PE20070244A1 - Biotejido de colageno derivado de placenta para el tratamiento de ulceras en la pierna - Google Patents

Biotejido de colageno derivado de placenta para el tratamiento de ulceras en la pierna

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Publication number
PE20070244A1
PE20070244A1 PE2006000843A PE2006000843A PE20070244A1 PE 20070244 A1 PE20070244 A1 PE 20070244A1 PE 2006000843 A PE2006000843 A PE 2006000843A PE 2006000843 A PE2006000843 A PE 2006000843A PE 20070244 A1 PE20070244 A1 PE 20070244A1
Authority
PE
Peru
Prior art keywords
ulcers
inhibitor
treatment
biothollagen
placenta
Prior art date
Application number
PE2006000843A
Other languages
English (en)
Inventor
Robert J Hariri
Janice M Smiell
Original Assignee
Anthrogenesis Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anthrogenesis Corp filed Critical Anthrogenesis Corp
Publication of PE20070244A1 publication Critical patent/PE20070244A1/es

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

REFERIDA A UN BIOTEJIDO DE COLAGENO SECO QUE TIENE 20% O MENOS DE AGUA POR PESO, RETIENE LAS PROTEINAS DEL AMION, CORION O AMBOS EN SU CONFORMACION NATURAL Y NO MODIFICADA, SE PRESENTA EN FORMA DE LAMINA, MEMBRANA, RED O TEJIDO, SE CORTA EN DADOS O DE MANERA QUE PUEDA FLUIR EN UNA CANULA O AGUJA Y SE COLOCA SOBRE UN SOPORTE (VENDAJE). DICHO BIOTEJIDO NO ES TRATADO CON PROTEASA; LAS PROTEINAS QUE SE ENCUENTRAN EN EL BIOTEJIDO NO PRESENTAN UN ENLACE CRUZADO ARTIFICIALMENTE QUIMICO; Y COMPRENDE, ADICIONALMENTE, UN COMPUESTO BIOACTIVO, EL CUAL PUEDE SER UNA MOLECULA ORGANICA PEQUENA, UN ANTIBIOTICO, UN AGENTE ANTIINFLAMATORIO, UNA CITOQUINA, UN FACTOR DE CRECIMIENTO, UN INHIBIDOR DE ENZIMA, UN INHIBIDOR DE CINASA, ENTRE OTROS. DICHO BIOTEJIDO ES UTIL EN EL TRATAMIENTO DE ULCERAS EN LAS PIERNAS TALES COMO ULCERA VENOSA, ARTERIAL, DIABETICA O DE DECUBITO
PE2006000843A 2005-07-13 2006-07-13 Biotejido de colageno derivado de placenta para el tratamiento de ulceras en la pierna PE20070244A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US69944105P 2005-07-13 2005-07-13

Publications (1)

Publication Number Publication Date
PE20070244A1 true PE20070244A1 (es) 2007-05-12

