PE20080094A1 - COMPUESTOS DE DIALQUILFENILO CON ACTIVIDAD AGONISTA DEL RECEPTOR ß2 ADRENERGICO Y ANTAGONISTA DEL RECEPTOR MUSCARINICO - Google Patents
COMPUESTOS DE DIALQUILFENILO CON ACTIVIDAD AGONISTA DEL RECEPTOR ß2 ADRENERGICO Y ANTAGONISTA DEL RECEPTOR MUSCARINICOInfo
- Publication number
- PE20080094A1 PE20080094A1 PE2007000509A PE2007000509A PE20080094A1 PE 20080094 A1 PE20080094 A1 PE 20080094A1 PE 2007000509 A PE2007000509 A PE 2007000509A PE 2007000509 A PE2007000509 A PE 2007000509A PE 20080094 A1 PE20080094 A1 PE 20080094A1
- Authority
- PE
- Peru
- Prior art keywords
- ethyl
- methyl
- compounds
- agonist activity
- hydroxyethylamine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000000556 agonist Substances 0.000 title abstract 2
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 title abstract 2
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 title 1
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 title 1
- 239000000971 adrenergic beta-2 receptor antagonist Substances 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000003149 muscarinic antagonist Substances 0.000 title 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical group C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 5
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- -1 3-FORMYLAMINO-4-HYDROXYPHENYL Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79470206P | 2006-04-25 | 2006-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080094A1 true PE20080094A1 (es) | 2008-02-17 |
Family
ID=38577470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000509A PE20080094A1 (es) | 2006-04-25 | 2007-04-24 | COMPUESTOS DE DIALQUILFENILO CON ACTIVIDAD AGONISTA DEL RECEPTOR ß2 ADRENERGICO Y ANTAGONISTA DEL RECEPTOR MUSCARINICO |
Country Status (20)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| TWI341836B (en) | 2004-03-11 | 2011-05-11 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
| WO2006023457A1 (en) * | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| TW200811104A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
| RS52557B (sr) * | 2008-02-06 | 2013-04-30 | Pulmagen Therapeutics (Synergy) Limited | Jedinjenja |
| SI3210981T1 (sl) | 2009-04-23 | 2019-05-31 | Theravance Respiratory Company, Llc | Diamidne spojine, ki imajo muskarinsko receptorsko antagonistično in beta 2 adrenergično receptorsko agonistično aktivnost |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| US20110020423A1 (en) | 2009-07-22 | 2011-01-27 | Puretech Ventures | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| GB201009801D0 (en) | 2010-06-11 | 2010-07-21 | Astrazeneca Ab | Compounds 950 |
| US10933020B2 (en) | 2018-09-28 | 2021-03-02 | Karuna Therapeutics, Inc. | Compositions and methods for treating disorders ameliorated by muscarinic receptor activation |
| CN114409556B (zh) * | 2022-01-28 | 2024-10-18 | 兰州康鹏威耳化工有限公司 | 一种3,4-二取代-2-氨基苯甲醛的制备方法 |
| CN117924216A (zh) * | 2024-01-12 | 2024-04-26 | 王叔和生物医药(武汉)有限公司 | 一种1-哌啶丙酸的合成方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995006635A1 (en) | 1993-09-02 | 1995-03-09 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| CA2182568A1 (en) | 1994-02-10 | 1995-08-17 | Makoto Takeuchi | Novel carbamate derivative and medicinal composition containing the same |
| US6040344A (en) | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| US6362371B1 (en) * | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| DE19921693A1 (de) | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| ATE381537T1 (de) | 2001-03-22 | 2008-01-15 | Glaxo Group Ltd | Formanilid-derivative als beta2-adrenorezeptor- agonisten |
| US20030018019A1 (en) | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| EP1685118B1 (en) * | 2003-11-21 | 2009-07-08 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| WO2005087735A1 (en) | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| TWI374883B (en) * | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
| JP2008510015A (ja) | 2004-08-16 | 2008-04-03 | セラヴァンス， インコーポレーテッド | β２アドレナリン作用性レセプターアゴニスト活性およびムスカリン性レセプターアンタゴニスト活性を有する化合物 |
| WO2006023457A1 (en) | 2004-08-16 | 2006-03-02 | Theravance, Inc. | COMPOUNDS HAVING β2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| TW200811104A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
-
2007
- 2007-04-23 TW TW096114175A patent/TW200811105A/zh unknown
- 2007-04-24 PE PE2007000509A patent/PE20080094A1/es not_active Application Discontinuation
- 2007-04-24 BR BRPI0710767-6A patent/BRPI0710767A2/pt not_active IP Right Cessation
- 2007-04-24 AU AU2007243481A patent/AU2007243481A1/en not_active Abandoned
- 2007-04-24 RU RU2008146383/04A patent/RU2008146383A/ru not_active Application Discontinuation
- 2007-04-24 KR KR1020087028589A patent/KR20090005389A/ko not_active Withdrawn
- 2007-04-24 CA CA002650530A patent/CA2650530A1/en not_active Abandoned
- 2007-04-24 US US11/789,300 patent/US7524965B2/en active Active
