WO2006052717A3 - Glucuronide metabolites and epimers thereof of tigecycline - Google Patents

Glucuronide metabolites and epimers thereof of tigecycline Download PDF

Info

Publication number
WO2006052717A3
WO2006052717A3 PCT/US2005/039944 US2005039944W WO2006052717A3 WO 2006052717 A3 WO2006052717 A3 WO 2006052717A3 US 2005039944 W US2005039944 W US 2005039944W WO 2006052717 A3 WO2006052717 A3 WO 2006052717A3
Authority
WO
WIPO (PCT)
Prior art keywords
tigecycline
epimers
glucuronide metabolites
glucuronide
metabolites
Prior art date
Application number
PCT/US2005/039944
Other languages
French (fr)
Other versions
WO2006052717A2 (en
Inventor
Ronald A Jordon
William Demaio
Matthew Hoffman
Original Assignee
Wyeth Corp
Ronald A Jordon
William Demaio
Matthew Hoffman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Ronald A Jordon, William Demaio, Matthew Hoffman filed Critical Wyeth Corp
Priority to RU2007116800/04A priority Critical patent/RU2007116800A/en
Priority to EP05825482A priority patent/EP1807441A2/en
Priority to JP2007540063A priority patent/JP2008519038A/en
Priority to MX2007005105A priority patent/MX2007005105A/en
Priority to CA002586245A priority patent/CA2586245A1/en
Priority to BRPI0517715-4A priority patent/BRPI0517715A/en
Priority to AU2005304957A priority patent/AU2005304957A1/en
Publication of WO2006052717A2 publication Critical patent/WO2006052717A2/en
Priority to IL182640A priority patent/IL182640A0/en
Priority to NO20072226A priority patent/NO20072226L/en
Publication of WO2006052717A3 publication Critical patent/WO2006052717A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A glucuronide metabolite of tigecycline, and its corresponding epimer, have been identified in humans treated with tigecycline. Mass spectral data have been used to identify these structures.
PCT/US2005/039944 2004-11-05 2005-11-03 Glucuronide metabolites and epimers thereof of tigecycline WO2006052717A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
RU2007116800/04A RU2007116800A (en) 2004-11-05 2005-11-03 Glucuronide Metabolites of Tigecycline and Their Epimers
EP05825482A EP1807441A2 (en) 2004-11-05 2005-11-03 Glucuronide metabolites and epimers thereof of tigecycline
JP2007540063A JP2008519038A (en) 2004-11-05 2005-11-03 Glucuronide metabolite of tigecycline and its epimer
MX2007005105A MX2007005105A (en) 2004-11-05 2005-11-03 Glucuronide metabolites and epimers thereof of tigecycline.
CA002586245A CA2586245A1 (en) 2004-11-05 2005-11-03 Glucuronide metabolites and epimers thereof of tigecycline
BRPI0517715-4A BRPI0517715A (en) 2004-11-05 2005-11-03 glycuronide metabolites and epitomers thereof of tigecycline
AU2005304957A AU2005304957A1 (en) 2004-11-05 2005-11-03 Glucuronide metabolites and epimers thereof of tigecycline
IL182640A IL182640A0 (en) 2004-11-05 2007-04-18 Glucuronide metabolites and epimers thereof of tigecycline
NO20072226A NO20072226L (en) 2004-11-05 2007-04-30 Glucuronide metabolites and their epimers of tigecycline

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62512104P 2004-11-05 2004-11-05
US60/625,121 2004-11-05

Publications (2)

Publication Number Publication Date
WO2006052717A2 WO2006052717A2 (en) 2006-05-18
WO2006052717A3 true WO2006052717A3 (en) 2007-11-15

Family

ID=36337018

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/039944 WO2006052717A2 (en) 2004-11-05 2005-11-03 Glucuronide metabolites and epimers thereof of tigecycline

Country Status (22)

Country Link
US (1) US7534766B2 (en)
EP (1) EP1807441A2 (en)
JP (1) JP2008519038A (en)
KR (1) KR20070085761A (en)
CN (1) CN101132799A (en)
AR (1) AR051236A1 (en)
AU (1) AU2005304957A1 (en)
BR (1) BRPI0517715A (en)
CA (1) CA2586245A1 (en)
CR (1) CR9111A (en)
GT (1) GT200500320A (en)
HN (1) HN2005030775A (en)
IL (1) IL182640A0 (en)
MX (1) MX2007005105A (en)
NO (1) NO20072226L (en)
PA (1) PA8652001A1 (en)
PE (1) PE20061048A1 (en)
RU (1) RU2007116800A (en)
SV (1) SV2006002294A (en)
TW (1) TW200628485A (en)
WO (1) WO2006052717A2 (en)
ZA (1) ZA200703624B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8217155B2 (en) * 2007-07-31 2012-07-10 Gilead Colorado, Inc. Metabolites and derivatives of ambrisentan
US8766177B2 (en) 2010-10-11 2014-07-01 University Of North Texas Nanomanipulation coupled nanospray mass spectrometry (NMS)
JP6134191B2 (en) 2013-04-07 2017-05-24 村川 惠美 Rotary semi-batch ALD equipment