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Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002046373A1 (en) * 2000-12-06 2002-06-13 Hariri Robert J Method of collecting placental stem cells
US20080152629A1 (en) * 2000-12-06 2008-06-26 James Edinger Placental stem cell populations
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
ES2549161T3 (es) * 2001-02-14 2015-10-23 Anthrogenesis Corporation Placenta post-parto de mamífero, su uso y células madre placentarias de la misma
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
EP1571910A4 (en) * 2002-11-26 2009-10-28 Anthrogenesis Corp CYTOTHERAPEUTIC AGENTS, CYTOTHERAPEUTIC UNITS AND METHODS OF TREATMENT IN WHICH THEY INTERVENE
GB0321337D0 (en) * 2003-09-11 2003-10-15 Massone Mobile Advertising Sys Method and system for distributing advertisements
CN101966183A (zh) * 2003-12-02 2011-02-09 细胞基因公司 用于治疗和控制血红蛋白病和贫血病的方法和组合物
KR20070002067A (ko) * 2004-03-26 2007-01-04 셀진 코포레이션 줄기 세포 은행의 제공 시스템 및 제공 방법
WO2007005807A2 (en) * 2005-06-30 2007-01-11 Anthrogenesis Corporation Repair of tympanic membrane using placenta derived collagen biofabric
US7928280B2 (en) * 2005-07-13 2011-04-19 Anthrogenesis Corporation Treatment of leg ulcers using placenta derived collagen biofabric
WO2007047465A1 (en) * 2005-10-13 2007-04-26 Anthrogenesis Corporation Production of oligodendrocytes from placenta-derived stem cells
WO2007047468A2 (en) 2005-10-13 2007-04-26 Anthrogenesis Corporation Immunomodulation using placental stem cells
AU2006332680A1 (en) * 2005-12-29 2007-07-12 Anthrogenesis Corporation Improved composition for collecting and preserving placental stem cells and methods of using the composition
ZA200804718B (en) * 2005-12-29 2010-04-28 Anthrogenesis Corp Co-culture of placental stem cells and stem cells from a second source
NZ595786A (en) * 2005-12-29 2013-05-31 Anthrogenesis Corp Placental stem cell populations
CN101501185A (zh) * 2006-06-09 2009-08-05 人类起源公司 胎盘巢(placental niche)及其培养干细胞的用途
DE102006032223A1 (de) * 2006-07-07 2007-07-12 Paul Hartmann Ag Kompressions- oder Stützstrumpf
US7993918B2 (en) 2006-08-04 2011-08-09 Anthrogenesis Corporation Tumor suppression using placental stem cells
WO2008021391A1 (en) * 2006-08-15 2008-02-21 Anthrogenesis Corporation Umbilical cord biomaterial for medical use
US8372437B2 (en) 2006-08-17 2013-02-12 Mimedx Group, Inc. Placental tissue grafts
WO2008033544A2 (en) * 2006-09-14 2008-03-20 Lee Kevin R Hemostatic bandage kit and method of use
WO2008042441A1 (en) * 2006-10-03 2008-04-10 Anthrogenesis Corporation Use of umbilical cord biomaterial for ocular surgery
WO2008060377A2 (en) 2006-10-04 2008-05-22 Anthrogenesis Corporation Placental or umbilical cord tissue compositions
EP2076279B1 (en) * 2006-10-06 2014-08-27 Anthrogenesis Corporation Native (telopeptide) placental collagen compositions
WO2008051568A2 (en) * 2006-10-23 2008-05-02 Anthrogenesis Corporation Methods and compositions for treatment of bone defects with placental cell populations
KR20100027091A (ko) 2006-11-15 2010-03-10 코다 테라퓨틱스, 인크. 상처 치유를 위한 개선 방법 및 조성물
US9056151B2 (en) * 2007-02-12 2015-06-16 Warsaw Orthopedic, Inc. Methods for collagen processing and products using processed collagen
