PE20040951A1 - Derivados ciclicos como moduladores de la actividad del receptor de quimiocina - Google Patents

Derivados ciclicos como moduladores de la actividad del receptor de quimiocina

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Publication number
PE20040951A1
PE20040951A1 PE2004000154A PE2004000154A PE20040951A1 PE 20040951 A1 PE20040951 A1 PE 20040951A1 PE 2004000154 A PE2004000154 A PE 2004000154A PE 2004000154 A PE2004000154 A PE 2004000154A PE 20040951 A1 PE20040951 A1 PE 20040951A1
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PE
Peru
Prior art keywords
alkyl
nr8c
pyrrolidin
oxo
trifluoromethyl
Prior art date
Application number
PE2004000154A
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English (en)
Inventor
Robert J Cherney
Percy Carter
John V Duncia
Daniel S Gardner
Joseph B Santella
Original Assignee
Bristol Myers Squibb Co
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Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20040951A1 publication Critical patent/PE20040951A1/es

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
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Abstract

SE REFIERE A DERIVADOS CICLICOS DE FORMULA I DONDE EL ANILLO B ES UN CICLOALQUILO C3-C8 SATURADO O PARCIALMENTE INSATURADO, UN HETEROCICLO DE 3-7 MIEMBROS SATURADO O PARCIALMENTE SATURADO CON HETEROATOMOS SELECCIONADOS DE O, S, S(=O), S(=O)2, ENTRE OTROS; X ES O o S; Z ES UN ENLACE, NR8C(O), NR8C(S), NR8C(O)NH, ENTRE OTROS; CON LA CONDICION DE QUE NI Z NI R13 SE CONECTAN CON EL CARBONO (b); EL ENLACE (a) ES UN ENLACE SENCILLO O DOBLE; E ES S(O)pCHRe, CHReNRe, C(O)NRe, ENTRE OTROS; Re ES H o ALQUILO C1-C3; R1 Y R2 SON ARILO C6-C10 o HETEROARILO DE 5-10 MIEMBROS CON 1-4 HETEROATOMOS SELECCIONADOS DE N, O y S; R8 ES H, ALQUILO C1-C4 o CICLOALQUILO C3-C8; R10 ES H o ALQUILO C1-C4 o DOS R10 FORMAN =O; R11 Y R12 SON, INDEPENDIENTEMENTE ENTRE SI, H, ALQUILO C1-C4, ENTRE OTROS; R13 ES H o ALQUILO C1-C4; m ES 0 o 1; n ES 0-3; p ES 0-2; s ES 0 o 1. SON COMPUESTOS PREFERIDOS: ESTER TERT-BUTILICO DEL ACIDO 2-{(3S)-1-[(1,2-CIS)-2-(4-METILSULFANIL-BENZOILAMINO)-CICLOHEXIL]-2-OXO-PIRROLIDIN-3-ILCARBAMOIL}-4-TRIFLUOROMETIL-FENIL)-CARBAMICO; 2-{(3S)-1-[(1,2-CIS)-2-(4-METILSULFANIL-BENZOILAMINO)-CICLOHEXIL]-2-OXO-PIRROLIDIN-3-ILCARBAMOIL}-4-TRIFLUOROMETIL-FENIL)-AMINO; N-{(3S)-1-[(1S,2R,4R)-(ISOPROPIL-METIL-AMINO)-2-(TOLUENO-4-SULFONILMETIL)-CICLOHEXIL]-2-OXO-PIRROLIDIN-3-IL}-3-TRIFLUOROMETIL-BENZAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON MODULADORES DE LA ACTIVIDAD DE QUIMIOCINA, ESPECIALMENTE DEL RECEPTOR MCP-1
PE2004000154A 2003-02-12 2004-02-12 Derivados ciclicos como moduladores de la actividad del receptor de quimiocina PE20040951A1 (es)

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AR (1) AR043694A1 (es)
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CA2432369A1 (en) 2000-12-20 2002-08-08 Bristol-Myers Squibb Pharma Company Cyclic derivatives as modulators of chemokine receptor activity
ITRE20010042A1 (it) * 2001-04-24 2002-10-24 Corghi Spa Dispositivo sollevatore per macchine smontagomme
AU2003218028A1 (en) 2002-03-08 2003-09-22 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
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