ZA200703624B - Glucuronide metabolites and epimers thereof of tigecycline - Google Patents

Glucuronide metabolites and epimers thereof of tigecycline

Info

Publication number
ZA200703624B
ZA200703624B ZA200703624A ZA200703624A ZA200703624B ZA 200703624 B ZA200703624 B ZA 200703624B ZA 200703624 A ZA200703624 A ZA 200703624A ZA 200703624 A ZA200703624 A ZA 200703624A ZA 200703624 B ZA200703624 B ZA 200703624B
Authority
ZA
South Africa
Prior art keywords
tigecycline
epimers
glucuronide metabolites
glucuronide
metabolites
Prior art date
Application number
ZA200703624A
Other languages
English (en)
Inventor
Ronald A Jordon
Demaio William
Hoffman Matthew
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ZA200703624B publication Critical patent/ZA200703624B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
ZA200703624A 2004-11-05 2007-05-04 Glucuronide metabolites and epimers thereof of tigecycline ZA200703624B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62512104P 2004-11-05 2004-11-05

Publications (1)

Publication Number Publication Date
ZA200703624B true ZA200703624B (en) 2009-10-28

Family

ID=36337018

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200703624A ZA200703624B (en) 2004-11-05 2007-05-04 Glucuronide metabolites and epimers thereof of tigecycline

Country Status (22)

Country Link
US (1) US7534766B2 (pt)
EP (1) EP1807441A2 (pt)
JP (1) JP2008519038A (pt)
KR (1) KR20070085761A (pt)
CN (1) CN101132799A (pt)
AR (1) AR051236A1 (pt)
AU (1) AU2005304957A1 (pt)
BR (1) BRPI0517715A (pt)
CA (1) CA2586245A1 (pt)
CR (1) CR9111A (pt)
GT (1) GT200500320A (pt)
HN (1) HN2005030775A (pt)
IL (1) IL182640A0 (pt)
MX (1) MX2007005105A (pt)
NO (1) NO20072226L (pt)
PA (1) PA8652001A1 (pt)
PE (1) PE20061048A1 (pt)
RU (1) RU2007116800A (pt)
SV (1) SV2006002294A (pt)
TW (1) TW200628485A (pt)
WO (1) WO2006052717A2 (pt)
ZA (1) ZA200703624B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2183223A2 (en) * 2007-07-31 2010-05-12 Gilead Colorado, Inc. Metabolites and derivatives of ambrisentan
US8766177B2 (en) * 2010-10-11 2014-07-01 University Of North Texas Nanomanipulation coupled nanospray mass spectrometry (NMS)
JP6134191B2 (ja) 2013-04-07 2017-05-24 村川 惠美 回転型セミバッチａｌｄ装置

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG52361A1 (en) 1991-10-04 1998-09-28 American Cyanamid Co Novel 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5420272A (en) 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
JP4738333B2 (ja) 2003-07-09 2011-08-03 パラテック ファーマシューティカルズ インコーポレイテッド ９−アミノメチルテトラサイクリン化合物のプロドラッグ
EP2298322A3 (en) 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20050148553A1 (en) * 2003-09-05 2005-07-07 Testa Raymond T. Use of tigecycline, alone, or in combination with rifampin to treat osteomyelitis and/or septic arthritis

Also Published As

Publication number Publication date
KR20070085761A (ko) 2007-08-27
RU2007116800A (ru) 2008-12-10
CN101132799A (zh) 2008-02-27
AR051236A1 (es) 2006-12-27
NO20072226L (no) 2007-06-04
CR9111A (es) 2008-01-21
WO2006052717A3 (en) 2007-11-15
US20060128950A1 (en) 2006-06-15
PE20061048A1 (es) 2006-11-15
JP2008519038A (ja) 2008-06-05
EP1807441A2 (en) 2007-07-18
HN2005030775A (es) 2006-12-18
TW200628485A (en) 2006-08-16
US7534766B2 (en) 2009-05-19
PA8652001A1 (es) 2006-10-13
GT200500320A (es) 2006-06-02
WO2006052717A2 (en) 2006-05-18
MX2007005105A (es) 2007-06-26
IL182640A0 (en) 2007-07-24
AU2005304957A1 (en) 2006-05-18
SV2006002294A (es) 2006-10-13
CA2586245A1 (en) 2006-05-18
BRPI0517715A (pt) 2008-10-21

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