US20080260794A1 (en) * 2007-02-12 2008-10-23 Lauritzen Nels J Collagen products and methods for producing collagen products
EP2630959A1 (en) * 2007-02-12 2013-08-28 Anthrogenesis Corporation Treatment of inflammatory diseases using placental stem cells
EP2129775A1 (en) * 2007-02-12 2009-12-09 Anthrogenesis Corporation Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations
US20100172830A1 (en) * 2007-03-29 2010-07-08 Cellx Inc. Extraembryonic Tissue cells and method of use thereof
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
EP2197270B8 (en) 2007-09-07 2020-03-04 Surgical Biologics, LLC Placental tissue grafts and improved methods of preparing and using the same
WO2009042201A1 (en) * 2007-09-26 2009-04-02 Celgene Cellular Therapeutics Angiogenic cells from human placental perfusate
KR20230065354A (ko) * 2007-09-28 2023-05-11 셀룰래리티 인코포레이티드 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법
WO2009061447A2 (en) * 2007-11-07 2009-05-14 Anthrogenesis Corporation Treatment of premature birth complications
KR100947765B1 (ko) * 2008-08-18 2010-03-18 (주)다림티센 조직수복재료로서의 콜라겐 기반 매트릭스 및 이의 제조방법
CA2734236C (en) * 2008-08-20 2020-08-25 Anthrogenesis Corporation Improved cell composition and methods of making the same
PE20110399A1 (es) * 2008-08-20 2011-06-22 Anthrogenesis Corp Tratamiento de la apoplejia utilizando celulas placentarias aisladas
NZ591293A (en) * 2008-08-22 2012-10-26 Anthrogenesis Corp Methods and compositions for treatment of bone defects with osteogenic placental adherent cells (OPACs)
NZ602455A (en) * 2008-11-19 2014-03-28 Anthrogenesis Corp Amnion derived adherent cells
BRPI0921999B8 (pt) * 2008-11-21 2021-05-25 Anthrogenesis Corp uso de uma quantidade terapeuticamente eficaz de células tronco placentárias
PL2387390T3 (pl) 2009-01-13 2013-12-31 Pergamum Ab Zawierające kwas hialuronowy kompozycje do leczenia ran, blizn oraz zrostów powstających po zabiegach chirurgicznych
AU2010266263B2 (en) * 2009-07-02 2016-05-19 Celularity Inc. Method of producing erythrocytes without feeder cells
US20140286911A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
CA2787992A1 (en) * 2010-01-26 2011-08-04 Anthrogenesis Corporation Treatment of bone-related cancers using placental stem cells
EP3345998A1 (en) 2010-02-18 2018-07-11 Osiris Therapeutics, Inc. Immunocompatible chorionic membrane products
KR20200047797A (ko) 2010-04-07 2020-05-07 안트로제네시스 코포레이션 태반 줄기 세포를 사용한 혈관신생
CN102933221A (zh) 2010-04-08 2013-02-13 人类起源公司 使用胎盘干细胞治疗结节病
US8460691B2 (en) 2010-04-23 2013-06-11 Warsaw Orthopedic, Inc. Fenestrated wound repair scaffold
US8790699B2 (en) 2010-04-23 2014-07-29 Warsaw Orthpedic, Inc. Foam-formed collagen strand
KR20230096132A (ko) 2010-07-13 2023-06-29 셀룰래리티 인코포레이티드 천연 킬러 세포의 생성 방법
US8969315B2 (en) 2010-12-31 2015-03-03 Anthrogenesis Corporation Enhancement of placental stem cell potency using modulatory RNA molecules
ES2707579T3 (es) 2011-06-01 2019-04-04 Celularity Inc Tratamiento del dolor usando citoblastos placentarios
US9925221B2 (en) 2011-09-09 2018-03-27 Celularity, Inc. Treatment of amyotrophic lateral sclerosis using placental stem cells
