PE20050669A1 - Biaril sulfonamidas - Google Patents
Biaril sulfonamidasInfo
- Publication number
- PE20050669A1 PE20050669A1 PE2004001190A PE2004001190A PE20050669A1 PE 20050669 A1 PE20050669 A1 PE 20050669A1 PE 2004001190 A PE2004001190 A PE 2004001190A PE 2004001190 A PE2004001190 A PE 2004001190A PE 20050669 A1 PE20050669 A1 PE 20050669A1
- Authority
- PE
- Peru
- Prior art keywords
- biaryl
- benzofuran
- biphenyl
- amino
- sulphonamides
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
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Abstract
REFERIDA A UN METODO DE MODULACION (INHIBICION) DE UNA METALOPROTEINA DONDE SE UNE UNA METALOPROTEINASA TAL COMO GELATINASA A, METALOELASTASA DE MACROFAGO, COLAGENASA-3, ENTRE OTRAS; CON UNA CANTIDAD DE BIARIL SULFONAMIDA UNIDA A UN GRUPO HETEROARILO TAL COMO FURANO, 1,2,4-OXADIAZOL, IMIDAZOL, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-({4'[1-BENZOFURAN-2-ILCARBONIL)-AMINO]-1,1'-BIFENIL-4-IL}-SULFONIL)-GLICINA, ACIDO L-2-{4'-[(BENZOFURAN-2-CARBONIL)-AMINO]-BIFENIL-4-SULFONILAMINO}-3-METIL-BUTIRICO, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE OSTEOARTRITIS, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA, ENTRE OTRAS
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US52684003P | 2003-12-04 | 2003-12-04 | |
PCT/US2003/040835 WO2005061477A1 (en) | 2003-12-04 | 2003-12-22 | Biaryl sulfonamides as mmp inhibitors |
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CN (1) | CN1623537A (es) |
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TW (1) | TW200519100A (es) |
WO (1) | WO2005061477A1 (es) |
ZA (1) | ZA200604551B (es) |
Families Citing this family (26)
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JP2007525406A (ja) * | 2003-12-04 | 2007-09-06 | ワイス | ビアリールスルホンアミドおよびその使用方法 |
US20080119513A1 (en) * | 2004-09-06 | 2008-05-22 | Fumihiko Watanabe | Sulfonamide Derivative Selectively Inhibiting Mmp-13 |
JP2009505962A (ja) * | 2005-07-29 | 2009-02-12 | バイエル・ヘルスケア・エルエルシー | 肥満を治療するためのビフェニルアミノ酸誘導体の製造および使用 |
CN101300345A (zh) * | 2005-08-25 | 2008-11-05 | 惠氏公司 | 聚集蛋白聚糖酶结构 |
US7615363B2 (en) * | 2005-08-25 | 2009-11-10 | Wyeth | Aggrecanase structure |
CN101378758A (zh) * | 2006-02-08 | 2009-03-04 | 惠氏公司 | 经由钯介导的偶联反应制备7-烯基-3氰基喹啉 |
ES2430115T3 (es) * | 2006-03-31 | 2013-11-19 | Novartis Ag | Inhibidor de DGAT |
WO2008147763A1 (en) * | 2007-05-23 | 2008-12-04 | Array Biopharma Inc. | Mmp inhibitors and methods of use thereof |
EP2321268A2 (en) * | 2008-08-15 | 2011-05-18 | F. Hoffmann-La Roche AG | Bi-aryl aminotetralines |
AU2009316786A1 (en) * | 2008-11-19 | 2010-05-27 | Merck Sharp & Dohme Corp. | Inhibitors of diacylglycerol acyltransferase |
WO2011031628A1 (en) * | 2009-09-14 | 2011-03-17 | Schering Corporation | Inhibitors of diacylglycerol acyltransferase |
US8530453B2 (en) * | 2009-09-28 | 2013-09-10 | Aquilus Pharmaceuticals, Inc. | Compounds and methods for the treatment of pain and other diseases |
US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
US8895737B2 (en) | 2010-07-16 | 2014-11-25 | Shashank Shekhar | Process for preparing antiviral compounds |
NZ704603A (en) | 2010-07-16 | 2016-06-24 | Abbvie Inc | Phosphine ligands for catalytic reactions |
US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