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050148553A1 (en) * 2003-09-05 2005-07-07 Testa Raymond T. Use of tigecycline, alone, or in combination with rifampin to treat osteomyelitis and/or septic arthritis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
EP0536515B1 (en) 1991-10-04 2001-12-19 American Cyanamid Company Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
WO2005009944A1 (en) 2003-07-09 2005-02-03 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CN101863841A (en) 2003-07-09 2010-10-20 帕拉特克药品公司 The tetracycline compound that replaces

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050148553A1 (en) * 2003-09-05 2005-07-07 Testa Raymond T. Use of tigecycline, alone, or in combination with rifampin to treat osteomyelitis and/or septic arthritis

Also Published As

Publication number Publication date
US7534766B2 (en) 2009-05-19
WO2006052717A2 (en) 2006-05-18
MX2007005105A (en) 2007-06-26
EP1807441A2 (en) 2007-07-18
PE20061048A1 (en) 2006-11-15
HN2005030775A (en) 2006-12-18
TW200628485A (en) 2006-08-16
US20060128950A1 (en) 2006-06-15
AU2005304957A1 (en) 2006-05-18
ZA200703624B (en) 2009-10-28
IL182640A0 (en) 2007-07-24
GT200500320A (en) 2006-06-02
SV2006002294A (en) 2006-10-13
AR051236A1 (en) 2006-12-27
CR9111A (en) 2008-01-21
RU2007116800A (en) 2008-12-10
CA2586245A1 (en) 2006-05-18
PA8652001A1 (en) 2006-10-13
NO20072226L (en) 2007-06-04
JP2008519038A (en) 2008-06-05
BRPI0517715A (en) 2008-10-21
KR20070085761A (en) 2007-08-27
CN101132799A (en) 2008-02-27

Similar Documents

Publication Publication Date Title
EP1738398B8 (en) Mass spectrometer
WO2005117596A3 (en) Transmission for a remote catheterization system
WO2006119186A3 (en) Systems, devices, and methods for interpreting movement
EP1891678A4 (en) Photocathode structure and operation
ATE444384T1 (en) ELASTIC COMPOSITE YARN, PRODUCTION PROCESS THEREOF AND PRODUCTS BASED THEREOF
WO2006039470A9 (en) Anti- amyloid antibodies, compositions, methods and uses
IL190472A (en) Anti-glypican-3 antibodies, methods of producing same and uses thereof
WO2008054676A3 (en) Medical devices and methods of using the same
WO2007127292A3 (en) Tigeycline crystalline forms and processes for preparation thereof
WO2006023889A3 (en) A method for preparing irbesartan and intermediates thereof
MX2007004137A (en) Lightweight structural panel and method for making same.
WO2006029398A8 (en) All-trans-retinol : all-trans-13,14-dihydroretinol saturase and methods of its use
WO2006052717A3 (en) Glucuronide metabolites and epimers thereof of tigecycline
NL1028300A1 (en) Crystallization stable aluminosilicate glass, its production and application.
JP2008514710A5 (en)
WO2008010685A8 (en) Key input device and character input method using center key
EP1696451B8 (en) Electron devices with non-evaporation-type getter and method for manufacturing the same
ITMI20051155A1 (en) NEW FLUORURED COMPOUNDS, THEIR SYNTHESIS AND USE.
AU2003292832A1 (en) Method of color specification and, using the same, color column structure and color chart
EP2133082B8 (en) THE USE OF GINSENOSIDE Rg1, ITS METABOLITES GINSENOSIDE Rh1 AND/OR PpT
EP1801840A4 (en) Columnar structure, method for the production thereof and devices based thereon
WO2007005513A3 (en) Storage system
NO20043092L (en) Construction of fairing, as well as the method of manufacture and assembly thereof
AU2005905098A0 (en) Herbal mixtures, methods of making them and methods using them
AU2005905768A0 (en) Therapeutic methods, compositions and kits

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200580045955.8

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 182640

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2005825482

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: MX/a/2007/005105

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 554859

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 2007540063

Country of ref document: JP

Ref document number: 2586245

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 3294/DELNP/2007

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 12007500961

Country of ref document: PH

Ref document number: 2005304957

Country of ref document: AU

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: CR2007-009111

Country of ref document: CR

WWE Wipo information: entry into national phase

Ref document number: 07048336

Country of ref document: CO

ENP Entry into the national phase

Ref document number: 2005304957

Country of ref document: AU

Date of ref document: 20051103

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020077012638

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2007116800

Country of ref document: RU

Ref document number: 1200701116

Country of ref document: VN

WWP Wipo information: published in national office

Ref document number: 2005825482

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0517715

Country of ref document: BR