AR060647A1 - Derivados de piperidina con actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarinico, composiciones farmaceuticas que los comprenden, el uso de los mismos para la fabricacion de medicamentos para el tratamiento de afecciones pulmonares, metodos para preparar estos der - Google Patents
Derivados de piperidina con actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarinico, composiciones farmaceuticas que los comprenden, el uso de los mismos para la fabricacion de medicamentos para el tratamiento de afecciones pulmonares, metodos para preparar estos derInfo
- Publication number
- AR060647A1 AR060647A1 ARP070101777A ARP070101777A AR060647A1 AR 060647 A1 AR060647 A1 AR 060647A1 AR P070101777 A ARP070101777 A AR P070101777A AR P070101777 A ARP070101777 A AR P070101777A AR 060647 A1 AR060647 A1 AR 060647A1
- Authority
- AR
- Argentina
- Prior art keywords
- receiver
- pharmaceutical compositions
- piperidine
- antagonist
- medicines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Reivindicacion 1: Un compuesto de formula (1): caracterizado porque R1 es metilo o etilo; R2 es metilo o etilo; o una sal o solvato o estereoisomero del mismo aceptable para uso farmacéutico. Reivindicacion 21: Un intermediario para preparar un compuesto de cualquiera de las reivindicaciones 1 a 4, caracterizado porque el intermediario es un compuesto de formula (3): donde Y1 se selecciona entre -CHO, -CN, -CH2OH, -CH(OR3a)OR3b, -C(O)OH, -C(O)OR3c, bromo y yodo, donde R3a y R3b se seleccionan independientemente entre alquilo C1-6, o R3a y R3b están unidos para formar un alquileno C2-6, R3c se selecciona entre alquilo C1-6; R1 es metilo o etilo; R2 es metilo o etilo; o una sal o estereoisomero de los mismos. Composiciones farmacéuticas y combinaciones que comprenden dichos compuestos, procesos e intermediarios para preparar dichos compuestos, y métodos para usar dicho compuesto, por ejemplo, para tratar trastornos pulmonares, como por ejemplo enfermedad pulmonar obstructiva cronica y asma.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79470206P | 2006-04-25 | 2006-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060647A1 true AR060647A1 (es) | 2008-07-02 |
Family
ID=38577470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101777A AR060647A1 (es) | 2006-04-25 | 2007-04-24 | Derivados de piperidina con actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarinico, composiciones farmaceuticas que los comprenden, el uso de los mismos para la fabricacion de medicamentos para el tratamiento de afecciones pulmonares, metodos para preparar estos der |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7524965B2 (es) |
| EP (1) | EP2010489B1 (es) |
| JP (1) | JP2009541209A (es) |
| KR (1) | KR20090005389A (es) |
| CN (1) | CN101426764A (es) |
| AR (1) | AR060647A1 (es) |
| AU (1) | AU2007243481A1 (es) |
| BR (1) | BRPI0710767A2 (es) |
| CA (1) | CA2650530A1 (es) |
| CO (1) | CO6140054A2 (es) |
| ES (1) | ES2391584T3 (es) |
| IL (1) | IL194334A0 (es) |
| MA (1) | MA30556B1 (es) |
| MX (1) | MX2008013555A (es) |
| NO (1) | NO20084603L (es) |
| PE (1) | PE20080094A1 (es) |
| RU (1) | RU2008146383A (es) |
| TW (1) | TW200811105A (es) |
| WO (1) | WO2007127196A2 (es) |
| ZA (1) | ZA200808817B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| TWI341836B (en) | 2004-03-11 | 2011-05-11 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
| US7528253B2 (en) * | 2004-08-16 | 2009-05-05 | Theravance, Inc. | Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| TW200811104A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| PL2242759T3 (pl) * | 2008-02-06 | 2013-06-28 | Astrazeneca Ab | Związki |
| SI3210981T1 (sl) | 2009-04-23 | 2019-05-31 | Theravance Respiratory Company, Llc | Diamidne spojine, ki imajo muskarinsko receptorsko antagonistično in beta 2 adrenergično receptorsko agonistično aktivnost |
| US20110020423A1 (en) | 2009-07-22 | 2011-01-27 | Puretech Ventures | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
| WO2011081937A1 (en) | 2009-12-15 | 2011-07-07 | Gilead Sciences, Inc. | Corticosteroid-beta-agonist-muscarinic antagonist compounds for use in therapy |
| GB201009801D0 (en) | 2010-06-11 | 2010-07-21 | Astrazeneca Ab | Compounds 950 |
| IL295341A (en) | 2018-09-28 | 2022-10-01 | Karuna Therapeutics Inc | Compositions and methods for the treatment of diseases improved by the activation of muscarinic receptors |
| CN114409556A (zh) * | 2022-01-28 | 2022-04-29 | 兰州康鹏威耳化工有限公司 | 一种3,4-二取代-2-氨基苯甲醛的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7545894A (en) | 1993-09-02 | 1995-03-22 | Yamanouchi Pharmaceutical Co., Ltd. | Carbamate derivative and medicine containing the same |
| EP0747355A4 (en) | 1994-02-10 | 1997-04-09 | Yamanouchi Pharma Co Ltd | NEW CARBAMATES AND MEDICINAL PRODUCTS CONTAINING THEM |
| US6040344A (en) | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
| US6362371B1 (en) * | 1998-06-08 | 2002-03-26 | Advanced Medicine, Inc. | β2- adrenergic receptor agonists |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| DE19921693A1 (de) | 1999-05-12 | 2000-11-16 | Boehringer Ingelheim Pharma | Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika |
| UA73965C2 (en) | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
| ATE381537T1 (de) * | 2001-03-22 | 2008-01-15 | Glaxo Group Ltd | Formanilid-derivative als beta2-adrenorezeptor- agonisten |
| US20030018019A1 (en) | 2001-06-23 | 2003-01-23 | Boehringer Ingelheim Pharma Kg | Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics |
| TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| PE20040950A1 (es) * | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| ATE435855T1 (de) | 2003-11-21 | 2009-07-15 | Theravance Inc | Verbindungen mit agonistischer wirkung am beta2- adrenergen rezeptor und am muscarinischen rezeptor |
| JP2007528416A (ja) | 2004-03-11 | 2007-10-11 | セラヴァンス， インコーポレーテッド | ムスカリンレセプターアンタゴニストとしての有用なビフェニル化合物 |
| EP1833822A2 (en) | 2004-08-16 | 2007-09-19 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| US7528253B2 (en) | 2004-08-16 | 2009-05-05 | Theravance, Inc. | Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| TWI374883B (en) * | 2004-08-16 | 2012-10-21 | Theravance Inc | Crystalline form of a biphenyl compound |
| TW200811104A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Crystalline forms of a dimethylphenyl compound |
| TW200811105A (en) * | 2006-04-25 | 2008-03-01 | Theravance Inc | Dialkylphenyl compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
-
2007
- 2007-04-23 TW TW096114175A patent/TW200811105A/zh unknown
- 2007-04-24 AR ARP070101777A patent/AR060647A1/es unknown
- 2007-04-24 EP EP07776093A patent/EP2010489B1/en active Active
- 2007-04-24 BR BRPI0710767-6A patent/BRPI0710767A2/pt not_active IP Right Cessation
- 2007-04-24 RU RU2008146383/04A patent/RU2008146383A/ru not_active Application Discontinuation
- 2007-04-24 CN CNA2007800140984A patent/CN101426764A/zh active Pending
- 2007-04-24 KR KR1020087028589A patent/KR20090005389A/ko not_active Application Discontinuation
- 2007-04-24 PE PE2007000509A patent/PE20080094A1/es not_active Application Discontinuation
- 2007-04-24 AU AU2007243481A patent/AU2007243481A1/en not_active Abandoned
- 2007-04-24 ES ES07776093T patent/ES2391584T3/es active Active
- 2007-04-24 WO PCT/US2007/009925 patent/WO2007127196A2/en active Application Filing
- 2007-04-24 US US11/789,300 patent/US7524965B2/en active Active
- 2007-04-24 MX MX2008013555A patent/MX2008013555A/es active IP Right Grant
- 2007-04-24 CA CA002650530A patent/CA2650530A1/en not_active Abandoned
- 2007-04-24 JP JP2009507757A patent/JP2009541209A/ja active Pending
-
2008
- 2008-09-25 IL IL194334A patent/IL194334A0/en unknown
- 2008-10-15 ZA ZA200808817A patent/ZA200808817B/xx unknown
- 2008-10-29 CO CO08115666A patent/CO6140054A2/es unknown
- 2008-10-30 NO NO20084603A patent/NO20084603L/no not_active Application Discontinuation
- 2008-11-14 MA MA31382A patent/MA30556B1/fr unknown
-
2009
- 2009-03-18 US US12/406,283 patent/US7687521B2/en active Active
-
2010
- 2010-02-05 US US12/701,108 patent/US8134006B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CO6140054A2 (es) | 2010-03-19 |
| CN101426764A (zh) | 2009-05-06 |
| RU2008146383A (ru) | 2010-05-27 |
| JP2009541209A (ja) | 2009-11-26 |
| BRPI0710767A2 (pt) | 2011-06-07 |
| WO2007127196A2 (en) | 2007-11-08 |
| AU2007243481A1 (en) | 2007-11-08 |
| US8134006B2 (en) | 2012-03-13 |
| WO2007127196A3 (en) | 2007-12-21 |
| US20100137603A1 (en) | 2010-06-03 |
| EP2010489B1 (en) | 2012-08-22 |
| IL194334A0 (en) | 2009-08-03 |
| MX2008013555A (es) | 2008-11-04 |
| US20090176833A1 (en) | 2009-07-09 |
| US7687521B2 (en) | 2010-03-30 |
| TW200811105A (en) | 2008-03-01 |
| EP2010489A2 (en) | 2009-01-07 |
| CA2650530A1 (en) | 2007-11-08 |
| MA30556B1 (fr) | 2009-07-01 |
| ZA200808817B (en) | 2010-03-31 |
| ES2391584T3 (es) | 2012-11-28 |
| US7524965B2 (en) | 2009-04-28 |
| KR20090005389A (ko) | 2009-01-13 |
| NO20084603L (no) | 2008-11-19 |
| US20070249675A1 (en) | 2007-10-25 |
| PE20080094A1 (es) | 2008-02-17 |
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