PE20030448A1 - Formas pseudopolimorficas de caverdilol - Google Patents
Formas pseudopolimorficas de caverdilolInfo
- Publication number
- PE20030448A1 PE20030448A1 PE2002000938A PE2002000938A PE20030448A1 PE 20030448 A1 PE20030448 A1 PE 20030448A1 PE 2002000938 A PE2002000938 A PE 2002000938A PE 2002000938 A PE2002000938 A PE 2002000938A PE 20030448 A1 PE20030448 A1 PE 20030448A1
- Authority
- PE
- Peru
- Prior art keywords
- refers
- forms
- pseudopolymorphic form
- pseudopolimorphic
- caverdilol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A LA FORMA PSEUDOPOLIMORFICA DE (+/-) 1-(4-CARBAZOLILOXI)-3-[2-(2-METOXIFENOXI)ETILAMINO]-2-PROPANOL O FORMAS OPTICAMENTE ACTIVAS O SALES FARMACEUTICAMENTE ACEPTABLES. LA FORMA PSEUDOPOLIMORFICA ES UN HIDRATO Y PRESENTA UN PATRON DE DIFRACCION DE RAYOS X CARACTERISTICO OBTENIDO CON UNA RADIACION DE Cu kO1- A 2 0 IGUAL 7,0; 8,3; 11,5; 15,7; 17,2, UN ESPECTRO INFRARROJO CON PICOS AGUDOS A 3526 cm-1, 3492 cm-1 Y 3400 cm-1 Y UN PUNTO DE FUSION APROXIMADO DE T = 94°C A 96°C. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DE 5% A 60% DEL COMPUESTO MENCIONADO; UNO O MAS ADYUVANTES QUE NO SON ACTIVOS EN SUPERFICIE SELECCIONADO DE POLIETILENGLICOL CON UN PESO MOLECULAR DE 200 A 20 000; UNO O MAS TENSIOACTIVOS NO INONICOS COMO POLIOXIETILEN-POLIOXIPROPILENO Y DIOXIDO DE SILICO ALTAMENTE DISPERSADO. LA COMPOSICION ES UTIL PARA EL TRATAMIENTO DE HIPERTENSION, INSUFICIENCIA CARDIACA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01123422 | 2001-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030448A1 true PE20030448A1 (es) | 2003-06-19 |
Family
ID=8178782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000938A PE20030448A1 (es) | 2001-09-28 | 2002-09-24 | Formas pseudopolimorficas de caverdilol |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20030119893A1 (es) |
| EP (1) | EP1432681B1 (es) |
| JP (1) | JP2005507899A (es) |
| KR (1) | KR100752549B1 (es) |
| CN (1) | CN1308307C (es) |
| AR (1) | AR036689A1 (es) |
| AT (1) | ATE369339T1 (es) |
| AU (1) | AU2002338726B2 (es) |
| BR (1) | BR0212927A (es) |
| CA (1) | CA2460486A1 (es) |
| DE (1) | DE60221683T2 (es) |
| ES (1) | ES2291503T3 (es) |
| GT (1) | GT200200198A (es) |
| MX (1) | MXPA04002826A (es) |
| PA (1) | PA8555201A1 (es) |
| PE (1) | PE20030448A1 (es) |
| PL (1) | PL370412A1 (es) |
| RU (1) | RU2308449C2 (es) |
| UY (1) | UY27461A1 (es) |
| WO (1) | WO2003029214A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1245974C (zh) * | 2000-06-28 | 2006-03-22 | 特瓦制药工业有限公司 | 卡维地洛 |
| MXPA04006909A (es) * | 2002-01-15 | 2005-04-19 | Teva Pharma | Solidos cristalinos de carvedilol y procesos para su preparacion. |
| CN1678305A (zh) | 2002-06-27 | 2005-10-05 | Sb药物波多黎各公司 | 卡维地洛磷酸盐和/或其溶剂合物和/或相应组合物和/或治疗方法 |
| SI21616A (sl) * | 2003-09-02 | 2005-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nove kristalne oblike karvedilola |
| US20070043099A1 (en) * | 2005-06-09 | 2007-02-22 | Igor Lifshitz | Crystalline forms of carvedilol and processes for their preparation |
| WO2008002683A2 (en) * | 2006-06-28 | 2008-01-03 | Teva Pharmaceutical Industries Ltd. | Polymorphous forms of carvedilol phosphate |
| US20080292695A1 (en) * | 2006-12-01 | 2008-11-27 | Kristin Arnold | Carvedilol forms, compositions, and methods of preparation thereof |
| US20090028935A1 (en) * | 2006-12-01 | 2009-01-29 | Kristin Arnold | Carvedilol forms, compositions, and methods of preparation thereof |
| EP2114881A1 (en) * | 2007-02-26 | 2009-11-11 | Teva Pharmaceutical Industries Ltd. | Process for the purification of carvedilol or its salts thereof |
| US20080249317A1 (en) * | 2007-04-04 | 2008-10-09 | Apotex Inc. | Novel amorphous form of carvedilol phosphate and processes for the preparation thereof |