US9162011B2 (en) 2011-12-19 2015-10-20 Allosource Flowable matrix compositions and methods
US20180126033A9 (en) 2012-03-14 2018-05-10 MAM Holdings of West Florida, L.L.C. Collagen compositions and uses for biomaterial implants
US10576037B2 (en) * 2012-03-14 2020-03-03 MAM Holdings of West Florida, L.L.C. Compositions comprising placental collagen for use in wound healing
RU2015127077A (ru) * 2012-12-07 2017-01-12 Антродженезис Корпорейшн Лечение поражений полости рта при помощи внеклеточного матрикса плаценты
US10517931B2 (en) 2013-01-17 2019-12-31 Mimedx Group, Inc. Non-surgical, localized delivery of compositions for placental growth factors
US9655948B1 (en) 2013-01-17 2017-05-23 Mimedx Group, Inc. Non-surgical, localized delivery of compositions for placental growth factors
US9827293B2 (en) 2013-01-17 2017-11-28 Mimedx Group, Inc. Non-surgical, localized delivery of compositions for placental growth factors
US10206977B1 (en) * 2013-01-18 2019-02-19 Mimedx Group, Inc. Isolated placental stem cell recruiting factors
EP3622960A1 (en) 2013-02-05 2020-03-18 Celularity, Inc. Natural killer cells from placenta
US9855301B1 (en) * 2013-03-13 2018-01-02 Biodlogics Llc Human birth tissue laminate and methods of use
US20140336600A1 (en) 2013-05-10 2014-11-13 Carl Randall Harrell Method for Obtaining Sterile Human Amniotic Fluid and Uses Thereof
US10485521B2 (en) 2013-05-10 2019-11-26 MAM Holdings of West Florida, L.L.C. Method for obtaining sterile human amniotic fluid and uses thereof
CN203259680U (zh) * 2013-05-15 2013-10-30 京东方科技集团股份有限公司 彩色滤光片及显示装置
WO2015077401A1 (en) 2013-11-20 2015-05-28 Drexel University Compositions and methods for macrophage conversion
EP3183346A4 (en) 2014-08-22 2018-10-24 Auckland Uniservices Limited Channel modulators
CA2973096A1 (en) 2015-01-06 2016-07-14 Cardiovascular Biotherapeutics, Inc. Angiogenic treatment of ischemic heart disease
WO2016133848A2 (en) 2015-02-16 2016-08-25 Cardiovascular Biotherapeutics, Inc. Therapeutic angiogenesis for treating erectile conditions
CA2999909A1 (en) 2015-09-23 2017-03-30 Osiris Therapeutics, Inc. Umbilical tissue compositions and methods of use
WO2017062948A1 (en) 2015-10-09 2017-04-13 Mam Holdings Of West Florida, Llc Amniotic fluid topical formulation for the treatment of eye disorders
US9907821B2 (en) 2015-10-09 2018-03-06 MAM Holdings of West Florida, L.L.C. Amniotic fluid formulation for treatment of joint pain or disorders
US11273183B2 (en) 2015-10-09 2022-03-15 MAM Holdings of West Florida, L.L.C. Amniotic fluid formulation for treatment of joint pain or disorders
US20170354692A1 (en) 2016-06-13 2017-12-14 MAM Holdings of West Florida, L.L.C. Amniotic fluid formulation for treatment of lung disorders
SG11201903899VA (en) * 2016-11-02 2019-05-30 Axogen Corp Amnion tissue grafts and methods of preparing and using same
US11559606B2 (en) 2016-12-09 2023-01-24 The Penn State Research Foundation Semi-synthetic tissue constructs for tissue regeneration
US20190060506A1 (en) * 2017-08-22 2019-02-28 The Board Of Trustees Of The Leland Stanford Junior University Elafin Incorporated Biomaterials for the Treatment of Chronic Tissue Ulcers

