BRPI0517715A - metabolitos de glicuronìdeo e epìmeros dos mesmos de tigeciclina - Google Patents

metabolitos de glicuronìdeo e epìmeros dos mesmos de tigeciclina

Info

Publication number
BRPI0517715A
BRPI0517715A BRPI0517715-4A BRPI0517715A BRPI0517715A BR PI0517715 A BRPI0517715 A BR PI0517715A BR PI0517715 A BRPI0517715 A BR PI0517715A BR PI0517715 A BRPI0517715 A BR PI0517715A
Authority
BR
Brazil
Prior art keywords
tigecycline
glycuronide
metabolites
epitomers
epigers
Prior art date
Application number
BRPI0517715-4A
Other languages
English (en)
Inventor
Ronald A Jordan
William Demaio
Matthew Hoffman
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0517715A publication Critical patent/BRPI0517715A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

METABOLITOS DE GLICURONìDEO E EPìMEROS DOS MESMOS DE TIGECICLINA.A presente invenção refere-se a um metabolito de glicuronídeo de tigeciclina, e seu epímero correspondente, que foi identificado em seres humanos tratados com tigeciclina. Dados espectrais de massa foram usados para identificar estas estruturas.
BRPI0517715-4A 2004-11-05 2005-11-03 metabolitos de glicuronìdeo e epìmeros dos mesmos de tigeciclina BRPI0517715A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62512104P 2004-11-05 2004-11-05
PCT/US2005/039944 WO2006052717A2 (en) 2004-11-05 2005-11-03 Glucuronide metabolites and epimers thereof of tigecycline

Publications (1)

Publication Number Publication Date
BRPI0517715A true BRPI0517715A (pt) 2008-10-21

Family

ID=36337018

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0517715-4A BRPI0517715A (pt) 2004-11-05 2005-11-03 metabolitos de glicuronìdeo e epìmeros dos mesmos de tigeciclina

Country Status (22)

Country Link
US (1) US7534766B2 (pt)
EP (1) EP1807441A2 (pt)
JP (1) JP2008519038A (pt)
KR (1) KR20070085761A (pt)
CN (1) CN101132799A (pt)
AR (1) AR051236A1 (pt)
AU (1) AU2005304957A1 (pt)
BR (1) BRPI0517715A (pt)
CA (1) CA2586245A1 (pt)
CR (1) CR9111A (pt)
GT (1) GT200500320A (pt)
HN (1) HN2005030775A (pt)
IL (1) IL182640A0 (pt)
MX (1) MX2007005105A (pt)
NO (1) NO20072226L (pt)
PA (1) PA8652001A1 (pt)
PE (1) PE20061048A1 (pt)
RU (1) RU2007116800A (pt)
SV (1) SV2006002294A (pt)
TW (1) TW200628485A (pt)
WO (1) WO2006052717A2 (pt)
ZA (1) ZA200703624B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8217155B2 (en) * 2007-07-31 2012-07-10 Gilead Colorado, Inc. Metabolites and derivatives of ambrisentan
US8766177B2 (en) 2010-10-11 2014-07-01 University Of North Texas Nanomanipulation coupled nanospray mass spectrometry (NMS)
JP6134191B2 (ja) 2013-04-07 2017-05-24 村川 惠美 回転型セミバッチａｌｄ装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69232302D1 (de) 1991-10-04 2002-01-31 American Cyanamid Co 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
WO2005009943A2 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP4738333B2 (ja) 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド ９−アミノメチルテトラサイクリン化合物のプロドラッグ
US20050148553A1 (en) * 2003-09-05 2005-07-07 Testa Raymond T. Use of tigecycline, alone, or in combination with rifampin to treat osteomyelitis and/or septic arthritis

Also Published As

Publication number Publication date
US20060128950A1 (en) 2006-06-15
WO2006052717A2 (en) 2006-05-18
NO20072226L (no) 2007-06-04
AR051236A1 (es) 2006-12-27
JP2008519038A (ja) 2008-06-05
PE20061048A1 (es) 2006-11-15
CN101132799A (zh) 2008-02-27
TW200628485A (en) 2006-08-16
WO2006052717A3 (en) 2007-11-15
US7534766B2 (en) 2009-05-19
EP1807441A2 (en) 2007-07-18
ZA200703624B (en) 2009-10-28
CA2586245A1 (en) 2006-05-18
AU2005304957A1 (en) 2006-05-18
IL182640A0 (en) 2007-07-24
GT200500320A (es) 2006-06-02
PA8652001A1 (es) 2006-10-13
KR20070085761A (ko) 2007-08-27
RU2007116800A (ru) 2008-12-10
SV2006002294A (es) 2006-10-13
CR9111A (es) 2008-01-21
HN2005030775A (es) 2006-12-18
MX2007005105A (es) 2007-06-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A E 6A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012.