PE20030119A1 - Derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6 - Google Patents
Derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6Info
- Publication number
- PE20030119A1 PE20030119A1 PE2002000503A PE2002000503A PE20030119A1 PE 20030119 A1 PE20030119 A1 PE 20030119A1 PE 2002000503 A PE2002000503 A PE 2002000503A PE 2002000503 A PE2002000503 A PE 2002000503A PE 20030119 A1 PE20030119 A1 PE 20030119A1
- Authority
- PE
- Peru
- Prior art keywords
- piperazin
- indol
- alkyl
- benzenosulfonil
- alcoxyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A DERIVADOS DE 4-PIPERAZINIL INDOL DE FORMULA I DONDE R1 ES H, HALO, HALOALQUILO, ALQUILO C1-C6; R2 ES H, ALQUILO C1-C6, ALCOXILO C1-C6, TIOALQUILO C1-C6; R3 ES SO2Ar; Ar ES ARILO, HETEROARILO OPCIONALMENTE SUSTITUIDO CON ALQUILO, ALCOXILO, TIOALQUILO, HALO, HALOALQUILO, HIDROXIALQUILO, NITRO, ENTRE OTROS; R4 ES H, HALOGENO, ALQUILO C1-C6, ALCOXILO C1-C6, TIOALQUILO C1-C6, TRIFLUOROMETILO, CIANO, ACILO; R5 ES H, BENCILO, ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS 1-(NAFTALEN-1-SULFONIL)-4-PIPERAZIN-1-IL-1H-INDOL; 1-(3,5-DICLORO-BENCENOSULFONIL)-4-PIPERAZIN-1-IL-1H-INDOL; 1-BENCENOSULFONIL-4-PIPERAZIN-1-IL-1H-INDOL; 4-PIPERAZIN-1-IL-1-(3-TRIFLUOROMETIL-BENCENOSULFONIL)-1H-INDOL; 1-(4-METOXI-BENCENOSULFONIL)-4-PIPERAZIN-1-IL-1H-INDOL, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON AGONISTAS DEL RECEPTOR 5-HIDROXITRIPTAMINA 5-HT6 Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE ALZHEIMER, HUNTINGTON, PSICOSIS, ESQUIZOFRENIA, DEPRESIONES MANIACAS, TRASTORNOS DE DEFICIT DE ATENCION, ESCLEROSIS LATERAL AMIOTROFICA
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29883401P | 2001-06-15 | 2001-06-15 | |
US37874802P | 2002-05-08 | 2002-05-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20030119A1 true PE20030119A1 (es) | 2003-02-13 |
Family
ID=26970893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2002000503A PE20030119A1 (es) | 2001-06-15 | 2002-06-12 | Derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6 |
Country Status (15)
Country | Link |
---|---|
US (1) | US6790848B2 (es) |
EP (1) | EP1401812B1 (es) |
JP (1) | JP2005501019A (es) |
KR (1) | KR20040010709A (es) |
AR (1) | AR036057A1 (es) |
AT (1) | ATE331707T1 (es) |
BR (1) | BR0210411A (es) |
CA (1) | CA2450245A1 (es) |
DE (1) | DE60212841T2 (es) |
ES (1) | ES2268113T3 (es) |
MX (1) | MXPA03011638A (es) |
PA (1) | PA8547901A1 (es) |
PE (1) | PE20030119A1 (es) |
UY (1) | UY27336A1 (es) |
WO (1) | WO2002102774A1 (es) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA006132B1 (ru) * | 2000-10-20 | 2005-10-27 | Биовитрум Аб | 2-, 3-, 4- или 5-замещенные n-(1-(арил-, гетероарил- или арилалкил)сульфонил)индолы и их применение в терапии |
JP4455064B2 (ja) | 2002-03-27 | 2010-04-21 | グラクソ グループ リミテッド | キノリン誘導体および5−ht6リガンドとしてのその使用 |
RU2327685C2 (ru) * | 2002-09-17 | 2008-06-27 | Ф.Хоффманн-Ля Рош Аг | 2,7-замещенные индолы и фармацевтическая композиция, проявляющая антагонистическую активность по отношению к 5-гт6 рецептору |
PL378754A1 (pl) * | 2003-03-03 | 2006-05-15 | F.Hoffmann-La Roche Ag | 2,5- i 2,6-Podstawione tetrahydroizochinoliny do stosowania jako modulatory 5-HT6 |
WO2004080407A2 (en) * | 2003-03-07 | 2004-09-23 | Predix Pharmaceuticals Holdings, Inc. | New serotonin modulating compounds and uses therefor |
ATE407671T1 (de) * | 2003-05-09 | 2008-09-15 | Esteve Labor Dr | Verwendung von sulfonamid-derivate zur herstellung eines medikaments für die vorbeugung oder behandlung von essstörungen |