JP2014514259A (ja) * | 2011-03-02 | 2014-06-19 | アクイラス ファーマシューティカルズ, インコーポレイテッド | 疼痛および他の障害の処置のための化合物および方法 |
EA201491606A1 (ru) | 2012-04-05 | 2015-03-31 | Схди Фаундейшн, Инк. | Ингибиторы кинуренин-3-монооксигеназы, фармацевтические композиции и способы их применения |
CN103333144B (zh) * | 2013-06-17 | 2014-12-10 | 温州大学 | 一种2-硫基-3-卤代苯并呋喃化合物及其合成方法和用途 |
US9938252B2 (en) | 2013-09-26 | 2018-04-10 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
US9884853B2 (en) | 2013-09-26 | 2018-02-06 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
KR20160066490A (ko) | 2014-12-02 | 2016-06-10 | 주식회사 씨앤드씨신약연구소 | 헤테로사이클 유도체 및 그의 용도 |
WO2017180723A1 (en) | 2016-04-12 | 2017-10-19 | Atrin Pharmaceuticals LLC | Ataxia telengiectasia and rad3-related (atr) inhibitors and methods of their use |
CN106905348B (zh) * | 2017-02-13 | 2018-12-04 | 牡丹江医学院 | 一种预防和治疗急性肾损伤的药物及其制备方法和用途 |
CN112480020B (zh) * | 2020-12-11 | 2023-10-10 | 东华理工大学 | 一种2-取代苯并恶唑化合物 |
CN113527152B (zh) * | 2021-08-09 | 2023-07-28 | 西北农林科技大学 | 一种联苯磺酰胺类化合物及其防治农作物害虫的方法 |
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TR199801419T2 (xx) * | 1996-01-23 | 1998-10-21 | Shionogi & Co.Ltd. | S�lfone amino asit t�revleri ve ayn� i�erikte metaloproteinez �nleyicileri. |
BR0009244A (pt) * | 1999-03-03 | 2002-04-16 | Procter & Gamble | Inibidores de metaloprotease di-hétero substituìdos |
TR200200977T2 (tr) * | 1999-10-14 | 2002-08-21 | The Procter & Gamble Company | Beta konumunda iki kere sübstitüe edilmiş metaloproteaz engelleyiciler |
JP2007525406A (ja) * | 2003-12-04 | 2007-09-06 | ワイス | ビアリールスルホンアミドおよびその使用方法 |
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- 2003-12-22 WO PCT/US2003/040835 patent/WO2005061477A1/en active Application Filing
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- 2003-12-22 AU AU2003299789A patent/AU2003299789A1/en not_active Abandoned
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- 2004-01-13 TW TW093100794A patent/TW200519100A/zh unknown
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- 2004-12-01 US US11/001,589 patent/US7420001B2/en not_active Expired - Fee Related
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- 2004-12-03 PA PA20048618901A patent/PA8618901A1/es unknown
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- 2006-06-13 EC EC2006006637A patent/ECSP066637A/es unknown
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EP1692124B1 (en) | 2008-10-15 |
CR8418A (es) | 2007-08-28 |
JP2007524567A (ja) | 2007-08-30 |
EP1692124A1 (en) | 2006-08-23 |
AU2003299789A1 (en) | 2005-07-14 |
AR046859A1 (es) | 2005-12-28 |
TW200519100A (en) | 2005-06-16 |
KR20060093735A (ko) | 2006-08-25 |
CN1623537A (zh) | 2005-06-08 |
ECSP066637A (es) | 2006-10-25 |
BR0318640A (pt) | 2006-11-28 |
DE60324208D1 (de) | 2008-11-27 |
PA8618901A1 (es) | 2005-11-25 |
RU2006123559A (ru) | 2008-01-10 |
WO2005061477A1 (en) | 2005-07-07 |
ATE411306T1 (de) | 2008-10-15 |
US20050143422A1 (en) | 2005-06-30 |
IL159679A0 (en) | 2004-06-20 |
US7420001B2 (en) | 2008-09-02 |
ZA200604551B (en) | 2008-11-26 |
AU2004200247A1 (en) | 2005-06-23 |
CA2548518A1 (en) | 2005-07-07 |
US20100137298A1 (en) | 2010-06-03 |
NO20062649L (no) | 2006-09-01 |
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