| TWI415604B (zh) | 2009-09-29 | 2013-11-21 | Tsh Biopharm Corp Ltd | 調控釋放卡菲蒂羅劑型 |
| US20110229564A1 (en) * | 2010-03-22 | 2011-09-22 | Amneal Pharmaceuticals, L.L.C. | Pharmaceutical Compositions Of Carvedilol Salts And Process For Preparation Thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3319027A1 (de) * | 1983-05-26 | 1984-11-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten |
| US5393772A (en) * | 1993-11-24 | 1995-02-28 | Boehringer Mannheim Pharmaceuticals Corporation | Use of, and method of treatment using, hydroxycarbazole compounds for inhibition of smooth muscle migration and proliferation |
| EP0893440A1 (en) * | 1997-07-22 | 1999-01-27 | Roche Diagnostics GmbH | Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it |
| US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
| CN1245974C (zh) * | 2000-06-28 | 2006-03-22 | 特瓦制药工业有限公司 | 卡维地洛 |
-
2002
- 2002-09-18 CN CNB028187415A patent/CN1308307C/zh not_active Expired - Fee Related
- 2002-09-18 AT AT02777139T patent/ATE369339T1/de not_active IP Right Cessation
- 2002-09-18 RU RU2004113209/04A patent/RU2308449C2/ru not_active IP Right Cessation
- 2002-09-18 BR BR0212927-2A patent/BR0212927A/pt not_active IP Right Cessation
- 2002-09-18 ES ES02777139T patent/ES2291503T3/es not_active Expired - Lifetime
- 2002-09-18 WO PCT/EP2002/010451 patent/WO2003029214A1/en active IP Right Grant
- 2002-09-18 CA CA002460486A patent/CA2460486A1/en not_active Abandoned
- 2002-09-18 EP EP02777139A patent/EP1432681B1/en not_active Expired - Lifetime
- 2002-09-18 DE DE60221683T patent/DE60221683T2/de not_active Expired - Fee Related
- 2002-09-18 PL PL02370412A patent/PL370412A1/xx not_active Application Discontinuation
- 2002-09-18 KR KR1020047004578A patent/KR100752549B1/ko not_active IP Right Cessation
- 2002-09-18 MX MXPA04002826A patent/MXPA04002826A/es active IP Right Grant
- 2002-09-18 JP JP2003532464A patent/JP2005507899A/ja active Pending
- 2002-09-18 AU AU2002338726A patent/AU2002338726B2/en not_active Ceased
- 2002-09-24 PE PE2002000938A patent/PE20030448A1/es not_active Application Discontinuation
- 2002-09-25 PA PA20028555201A patent/PA8555201A1/es unknown
- 2002-09-26 US US10/255,290 patent/US20030119893A1/en not_active Abandoned
- 2002-09-27 AR ARP020103656A patent/AR036689A1/es not_active Application Discontinuation
- 2002-09-27 UY UY27461A patent/UY27461A1/es not_active Application Discontinuation
- 2002-09-27 GT GT200200198A patent/GT200200198A/es unknown
-
2004
- 2004-04-20 US US10/827,859 patent/US20040198812A1/en not_active Abandoned
-
2006
- 2006-01-05 US US11/325,754 patent/US20060148878A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002338726B9 (en) | 2003-04-14 |
| GT200200198A (es) | 2003-06-19 |
| EP1432681B1 (en) | 2007-08-08 |
| CN1558900A (zh) | 2004-12-29 |
| RU2308449C2 (ru) | 2007-10-20 |
| PL370412A1 (en) | 2005-05-30 |
| KR20040047872A (ko) | 2004-06-05 |
| MXPA04002826A (es) | 2004-07-02 |
| ATE369339T1 (de) | 2007-08-15 |
| ES2291503T3 (es) | 2008-03-01 |
| DE60221683D1 (en) | 2007-09-20 |
| UY27461A1 (es) | 2003-06-30 |
| CA2460486A1 (en) | 2003-04-10 |
| US20030119893A1 (en) | 2003-06-26 |
| RU2004113209A (ru) | 2005-05-20 |
| JP2005507899A (ja) | 2005-03-24 |
| CN1308307C (zh) | 2007-04-04 |
| AR036689A1 (es) | 2004-09-29 |
| US20040198812A1 (en) | 2004-10-07 |
| WO2003029214A1 (en) | 2003-04-10 |
| AU2002338726B2 (en) | 2007-03-15 |
| KR100752549B1 (ko) | 2007-08-30 |
| DE60221683T2 (de) | 2008-04-30 |
| US20060148878A1 (en) | 2006-07-06 |
| BR0212927A (pt) | 2004-10-13 |
| PA8555201A1 (es) | 2003-12-10 |
| EP1432681A1 (en) | 2004-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |