PE20061048A1 - Metabolitos de glucuronida y sus epimeros de tigeciclina - Google Patents

Metabolitos de glucuronida y sus epimeros de tigeciclina

Info

Publication number
PE20061048A1
PE20061048A1 PE2005001298A PE2005001298A PE20061048A1 PE 20061048 A1 PE20061048 A1 PE 20061048A1 PE 2005001298 A PE2005001298 A PE 2005001298A PE 2005001298 A PE2005001298 A PE 2005001298A PE 20061048 A1 PE20061048 A1 PE 20061048A1
Authority
PE
Peru
Prior art keywords
metabolites
tigecycline
epimers
glycuronide
refers
Prior art date
Application number
PE2005001298A
Other languages
English (en)
Inventor
Ronald A Jordan
William Demaio
Matthew Hoffmann
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20061048A1 publication Critical patent/PE20061048A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A METABOLITOS DE GLUCURONIDA DE TIGECICLINA Y SUS EPIMEROS OBTENIDOS MEDIANTE LA EXTRACCION DEL SUERO, ORINA O HECES DE UN HUMANO TRATADO CON TIGECICLINA. DICHOS METABOLITOS PRESENTAN UN PICO DE ESPECTRO DE MASA DE 762, 586, 569, 513, 211, 154 Y 86 m/z. SON METABOLITOS PREFERIDOS LOS DE FORMULA (I), (III), (V), ENTRE OTROS TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS METABOLITOS SE UTILIZAN EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS TALES COMO NEUMONIA, INFECCIONES SEVERAS DE LA PIEL
PE2005001298A 2004-11-05 2005-11-04 Metabolitos de glucuronida y sus epimeros de tigeciclina PE20061048A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62512104P 2004-11-05 2004-11-05

Publications (1)

Publication Number Publication Date
PE20061048A1 true PE20061048A1 (es) 2006-11-15

Family

ID=36337018

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2005001298A PE20061048A1 (es) 2004-11-05 2005-11-04 Metabolitos de glucuronida y sus epimeros de tigeciclina

Country Status (22)

Country Link
US (1) US7534766B2 (es)
EP (1) EP1807441A2 (es)
JP (1) JP2008519038A (es)
KR (1) KR20070085761A (es)
CN (1) CN101132799A (es)
AR (1) AR051236A1 (es)
AU (1) AU2005304957A1 (es)
BR (1) BRPI0517715A (es)
CA (1) CA2586245A1 (es)
CR (1) CR9111A (es)
GT (1) GT200500320A (es)
HN (1) HN2005030775A (es)
IL (1) IL182640A0 (es)
MX (1) MX2007005105A (es)
NO (1) NO20072226L (es)
PA (1) PA8652001A1 (es)
PE (1) PE20061048A1 (es)
RU (1) RU2007116800A (es)
SV (1) SV2006002294A (es)
TW (1) TW200628485A (es)
WO (1) WO2006052717A2 (es)
ZA (1) ZA200703624B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8217155B2 (en) * 2007-07-31 2012-07-10 Gilead Colorado, Inc. Metabolites and derivatives of ambrisentan
US8766177B2 (en) 2010-10-11 2014-07-01 University Of North Texas Nanomanipulation coupled nanospray mass spectrometry (NMS)
JP6134191B2 (ja) 2013-04-07 2017-05-24 村川 惠美 回転型セミバッチａｌｄ装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69232302D1 (de) 1991-10-04 2002-01-31 American Cyanamid Co 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
WO2005009943A2 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP4738333B2 (ja) 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド ９−アミノメチルテトラサイクリン化合物のプロドラッグ
US20050148553A1 (en) * 2003-09-05 2005-07-07 Testa Raymond T. Use of tigecycline, alone, or in combination with rifampin to treat osteomyelitis and/or septic arthritis

Also Published As

Publication number Publication date
US20060128950A1 (en) 2006-06-15
WO2006052717A2 (en) 2006-05-18
NO20072226L (no) 2007-06-04
AR051236A1 (es) 2006-12-27
BRPI0517715A (pt) 2008-10-21
JP2008519038A (ja) 2008-06-05
CN101132799A (zh) 2008-02-27
TW200628485A (en) 2006-08-16
WO2006052717A3 (en) 2007-11-15
US7534766B2 (en) 2009-05-19
EP1807441A2 (en) 2007-07-18
ZA200703624B (en) 2009-10-28
CA2586245A1 (en) 2006-05-18
AU2005304957A1 (en) 2006-05-18
IL182640A0 (en) 2007-07-24
GT200500320A (es) 2006-06-02
PA8652001A1 (es) 2006-10-13
KR20070085761A (ko) 2007-08-27
RU2007116800A (ru) 2008-12-10
SV2006002294A (es) 2006-10-13
CR9111A (es) 2008-01-21
HN2005030775A (es) 2006-12-18
MX2007005105A (es) 2007-06-26

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