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2801008A (en) * 1954-02-10 1957-07-30 J A Zurn Mfg Co Strainer
US4420339A (en) * 1981-03-27 1983-12-13 Kureha Kagaku Kogyo Kabushiki Kaisha Collagen fibers for use in medical treatments
US4837024A (en) * 1984-02-24 1989-06-06 The Regents Of The University Of California Compositions, articles and mehtod for improving wound healing
US5436135A (en) * 1985-09-02 1995-07-25 Pasteur Merieux Serums Et Vaccins New preparation of placenta collagen, their extraction method and their applications
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5698579A (en) * 1993-07-02 1997-12-16 Celgene Corporation Cyclic amides
US20030039695A1 (en) * 2001-08-10 2003-02-27 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen carrier of therapeutic genetic material, and method
HU228769B1 (en) 1996-07-24 2013-05-28 Celgene Corp Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha
US5635517B1 (en) * 1996-07-24 1999-06-29 Celgene Corp Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines
ATE530542T1 (de) 1996-07-24 2011-11-15 Celgene Corp Amino substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide zur verringerung der tnf-alpha-stufen
US6281230B1 (en) * 1996-07-24 2001-08-28 Celgene Corporation Isoindolines, method of use, and pharmaceutical compositions
US5798368A (en) * 1996-08-22 1998-08-25 Celgene Corporation Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels
WO1998006692A1 (en) * 1996-08-12 1998-02-19 Celgene Corporation Novel immunotherapeutic agents and their use in the reduction of cytokine levels
US5814328A (en) * 1997-01-13 1998-09-29 Gunasekaran; Subramanian Preparation of collagen using papain and a reducing agent
US20030203008A1 (en) * 1997-01-13 2003-10-30 Subramanian Gunasekaran Preparation of collagen
ATE358493T1 (de) * 1997-07-03 2007-04-15 Osiris Therapeutics Inc Menschliche mesenchymale stammzellen aus peripherem blut
US5874448A (en) * 1997-11-18 1999-02-23 Celgene Corporation Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels
US5955476A (en) * 1997-11-18 1999-09-21 Celgene Corporation Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels
BR9908811A (pt) * 1998-03-16 2000-12-05 Celgene Corp Composto, composição farmacêutica e seu uso no tratamento de mamìferos
CA2328524A1 (en) * 1998-05-29 1999-12-02 Osiris Therapeutics, Inc. Human cd45+ and/or fibroblast + mesenchymal stem cells
AU5526399A (en) * 1998-08-28 2000-03-21 University Of Bath, The Improvements in or relating to the treatment of lesions
CA2361806C (en) * 1999-03-18 2012-03-13 Celgene Corporation Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels
MXPA03002414A (es) * 2000-09-18 2004-07-08 Organogenesis Inc Protesis con injerto de hoja plana tratada por bioingenieria y su uso.
US6458810B1 (en) * 2000-11-14 2002-10-01 George Muller Pharmaceutically active isoindoline derivatives
WO2002046373A1 (en) * 2000-12-06 2002-06-13 Hariri Robert J Method of collecting placental stem cells
US7311905B2 (en) * 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
US20030045552A1 (en) * 2000-12-27 2003-03-06 Robarge Michael J. Isoindole-imide compounds, compositions, and uses thereof
US7091353B2 (en) * 2000-12-27 2006-08-15 Celgene Corporation Isoindole-imide compounds, compositions, and uses thereof
EP2336299A1 (en) * 2001-02-14 2011-06-22 Anthrogenesis Corporation Post-partum mammalian placenta, its use and placental stem cells therefrom
DE60225824T2 (de) * 2001-10-26 2009-04-16 Cook Biotech, Inc., West Lafayette Medizinisches implantat mit netzartiger struktur
US20050171616A1 (en) * 2002-02-04 2005-08-04 Hsing-Wen Sung Peritoneal regeneration with acellular pericardial patch
US20030187515A1 (en) * 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
AU2003262187A1 (en) 2002-04-12 2003-10-27 Celgene Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
CN1668733A (zh) * 2002-05-30 2005-09-14 细胞基因公司 利用jnk或mkk抑制剂调节细胞分化并治疗骨髓增生异常和脊髓发育不良综合症的方法
UA83504C2 (en) * 2003-09-04 2008-07-25 Селджин Корпорейшн Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
US20050079147A1 (en) * 2003-10-14 2005-04-14 Bernard Delaey Wound healing compositions and uses
US7244759B2 (en) * 2004-07-28 2007-07-17 Celgene Corporation Isoindoline compounds and methods of making and using the same
BRPI0611739A2 (pt) * 2005-06-10 2011-12-20 Celgene Corp colágeno de atelopeptìdeo, composição, método e kit para aumentar, avolumar ou substituir tecido de um mamìfero, e, processos para preparar e para reticular colágeno de atelopeptìdeo, e para reduzir a quantidade de partìculas virais em uma composição de colágeno
US7928280B2 (en) * 2005-07-13 2011-04-19 Anthrogenesis Corporation Treatment of leg ulcers using placenta derived collagen biofabric

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WO2007009062A3 (en) 2007-04-19
US20110318401A1 (en) 2011-12-29
US20070021704A1 (en) 2007-01-25
US20130184821A1 (en) 2013-07-18
US20150224219A1 (en) 2015-08-13
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US7928280B2 (en) 2011-04-19
US20150165085A1 (en) 2015-06-18

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