ES2219181B1 (es) * | 2003-05-09 | 2005-12-16 | Laboratorios Del Dr. Esteve, S.A. | Uso de derivados de sulfonamidas para la fabricacion de un medicamento para la profilaxis y/o tratamiento de las disfunciones alimentarias. |
ATE313532T1 (de) | 2003-07-22 | 2006-01-15 | Arena Pharm Inc | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
US7795266B2 (en) * | 2003-09-25 | 2010-09-14 | Helton David R | Tetrahydroindolone derivatives for treament of neurological conditions |
SE0302760D0 (sv) * | 2003-10-20 | 2003-10-20 | Biovitrum Ab | New compounds |
KR100843053B1 (ko) * | 2004-01-16 | 2008-07-01 | 에프. 호프만-라 로슈 아게 | 중추 신경계 질환의 치료를 위한 5-하이드록시트립트아민수용체(5-ht)의 조절제로서1-벤질-5-피페라진-1-일-3,4-다이하이드로-1h-퀴나졸린-2-온 유도체 및 각각의1h-벤조(1,2,6)티아다이아진-2,2-다이옥사이드 및1,4-다이하이드로-벤조(d)(1,3)옥사진-2-온 유도체 |
US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
RU2420318C2 (ru) | 2004-09-30 | 2011-06-10 | Ф.Хоффманн-Ля Рош Аг | Композиции и способы для лечения когнитивных расстройств |
US7678823B2 (en) * | 2004-10-04 | 2010-03-16 | Myriad Pharmaceticals, Inc. | Compounds for alzheimer's disease |
US9216966B2 (en) | 2004-10-04 | 2015-12-22 | John Manfredi | Compounds for Alzheimer's disease |
MX2008010481A (es) * | 2006-02-17 | 2008-12-19 | Memory Pharm Corp | Compuestos que tienen afinado para el receptor f-ht6. |
AU2007234399A1 (en) * | 2006-04-04 | 2007-10-11 | Myriad Genetics, Inc. | Compounds for diseases and disorders |
WO2008003703A1 (en) | 2006-07-03 | 2008-01-10 | Biovitrum Ab (Publ) | Indoles as 5-ht6 modulators |
MX2009004898A (es) * | 2006-11-09 | 2009-05-19 | Hoffmann La Roche | Derivados de indol y de benzofurano-2-carboxamida. |
CN101730680A (zh) * | 2007-05-24 | 2010-06-09 | 记忆医药公司 | 具有5-ht6受体亲和力的4’取代的化合物 |
KR20100053626A (ko) * | 2007-08-15 | 2010-05-20 | 메모리 파마슈티칼스 코포레이션 | 5-ht6 수용체 친화성을 나타내는 3'-치환된 화합물 |
WO2009062134A1 (en) * | 2007-11-09 | 2009-05-14 | Cenomed Biosciences, Llc | Treatment of post-traumatic stress disorder with tetrahydroindolone arylpiperazine compounds |
WO2009074607A1 (en) | 2007-12-12 | 2009-06-18 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US20090264443A1 (en) * | 2008-04-18 | 2009-10-22 | David Helton | Treatment of organophosphate exposure with tetrahydroindolone arylpiperazine compounds |
US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
WO2010062321A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2h-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto |
UA100192C2 (en) | 2008-11-11 | 2012-11-26 | УАЙТ ЭлЭлСи | 1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands |
US8367676B2 (en) | 2009-06-30 | 2013-02-05 | Astrazeneca Ab | 2-carboxamide-7-piperazinyl-benzofuran derivatives 774 |
WO2011088836A1 (en) | 2010-01-25 | 2011-07-28 | H. Lundbeck A/S | NOVEL 4-(ARYL-4-SULFONYL)-6,6a,7,8,9,10-HEXAHYDRO-4H-4,8,10a-TRIAZA-ACEPHENANTHRYLENE AND 3-ARYLSULFONYL-6,6a,7,8,9,10-HEXAHYDRO-3H-3,8,10a-TRIAZA-CYCLOPENTA[C]FLUORENE DERIVATIVES AS SEROTONIN 5-HT6 LIGANDS |
US20120157494A1 (en) * | 2010-12-16 | 2012-06-21 | Harris Iii Ralph New | Isoindolyl compounds |
KR20130132932A (ko) | 2010-12-20 | 2013-12-05 | 아스트라제네카 아베 | 2-카르복스아미드-4-피페라지닐-벤조푸란 유도체 |
WO2015090233A1 (en) | 2013-12-20 | 2015-06-25 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
AU2015286049B2 (en) * | 2014-07-08 | 2018-03-01 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
WO2016201373A1 (en) | 2015-06-12 | 2016-12-15 | Axovant Sciences Ltd. | Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of rem sleep behavior disorder |
CN108472285A (zh) | 2015-07-15 | 2018-08-31 | 阿速万科学有限责任公司 | 用于预防和治疗与神经退行性疾病相关联的幻觉的二芳基和芳基杂芳基脲衍生物 |
