AR043694A1 - Derivados ciclicos como moduladores de la actividad del receptor de quimiocina - Google Patents

Derivados ciclicos como moduladores de la actividad del receptor de quimiocina

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Publication number
AR043694A1
AR043694A1 ARP040100419A ARP040100419A AR043694A1 AR 043694 A1 AR043694 A1 AR 043694A1 AR P040100419 A ARP040100419 A AR P040100419A AR P040100419 A ARP040100419 A AR P040100419A AR 043694 A1 AR043694 A1 AR 043694A1
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AR
Argentina
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substituted
crr
alkyl
alkynyl
alkenyl
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ARP040100419A
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R J Cherney
P H Carter
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Bristol Myers Squibb Co
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Publication of AR043694A1 publication Critical patent/AR043694A1/es

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    • C07D207/36—Oxygen or sulfur atoms
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Abstract

Un compuesto cíclico de la fórmula (1) o un estereoisómero o una sal farmacéuticamente aceptable de los mismos, en donde el anillo B es un grupo cicloalquilo de 3 hasta 8 átomos de carbono en donde el grupo cicloalquilo está saturado o parcialmente insaturado; o un heterociclo de 3 hasta 7 átomos en donde el heterociclo está saturado o parcialmente insaturado, el heterociclo contiene un heteroátomo seleccionado de -O-, -S-, -S(=O)-, -S(=O)2-, y -N(R4)-, el heterociclo contiene opcionalmente un -C(O)-; el anillo B está substituido con 0-2 R5; X se selecciona de O ó S; Z se selecciona de un enlace, -C(O)-, y -C(O)NR8-, NR8C(S)-, NR8C(O)NH-, NR8C(S)NH-, NR8SO2-, NR8SO2NH-, -C(O)NR8-, -OC(O)NR8-, -NR8C(O)O-, -(CR15R15)-, -CR14=CR14-, -CR15R15C(O)-, -C(O)R15R15-, -CR15R15C(=N-OR16)-, -O-CR14R14-, -CR14R14-O-, -O-, _NR9-, -NR9-CR14R14-, -CR14R14-NR9-, -S(O)p-, -S(O)p-CR14R14-, -CR14R14-S(O)p-, y -S(O)p-NR9; en donde ni Z ni R13 se conectan al átomo de carbono etiquetado (b); el enlace (a) es un enlace sencillo o doble; alternativamente, cuando n es igual a 2, dos átomos etiquetados (b) pueden unirse a través de un enlace doble; E se selecciona de -S(O)pCHRe-, -CHReNRe-, -C(O)-NRe-, -NReC(O)NRe-, -SO2-NRe-, y -NReSO2NRe ;Re se selecciona independientemente de H y alquilo C1-3; R1 se selecciona de un grupo arilo C6-10 substituido con 0-5 R6 y un sistema heteroarilo de 5-10 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-3 R6 ;R2 se selecciona de un grupo C6-10 arilo substituido con 0-5 R7 y un sistema heteroarilo de 5-10 miembros que contiene 1-4 heteroátomos seleccionados de N, O, y S, substituido con 0-3 R7; R4 se selecciona de H, alquilo C1-6, alquenilo C3-8, alquinilo C3-8, (CRR)tOH, (CRR)tSH, (CRR)tOR4d, (CHR)tSR4d, (CRR)tNR4aR4a, (CRR)qC(O)OH, (CRR)rC(O)R4b, (CRR)rC(O)NR4aR4a, (CRR)tOC(O)NR4aR4a, (CRR)tNR4aC(O)OR4d, (CRR)tNR4aC(O)R4b, (CRR)rC(O)OR4d, (CRR)tOC(O)R4b, (CRR)rS(O)pR4b, (CRR)rS(O)2NR4aR4a, (CRR)tNR4aS(O)2R4b, haloalquilo C1-6, un residuo carbocíclico (CRR)r-C3-10 substituido con 0-3 R4e, y un sistema heterocíclico (CHR)r- de 4-10 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-2 R4e ; R4a, cada vez que se presenta, se selecciona independientemente de H, metilo substituido con 0-1R4C, alquilo C2-6 substituido con 0-3 R4e, alquenilo C3-8 substituido con 0-3 R4e, alquinilo C3-8 substituido con 0-3 R4e, un residuo carbocíclico(CH2)r- C3-10 substituido con 0-4 R4e, y un sistema heterocíclico (CHR)r- de 4-10 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-2 R4e ; R4b, cada vez que se presenta, se selecciona de H, alquilo C1-6 substituido con 0-3R4e, alquenilo C3-8 substituido con 0-3 R4e, alquinilo C3-8 substituido con 0-3 R4e, un residuo carbocíclico (CH2)r- C3-6 substituido con 0-2 R4e, y un sistema heterocíclico (CHR)r- de 4-10 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-2 R4e; R4c se selecciona independientemente de -C(O)R4b, -C(O)OR4d, -C(O)NR4fR4f, y (CH2)rfenilo; R4d, cada vez que se presenta, se selecciona de metilo, CF3, alquilo C2-6 substituido con 0-3R4e, alquenilo C3-8 substituido con 0-3R4e, alquinilo C3-8 substituido con 0-3 R4e, y un residuo carbocíclico C3-10 substituido con 0-3 R4e ; R4e, cada vez que se presenta, se selecciona de alquilo C1-6, alquenilo C2-8, alquinilo C2-8, cicloalquilo (CH2)rC3-6, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOalquilo C1-5, OH, SH, (CH2)rSalquilo C1-5, (CH2)rNR4fR4f, -C(O)R4i, -C(O)OR4j, -C(O)NR4hR4h, -OC(O)NR4hR4h, -NR4hC(O)NR4hR4h, -NR4hC(O)OR4h, y (CH2)rfenilo; R4f cada vez que se presenta, se selecciona de H, alquilo C1-6, cicloalquilo C3-6 y fenilo; R4h cada vez que se presenta, se selecciona independientemente de H, alquilo C1-6, alquenilo C3-8, alquinilo C3-8 y un carbociclo (CH2)r C3-10; R4i cada vez que se presenta, se selecciona de H, alquilo C1-6, alquenilo C3-8, alquinilo C3-8 y un carbociclo (CH2)r C3-10; R4j cada vez que se presenta, se selecciona de CF3, alquilo C1-6, alquenilo C3-8, alquinilo C3-8 y un residuo carbocíclico C3-10; R5, cada vez que se presenta, se selecciona independientemente H, =O, alquilo C1-6, alquenilo C2-8, alquinilo C2-8, (CRR)rOH, (CRR)rSH, (CRR)rOR5d, (CRR)rSR5d, (CRR)rNR5aR5a, (CRR)rN(->O)R5aR5a, N3, (CRR)rC(O)OH, (CRR)rC(O)R5b, (CRR)rC(O)NR5aR5a, (CRR)rNR5aC(O)R5b, (CRR)rOC(O)NR5aR5a, (CRR)rNR5aC(O)OR5d, (CRR)rNR5aC(O)NR5aR5a, (CRR)rNR5aC(O)H, (CRR)rC(O)OR5d, (CRR)rOC(O)R5b, (CRR)rS(O)pR5b, (CRR)rS(O)2NR5aR5a, (CRR)rNR5aS(O)2R5b, (CRR)rNR5aS(O)2NR5aR5a, haloalquilo C1-6, un residuo carbocíclico (CRR)r- C3-10 substituido con 0-3 R5c, y un sistema heterocíclico (CRR)r de 5-10 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-2 R5c; R5a, cada vez que se presenta, se selecciona independientemente de H, metilo substituido con 0-1 R5g, alquilo C2-6 substituido con 0-2 R5e, alquenilo C3-8 substituido con 0-2 R5e, alquinilo C3-8 substituido con 0-2 R5e, un residuo carbocíclico (CH2)r- C3-10 substituido con 0-5 R5e, un sistema heterocíclico (CH2)r de 5-10 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-3R5e; R5b cada vez que se presenta, se selecciona de alquilo C1-6 substituido con 0-3 R5e, alquenilo C3-8 substituido con 0-2 R5e, alquinilo C3-8 substituido con 0-2 R5e, un residuo carbocíclico(CH2)r- substituido con 0-2 R5e y un sistema heterocíclico(CH2)r de 5-6 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-3 R5e; R5c, cada vez que se presenta, se selecciona de alquilo C1-6, alquenilo C2-8, alquinilo C2-8, cicloalquilo(CH2)r C3-6, Cl, Br, I, F, (CF2)rCF3, NO2, CN, (CH2)rNR5fR5f, (CH2)rOH, (CH2)rOalquilo C1-4, (CH2)rSalquilo C1-4, (CH2)rC(O)OH, (CH2)rC(O)R5b, (CH2)rC(O)NR5fR5f, (CH2)rOC(O)NR5fR5f, (CH2)rNR5fC(O)R5b, (CH2)rC(O)Oalquilo C1-4, (CH2)rNR5fC(O)Oalquilo C1-4, (CH2)rOC(O)R5b, (CH2)C(=NR5f)R5fR5f, (CH2)rS(O)pR5b, (CH2)rNHC(=NR5f)NR5fR5f, (CH2)rS(O)2NR5fR5f, (CH2)NR5fS(O)2R5b y (CH2)rfenilo substituido con 0-3 R5e; R5d cada vez que se presenta, se selecciona de metilo, CF3, alquilo C2-6 substituido con 0-2 R5e, alquenilo C3-8 substituido con 0-2 R5e, alquinilo C3-8 substituido con 0-2 R5e, un residuo carbocíclico C3-10 substituido con 0-3 R5e; R5e cada vez que se presenta, se selecciona de alquilo C1-6, alquenilo C2-8, alquinilo C2-8,cicloalquilo C3-6, Cl, F, Br, I, CN, NO2, (CF2)rCF3, (CH2)rOalquilo C1-5, OH, SH, (CH2)rSalquilo C1-5, (CH2)rNR5fR5f, y (CH2)rfenilo; R5f, cada vez que se presenta, se selecciona de H, alquilo, y cicloalquilo ; R5g se selecciona independientemente de -C(O)R5b, -C(O)OR5d, - C(O)NR5fR5f, CN, y (CH2)rfenilo ; R, cada vez que se presenta, se selecciona de H, alquilo C1-6 substituido con R5e, alquenilo C2-8, alquinilo C2-8, cicloalquilo(CH2)r C3-6, y (CH2)rfenilo substituido con R5e ;R6, cada vez que se presenta, se selecciona de alquilo C1-8, alquenilo, alquinilo, cicloalquilo(CH2)r C3-6, Cl, Br, I, F, NO2, CN, (CR'R')rNR6aR6a, (CR'R')rOH, (CR'R')rO(CR'R')rR6d, (CR'R')rSH, (CR'R')rC(O)H, (CR'R')rS(CR'R')rR6d, (CR'R')rSC(O)(CR'R')rR6b, (CR'R')rC(O)OH, (CR'R')rC(O)(CR'R')rR6b, (CR'R')rNR6aR6a, (CR'R')rC(O)NR6aR6a, (CR'R')rNR6fC(O)(CR'R')rR6b, (CR'R')rC(O)O(CR'R')rR6d, (CR'R')rOC(O)(CR'R')rR6b, (CR'R')rOC(O)NR6a(CR'R')rR6d, (CR'R')rNR6aC(O)NR6a(CR'R')rR6d, (CR'R')rNR6aC(S)NR6a(CR'R')rR6d, (CR'R')rNR6fC(O)O(CR'R')rR6b, (CR'R')rC(=NR6f)NR6aR6a, (CR'R')rNHC(=NR6f)NR6fR6f, (CR'R')rS(O)p(CR'R')rR6b, (CR'R')rS(O)2NR6aR6a, (CR'R')rNR6fS(O)2NR6aR6a, (CR'R')rNR6fS(O)2(CR'R')rR6b, haloalquilo, alquenilo substituido con 0-3 R', alquinilo substituido con 0-3 R', (CR'R')rfenilo substituido con 0-3 R6e, y un sistema heterocíclico(CH2)r de 5-6 miembros que contiene 1-2 heteroátomos seleccionado de N, O, y S, substituido con 0-2 R6e ; alternativamente, dos R6 en los átomos adyacentes en R1 pueden unirse para formar un acetal cíclico; R6a, cada vez que se presenta, se selecciona de H, metilo substituido con 0-1 R6g,alquilo substituido con 0-2 R6e, alquenilo substituido con 0-2 R6e, alquinilo substituido con 0-2 R6e, un residuo carbocíclico (CH2)r- C3-10 substituido con 0-5 R5e, un sistema heterocíclico(CH2)r de 5-10 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-2 R6e ; R6b, cada vez que se presenta, se selecciona de H, alquilo C1-6 substituido con 0-2 R6e, alquenilo C3-8 substituido con 0-2 R6e, alquinilo C3-8 substituido con 0-2 R6e, un residuo carbocíclico(CH2)r- C3-6 substituido con 0-3 R6e, un sistema heterocíclico(CH2)r de 5-6 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-2 R6e ; R6d cada vez que se presenta, se selecciona de alquenilo C3-8 substituido con 0-2 R6e, alquinilo C3-8 substituido con 0-2 R6e, metilo, CF3, alquilo C2-6 substituido con R6e, haloalquilo C2-4, un residuo carbocíclico(CH2)r- C3-10 substituido con 0-3 R6e, un sistema heterocíclico(CH2)r de 5-6 miembros que contiene 1-4 heteroátomos seleccionado de N, O, y S, substituido con 0-3 R6e; R6e, cada vez que se presenta, se selecciona de alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo(CH2)r C3-6, Cl, F, Br, I, CN, NO2, (CF2)rCFu, alquilo(CH2)rO C1-6OH, SH, alquilo (CH2)rS C1-6, (CH2)rNR6fR6f, y (CH2)rfenilo; R6f, cada vez que se presenta, se selecciona de H, alquilo C1-5, y cicloalquilo C3-6, y fenilo; R6g se selecciona independientemente de -C(O)R6b, -C(O)OR6d, -C(O)NR6fR6f, y (CH2)rfenilo; R7, cada vez que se presenta, se selecciona de alquilo C1-6, alquenilo C2-8, alquinilo C2-8, cicloalquilo(CH2)r C3-6, Cl, Br, I, F, NO2, CN, (CR'R')rNR7aR7a, (CR'R')rOH, (CR'R')rO(CR'R')rR7d, (CR'R')rSH, (CR'R')rC(O)H, (CR'R')rS(CR'R')rR7d, (CR'R')rC(O)OH, (CR'R')rC(O)(CR'R')rR7b, (CR'R')rC(O)NR7aR7a, (CR'R')rNR7fC(O)(CR'R')rR7b, (CR'R')rC(O)O(CR'R')rR7d, (CR'R')rOC(O)(CR'R') rR7b, (CR'R')rOC(O)NR7a(CR'R')rR7a, (CR'R')rNR7aC(O)NR7a(CR'R')rR7a, (CR'R')rNR7fC(O)O(CR'R')rR7d, (CR'R')rC(=NR7f)NR7aR7a, (CR'R')rNHC(=NR7f)NR7f
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Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005506949A (ja) 2000-12-20 2005-03-10 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体の調節剤としてのジアミン
CA2432369A1 (en) 2000-12-20 2002-08-08 Bristol-Myers Squibb Pharma Company Cyclic derivatives as modulators of chemokine receptor activity
ITRE20010042A1 (it) * 2001-04-24 2002-10-24 Corghi Spa Dispositivo sollevatore per macchine smontagomme
WO2003075853A2 (en) 2002-03-08 2003-09-18 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US7338975B2 (en) 2003-02-12 2008-03-04 Bristol-Myers Squibb Co. Lactams as modulators of chemokine receptor activity
TW200508224A (en) * 2003-02-12 2005-03-01 Bristol Myers Squibb Co Cyclic derivatives as modulators of chemokine receptor activity
US7291615B2 (en) 2003-05-01 2007-11-06 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US7230133B2 (en) 2003-05-01 2007-06-12 Bristol-Myers Squibb Company Malonamides and malonamide derivatives as modulators of chemokine receptor activity
US7163937B2 (en) 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US7317019B2 (en) * 2003-08-21 2008-01-08 Bristol Myers Squibb Co. N-alkylated diaminopropane derivatives as modulators of chemokine receptor activity
EP1692506A4 (en) * 2003-11-17 2008-01-09 Janssen Pharmaceutica Nv MODELING A SYSTEMIC INFLAMMATORY RESPONSE TO INFECTION
US7541468B2 (en) * 2004-06-10 2009-06-02 Bristol-Myers Squibb Company Process of preparing N-ureidoalkyl-piperidines
EP1830841B1 (en) * 2004-12-20 2008-07-02 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JPWO2006104280A1 (ja) * 2005-03-31 2008-09-11 武田薬品工業株式会社 糖尿病の予防・治療剤
US7825244B2 (en) 2005-06-10 2010-11-02 Janssen Pharmaceutica Nv Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
US8071768B2 (en) 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
US20100016289A1 (en) * 2005-11-01 2010-01-21 Kevin Sprott Compounds Useful as Antagonists of CCR2
US8067415B2 (en) * 2005-11-01 2011-11-29 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of CCR2
WO2007053498A1 (en) 2005-11-01 2007-05-10 Millennium Pharmaceuticals, Inc. Compounds useful as antagonists of ccr2
WO2007076034A2 (en) * 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
WO2007081517A2 (en) 2005-12-21 2007-07-19 Abbott Laboratories Anti-viral compounds
US7629351B2 (en) 2006-07-28 2009-12-08 Bristol-Myers Squibb Company N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino) pyrrolidin-1-yl)cyclohexyl)acetamide and other modulators of chemokine receptor activity, crystalline forms and process
US7671062B2 (en) 2006-07-28 2010-03-02 Bristol-Myers Squibb Company Modulators of chemokine receptor activity, crystalline forms and process
US7687508B2 (en) 2006-07-28 2010-03-30 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
AU2007303846B2 (en) 2006-10-04 2011-03-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists
TWI399380B (zh) 2006-12-20 2013-06-21 Abbott Lab 抗病毒化合物
US20090324596A1 (en) 2008-06-30 2009-12-31 The Trustees Of Princeton University Methods of identifying and treating poor-prognosis cancers
US10745701B2 (en) 2007-06-28 2020-08-18 The Trustees Of Princeton University Methods of identifying and treating poor-prognosis cancers
AR074830A1 (es) 2008-12-19 2011-02-16 Cephalon Inc Pirrolotriazinas como inhibidores de alk y jak2
JP2012513410A (ja) 2008-12-23 2012-06-14 アボット・ラボラトリーズ 抗ウイルス化合物
US8541424B2 (en) * 2008-12-23 2013-09-24 Abbott Laboratories Anti-viral compounds
RU2541571C2 (ru) * 2009-04-15 2015-02-20 Эббви Инк. Противовирусные соединения
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
SG171708A1 (en) 2009-06-11 2011-07-28 Abbott Lab Anti-viral compounds to treat hcv infection
US8383812B2 (en) 2009-10-13 2013-02-26 Bristol-Myers Squibb Company N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
WO2013019966A1 (en) 2011-08-04 2013-02-07 Allergan, Inc. Aromatic bycyclic derivatives as cxcr4 receptor modulators
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
CN103910688B (zh) * 2013-01-04 2016-05-25 陈春麟 2-丙基-4-氯喹唑啉衍生物及其制备方法和应用
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
EP3409674B1 (en) 2013-10-17 2022-04-06 Blueprint Medicines Corporation Process for preparing compositions useful for treating disorders related to kit
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
SG11201804901WA (en) 2015-12-22 2018-07-30 SHY Therapeutics LLC Compounds for the treatment of cancer and inflammatory disease
CN106831441B (zh) * 2017-01-23 2019-04-02 江苏康思尔医药科技有限公司 一种盐酸西那卡塞的制备方法
WO2018183712A1 (en) 2017-03-31 2018-10-04 Blueprint Medicines Corporation Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr
US10588894B2 (en) 2017-06-21 2020-03-17 SHY Therapeutics LLC Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
BR112020008833A2 (pt) * 2017-11-02 2020-10-20 Calico Life Sciences Llc moduladores da via de estresse integrada
EP3704115A1 (en) 2017-11-02 2020-09-09 Calico Life Sciences LLC Modulators of the integrated stress pathway
AU2019232704B2 (en) 2018-03-05 2024-03-21 Bristol-Myers Squibb Company Phenylpyrrolidinone formyl peptide 2 receptor agonists
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
WO2020210293A1 (en) 2019-04-12 2020-10-15 Blueprint Medicines Corporation Pyrrolotriazine derivatives for treating kit- and pdgfra-mediated diseases
DK3856341T3 (da) 2019-04-12 2023-12-04 Blueprint Medicines Corp Krystallinske former af (s)-1-(4-fluorphenyl)-1-(2-(4-(6-(1-methyl-1h-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazinyl)-pyrimidin-5-yl)ethan-1-amin og fremgangsmåder til fremstilling deraf
KR20220158290A (ko) * 2020-02-21 2022-11-30 미토키닌, 인크. 신경퇴행성 및 미토콘드리아 질환의 치료를 위한 조성물 및 이를 사용하는 방법
US20230357239A1 (en) 2020-09-18 2023-11-09 Bayer Aktiengesellschaft Pyrido[2,3-d]pyrimidin-4-amines as sos1 inhibitors
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
BG113517A (bg) * 2022-04-04 2023-10-16 "Мицар Иновейшън" ООД Пан-хемокинови антагонисти за използване при превенция и намаляване на ракови метастази
WO2024056782A1 (en) 2022-09-16 2024-03-21 Bayer Aktiengesellschaft Sulfone-substituted pyrido[3,4-d]pyrimidine derivatives for the treatment of cancer
WO2024079252A1 (en) 2022-10-13 2024-04-18 Bayer Aktiengesellschaft Sos1 inhibitors

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2653123B1 (fr) * 1989-10-17 1992-01-17 Roussel Uclaf Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5892039A (en) 1995-08-31 1999-04-06 Schering Corporation Piperazino derivatives as neurokinin antagonists
DE19614204A1 (de) 1996-04-10 1997-10-16 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
US6011052A (en) * 1996-04-30 2000-01-04 Warner-Lambert Company Pyrazolone derivatives as MCP-1 antagonists
WO1997044329A1 (en) 1996-05-20 1997-11-27 Teijin Limited Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
WO1998006703A1 (en) 1996-08-14 1998-02-19 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9716656D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
CN1279668A (zh) 1997-11-18 2001-01-10 帝人株式会社 环胺衍生物及其作为药物的用途
UA59433C2 (uk) * 1998-01-27 2003-09-15 Авентіс Фармасьютікалс Продактс Інк. ЗАМІЩЕНІ ОКСОАЗАГЕТЕРОЦИКЛІЧНІ ІНГІБІТОРИ ФАКТОРА Хa ТА ПРОМІЖНІ СПОЛУКИ ДЛЯ ЇХ ОТРИМАННЯ
GB9803228D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
US6541208B1 (en) 1998-03-17 2003-04-01 University Of Maryland Biotechnology Institute Diagnostic method for distinguishing HIV-associated dementia from other forms of dementia
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
WO2000069815A1 (en) 1999-05-13 2000-11-23 Teijin Limited Ureido-substituted cyclic amine derivatives and their use as drug
ATE277903T1 (de) 1999-05-14 2004-10-15 Bristol Myers Squibb Pharma Re Zyklische aminderivate und ihre verwendung
TWI263636B (en) 1999-09-16 2006-10-11 Ciba Sc Holding Ag Fluorescent maleimides and use thereof
US6957214B2 (en) 2000-06-23 2005-10-18 The Johns Hopkins University Architecture for distributed database information access
US6620823B2 (en) 2000-07-11 2003-09-16 Bristol-Myers Squibb Pharme Company Lactam metalloprotease inhibitors
US20040072860A1 (en) 2000-09-29 2004-04-15 Bing-Yan Zhu Piperazin-2-one amides as inhibitors of factor xa
CA2432369A1 (en) * 2000-12-20 2002-08-08 Bristol-Myers Squibb Pharma Company Cyclic derivatives as modulators of chemokine receptor activity
JP2005506949A (ja) 2000-12-20 2005-03-10 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー ケモカイン受容体の調節剤としてのジアミン
EP1368354A1 (en) 2001-03-07 2003-12-10 Pfizer Products Inc. Modulators of chemokine receptor activity
CA2341779A1 (en) 2001-03-20 2002-09-20 Marco Blouin Inert electrode material in nanocrystalline powder form
GB0114867D0 (en) 2001-06-18 2001-08-08 Merck Sharp & Dohme Therapeutic agents
WO2003043988A1 (fr) 2001-11-22 2003-05-30 Ono Pharmaceutical Co., Ltd. Composes derives de piperidine-2-one et medicaments contenant lesdits composes comme principes actifs
WO2003075853A2 (en) 2002-03-08 2003-09-18 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
TW200508224A (en) * 2003-02-12 2005-03-01 Bristol Myers Squibb Co Cyclic derivatives as modulators of chemokine receptor activity
US7338975B2 (en) * 2003-02-12 2008-03-04 Bristol-Myers Squibb Co. Lactams as modulators of chemokine receptor activity
US7230133B2 (en) * 2003-05-01 2007-06-12 Bristol-Myers Squibb Company Malonamides and malonamide derivatives as modulators of chemokine receptor activity
US7291615B2 (en) 2003-05-01 2007-11-06 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity

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ATE448200T1 (de) 2009-11-15
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