EL DERIVADO 1,14 CARBONATO; C) REACCION CON CLORURO DE TRICLOROACETICO Y DESPUES CON ACIDO (4S,5R)-N-BOC-2-(2,4-DIMETOXIFENIL)-4-ISOBUTIL-1-OXAZOLIDIN-5-CARBOXILO; D) LA ELIMINACION DEL GRUPO PROTECTOR TRICLOROACETILO CON ALCALI; E) LA ELIMIANCION DEL GRUPO PRTECTOR DIMETOXIBENCILIDENO. LA UTILIZACION DE BIS(TRICLOROMETIL)CARBONATO EN DICHO PROCESO AUMENTA EL RENDIMIENTO Y EVITA LA FORMACION DE IMPUREZA
PE2007000562A 2006-05-12 2007-05-10 Proceso para la preparacion de un derivado taxano PE20080398A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06009813A EP1854799B1 (en) 2006-05-12 2006-05-12 Process for the preparation of a taxane derivative

Publications (1)

Publication Number Publication Date
PE20080398A1 true PE20080398A1 (es) 2008-05-26

Family

ID=37708167

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000562A PE20080398A1 (es) 2006-05-12 2007-05-10 Proceso para la preparacion de un derivado taxano

Country Status (20)

Country Link
EP (1) EP1854799B1 (es)
JP (1) JP5154546B2 (es)
KR (1) KR101402122B1 (es)
CN (1) CN101448839B (es)
AR (1) AR061088A1 (es)
AT (1) ATE507231T1 (es)
BR (1) BRPI0711805B8 (es)
CA (1) CA2652008C (es)
DE (1) DE602006021546D1 (es)
DK (1) DK1854799T3 (es)
ES (1) ES2363524T3 (es)
HK (1) HK1111985A1 (es)
IL (1) IL195220A (es)
MX (1) MX2008014447A (es)
NO (1) NO334210B1 (es)
PE (1) PE20080398A1 (es)
RU (1) RU2434014C2 (es)
UY (1) UY30341A1 (es)
WO (1) WO2007131601A1 (es)
ZA (1) ZA200809613B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
CN105985353B (zh) 2015-02-11 2020-07-21 中国科学院上海药物研究所 一种化合物的a晶型及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3269190D1 (en) * 1982-09-03 1986-03-27 Wieland Werke Ag Finned tube with internal projections and method and apparatus for its manufacture
DE3440141A1 (de) * 1984-11-02 1986-05-07 Heiner Dipl.-Chem. Dr. 8000 München Eckert Verwendung von kohlensaeure-bis-trichlormethylester als proreagens fuer phosgen
KR100225535B1 (ko) * 1996-08-27 1999-10-15 정지석 파클리탁셀의 제조방법
ITMI991483A1 (it) * 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
IT1319682B1 (it) * 2000-12-06 2003-10-23 Indena Spa Procedimento di sintesi del paclitaxel.

Also Published As

Publication number Publication date
ATE507231T1 (de) 2011-05-15
AR061088A1 (es) 2008-08-06
MX2008014447A (es) 2008-11-26
CN101448839B (zh) 2011-09-21
NO20084753L (no) 2008-11-11
ZA200809613B (en) 2010-02-24
RU2008144391A (ru) 2010-05-20
DE602006021546D1 (de) 2011-06-09
CN101448839A (zh) 2009-06-03
EP1854799A1 (en) 2007-11-14
JP2009536928A (ja) 2009-10-22
ES2363524T3 (es) 2011-08-08
DK1854799T3 (da) 2011-07-18
KR101402122B1 (ko) 2014-05-30
EP1854799B1 (en) 2011-04-27
KR20090015923A (ko) 2009-02-12
UY30341A1 (es) 2007-11-30
RU2434014C2 (ru) 2011-11-20
BRPI0711805B8 (pt) 2021-05-25
HK1111985A1 (en) 2008-08-22
IL195220A (en) 2014-03-31
JP5154546B2 (ja) 2013-02-27
WO2007131601A1 (en) 2007-11-22
BRPI0711805B1 (pt) 2020-09-24
CA2652008A1 (en) 2007-11-22
IL195220A0 (en) 2009-08-03
NO334210B1 (no) 2014-01-13
CA2652008C (en) 2014-12-30
BRPI0711805A2 (pt) 2011-12-06

Similar Documents

Publication Publication Date Title
BR112012014695A2 (pt) processo para start-up de epoxidação
WO2008128934A3 (en) Fluorinated dyes and their use in electrophoretic display devices
MX2008010921A (es) Procesos para preparar productos de morfinan-6-ona con bajos niveles de compuestos de cetona alfa, beta-insaturados.
PT1873142E (pt) Processo para a preparação contínua de isocianatos
HK1112238A1 (en) Substituted benzo(d)isoxazol-3-yl amine compounds as analgesics
AR076974A1 (es) Metodo para sintetizar pirfenidona
JO3243B1 (ar) عملية لتصنيع الديغارليكس ومركباته الوسيطة
AR065775A1 (es) Procedimiento para preparar 2,6-dicloro-4-(trifluorometil)-fenilhidracina usando mezclas de dicloro-fluoro-trifluorometilbencenos
NZ595591A (en) Processes for the preparation of morphinane and morphinone compounds
BR112016008354A2 (pt) processo de preparação de alquilaluminoxanos por meio da reação de alquilalumínio com um álcool alílico substituído da fórmula, produto que pode ser obtido por meio do processo, e, uso do produto
WO2006091731A3 (en) Processes for the preparation of linezolid intermediate
TW201129535A (en) Alcoholic hydroxyl-containing compounds and making method
BR112012015219A2 (pt) processo para iniciar um catalisador de óxido de etileno altamente seletivo
EA201100361A1 (ru) Получение кремния взаимодействием оксида кремния и карбида кремния при необходимости в присутствии второго источника углерода
MY146360A (en) Process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof
NO20080812L (no) Fremgangsmate for fremstilling av 4 β-amino-4'demetyl-4-4-desoksy podofyllotoksin
TW200738650A (en) Process for synthesis of aryloxy diaminopyrimidines
PE20080398A1 (es) Proceso para la preparacion de un derivado taxano
IN2015DN01009A (es)
MX2012007447A (es) Proceso de epoxidacion y microestructura.
IN2014MN01770A (es)
CN106687441A8 (zh) 用于将第一化合物偶合到第二化合物的方法
MX2010002726A (es) Metodo de optimizacion de proceso quimico que considera la seguridad de la planta de proceso quimico.
CA3048084C (en) Protected oxadiazacyclic compounds, method for preparing oxadiazacyclic compounds and uses thereof
NZ592831A (en) Stereoselective synthesis of piperidine derivatives

Legal Events

Date Code Title Description
FC Refusal