WO2017052394A1 (en) | 2015-09-23 | 2017-03-30 | Uniwersytet Jagielloński | Imidazopyridine compounds and their use as 5-ht6 receptor ligands |
WO2020148679A1 (en) | 2019-01-17 | 2020-07-23 | ViiV Healthcare UK (No.4) Limited | Process for preparing fostemsavir |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60190761A (ja) | 1984-03-09 | 1985-09-28 | Sagami Chem Res Center | 4−アミノインド−ルの製造方法 |
DE69417427T2 (de) * | 1993-09-03 | 1999-11-25 | Smithkline Beecham P.L.C., Brentford | Indol- und indolin-derivate als 5ht1d rezeptor antagonisten |
MX9700693A (es) | 1994-07-26 | 1997-04-30 | Pfizer | Derivados del 4-indol. |
DZ2376A1 (fr) | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
US6194410B1 (en) | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
US6251893B1 (en) | 1998-06-15 | 2001-06-26 | Nps Allelix Corp. | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
DE19934433A1 (de) * | 1999-07-22 | 2001-01-25 | Merck Patent Gmbh | N-(Indolcarbonyl-)piperazinderivate |
AU1542201A (en) | 1999-11-05 | 2001-05-14 | Nps Allelix Corp. | Compounds having 5-HT6 receptor antagonist activity |
SE0002754D0 (sv) * | 2000-07-21 | 2000-07-21 | Pharmacia & Upjohn Ab | New pharmaceutical combination formulation and method of treatment with the combination |
EA006132B1 (ru) * | 2000-10-20 | 2005-10-27 | Биовитрум Аб | 2-, 3-, 4- или 5-замещенные n-(1-(арил-, гетероарил- или арилалкил)сульфонил)индолы и их применение в терапии |
EA006205B1 (ru) * | 2000-11-02 | 2005-10-27 | Уайт | 1-арил- или 1-алкилсульфонилгетероциклилбензазолы в качестве лигандов 5-гидрокситриптамина-6 |
ATE337780T1 (de) * | 2000-11-24 | 2006-09-15 | Smithkline Beecham Plc | Indoly-lsulphonyl-verbindungen zur behandlung von störungen des zns |
-
2002
- 2002-06-06 ES ES02780760T patent/ES2268113T3/es not_active Expired - Lifetime
- 2002-06-06 BR BR0210411-3A patent/BR0210411A/pt not_active Application Discontinuation
- 2002-06-06 CA CA002450245A patent/CA2450245A1/en not_active Abandoned
- 2002-06-06 MX MXPA03011638A patent/MXPA03011638A/es unknown
- 2002-06-06 DE DE60212841T patent/DE60212841T2/de not_active Expired - Fee Related
- 2002-06-06 EP EP02780760A patent/EP1401812B1/en not_active Expired - Lifetime
- 2002-06-06 JP JP2003505317A patent/JP2005501019A/ja active Pending
- 2002-06-06 WO PCT/EP2002/006201 patent/WO2002102774A1/en active IP Right Grant
- 2002-06-06 KR KR10-2003-7016359A patent/KR20040010709A/ko not_active Application Discontinuation
- 2002-06-06 AT AT02780760T patent/ATE331707T1/de not_active IP Right Cessation
- 2002-06-12 PA PA20028547901A patent/PA8547901A1/es unknown
- 2002-06-12 PE PE2002000503A patent/PE20030119A1/es not_active Application Discontinuation
- 2002-06-14 UY UY27336A patent/UY27336A1/es not_active Application Discontinuation
- 2002-06-14 US US10/172,360 patent/US6790848B2/en not_active Expired - Fee Related
- 2002-06-14 AR ARP020102239A patent/AR036057A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
JP2005501019A (ja) | 2005-01-13 |
DE60212841D1 (de) | 2006-08-10 |
WO2002102774A1 (en) | 2002-12-27 |
MXPA03011638A (es) | 2004-04-02 |
ATE331707T1 (de) | 2006-07-15 |
DE60212841T2 (de) | 2007-06-21 |
EP1401812A1 (en) | 2004-03-31 |
BR0210411A (pt) | 2004-08-17 |
PA8547901A1 (es) | 2003-12-10 |
AR036057A1 (es) | 2004-08-04 |
US20030045527A1 (en) | 2003-03-06 |
US6790848B2 (en) | 2004-09-14 |
KR20040010709A (ko) | 2004-01-31 |
CA2450245A1 (en) | 2002-12-27 |
ES2268113T3 (es) | 2007-03-16 |
UY27336A1 (es) | 2002-12-31 |
EP1401812B1 (en) | 2006-06-28 |
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