- 2007-04-24 CN CNA2007800140984A patent/CN101426764A/zh active Pending
- 2007-04-24 EP EP07776093A patent/EP2010489B1/en active Active
- 2007-04-24 MX MX2008013555A patent/MX2008013555A/es active IP Right Grant
- 2007-04-24 WO PCT/US2007/009925 patent/WO2007127196A2/en not_active Ceased
- 2007-04-24 ES ES07776093T patent/ES2391584T3/es active Active
- 2007-04-24 AR ARP070101777A patent/AR060647A1/es unknown
- 2007-04-24 JP JP2009507757A patent/JP2009541209A/ja active Pending
-
2008
- 2008-09-25 IL IL194334A patent/IL194334A0/en unknown
- 2008-10-15 ZA ZA200808817A patent/ZA200808817B/xx unknown
- 2008-10-29 CO CO08115666A patent/CO6140054A2/es unknown
- 2008-10-30 NO NO20084603A patent/NO20084603L/no not_active Application Discontinuation
- 2008-11-14 MA MA31382A patent/MA30556B1/fr unknown
-
2009
- 2009-03-18 US US12/406,283 patent/US7687521B2/en active Active
-
2010
- 2010-02-05 US US12/701,108 patent/US8134006B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009541209A (ja) | 2009-11-26 |
| US7524965B2 (en) | 2009-04-28 |
| EP2010489B1 (en) | 2012-08-22 |
| KR20090005389A (ko) | 2009-01-13 |
| EP2010489A2 (en) | 2009-01-07 |
| RU2008146383A (ru) | 2010-05-27 |
| WO2007127196A3 (en) | 2007-12-21 |
| US20090176833A1 (en) | 2009-07-09 |
| ZA200808817B (en) | 2010-03-31 |
| US7687521B2 (en) | 2010-03-30 |
| NO20084603L (no) | 2008-11-19 |
| CO6140054A2 (es) | 2010-03-19 |
| CA2650530A1 (en) | 2007-11-08 |
| MA30556B1 (fr) | 2009-07-01 |
| US20100137603A1 (en) | 2010-06-03 |
| BRPI0710767A2 (pt) | 2011-06-07 |
| US20070249675A1 (en) | 2007-10-25 |
| CN101426764A (zh) | 2009-05-06 |
| MX2008013555A (es) | 2008-11-04 |
| AR060647A1 (es) | 2008-07-02 |
| ES2391584T3 (es) | 2012-11-28 |
| TW200811105A (en) | 2008-03-01 |
| AU2007243481A1 (en) | 2007-11-08 |
| WO2007127196A2 (en) | 2007-11-08 |
| IL194334A0 (en) | 2009-08-03 |
| US8134006B2 (en) | 2012-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20080094A1 (es) | COMPUESTOS DE DIALQUILFENILO CON ACTIVIDAD AGONISTA DEL RECEPTOR ß2 ADRENERGICO Y ANTAGONISTA DEL RECEPTOR MUSCARINICO | |
| NI200700161A (es) | Derivados de pirazol fusionado y métodos de tratamiento de los desórdenes relacionados con el metabolismo | |
| PE20120578A1 (es) | Agonistas y antagonistas del receptor de s1p5, y metodos de uso de los mismos | |
| DE602006009773D1 (de) | Substituierte thiophenderivate als glucagonrezeptorantagonisten, herstellung und therapeutische anwendungen | |
| PE20060306A1 (es) | Compuestos de heteroaril-amida sustituida | |
| ATE459619T1 (de) | Glucagonrezeptorantagonisten, deren herstellung und therapeutische verwendung | |
| DE602005019043D1 (de) | Glucagonrezeptorantagonisten, deren herstellung und therapeutische verwendung | |
| PE20121433A1 (es) | Compuestos de indazol y pirazolopiridina como antagonistas del receptor de ccr1 | |
| CL2008001946A1 (es) | Compuestos derivados de imidazol, antagonistas de receptores ccr2, ccr3, ccr5; procedimiento de preparacion; y uso en el tratamiento de enfermedades vasculares perifericas. | |
| PE20091653A1 (es) | Derivados sustituidos de pirazol y su uso | |
| EP4537899A3 (en) | Benzimidazole carboxylic acids as glp-1r agonists | |
| MX2009003939A (es) | Derivados de imidazolona e imidazolidinona como inhibidores de la 11-beta-hidroxiesteroide deshidrogenasa de tipo 1 para diabetes. | |
| SMT201300060B (it) | Composti diammidici aventi attivita' di antagonista al recettore muscarinico e di agonista al recettore beta 2 adrenergico | |
| PE20071112A1 (es) | Derivados azufrados de urea ciclica como inhibidores de quinasas y su preparacion | |
| NO20084853L (no) | Forbindelser som er agonister av muscarinreseptorer og som kan vaere effektive i behandling av smerte, Alzheimers sykdom og/eller schizofreni | |
| PE20090992A1 (es) | Derivados de fenil-amino-pirimidina como agentes inhibidores de cinasa | |
| DE602007005160D1 (de) | Benzimidazol-cannabinoid-agonisten mit einer substituierten heterocyclischen gruppe | |
| PE20060736A1 (es) | DERIVADOS DE PIRROL COMO ANTAGONISTAS DE CRTh2 | |
| WO2007120270A3 (en) | Glucagon receptor antagonists, preparation and therapeutic uses | |
| PE20060937A1 (es) | Derivados de sulfonilbencimidazol como agonistas del receptor cannabinoide 2 (cb2) | |
| PE20091243A1 (es) | Compuesto heterociclico fusionado | |
| PE20090592A1 (es) | Nuevos derivados de piperazina-amida | |
| RU2011121665A (ru) | Производные 7-гидроксибензимидазол-4-илметанона и содержащие их ингибиторы рвк | |
| CR10207A (es) | "derivados de acido acético benzo (f) isoindol-2-ilfenil como receptores agonistas de ep4" | |
| AR074353A1 (es) | Acidos naftalen-2-il-aceticos sustituidos, composiciones farmaceuticas que los contienen, y uso de los mismos en el tratamiento de enfermedades alergicas,tales como rinitis, asma y dermatititis atopica. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |