PE20040122A1 - Derivados de aminometil cromano di-sustituido como agonistas de beta-3-adreno-receptores - Google Patents

Derivados de aminometil cromano di-sustituido como agonistas de beta-3-adreno-receptores

Info

Publication number
PE20040122A1
PE20040122A1 PE2002000489A PE2002000489A PE20040122A1 PE 20040122 A1 PE20040122 A1 PE 20040122A1 PE 2002000489 A PE2002000489 A PE 2002000489A PE 2002000489 A PE2002000489 A PE 2002000489A PE 20040122 A1 PE20040122 A1 PE 20040122A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
hypertriglyceridemia
nr1r1
halo
Prior art date
Application number
PE2002000489A
Other languages
English (en)
Inventor
Gaetan H Ladouceur
William H Bullock
Steven R Magnuson
Stephen J O'connor
Roger A Smith
Quanrong Shen
Qingjie Liu
Ning Su
Emil J Velthuisen
Ann-Marie Campbell
Paul P Ehrlich
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of PE20040122A1 publication Critical patent/PE20040122A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A DERIVADOS CROMANOS DE FORMULA I, DONDE: R ES HIDROXI, OXO, HALO, CIANO, NITRO, ALQUILO C1-C10 OPCIONALMENTE SUSTITUIDO CON FENILO, HALOALQUILO C1-C10, CF3, NR1R1, SR1, OR1, SO2R2, ENTRE OTROS; R1 ES H, (CH2)d-O-(CH2)dR5, ALQUILO C1-C10 OPCIONALMENTE SUSTITUIDO CON HIDROXI, HALO, CO2-ALQUILO C1-C4, ENTRE OTROS; d ES 1-3; R2 ES R1, OR1, NR1R1, NHS(O)bFENILO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; R3 ES H, ALQUILO C1-C10, BENCILO, COR2; R4 ES H, ALQUILO C1-C10, ALQUILO C1-C10-FENILO, ALQUILO C1-C10-PIRIDINA, ENTRE OTROS; R5 ES H O COOH; Ar ES FENILO OPCIONALMENTE FUSIONADO A UN CICLOHEXILO, FENILO, HETEROCICLO DE 5-6 MIEMBROS; X ES O, S(O)b; Y ES HALO, R1, OR1, SR1, CO2R1, NR1R1, S(O)b-FENILO-CO2R1, FENILO OPCIONALMENTE FUSIONADO CON FENILO, HETEROCICLO; a ES 0-5; b ES 0-2; e ES 1-2. SON COMPUESTOS PREFERIDOS (2S)-1-({[(2R)-6-YODO-3,4-DIHIDRO-2H-CROMEN-2-IL]METIL}AMINO)-3-FENOXI-2-PROPANOL; (2S)-1-(BENCIL{[(2R)-6-BROMO-3,4-DIHIDRO-2H-CROMEN-2-IL]METIL}AMINO)-3-FENOXI-2-PROPANOL, ENTRE OTROS; TAMBIEN SE REFIERE A UN METODO PARA LA PREPARACION Y A UNA COMPOSICION FARMACEUTICA . LOS COMPUESTOS SON AGONISTAS DEL RECEPTOR BETA-3 ADRENERGICO Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE DIABETES, TRASTORNOS DE LA GLUCOSA EN AYUNAS, TOLERANCIA DE LA GLUCOSA DETERIORADA, OBESIDAD, HIPERTRIGLICERIDEMIA, HIPERPLASIA PROSTATICA BENIGNA ,EFERMEDADES CARDIOVASCULARES Y ENFERMEDADES RELACIONADAS.
PE2002000489A 2000-12-11 2002-06-07 Derivados de aminometil cromano di-sustituido como agonistas de beta-3-adreno-receptores PE20040122A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25473500P 2000-12-11 2000-12-11

Publications (1)

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PE20040122A1 true PE20040122A1 (es) 2004-03-10

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ID=22965389

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Country Status (11)

Country Link
US (1) US6699860B2 (es)
EP (1) EP1343778A2 (es)
JP (1) JP2004524286A (es)
AR (1) AR035605A1 (es)
AU (1) AU2002228816A1 (es)
CA (1) CA2430992A1 (es)
HN (1) HN2001000275A (es)
PE (1) PE20040122A1 (es)
SV (1) SV2003000756A (es)
UY (1) UY27065A1 (es)
WO (1) WO2002048134A2 (es)

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Also Published As

Publication number Publication date
WO2002048134A3 (en) 2003-02-06
UY27065A1 (es) 2002-07-31
US20030078258A1 (en) 2003-04-24
US6699860B2 (en) 2004-03-02
EP1343778A2 (en) 2003-09-17
SV2003000756A (es) 2003-01-13
JP2004524286A (ja) 2004-08-12
AU2002228816A1 (en) 2002-06-24
WO2002048134A2 (en) 2002-06-20
CA2430992A1 (en) 2002-06-20
AR035605A1 (es) 2004-06-16
HN2001000275A (es) 2003-10-17

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